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Original Article

Localization of cytochromes P450 in human tissues: Implications for chemical toxicity

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Pages 148-155 | Accepted 11 Jan 1996, Published online: 06 Jul 2009

References

  • Nebert DW. Proposed role of drug-metabolizing enzymes: regulation of steady state ligands that affect growth, homeostasis, differentiation, and neuroendocrine functions. Mol Endocrinol 1991; 5: 1203–1214
  • Nebert DW. Growth signal pathways. Nature 1991; 347: 709–710
  • Nelson, DR, Kamataki, T, Waxman, DJ, et al. The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. DNA Cell Biol 1993; 12: 1–51
  • Gonzalez FJ. The molecular biology of cytochrome P450s. Pharmacol Rev 1989; 40: 243–288
  • Nebert DW, McKinnon RA. Cytochrome P450: evolution and diversity. Progress in Liver Diseases 1994; 14: 1–31
  • Johnson EF, Muller-Eberhard U. Resolution of two forms of cytochrome P-450 from liver microsomes of rabbits treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Biol Chem 1977; 252: 2839–2845
  • Goldstein, JA, Linko, P, Luster, MI, et al. Purification and characterizatin of a second form of hepatic cytochrome P-448 from rats treated with a pure polychlorinated biphenyl isomer. J Biol Chem 1982; 257: 2702–2707
  • Guengerich, FP, Dannan, GA, Wright, ST, et al. Purification and characterization of liver microsomal cytochromes P-450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or o-naphoflavone. Biochemistry 1982; 21: 6019–6030
  • McManus, ME, Burgess, WM, Veronese, ME, et al. Metabolism of 2-acetylaminofluorene and benzo(a)pyrene and activation of food-derived heterocyclic amine mutagens by human cytochromes P-450. Cancer Res 1990; 50: 3367–3376
  • Johnson, EF, Levitt, DS, Muller-Eberhard, U, et al. Catalysis of divergent pathways of 2-acetylaminofluorene metabolism by multiple forms of cytochrome P-450. Cancer Res 1980; 40: 4456–4459
  • McManus, ME, Minchin, RF, Sanderson, N, et al. Kinetics of 2-acetylaminofluorene metabolism by six highly purified forms of rabbit liver cytochrome P450. Carcinogenesis 1984; 5: 1717–1723
  • McManus, ME, Burgess, W, Synderwine, EG, et al. Specificity of rabbit cytochrome P-450 isozymes involved in the metabolic activation of the food derived mutagen 2-amino-3-methylimidazo[4,5-f]quinolone. Cancer Res 1988; 48: 4513–4519
  • McManus, ME, Burgess, W, Stupans, I, et al. Activation of the food-derived mutagen 2-amino-3-methylimidazo[4,5-f]quinolone by human-liver microsomes [published erratum appears in Mutat Res 1988; 206(1): 130]. Mutat Res 1988; 204: 185–193
  • McManus, ME, Felton, JS, Knize, MG, et al. Activation of the food-derived mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by rabbit and human liver microsomes and purified forms of cytochrome P-450. Carcinogenesis 1989; 10: 357–363
  • Aoyama T, Gonzalez FJ, Gelboin HV. Human cDNA-expressed cytochrome P450 1A2: mutagen activation and substrate specificity. Mol Carcinog 1989; 2: 192–198
  • Koop DR, Coon MJ. Ethanol oxidation and toxicity: role of alcohol P-450 oxygenase. Alcohol Clin Exp Res 1986; 10: 445–495
  • Feierman DE, Cederbaum AI. Increased sensitivity of the microsomal oxidation of ethanol to inhibition by pyrazole and 4-methylpyrazole after chronic ethanol treatment. Biochem Pharmacol 1987; 36: 3277–3283
  • Tredger, JM, Smith, HM, Read, RB, et al. Effects of ethanol ingestion on the hepatotoxicity and metabolism of paracetamol in mice. Toxicology 1985; 36: 341–345
  • Seeff, LB, Cuccherini, BA, Zimmerman, HJ, et al. Acetaminophen toxicity in alcoholics. Clin Rev 1986; 104: 399–404
  • Wrighton, SA, Thomas, PE, Ryan, DE, et al. Purification and characterization of ethanol-inducible human hepatic cytochrome P-450HLj. Arch Biochem Biophys 1987; 258: 292–297
  • Umeno, M, McBride, OW, Yang, CS, et al. Human ethanol-inducible P450IIE1: complete gene sequence, promoter characterization, chromosome mapping and cDNA-directed expression. Biochemistry 1987; 27: 9006–9013
  • Molowa, DT, Schuetz, EG, Wrighton, SA, et al. Complete cDNA sequence of a cytochrome P-450 inducible by glucocorticoids in human liver. Proc Natl Acad Sci USA 1986; 83: 8064–8068
  • Beaune, PH, Umbenhauer, DR, Bork, RW, et al. Isolation and sequence determination of a cDNA clone related to human cytochrome P-450 nifedipine oxidase. Proc Natl Acad Sci USA 1986; 83: 5311–5315
  • Gonzalez, FJ, Schmid, BJ, Umeno, M, et al. Human P450PCN1: sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase. DNA 1988; 7: 79–86
  • Aoyama, T, Yamano, S, Waxman, DJ, et al. Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. J Biol Chem 1989; 264: 10388–10395
  • Schuetz JD, Molowa DT, Guzelian PS. Characterization of a cDNA encoding a new member of the glucocorticoid-responsive cytochromes P450 in human liver. Arch Biochem Biophys 1989; 274: 355–365
  • Komori, M, Nishio, K, Ohi, H, et al. Molecular cloning and sequence analysis of cDNA containing the entire coding region for human fetal liver cytochrome P450. J Biochem 1989; 105: 161–163
  • Bork, RW, Muto, T, Beaune, P, et al. Characterization of mRNA species related to human liver cytochrome P-450 nifedipine oxidase and the regulation of catalytic activity. J Biol Chem 1989; 264: 910–919
  • Wrighton, SA, Brian, WR, Sari, M-A, et al. Studies on the expression and metabolic capabilities of human liver cytochrome P450IIIA5 (HLp3). Mol Pharmacol 1990; 38: 207–213
  • Wrighton, SA, Ring, BJ, Watkins, PB, et al. Identification of a polymorphically expressed member of the human cytochrome P-450III family. Mol Pharmacol 1989; 36: 97–105
  • Komori, M, Nishio, M, Fujitani, T, et al. Isolation of a new human fetal liver cDNA clone: evidence for a limited number of forms of cytochrome P450 in human fetal livers. Arch Biochem Biophys 1989; 272: 219–225
  • Bertault-Peres, P, Bonfils, C, Fabre, G, et al. Metabolism of cyclosporin A. II. Implication of the macrolide antibiotic inducible cytochrome P-450 3c from rabbit liver microsomes. Drug Metab Dispos 1987; 15: 391–398
  • Kronbach T, Fischer V, Meyer UA. Cyclosporine metabolism in human liver: identification of a cytochrome P-450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs. Clin Pharmacol Ther 1988; 43: 630–635
  • Shimada, T, Martin, MV, Pruess-Schwartz, D, et al. Roles of individual human cytochrome P450 enzymes in the bioactivation of benzo(a)pyrene, 7,8-dihydroxy-7,8- dihydrobenzo(a)pyrene, and other dihydrodiol derivatives of polycyclic aromatic hydrocarbons. Cancer Res 1989; 49: 6304–6312
  • Roberts-Thomson, SJ, McManus, ME, Tukey, RH, et al. The catalytic activity of four expressed human cytochrome P450s towards benzo[a]pyrene and the isomers of its proximate carcinogen. Biochem Biophys Res Commun 1993; 192: 1373–1379
  • Shimada, T, Iwasaki, M, Martin, MV, et al. Human liver microsomal cytochrome P-450 enzymes involved in the bioactivation of procarcinogens detected by umu gene response in salmonella typhimurium TA1535/pSK1002. Cancer Res 1989; 49: 3218–3228
  • Shimada T, Guengerich FP. Evidence for cytochrome P-450NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver. Proc Natl Acad Sci USA 1989; 86: 462–465
  • Robertson, IGC, Serabjit-Singh, C, Croft, JE, et al. The relationship between increases in the hepatic content of cytochrome P450, form 5, and in the metabolism of aromatic amines to mutagenic products following treatment of rabbits with phenobarbital. Mol Pharmacol 1983; 24: 156–162
  • Aune, T, Vanderslice, RR, Croft, JE, et al. Deacetylation to 2-aminofluorene as a major initial reaction in the microsomal metabolism of 2-acetylaminofluorene to mutagenic products in preparations from rabbit lung and liver. Cancer Res 1985; 45: 5859–5866
  • Vanderslice, RR, Boyd, JA, Eling, TE, et al. The cytochrome P450 monooxygenase system of rabbit bladder mucosa:enzyme components and isozyme 5-dependent metabolism of 2-aminofluorene. Cancer Res 1985; 45: 5851–5858
  • Vanderslice, RR, Domin, BA, Carver, GT, et al. Species-dependent expression and induction of homologous of rabbit cytochrome P-450 isozyme 5 in liver and lung. Mol Pharmacol 1987; 31: 320–325
  • Wrighton, SA, Vandenbranden, M, Becker, GW, et al. Two monoclonal antibodies recognizing different epitopes on rat cytochrome IIB1 react with human IIE1. Mol Pharmacol 1992; 41: 76–82
  • Hassett C, Luchtel DL, Omiecinski CJ. Hepatic expression of rat P450 mRNA assessed by in situ hybridization to oligomer probes. DNA 1989; 8: 29–37
  • Gowans EJ, Jilbert AR, Burrell CJ. Detection of specific DNA and RNA sequences in tissues and cells by in situ hybridization. Nucleic Acid Probes, RH Symonds. CRC Press, Boca Raton 1989; 139–161, In
  • McKinnon, RA, Hall, P de M, Quattrochi, LC, et al. Localization of CYP1A1 and CYP1A2 mRNA in normal human liver and hepatocellular carcinoma by in situ hybridization. Hepatology 1991; 14: 848–856
  • McKinnon, RA, Burgess, WM, Gonzalez, FJ, et al. Metabolic differences in colon mucosal cells. Mutat Res 1993; 290: 27–33
  • McManus, ME, Hall, PM, Stupans, I, et al. Immunohistochemical localization and quantitation of NADPH-cytochrome P450 reductase in human liver. Mol Pharmacol 1987; 32: 189–194
  • Ikeya, K, Jaiswal, AK, Owens, RA, et al. Human CYP1A2: sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver. 1A2 mRNA expression. Mol Endocrinol 1989; 3: 1399–1408
  • Murray, GI, Foster, CO, Barnes, TS, et al. Cytochrome P450IA expression in adult and fetal human liver. Carcinogenesis 1992; 13: 165–169
  • Traber, PG, Maganto, P, Wojcik, E, et al. Induction of P450IIB genes within the rat liver acinus is not dependent on the chemical inducer or the acinar organization. J Biol Chem 1989; 264: 10292–10298
  • Omiecinski CJ, Hassett C, Costa P. Developmental expression and in situ localization of the phenobarbital-inducible rat hepatic mRNAs for cytochromes CYP2B1, CYP2B2, CYP2C6, and CYP3A1. Mol Pharmacol 1990; 38: 462–470
  • Buhler, R, Lindros, KO, Nordling, A, et al. Zonation of cytochrome P450 isozyme expression and induction in rat liver. Eur J Biochem 1992; 204: 407–412
  • Schweikl, H, Taylor, JL, Kitareewan, S, et al. Expression of CYP1A1 and CYP1A2 genes in human liver. Pharmacogenetics 1993; 3: 239–249
  • Robertson JA, Hankinson O, Nebert DW. Autoregulation plus positive and negative elements controlling transcription of genes in the [Ah] gene battery. Chem Scripta 1987; 27A: 83–87
  • Murray, BP, Edwards, RJ, Murray, S, et al. Human hepatic CYP1A1 and CYP1A2 content, determined with specific anti-peptide antibodies, correlates with the mutagenic activation of PhIP. Carcinogenesis 1993; 14: 585–592
  • Puga, A, Raychaudhuri, B, Salata, K, et al. Stable expression of mouse Cyp1A1 and human CYP1A2 cDNAs transfected into mouse hepatoma cells lacking detectable P450 enzyme activity. DNA cell Biol 1990; 9: 425–436
  • McManus, ME, Boobis, AR, Minchin, RF, et al. Relationship between oxidative metabolism of 2-acetylaminofluorene, debrisoquine, bufuralol and aldrin in human liver microsomes. Cancer Res 1984; 44: 5692–5697
  • Hammons, GJ, Guengerich, FP, Weis, CC, et al. Metabolic oxidation of carcinogenic arylamines by rat, dog and human hepatic microsomes and by purified Flavin-containing and cytochrome P450 monooxygenases. Cancer Res 1985; 45: 3578–3585
  • Minchin, RF, McManus, ME, Boobis, AR, et al. Polymorphic metabolism of the carcinogen 2-acetylaminofluorene in human liver microsomes. Carcinogenesis 1985; 6: 1721–1724
  • Butler MA, Guengerich FP, Kadlubar FF. Metabolic oxidation of the carcinogens 4-aminobiphenyl and 4,4'-methylene-bis(2-chloroaniline) by human hepatic microsomes and by purified rat hepatic cytochrome P-450 monooxygenases. Cancer Res 1989; 49: 25–31
  • Butler, MA, Iwasaki, M, Guengerich, FP, et al. Human cytochrome P450PA (P450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and the N-oxidation of carcinogenic arylamines. Proc Natl Acad Sci USA 1898; 86: 7696–7700
  • Shimada, T, Iwasaki, M, Martin, MV, et al. Human liver microsomal cytochrome P450 enzymes involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella Typhimurium TA 1535/pSK1002. Cancer Res 1989; 49: 3219–3228
  • Sesardic D, Boobis AR, Davies DS. A form of cytochrome P450 in man orthologous to form d in the rat, catalyses the O-deethylation of phenacetin and is inducible by cigarette smoking. Br J Clin Pharmacol 1988; 26: 363–372
  • Tassaneeyakul, W, Mohamed, Z, Birkett, DJ, et al. Caffeine as a probe for human cytochromes P450: Validation using cDNA-expression, immunoinhibition and microsomal and inhibitor techniques. Pharmacogenetics 1992; 2: 173–183
  • Popper H, Lieber CS. Histogenesis of alcoholic fibrosis and cirrhosis in the baboon. Am J Pathol 1980; 98: 695–716
  • Takahashi, T, Lasker, JM, Rosman, AS, et al. Induction of cytochrome P-4502E1 in the human liver by ethanol is caused by a corresponding increase in encoding messenger RNA. Hepatology 1992; 17: 236–245
  • Wrighton, SA, Thomas, PE, Molowa, DT, et al. Characterization of ethanol-inducible human liver N-nitrosodimethylamine demethylase. Biochemistry 1986; 25: 6371–6375
  • Johansson, I, Ekstrom, G, Scholte, B, et al. Ethanol-, fasting-, and acetone-inducible cytochromes P-450 in rat liver: regulation and characteristics of enzymes belonging to the IIB and IIE gene subfamilies. Biochemistry 1988; 84: 638–642
  • Koop DR, Tierney DJ. Multiple mechanism in the regulation of the ethanol-inducible cytochrome P-450IIE1 in livers from alcoholics and chronically ethanol-fed rats. Bioessays 1990; 12: 429–435
  • Slaughter, SR, Wolf, CR, Marciniszyn, JP, et al. The rabbit pulmonary monooxygenase system: Partial structural characterization of the ctyochrome P450 components and comparison to the hepatic cytochrome P450. J Biol Chem 1981; 256: 2499–2503
  • McKinnon, RA, Burgess, WM, Gonzalez, FJ, et al. Species-specific expression of CYP4B1 in rabbit and human gastrointestinal tissues. Pharmacogenetics 1994; 4: 260–270
  • Ames BN. Mutagenesis and carcinogenesis: endogenous and exogenous factors. Environ Mol Mutat 1989; 16: S66–S67
  • Sugimura, T, Sato, S, Wakabayashi, K. Mutagens/Carcinogens in pyrolysates of amino acids and proteins in cooked foods: heterocyclic aromatic amines. Chemical Induction of Cancer, Structural Bases and Biological Mechanisms, YT Woo, Lai, DY, Arcos, JC, et al. Academic Press. 1988; 681–701, In
  • Felton JS, Knize MG. Heterocyclic-amine mutagens/carcinogens in foods. Chemical Carcinogenesis and Mutagenesis I, Handbook of Experimental Pharmacology, CS Cooper, PL Grover. Springer-Verlag, Berlin 1990; 94/1: 471–502, In
  • McKinnon, RA, Burgess, WM, Hall, P de la M, et al. Metabolism of food-derived heterocyclic amines in human and rabbit tissues by P4503A proteins in the presence of flavonoids. Cancer Res 1992; 52: 2108s–2113s
  • McKinnon, RA, Burgess, WM, Hall, P de la M, et al. Characterisation of CYP3A gene subfamily expression in human gastrointestinal tissues. Gut 1995; 36: 259–267
  • Penschow J, Coghlan J. Location of gene expression by hybridization histochemistry. Today's Life Sci Oct, 1991; 50–57
  • Penschow, J, Haralambidis, J, Senior, P, et al. Hybridization histochemistry: recent developments and applications. Today's Life Sci Nov, 1991; 44–51

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