Metastasis of renal cell carcinoma to haemangioblastoma of the spinal cord in von Hippel-Lindau disease: case report and review of the literature

References

• McLendon RE, Tien RD. Russell and Rubinstein's Pathology of Tumours of the Nervous System. Vol. 2.6th ed. London: Arnold, 1998; Chapter 16, Genetic syndromes associated with tumors and/or hamartomas.
   Google Scholar
• Conway JE, Chou D, Clatterbuck RE, et al. Hemangioblastomas of the central nervous system in von Hippel-Lindau syndrome and sporadic disease. Neurosurgery 2001; 48: 55–63.
   PubMed Web of Science ®Google Scholar
• McEvoy AW, Benjamin E, Powell MP. Haemangioblastoma of a cervical sensory nerve root in von Hippel-Lindau syndrome. Eur Spine J 2000; 9: 434–6.
   Google Scholar
• Bret P, Streichenberger N, Guyotat J. Metastasis of renal cell carcinoma to a cerebellar haemangioblastoma in a patient with von Hippel-Lindau disease: a case report. Br J Neurosurg 1999; 13: 413–6.
   Google Scholar
• Crockard HA, Barnard RO, Isaacson PG. Metastasis of carcinoma to hemangioblastoma cerebelli: case report. Neurosurgery 1988; 23: 382–4.
   Google Scholar
• Jamjoon A, Kane N, Nicoll J. Metastasis of a renal cell carcinoma to a cerebellar hemangioblastoma in a case of von Hippel-Lindau disease. Neurosurg Rev 1992; 15: 231–4.
   Google Scholar
• Chacko AG, Rajshekar V, Chacko G. Testicular embryonal carci-noma metastasising to the site of a previously excised cerebellar hemangioblastoma. Br J Neurosurg 1996; 10: 194–200.
   Google Scholar
• Schmitt HP. Metastases of malignant neoplasms to intracranial tumours: the `tumour-in-a-tumour' phenomenon. Virchows Arch 1984; 405: 155–60.
   Web of Science ®Google Scholar
• Conzen M, Sollmann H, Schnabel R. Metastasis of lung carcinoma to intracranial meningioma. Case report and review of the literature. Neurochirurgia 1986; 29: 206–9.
   Google Scholar
• Pamphlett R. Carcinoma metastasis to meningioma. J Neurol Neurosurg Psychiatry 1984; 47: 561–3.
   PubMed Web of Science ®Google Scholar
• Andrew SM, Gradwell E. Immunoperoxidase labelled antibody staining in differential diagnosis of central nervous system haeman-gioblastomas and central nervous system metastases of renal carcinomas. J Clin Pathol 1986; 39: 917–9.
   PubMed Web of Science ®Google Scholar
• Clelland CA, Treip CS. Histological differentiation of metastatic renal cell carcinoma of the cerebellum from cerebellar haemangioblastoma in von Hippel-Lindau's disease. J Neurol Neurosurg Psychiatry 1989; 52: 162–6.
   PubMed Web of Science ®Google Scholar
• Gouldsborough DR, Bell JE, Gordon A. Use of immunohistochem-ical methods in the differential diagnosis between primary cerebellar haemangioblastoma and metastatic renal carcinoma. J Clin Pathol 1988; 41: 861–5.
   Google Scholar
• Mills SE, Ross GW, Perentes E, et al. Cerebellar hemangioblastoma: immunohistochemical distinction from metastatic renal cell carci-noma. Surg Pathol 1990; 3: 121–32.
   Google Scholar
• Decker HJH, Weidt EJ, Brieger J. The von Hippel-Lindau tumour suppressor gene. Cancer Genet Cytogenet 1997; 93: 74–83.
   PubMedGoogle Scholar
• Richards FM, Webster AR, McMahon R, et al. Molecular genetic analysis of von Hippel-Lindau disease. J Intern Med 1998; 243: 527–33.
   PubMed Web of Science ®Google Scholar
• Shui T, Kondo K, Torigoe S, et al. Frequent somatic mutations and loss of heterozygosity of the von Hippel-Lindau tumor suppressor gene in primary renal cell carcinomas. Cancer Res 1994; 54: 2852–5.
   PubMed Web of Science ®Google Scholar
• Ohh M, Kaelin WG. The von Hippel-Lindau tumor suppressor protein: new perspectives. Mol Med Today 1999; 5: 257–63.
   PubMedGoogle Scholar
• Iliopolous 0, Levy AP, Jiang C, et al. Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein. Proc Natl Acad Sci USA 1996; 93: 10 595–9.
   Google Scholar
• Gnarra JR, Zhou S, Merril MJ, et al. Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene. Proc Natl Acad Sci USA 1996; 93: 10 589–94.
   PubMed Web of Science ®Google Scholar
• Krieg M, Marti HH, Plate KH. Coexpression of erythropoietin and vascular endothelial growth factor in nervous system tumors associated with von Hippel-Lindau tumor suppressor gene loss of function. Blood 1998; 92: 3388–93.
   Google Scholar
• Yu F, White SB, Zhao Q, et al. Dynamic site specific interaction of hypoxia inducible factor 1a with the von Hippel-Lindau tumor suppressor protein. Cancer Res 2001; 61: 4136–42.
   PubMed Web of Science ®Google Scholar
• Tanimoto K, Makino Y, Pereira T, et al. Mechanism of regulation of the hypoxia-inducible factor 1a by the von Hippel-Lindau tumor suppressor protein. EMBO J 2000; 19: 4298–309.
   PubMed Web of Science ®Google Scholar
• Kamada M, Suzuki K, Kato Y, et al. von Hippel-Lindau protein promotes the assembly of actin and vinculin and inhibits cells motility. Cancer Res 2001; 61: 4184–9.
   PubMed Web of Science ®Google Scholar
• Ohh M, Yauch RL, Lonergan KM, et al. The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix. Mol Cell 1998; 1: 959–68.
   PubMed Web of Science ®Google Scholar
• Koochekpur S, Jeffers M, Wang PH, et al. The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphology in renal cell carcinoma cells. Mol Cell Biol 1999; 19: 5902–12.
   PubMed Web of Science ®Google Scholar
• Knebelmann B, Ananth S, Cohen HT, et al. Transforming growth factor a is a target for the von Hippel-Lindau tumor suppressor. Cancer Res 1998; 58: 226–31.
   PubMed Web of Science ®Google Scholar
• Ananth S, Knebelmann B, Gruning W, et al. Transforming growth factor ri1 is a target for the von Hippel-Lindau tumor suppressor and a critical growth factor for clear cell carcinoma. Cancer Res 1999; 59: 2210–6.
   PubMed Web of Science ®Google Scholar
• Campbell LV, Gilbert E, Chamberlain CR, et al. Metastases of cancer to cancer. Cancer 1968; 22: 635–43.
   PubMed Web of Science ®Google Scholar
• Pasqualini R, Bourdoulous S, Koivunen E, et al. A polymeric form of fibronectin has antimetastatic effects against multiple tumor types. Nat Med 1996; 2: 1197–203.
   PubMed Web of Science ®Google Scholar