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Melanocytic Pathology

Spitz naevus: diagnostic problems and their management implications

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Pages 452-457 | Received 28 Jun 2004, Accepted 28 Jun 2004, Published online: 06 Jul 2009

References

  • Weedon D, Little JH. Spindle and epithelioid cell naevi in children and adults. A review of 211 cases of the Spitz nevus. Cancer 1977; 40: 217–25.
  • Mooi WJ. Spitz nevus and its histological simulators. Adv Anat Pathol 2002; 9: 209–21.
  • Binder SW, Asnong C, Paul E, Cochran AJ. The histology and differential diagnosis of Spitz nevus. Semin Diagn Pathol 1993; 10: 36–46.
  • Crotty KA, Scolyer RA, Li LW, Palmer AA, Wang L, McCarthy SW. Spitz naevus versus Spitzoid melanoma: when and how can they be distinguished? Pathology 2002; 34: 6–12.
  • Weedon D. In: Skin Pathology. 2nd ed. London: Churchill Living-stone, 2002; 810–4.
  • Elder DE, Murphy GF. Atlas of Tumor Pathology: Melanocytic Tumors of the Skin. 3rd Series, Fascicle 2. Washington, DC: Armed Forces Institute of Pathology, 1991; 40–57.
  • Barnhill RL, Barnhill MA, Berwick M, Mihm Jr MC. The histologic spectrum of pigmented spindle cell nevus: a review of 120 cases with emphasis on atypical variants. Hum Pathol 1991; 22: 52–8.
  • Busam KJ, Barnhill RL. Pagetoid Spitz nevus. Intraepidermal Spitz tumor with prominent pagetoid spread. Am J Surg Pathol 1995; 19: 1061–7.
  • Hoang MP. Myxoid Spitz nevus. J Cutan Pathol 2003; 30: 566–8.
  • Liu J, Cohen PR, Farhood A. Hyalinizing Spitz nevus: spindle and epithelioid cell nevus with paucicellular collagenous stroma. South Med J 2004; 97: 102–6.
  • Barnhill RL, Flotte TJ, Fleischli M, Perez-Atayde A. Cutaneous melanoma and atypical Spitz tumours in childhood. Cancer 1995; 76: 1833–45.
  • Spatz A, Calonje E, Handfield-Jones S, Barnhill RL. Spitz tumors in children: a grading system for risk stratification. Arch Dermatol 1999; 135: 282–5.
  • Peters MS, Goellner JR. Spitz naevi and malignant melanomas of childhood and adolescence. Histopathology 1986; 10: 1289–302.
  • McCarthy SW, Crotty KA, Palmer AA, Ng ABP, McCarthy WH, Shaw HM. Cutaneous malignant melanoma in teenagers. Histopathology 1994; 24: 453–61.
  • Orchard D, Dowling J, Kelly J. Spitz naevi histologically mis-diagnosed as melanoma: prevalence and clinical profile. Australas J Dermatol 1997; 38: 12–4.
  • Walsh N, Crotty K, Palmer A, McCarthy S. Spitz nevus versus spitzoid malignant melanoma: An evaluation of the current distin-guishing histopathologic criteria. Hum Pathol 1998; 29: 1105–12.
  • Kanter-Lewensohn L, Hedbald M-A, Wejde J, Larsson 0. Immuno-histochemical markers for distinguishing Spitz naevi from malignant melanomas. Mod Pathol 1997; 10: 917–20.
  • Li LX, Crotty KA, McCarthy SW, Palmer AA, Kril H. A zonal comparison of MIB1-Ki67 immunoreactivity in benign and malignant melanocytic lesions. Am J Dermatopathol 2000; 22: 489–95.
  • Bergman R, Dromi R, Trau H, Cohen I, Lichtig C. The pattern of HMB-45 antibody staining in compound Spitz nevi. Am J Dematopathol 1995; 17: 542–6.
  • Ribe A, McNutt NS. S100A6 protein expression is different in Spitz nevi and melanomas. Mod Pathol 2003; 16: 5005–11.
  • Harvell JD, Bastian BC, LeBoit PE. Persistent (recurrent) Spitz nevi: a histolopathologic, immunohistochemical, and molecular pathologic study of 22 cases. Am J Surg Pathol 2002; 26: 654–61.
  • Llewellyn K, Barnhill RL. Distinguishing Spitz tumours from malignant melanoma: potential role of comparative genomic hybri-dization and fluorescence in situ hybridization in diagnosis and prognosis. Adv Anatom Pathol 2001; 8: 249–54.
  • Bastian BC, Wesselmann U, Pinkel D, Leboit PE. Molecular cytogenetic analysis of Spitz nevi shows clear differences to melanoma. J Invest Dermatol 1999; 113: 1065–9.
  • Harvell JD, Kohler S, Zhu S, Hernandez-Boussard T, Pollack JR, van de Rijn M. High-resolution array-based comparative genomic hybridization for distinguishing paraffin-embedded Spitz nevi and melanomas. Diagn Mol Pathol 2004; 13: 22–5.
  • De Wit PE, Kerstens HM, Poddighe PJ, Van Muijen GN, Ruiter DJ. DNA insitu hybridization as a diagnostic tool in the discrimination of melanomas and Spitz naevus. J Pathol 1994; 173: 227–33.
  • Bastian BC, LeBoit PE, Pinkel D. Mutations and copy number increase of HRAS in Spitz nevi with distinctive histopathological features. Am J Pathol 2000; 157: 967–72.
  • Li LX, Crotty KA, Palmer AA, et al. Differentiating benign nevi from malignant melanoma using DNA microdensitometry and karyometry and maturation: a zonal comparison, correlation and multivariate analysis. Anal Quant Cytol Histol 2002; 24: 234–43.
  • Barnhill RL, Argenyi ZB, From L, et al. Atypical Spitz nevi/tumours: lack of consensus for diagnosis, discrimination from melanoma, and prediction of outcome. Hum Pathol 1999; 30: 513–20.
  • Gelbard SN, Tripp JM, Marghoob AA, et al. Management of Spitz nevi: a survey of dermatologists in the United States. J Am Acad Dermatol 2002; 47: 224–30.
  • LeBoit PE. "Safe" Spitz and its alternatives. Pediatr Dermatol 2002; 19: 163–5.
  • Murphy ME, Boyer JD, Stashower ME, Zitelli JA. The surgical management of Spitz nevi. Dermatol Surg 2002; 28: 1065–9.
  • Smith KJ, Barrett TL, Skelton HG 3rd, Lupton GP, Graham JH. Spindle cell and epithelioid cell nevi with atypia and metastasis (malignant Spitz nevus). Am J Surg Pathol 1989; 13: 931–9.
  • Ackerman AB, Mendonca AMN, Guo Y. Differential Diagnosis in Dermatopathology I. Philadelphia: Lea and Febiger, 1992; 146–9.
  • Su LD, Fullen DR, Sondak VK, Johnson TM, Lowe L. Sentinel lymph node biopsy for patients with problematic spitzoid melanocytic lesions: a report on 18 patients. Cancer 2003; 97: 499–507.
  • Lohmann CM, Coit DG, Brady MS, Berwick M, Busam KJ. Sentinel lymph node biopsy in patients with diagnostically controversial spitzoid melanocytic tumors. Am J Surg Pathol 2002; 26: 47–55.
  • Cascinelli N, Belli F, Santinami M, et al. Sentinel lymph node biopsy in cutaneous melanoma: the WHO Melanoma Program experience. Ann Surg Oncol 2000; 7: 469–74.
  • Gershenwald JE, Thompson W, Mansfield PF, et al. Multi-institutional melanoma lymphatic mapping experience: the prognostic value of sentinel lymph node status in 612 stage I or II melanoma patients. J Clin Oncol 1999; 17: 976–83.
  • Li LX, Scolyer RA, Ka VS, et al. Pathologic review of negative sentinel lymph nodes in melanoma patients with regional recurrence: a clinicopathologic study of 1152 patients undergoing sentinel lymph node biopsy. Am J Surg Pathol 2003; 27: 1197–202.
  • Morton DL, Thompson JF, Essner R, et al. Validation of the accuracy of intraoperative lymphatic mapping and sentinel lympha-denectomy for early-stage melanoma: a multicenter trial. Multicenter Selective Lymphadenectomy Trial Group. Ann Surg 1999; 230: 453–63.
  • Starz H, Balda BR, Kramer KU, Buchels H, Wang H. A micromorphometry-based concept for routine classification of sentinel lymph node metastases and its clinical relevance for patients with melanoma. Cancer 2001; 91: 2110–21.
  • Thompson JF, Shaw HM. Should tumor mitotic rate and patient age, as well as tumor thickness, be used to select melanoma patients for sentinel node biopsy? Ann Surg Oncol 2004; 11: 233–5.
  • Sondak VK, Taylor JMG, Sabel MS, et al. Mitotic rate and younger age are predictors of sentinel node positivity: lessons learned from the generation of a probabilistic model. Ann Surg Oncol 2004; 11: 247–58.

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