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OPPI BRIEFS

A FACILE SYNTHESIS OF ACYL-PROTECTED FORMALDEHYDE CYANOHYDRINS

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Pages 373-374 | Received 17 Dec 1990, Published online: 18 Feb 2009

References

  • Dinizo , S. E. , Freerksen , R. W. , Pabst , W. E. and Watt , D. S. 1976 . J. Org. Chem. , 41 : 2846
  • Schwyzer , R. , Iselin , B. and Feurer , M. 1955 . Helv. Chim. Acta. , 38 : 69 (b) B. Iselin, M. Feurer and R. Schwyzer, ibid., 38, 1508(1955). (c) R. Schwyzer, B. Iselin, W. Rittel and P. Sieber, ibid., 39, 872(1956).
  • Sidhu , G. H. , Thyagarajan , G. and Mazharuddin , M. 1964 . Indian J. Chem. , 2 : 170 Due to the fact that there were two nucleophilic sites in salicylic acid, the amounts of chloroacetonitrile and Na2CO3 were doubled, to 10 mmol and 20 mmol, respectively. Attempts at selective cyanomethylation of either the acid or phenol were not successful, as only 5 was obtained when the usual quantities of reagents were used. The synthesis of aryl-protected formaldehyde cyanohydrins upon reaction of phenol with chloroacetonitrile under basic conditions has been noted

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