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Research Article

Broadsheet Number 52: Molecular Genetics of Colorectal Cancer

Jeremy R. Jass Department of Pathology, University of Queensland Medical School, Brisbane, Australia
Pages 354-364 | Published online: 06 Jul 2009

  • Vogelstein B, Fearon ER, Hamilton SR. et al. Genetic alterations during colorectal-tumor development. N Engl J Med 1988; 319: 525-32.
  • Tomlinson IP, Novell! MR, Bodmer WF. The mutation rate and cancer. Proc Natl Acad Sci USA 1996; 93: 14800-3.
  • Nowell PC. The clonal evolution of tumor cell populations. Science 1976; 194: 23-8.
  • Loeb LA. Mutator phenotype may be required for multistage carcinogenesis. Cancer Res 1991; Sl: 307S-9.
  • Hartwell L. Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells. Cell 1992; 71: 543-6.
  • Lengauer C, Kinzler KW, Vogelstein B. Genetic instabilities in human cancers. Nature 1998; 396: 643-9.
  • Thibodeau SN, Bren G, Schaid D. Microsatellite instability in cancer of the proximal colon. Science 1993; 260: 816-9.
  • lonov Y, Peinado MA, Malkhosyan S, et al. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonie carcinogenesis. Nature 1993; 363: 558-61.
  • Strand M, Prolla TA, Liskay RM, Petes T. Déstabilisation of tracts of simple repetitive DNA in yeast by mutation affecting DNA mismatch repair. Nature 1993; 365: 274-6.
  • Peltomäki P, de la Chapelle A. Mutations predisposing to hereditary nonpolyposis colorectal cancer. Adv Cancer Res 1997; 71: 93-119.
  • Cunningham JM, Christensen ER, Tester DJ, et al. Hypermethylation of the MALHl promoter in colon cancer with microsatellite instability. Cancer Res 1998; 58: 3455-60.
  • Leach FS, Nicolaides NC, Papadopoulos N, et al. Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer. Cell 1993; 75: 1215-25.
  • Fishel R, Lescoe MK, Rao MRS, et al. The Human Mutator Gene Homolog MSH2 and Its Association with Hereditary Nonpolyposis Colon Cancer. CiH 1993; 75: 1027-38.
  • Bronner CE, Baker SM, Morn son PT, et al. Mutation in the DNA mismatch repair gene homologue HMLHl is associated with hereditary non-polyposis colon cancer. Nature 1994; 368: 258-61.
  • Papadopoulos N, Nicolaides NC, Wei Y-F, et al. Mutation of a mutL Homolog in Hereditary Colon Cancer. Science 1994; 263: 1625-9.
  • Nyström-Lahti M, Kristo P, Nicolaides NC, et al. Founding mutations and Alu-mediated recombination in hereditary colon cancer. Nature Med 1995; 1: 1203-6.
  • Miyaki M. Konishi M. Tanaka K. et al. Germ line mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer. Nature Genet 1997; 17: 271-2.
  • Akiyama Y, Sato H, Yamada T, et al. Germ-line mutation of the hMSH6/GTBP gene in an atypical hereditary nonpolyposis colorectal cancer kindred. Cancer Res 1997; 57: 3920-3.
  • Nicolaides NC, Papadopoulos N, Liu B, et al. Mutations of two PMS homologues in hereditary nonpolyposis colon cancer. Nature 1994; 371:75-80.
  • Lynch HT, Smyrk TC, Watson P, et al. Genetics, natural history, tumor spectrum, and pathology of hereditary nonpolyposis colorectal cancer: an updated review. Gastroenterology 1993; 104: 1535-49.
  • Lynch HT, Smyrk T, Lynch JF. Overview of natural history, pathology, molecular genetics and mangement of HNPCC (Lynch syndrome). Int J Cancer 1996; 69: 38-43.
  • Solomon E, Voss R, Hall V, et al. Chromosome 5 allele loss in human colorectal carcinomas. Nature 1987; 328: 616-9.
  • Lengauer C, Kinzler KW, Vogelstein B. Genetic instability in colorectal cancers. Nature 1997; 386: 623-7.
  • Cahill DP, Lengauer C, Yu J, et al. Mutations of mitotic checkpoint genes in human cancers. Nature 1998; 392: 300-3.
  • Longacre TA, Fenoglio-Preiser CM. Mixed hyperplastic adenomatous polyps/serrated adenomas. A distinct form of colorectal neoplasia. Am J Surg Pathol 1990; 14: 524-37.
  • Shimoda T, Ikegami M, Fujisaki J, et al. Early colorectal carcinoma with special reference to its development de novo. Cancer 1989; 64: 1138-46.
  • Shibata D, Peinado MA, lonov Y, et al. Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation. Nat Genet 1994; 6: 273-81.
  • Goh HS, Jass JR. DNA content and the adenoma-carcinoma sequence in the colorectum. J Clin Pathol 1986; 39: 387-92.
  • Meijer GA, Hermsen MAJA, Baak JPA, et al. Progression from colorectal adenoma to carcinoma is associated with non-random chromosomal gains as detected by comparative genomic hybridisation. 1 Clin Pathol 1998; 51: 901-9.
  • Jen J, Powell SM, Papadopoulos N, et al. Molecular determinants of dysplasia in colorectal lesions. Cancer Res 1994; 54: 5523-6.
  • Jass JR. Relation between metaplastic polyp and carcinoma of the colorectum. Lancet 1983; i: 28-30.
  • Minamoto T, Sawaguchi K, Mai M, «r al. Infrequent K-raj activation in superficial-type (flat) colorectal adenomas and adenocarcinomas. Cancer Res 1994; 54: 2841-4.
  • lino H, Jass JR, Simms LA, et al. DNA microsatellite instability in hyperplastic polyps, serrated adenomas, and mixed polyps: a mild mutator pathway for colorectal cancer? y Clin Pathol 1999; 52:5-9.
  • Jass JR. Serrated adenoma and colorectal cancer. J Pathol 1999; 187: 499-502.
  • Hiyama T, Yokozaki H, Shimamoto F, et al. Frequent p53 gene mutations in serrated adenomas of the colorectum. J Pathol 1998; 186: 131-9.
  • Jass JR, Biden KG, Cummings M, et al. Characterisation of a subtype of colorectal cancer combining features of the suppressor and mild mutator pathways. J Clin Pathol 1999; 52: 455-60.
  • Burmer GC, Rabinovitch PS, Haggitt RC, et al. Neoplastic progression in ulcerative colitis: histology, DNA content, and loss of p53 allele. Gastroenterology 1992; 103: 1602-10.
  • Willenbucher RF, Zelman SJ, Ferrell LD, et al. Chromosomal alterations in ulcerative colitis-related neoplastic progression. Gastroenterology 1997; 113: 791-801.
  • Minamoto T, Sawaguchi K, Ohta T, et al. Superficial-type adenomas and adenocarcinomas of the colon and rectum: a comparative morphological study. Gastroenterology 1994; 106: 1436-43.
  • Okamoto T, Konishi F, Kojima M, et al. Significance of microsatellite instability in different types of early-stage nonfamilial colorectal carcinomas. Dis Colon Rectum 1998; 41: 1385-91.
  • Jass JR, Do K-A, Simms LA, et al. Morphology of sporadic colorectal cancer with DNA replication errors. Gut 1998; 42: 673-9.
  • Grady WM, Myeroff LL, Swinler SE, et al. Mutational inactivation of transforming growth factor â receptor type II in microsatellite stable colon cancers. Cancer Res 1999; 59: 320-4.
  • Markowitz S, Wang J, Myeroff L, et al. Inactivation of the type II TGF-ß receptor in colon cancer cells with microsatellite instability. Science 1995:268: 1336-8.
  • Akiyama Y, Iwanaga R, Saitoh K, et al. Transforming growth factor â type II receptor gene mutations in adenomas from hereditary nonpolyposis colorectal cancer. Gastroenterology 1997; 112: 33-9.
  • Grady WM, Rajput A, Myeroff L, et al. Mutation of the type II transforming growth factor-ß receptor is coincident with the transformation of human colon adenomas to malignant carcinomas. Cancer Res 1998; 58: 3101-4.
  • Iacopetta BJ, Welch J, Soong R, et al. Mutation of the transforming growth factor-ß type II receptor gene in right-sided colorectal cancer: relationship to clinicopathological features and genetic alterations. J Pathol 1998; 184: 390-5.
  • Souza RF, Appel R, Yin J, et al. The insulin-like growth factor II receptor gene is a target of microsatellite instability in human gastrointestinal tumours. Nat Genet 1996; 14: 255-7.
  • Rampino N, Yamamoto H, lonov Y, et al. Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science 1997; 275: 967-9.
  • Yagi OK, Akiyama Y, Nomizu T, et al. Proapoptotic gene BAX is frequently mutated in hereditary nonpolyposis colorectal cancers but not in adenomas. Gastroenterology 1998; 114: 268-74.
  • Yamamoto H, Sawai H, Perucho M. Frameshift somatic mutations in gastrointestinal cancer of the microsatellite mutator phenotype. Cancer Res 1997; 57: 4420-6.
  • Yamamoto H, Sawai H, Weber TK, et al. Somatic frameshift mutations in DNA mismatch repair and proapoptosis genes in hereditary nonpolyposis colorectal cancer. Cancer Res 1998; 58: 997-1003.
  • Souza RF, Yin J, Smolinski KN, et al. Frequent mutation of the E2F4 cell cycle gene in primary human gastrointestinal tumors. Cancer Res 1997; 57: 2350-3.
  • Ikeda M, Orimo H, Moriyzma H, et al. Close correlation between mutations of E2F4 and HMSH3 genes in colorectal cancers with microsatellite instability. Cancer Res 1998; 58: 594-8.
  • Wicking C, Simms LA, Evans T, et al. CDX2, a human homologue of Drosophila caudal, is mutated in both alleles in a replication error positive colorectal cancer. Oncogene 1998; 17: 657-9.
  • Jass JR, Stewart SM, Stewart J, et al. Hereditary non-polyposis colorectal cancer: morphologies, genes and mutations. Mut Res 1994; 290: 125-33.
  • Young J, Searle J, Buttenshaw R, et al. An AIu VpA marker on chromosome I demonstrates that replication errors manifest at the adenoma-carcinoma transition in sporadic colorectal tumors. Genes Chromosomes Cancer 1995; 12: 251-4.
  • Jass JR, Young PJ, Robinson EM. Predictors of presence, multiplicity, size and dysplasia of colorectal adenomas. A necropsy study in New Zealand. Gut 1992; 33: 1508-14.
  • Meinen CD, Shivapurkar N, Tang Z, et al. Microsatellite instability in aberrant crypt foci from human colons. Cancer Res 1996; 56: 5339-41.
  • Kinzler KW, Vogelstein B. Lessons from hereditary colorectal cancer. CiH 1996; 87: 159-70.
  • Konishi M, Kikuchi-Yanoshita R, Tanaka K, et al. Molecular nature of colon tumors in hereditary nonpolyposis colon cancer, familial polyposis, and sporadic colon cancer. Gastroenterology 1996; 111: 307-17.
  • Meinen CD, Richardson D, White R, Groden J. Microsatellite instability in colorectal adenocarcinoma cell lines that have fulllength adenomatous polyposis coli protein. Cancer Res 1995; 55: 4797-9.
  • Los! L, Ponz de Leon M, Jiricny J, et al. K-ras and p53 mutations in hereditary non- polyposis colorectal cancers. Int J Cancer 1997; 74: 94-6.
  • Cottu PH, Muzeau F, Estreicher A, et at. Inverse correlation between RER+ status and p53 mutation in colorectal cancer cell lines. Oncogene 1996; 13: 2727-30.
  • Kahlenberg MS, Stoler DL, Basik M, p53 tumor suppressor gene status and the degree of genomic instability in sporadic colorectal cancers. J Natl Cancer lnst 1996; 88: 1665-70.
  • Simms LA, Radford-Smith G, Biden KG, et al. Reciprocal relationship between the tumor suppressors p53 and BAX in primary colorectal cancers. Oncogene 1998; 17: 2003-8.
  • Fujiwara T, Stoker JM, Watanabe T, et al. Accumulated clonal genetic alterations in familial and sporadic colorectal carcinomas with widespread instability in microsatellite sequences. Am J P at hoi 1998; 153: 1063-78.
  • de Wind N, Dekker M, van Rossum A et al. Mouse models for hereditary nonpolyposis colorectal cancer. Cancer Res 1998; 58: 248-55.
  • Lynch HT, Smyrk T, Jass JR. Hereditary nonpolyposis colorectal cancer and colonie adenomas: aggressive adenomas? Semin Surg Oncol 1995; 11:406-10.
  • Jacoby RF, Marshall DJ, Kailas S, et al. Genetic instability associated with adenoma to carcinoma progression in hereditary nonpolyposis colon cancer. Gastroenterology 1995; 109: 73-82.
  • Jones D, Fletcher CDM. How shall we apply the new biology to diagnostics in surgical pathology? J Pathol 1999; 187: 147-54.
  • Tom lin son I, I Iy as M, Johnson V, et al. A comparison of the genetic pathways involved in the pathogenesis of three types of colorectal cancer. J Pathol 1998; 184: 148-52.
  • Boland CR, Thibodeau SN, Hamilton SR, et al. A National Cancer Institute Workshop on microsatellite instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res 1998; 58: 5248-57.
  • Biden KG, Simms LA, Cummings M, et al. Expression of Bcl-2 protein is decreased in colorectal adenocarcinomas with microsatellite instability. Oncogene 1999; 17: 1245-1249.
  • Dietmaier W, Wallinger S, Bocker T, et al. Diagnostic microsatellite instability: definition and correlation with mismatch repair protein expression. Cancer Res 1997; 57: 4749-56.
  • Aaltonen LA, Salovaara R, Kristo P, et al. Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease. New Engl J Med 1998; 338: 1481-7.
  • Evans DGR, Walsh S, Jeacock J, et al. Incidence of hereditary nonpolyposis colorectal cancer in a population-based study of 1137 consecutive cases of colorectal cancer. Br J Surg 1997; 84: 1281-5.
  • Jass JR, Smyrk TC, Stewart SM, et al. Pathology of hereditary nonpolyposis colorectal cancer. Anticancer Res 1994; 14: 1631-4.
  • Messerini L, Vitelli F, de Vitis LR, et al. Microsatellite instability in sporadic mucinous colorectal carcinomas: relationship to clinicopathological variables. J Pathol 1997; 182: 380-4.
  • Rüschoff J, Dietmaier W, Luttges J, et al. Poorly differentiated colonie adenocarcinoma, medullary type: Clinical, phenotypic, and molecular characteristics. Am J Pathol 1997; 150: 1815-25.
  • Kirn H, Jen J, Vogelstein B, Hamilton SR. Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences. Am J Pathol 1994; 145: 148-56.
  • Graham DM, Appelman HD. Crohn's-like lymphoid reaction and colorectal carcinoma: a potential histologie prognosticator. Modern Pathol 1990; 3: 332-5.
  • Senba S, Konishi F, Okamoto T, et al. Clinicopathologic and genetic features of nonfamilial colorectal carcinomas with DNA replication errors. Cancer 1998; 82: 279-85.
  • Thibodeau SN, French AJ, Roche PC, et al. Altered expression of HMSH2 and hMLHl in tumors with microsatellite instability and genetic alterations in mismatch repair genes. Cancer Res 1996; 56: 4836-40.
  • Thibodeau SN, French AJ, Cunningham JM, et al. Microsatellite instability in colorectal cancer: different mutator phenotypes and the principle involvement of HMLHl. Cancer Res 1998; 58: 1713-8.
  • Watson P, Lin KM, Rodriguez-Bigas MA, et at. Colorectal carcinoma survival among hereditary nonpolyposis colorectal carcinoma family members. Cancer 1998; 83: 259-66.
  • Sankila R, Aaltonen LA, JSrvinen HJ, Mecklin J-P. Better survival rates in patients with MLHl -associated hereditary colorectal cancer. Gastroenterology 1996; 110: 682-7.
  • Kirn WH. Lee HW. Park SH. et al. Microsatellite instability in young patients with colorectal cancer. Pathol lnt 1998; 48: 586-94.
  • Carethers JM, Hawn MT, Chauhan DP, et al. Competency in mismatch repair prohibits clonal expansion of cancer cells treated with JV-methyl-JV'-nitro-Jv'-nitrosoguanidine. J Clin Invest 1996; 98: 199-206.
  • Karnes WE, Jr., Shattuck-Brandt R, Burgart LJ, et al. Reduced COX2 protein in colorectal cancer with defective mismatch repair. Cancer Res 1998; 58: 5473-7.
  • Tsujii M, Kawano S, Tsuji S, et al. Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell 1998; 93:705-16.
  • Nelen MR, Padberg GW, Peelers EAJ, et al. Localization of the gene for Cowden disease to chromosome 10q22-23. Nat Genet 1996; 13: 114-6.
  • Marsh DJ, Dahia PLM, Zheng Z, et al. Germline mutations in PTEN are present in Bannayan-Zonana syndrome. Nat Genet 1997; 16: 333-4.
  • Arch EM, Goodman BK, Van Wesep RA, et al. Deletion of PTEN in a patient with Bannayan-Riley- Ruvalcaba syndrome suggests allelism with Cowden disease. Am J Med Genet 1997; 71: 489-93.
  • Olschwang S, Serova-Sinilnikova OM, Lenoir GM, Thomas G. PTEN germ-line mutations in juvenile polyposis coli. Nat Genet 1998; 18: 12-4.
  • Jacoby RF, Schlack S, Cole CE, et al. A juvenile polyposis tumor suppressor locus at 10q22 is deleted from nonepithelial cells in the lamina propria. Gastroenterology 1997; 112: 1398-403.
  • Howe JR. Roth S. Ringold JC. et al. Mutations in the SMAD4/DPC4 gene in juvenile polyposis. Science 1998; 280: 1086-8.
  • Jenne DE, Reimann H, Nezu J-I, et al. Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. Nat Genet 1998; 18: 38-43.
  • Hemminki A, Markie D, Tomlinson I, et al. A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. Nature 1998; 391: 184-7.
  • Thomas HJW, Whitelaw SC, Cottrell SE, et al. Genetic mapping of the hereditary mixed polyposis syndrome to chromosome 6q. Am J Hum Genet 1996; 58: 770-6.
  • Jeevaratnam P, Cottier DS, Browett PJ, et al. Familial giant hyperplastic polyposis predisposing to colorectal cancer: a new hereditary bowel cancer syndrome. J Pathol 1996; 179: 20-5.
  • Carlson GJ, Nivatvongs S, Snover DC. Colorectal polyps in Cowden's disease (multiple hamartoma syndrome). Am J Surg Pathol 1984; 8: 763-70.
  • Gorlin RJ, Cohen MM Jr, Condon LM, Burke BA. Bannayan-RileyRuvalcaba syndrome. Am J Med Genet 1992; 44: 307-14.
  • Jass JR, Williams CB, Bussey HJR, Morson BC. Juvenile polyposis: a precancerous condition. Histopathology 1988; 13: 619-30.
  • Vasen HFA. Mecklin J-P, Khan PM. Lynch HT. The international collaborative group on hereditary non-polyposis colorectal cancer (ICG- HNPCC). Dis Colon Rectum 1991; 34: 424-5.
  • Jass JR. Diagnosis of hereditary non-polyposis colorectal cancer. Histopathology 1998; 32: 491-7.
  • Peltomäki P, Vasen HFA, The International Collaborative Group on Hereditary Nonpolyposis Colorectal Cancer. Mutations predisposing to hereditary nonpolyposis colorectal cancer: database and results of a collaborative study. Gastroenterology 1997; 113: 1146-58.
  • Jass JR, Cottier DS, Jeevaratnam P, et al. Diagnostic use of microsatellite instability in hereditary non- polyposis colorectal cancer. Lancet 1995; 346: 1200-1.
  • Aaltonen LA, Peltomaki P, Mecklin J-P, et al. Replication errors in benign and malignant tumours from hereditary nonpolyposis colorectal cancer patients. Cancer Res 1994; 54: 1645-8.
  • Liu B, Farrington SM, Petersen GM, et al. Genetic instability occurs in the majority of young patients with colorectal cancer. Nat Med 1995; 1: 348-52.
  • Beck NE, Tomlinson IPM, Homfray T, et al. Genetic testing is important in families with a history suggestive of hereditary nonpolyposis colorectal cancer even if the Amsterdam criteria are not fulfilled. Br J Surg 1997; 84: 233-7.
  • Rodriguez-Bigas MA, Boland CR, Hamilton SR, et al. A National Cancer Institute Workshop on Hereditary Nonpolyposis Colorectal Cancer Syndrome: Meeting Highlights and Bethesda Guidelines. J Natl Cancer lnst 1997; 89: 1758-62.
  • Brown SR, Finan PJ, Cawkwell L, et al. Frequency of replication errors in colorectal cancer and their association with family history. Gut 1998; 43: 553-7.
  • Spirio L, Olschwang S, Groden J, et al. Alleles of the APC gene: An attenuated form of familial polyposis. Cell 1993; 75: 951-7.
  • Leggett BA, Young JP, Biden K, et al. Severe upper gastrointestinal polyposis associated with sparse colonie polyposis in a familial adenomatous polyposis family with an APC mutation at codon 1520. Gut 1997:41:518-21.
  • Laken SJ, Petersen GM, Gruber SB, et al. Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC. Nat Genet 1997; 17: 79-83.
  • Rozen P, Shomrat R, Strul H, et al. Prevalence of the I1307K APC gene variant in Israeli Jews of differing ethnic origin and risk for colorectal cancer. Gastroenterology 1999; 116: 54-7.
  • Gryfe R, Di Nicola N, Gallinger S, Redston M. Somatic instability of the APC D307K allele in colorectal neoplasia. Cancer Res 1998; 58: 4040-3.
  • Lewis CM, Neuhausen SL, Daley D, et al. Genetic heterogeneity and unmapped genes for colorectal cancer. Cancer Res 1996; 56: 1382-8.
  • Tomlinson I, Rahman N, Frayling I, et al. Inherited susceptibility to colorectal adenomas and carcinomas: evidence for a new predisposition gene on 15ql4-q22. Gastroenterology 1999; 116: 789-95.
  • Jeffers M, O'Dowd G, Mulcahy H, etal. The prognostic significance of immunohistochemically detected lymph node micrometastases in colorectal carcinoma. J Pathol 1994; 172: 183-7.
  • Mayall F, Jacobson G, Wilkins R, Chang B. Mutations of p53 gene can be detected in the plasma of patients with large bowel carcinoma. J Clin Pathol 1998; 51: 611-3.
  • Yamamoto N, Kato Y, Yanagisawa A, et al. Predictive value of genetic diagnosis for cancer micrometastasis. Cancer 1997; 80: 1393-8.
  • Liefers G-J, Cleton-Jansen A-M, van de Velde CJH, et al. Micrometastases and survival in stage II colorectal cancer. New Engl J Med 1998; 339: 223-8.
  • Newland RC, Dent OF, Chapuis PH, Bokey L. Survival after curative resection of lymph node negative colorectal carcinoma: a prospective study of 910 patients. Cancer 1995; 76: 564-71.
  • Caplin S, Cerottini JP, Bosman FT, et al. For patients with Dukes' B (TNM stage II) colorectal carcinoma, examination of six or fewer lymph nodes is related to poor prognosis. Cancer 1998; 83: 666-72.
  • Carethers JM, Hawn MT, Greenson JK, et al. Prognostic significance of allelic loss at chromosome 18q21 for stage II colorectal cancer. Gastroenterology 1998; 114: 1188-95.
  • Marb'nez-Lopez E, Abad A, Font A, et al. Allelic loss on chromosome 18q as a prognostic marker in stage II colorectal cancer. Gastroenterology 1998; 114: 1180-7.
  • Lanza G, Matteuzzi M, Gafâ R, et al. Chromosome 18q allelic loss and prognosis in stage II and III colon cancer, lnt J Cancer 1998; 79: 390-5.
  • Leahy DT, Salman R, Mulcahy H, et al. Prognostic significance of p53 abnormalities in colorectal carcinoma detected by PCRSSCP and immunohistochemical analysis. J Pathol 1996; 180: 364-70.
  • Pricolo VE, Finkelstein SD, Hansen K, et al. Mutated p53 gene is an independent adverse predictor of survival in colon carcinoma. Arch Surg 1997; 132: 371-5.
  • Manne U, Weiss HL, Myers RB, et al. Nuclear accumulation of p53 in colorectal adenocarcinoma. Cancer 1998; 83: 2456-67.

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