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Melanocytic Pathology

Pagetoid melanocytosis: when is it significant?

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Pages 435-444 | Received 23 Apr 2004, Accepted 26 Jun 2004, Published online: 06 Jul 2009

References

  • Haupt HM, Stern JB. Pagetoid melanocytosis. Histologic features in benign and malignant lesions. Am J Surg Pathol 1995; 19: 792–7.
  • Urso C. Pseudoinfiltration: an underrecognized feature in melanocytic lesions. Am J Dermatopathol 2002; 24: 183–4.
  • Cramer SF. Pagetoid infiltration and pseudoinfiltration - Another point of view. Am J Dermatopathol 2002; 24: 451.
  • Mooi WJ, Krausz T. Biopsy Pathology of Melanocytic Disorders. London: Chapman and Hall Medical, 1992.
  • Ainsworth AM, Folberg R, Reed RJ, Clark WH. Melanocytic nevi, melanocytomas, melanocytic dysplasias, and uncommon forms of melanoma. In: Clark WH, Goldman LI, Mastrangelo MJ, editors. Human Malignant Melanoma. New York: Grune and Stratton, 1979; 167–208.
  • Mancianti ML, Clark WH, Hayes FA, Herlyn M. Malignant melanoma simulants arising in congenital melanocytic nevi do not show experimental evidence for a malignant phenotype. Am J Pathol 1990; 136: 817–29.
  • Weedon D, Little JH. Spindle and epithelioid cell nevi in children and adults. A review of 211 cases of the Spitz nevus. Cancer 1977; 40: 217–25.
  • Mooi W. Spitz nevus and its histologic simulators. Adv Anat Pathol 2002; 9: 209–21.
  • Busam KJ, Barnhill RL. Pagetoid Spitz nevus. Intraepidermal Spitz tumor with prominent pagetoid spread. Am J Surg Pathol 1995; 19: 1061–7.
  • Crotty AK, Scolyer RA, Li LX, et al. Spitz naevus versus spitzoid melanoma: when and how can they be distinguished? Pathology 2002; 34: 6–12.
  • Scolyer RA, Crotty KA, Palmer AA, McCarthy SW. Pagetoid melanocytosis in Spitz naevi. Pathology 2002; 34: 592.
  • Walsh N, Crotty K, Palmer A, McCarthy S. Spitz nevus versus spitzoid malignant melanoma: An evaluation of the current distin-guishing histopathologic criteria. Hum Pathol 1998; 29: 1105–12.
  • Mones JM, Ackerman AB. Melanomas in prepubescent children. Am J Dermatopathol 2003; 25: 223–38.
  • Barnhill RL, Flotte Ti, Fleischli M, et al. Cutaneous melanoma and atypical Spitz tumors in childhood. Cancer 1995; 76: 1833–45.
  • Barnhill RL, Argenyi ZB, From L, et al. Atypical Spitz nevi/tumors: lack of consensus for diagnosis, discrimination from melanoma, and prediction of outcome. Hum Pathol 1999; 30: 513–20.
  • Bergman R, Dromi R, Trau H, et al. The pattern of HMB-45 antibody staining in compound Spitz nevi. Am J Dermatopathol 1995; 17: 542–6.
  • Kanter-Lewensohn L, Hedbald M-A, Wejde J, Larsson 0. Immuno-histochemical markers for distinguishing Spitz nevi from malignant melanomas. Mod Pathol 1997; 10: 917–20.
  • Nagasaki T, Lai R, Medeiros Li, et al. Cyclin DI expression in Spitz nevi: an immunohistochemical study. Am J Dermatopathol 1999; 21: 115–20.
  • Bergman R, Shemer A, Levy R, et al. Immunohistochemical study of p53 protein expression in Spitz nevus as compared with other melanocytic lesions. Am J Dermatopathol 1995; 17: 547–50.
  • Kaleem Z, Lind AC, Humphrey PA, et al. Concurrent Ki-67 and p53 immunolabeling in cutaneous melanocytic neoplasms: an adjunct for recognition of the vertical growth phase in malignant melanomas? Mod Pathol 2000; 13: 217–22.
  • Li LX, Crotty K, McCarthy S, Palmer A, Ng A, Stankovic R. Discrimination of Spitz nevi from melanoma by video image analysis. Int j Surg Pathol 1995; 2: 256–7.
  • Bastian BC, Wesselmann U, Pinkel D, LeBoit PE. Molecular cytogenetic analysis of Spitz nevi shows clear differences to melanoma. J Invest Dermatol 1999; 113: 1065–9.
  • Bastian BC, LeBoit PE, Pinkel D. Mutations and copy number increase of HRAS in Spitz nevi with distinctive histopathological features. Am J Pathol 2000; 157: 967–72.
  • Howat Ai, Wright AL, Cotton DW, Reeve S. AgNOR's in benign, dysplastic, and malignant melanocytic skin lesions. Am J Dermatopathol 1990; 12: 156–61.
  • Barnhill RL, Barnhill MA, Berwick M, Mihm MC Jr. The histologic spectrum of pigmented spindle cell nevus: a review of 120 cases with emphasis on atypical variants. Hum Pathol 1991; 22: 52–58.
  • Harvell J, White W. Persistent and recurrent blue nevi. Am J Dermatopathol 1999; 21: 506–17.
  • Ackerman AB, Cerroni L, Kerl H. Benign simulators of melanoma. In: Ackerman AB, Cerroni L, Kerl H. Pitfall In Histopathologic Diagnosis Of Malignant Melanoma. Philadelphia: Lea and Febiger, 1994; 182–247.
  • LeBoit, Philip E. Nevus, redux. Am J Dermatopathol 2001; 23: 491–3.
  • Hoang MP, Prieto VG, Burchette JL, Shea CR. Recurrent melanocytic nevus: a histologic and immunohistochemical evaluation. J Cutan Pathol 2001; 28: 400–6.
  • Tronnier M, Rudolph P, Koser T, et al. One single erythemagenic UV irradiation is more effective in increasing the proliferative activity of melanocytes in melanocytic naevi compared with fractionally applied high doses. Br J Dermatol 1997; 137: 534–9.
  • Tronnier M, Smolle J, Wolff HH. UV-irradiation induces acute changes in melanocytic nevi. J Invest Dermatol 1995; 104: 475–8.
  • Tronnier M, Wolff HH. UV-irradiated melanocytic nevi simulating melanoma in situ. Am J Dermatopathol 1995; 17: 1–6.
  • Rudolph P, Tronnier M, Menzel R, et al. Enhanced expression of Ki-67, topoisomerase II, PCNA, p53 and p2IWAFI/Cipl reflecting proliferation and repair activity in UV-irradiated melanocytic nevi. Hum Pathol 1998; 29: 1480–7.
  • Boni R, Matt D, Burg G, et al. Ultraviolet-induced acute histological changes in irradiated nevi are not associated with allelic loss. Arch Dermatol 1998; 134: 853–6.
  • Boyd AS, Rapini RP. Acral melanocytic neoplasms: A histologic analysis of 158 lesions. J Am Acad Dermatol 1994; 31: 740–5.
  • Clemente C, Zurrida S, Bartoli C, et al. Acral-lentiginous naevus of plantar skin. Histopathology 1995; 27: 549–55.
  • LeBoit PH. A diagnosis for maniacs. Am J Dermatopathol 2000; 22: 556.
  • Signoretti S, Annessi G, Puddu P, Faraggiana T. Melanocytic nevi of palms and soles: a histological study according to the plane of section. Am J Surg Pathol 1999; 23: 283–7.
  • Kerl H, Trau H, Ackerman AB. Differentiation of melanocytic nevi from malignant melanoma in palms, soles, and nail beds solely by signs in the cornified layer of the epidermis. Am J Dermatopathol 1994; 6: 159–61.
  • Rongioletti F, Urso C, Batolo D, et al. Melanocytic nevi of the breast: a histologic case-control study. J Cutan Pathol 2004; 31: 137–40.
  • Clark WH, Hood AF, Tucker MA, Jampel RM. Atypical melanocytic nevi of the genital type with a discussion of reciprocal parenchymal-stromal interactions in the biology of neoplasia. Hum Pathol 1998; 29 (Suppl 1): SI–24.
  • Christensen WN, Friedman KJ, Woodruff JD, Hood AF. Histologic characteristics of vulvar nevocellular nevi. J Cutan Pathol 1987; 14: 87–91.
  • Rongioletti F, Ball RA, Marcus R, Barnhill RL. Histopathological features of flexural melanocytic nevi: a study of 40 cases. J Cutan Pathol 2000; 27: 215.
  • Li G, Satyamoorthy K, Meier F, et al. Function and regulation of melanoma-stromal fibroblast interactions: when seed meets soil. Oncogene 2003; 22: 3162–71.
  • Ruiter D, Bogenrieder T, Elder D, Herlyn M. Melanoma-stroma interactions: structural and functional aspects. Lancet Oncology 2002; 3:35–43.
  • Gordon PR, Mansur CP, Gilchrest BA. Regulation of human melanocyte growth, dendricity, and melanization by keratinocytes derived factors. J Invest Dermatol 1989; 92: 565–72.
  • Tronnier M, Kammerer R, Wolff HH. Proliferative activity of keratinocytes correlates with that of melanocytes in nevi and melanomas. Arch Dermatol Res 1995; 287: 509–11.
  • Scott GA, Haake AR. Keratinocytes regulate melanocyte number in human fetal and neonatal skin equivalents. J Invest Dermatol 1991; 97: 776–81.
  • Tronnier M, Rasheed A. Relationship between keratinocyte proliferative activity, HMB-45 reactivity, and the presence of suprabasal melanocytes in acral nevi. Arch Dermatol Res 1998; 290: 167–70.
  • Maldonado JL, Fridlyand J, Patel H, et al. Determinants of BRAF mutations in primary melanomas. J Natl Cancer Inst 2003; 95: 1878–90.
  • Elwood JM, Gallagher RP. Body site distribution of cutaneous malignant melanoma in relationship to patterns of sun exposure. Int J Cancer 1998; 78: 276–80.
  • Morelli JG, Yohn JJ, Zekman T, Norris DA. Melanocyte movement in vitro: role of matrix proteins and integrin receptors. J Invest Dermatol 1993; 101: 605–8.
  • Zambruno G, Marchisio PC, Melchiori A, et al. Expression of integrin receptors and their role in adhesion, spreading and migration of normal human melanocytes. J Cell Sci 1993; 105: 179–90.
  • Tronnier M, Alexander M, Wolff HH. Adhesion molecule expression in normal skin and melanocytic lesions. Role of UV-irradiation and architectural characteristics in nevi. J Cutan Pathol 1997; 24: 278–85.
  • Tronnier M, Alexander M, Neitmann M, Brinckmann J, Wolff HH. Morphological changes in melanocytic nevi induced by exogenous factors. Hautarzt 2000; 51: 561–6.
  • Jamal S. Endothelin-1 down-regulates E-cadherin in melanocytic cells by apoptosis-independent activation of caspase-8. J Am Acad Dermatol 2000; 43: 703–4.
  • Jamal S, Schneider RJ. UV-induction of keratinocyte endothelin-1 downregulates E-cadherin in melanocytes and melanoma cells. J Clin Invest 2002; 110: 443–52.
  • Bagnato A, Rosano L, Spinella F, et al. Endothelin B receptor blockade inhibits dynamics of cell interactions and communications in melanoma cell progression. Cancer Res 2004; 64: 1436–43.
  • Baynash AG, Hosoda K, Giaid A, et al. Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons. Cell 1994; 79: 1277–85.
  • Forget MA, Desrosiers RR, Beliveau R. Physiological roles of matrix metalloproteinases: implications for tumour growth and metastasis. Can J Physiol Pharmacol 1999; 77: 465–80.
  • Elder D. Tumor progression, early diagnosis and prognosis of melanoma. Acta Oncologica 1999; 38: 535–47.
  • Hofmann UB, Westphal JR, Van Muijen GN, Ruiter DJ. Matrix metalloproteinases in human melanoma. J Invest Dermatol 2000; 115: 337–44.
  • Krengel S, Alexander M, Brinckmann J, Tronnier M. MMP-2, TIMP-2 and MT1-MMP are differentially expressed in lesional skin of melanocytic nevi and their expression is modulated by UVB-light. J Cutan Pathol 2002; 29: 390–6.

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