Advanced search
Publication Cover
Pathology Volume 31, 1999 - Issue 4
Submit an article Journal homepage
7
Views
1
CrossRef citations to date
0
Altmetric
Research Article

Telomeric Fusion is a Major Cytogenetic Aberration of Giant Cell Tumors of Bone

M.H. Zheng
,
P. Siu
,
J. M. Papadimitriou
,
D. J. Wood
&
A. R. Murch Departments of Orthopaedic Surgery and Pathology, University of Western Australia, Nedlands, and Cytogenetics Department King Edward Memorial Hospital, Subiaco, WA, Australia
Pages 373-378 | Published online: 06 Jul 2009

  • Robbins SL, Cotran RS, Kumar V. Pathological basis of disease. 5th ed. Pennsylvania: W.B. Saunders Co, 1994; 1245-6.
  • Schajowicz F. Tumours and tumor-like lesions of bone: pathology, radiology, and treatment. 2nd ed. Berlin: Springer-Verlag, 1994; 257-95.
  • Schwarte HS, Juliao SF, Sciandini MF, et al. Telomerase activity and oncogenesis in giant cell tumours of bone. Cancer 1995; 75: 1094-9.
  • Bridge JA, Neff JR, Bhatia PS, et al. Cytogenetic findings and biological behavior of giant cell tumours of bone. Cancer 1990; 65: 2697-703.
  • Huvos AG. Bone tumours: diagnosis, treatment and prognosis. 2nd ed. Tumours of histiocytic or fibrohistiocytic origin. Philadelphia: Saunders, 1991:429-67.
  • Zheng MH, Fan Y, Wysocki SJ, et al. Gene expression of TGF-ß1 and its type II receptor in GCT. Am J Pathol. 1994; 145: 1095-104.
  • Zheng MH, Fan Y, Smith A, et al. Gene expression of monocyte chemoattractant protein-1 in giant cell tumourof bone: possible involvement in CD68 + macrophage-like cell migration. J Cell Biochem 1998, 70: 121-9.
  • Roessner A. Current topics in pathology: biological characterization of bone tumours. The cytogenesis of macrophages and osteoclast-like GCT with special emphasis on the so-called fibrohistiocytic tumours. Berlin: Springer-Verlag, 1989. 205-25.
  • Zheng MH, Fan Y, Panicker A. et al. Detection of mRNAs for urokinase-type plasminogen activator, its receptor and type I inhibitor in GCT with in situ hybridization. Am J Pathol 1995; 147: 1559-66.
  • Fornasier VL, Protzner K, Zhang I, Mason L. The prognostic significance of histomorphometry and immunohistochemistry in giant cell tumours of bone. Hum Pathol. 1996; 27: 754-60.
  • Goldring SR. Roelke MS, Petrison KK. Bhan AK. Human giant cell tumours of bone: identification and characterization of cell types. J CKn Invest. 1987; 79: 483-91.
  • Zheng MH, Fan Y, Wysocki S, et al. Detection of mRNA for carbonic anhydrase II in human osteoclast-like cells by in situ hybridization. J Bone Miner Res 1993; 8: 113-8.
  • Unni K. K. Dahlin's bone tumours: general aspects and data on 11,087 cases. 5th ed. Philadelphia: Lippincott-Raven, 1996. 263-85.
  • Schwarte HS, Dahir GA, Butler MG. Telomere reduction in giant cell tumours of bone with aging. Cancer Genet Cytogenet. 1993; 71: 132-8.
  • Noguera R, Llombart-Bosch A, Lopez-Gines C, et al. GCT-stage II, displaying translocation t(12;19) (ql3;q!3). Virchows Archiv A P at hoi Anat 1993:415: 377-82.
  • Bridge JA, Neff JR, Mouron BJ. Giant Cell Tumours of bone: chromosomal analysis of 48 specimens and review of the literature. Cancer Genet Cytogenet 1992; 58: 2-13.
  • McComb E.N, Johansson SL, Neff JR, et al. Chromosomal anomalies exclusive of telomeric association in giant cell tumours of bone. Cancer Genet Cytogenet. 1996; 88: 163-6.
  • Bridge JA. Cytogenetic and molecular cytogenetic techniques in orthapedic surgery. J Bone Jt Surg. 1993; 75A: 606-14.
  • Heim S, Mitelmon F. Cancer cytogenetics 2nd ed. Tumours of bone and soft tissue. New York: Wiley-Liss. 1995. Chapter 21.
  • Mehle C, Piatyszek MA, Ljungberg B, et al. Telomerase activity in human renal cell carcinoma. Oncogene 1996; 13: 161-6.
  • Tarkkanen M, Kaipainen A, Karaharju E, et al. Cytogenetic study of 249 consecutive patients examined for a bone tumour. Cancer Genet Cytogenet 1993; 68: 1-21.
  • Sawyer JR, Goosen LS, Stine KC, Thomas JR. Telomere fusion as a mechanism for the progressive loss of the short arm of chromosome 11 in an anaplastic Wilm's tumor. Cancer 1994; 74: 767-73.
  • Rooney DE, Czepulkowski BH, editors. Human cytogenetics: a practical approach. VoI 1: Constitutional analysis. 2nd ed. Oxford: Oxford University Press, 1992. Chapter 1,An Introduction to human chromsomes and their analysis.
  • Strachan T, Read AP. Human Molecular Genetics. Chromosome Structure and Function. Oxford: BIOS Scientific Publishers, 1996. Chapter 2.
  • Riboni R, Casati A, Nardo T, et al. Telomeric fusions in cultured human fibroblasts as a source of genomic instability. Cancer Genetics Cytogenetics 1997; 95: 130-6.
  • McClintock B. The behaviour in successive nuclear divisions of a chromsome broken at meiosis. Proc Natl Acad Sd USA 1939; 25: 405-16.
  • McClintock B. Spontaneous alterations in chromosome size and form in Zea Mays. Cold Spring Harbour Symp Quant Biol 1941; 9: 72-81.
  • Schmitt H, Blin N, Zankl H, Scherthan H. Telomere length variation in normal and malignant human tissues. Genes Chromosomes Cancer 1994; 11: 171-7.
  • Harrison KJ, Neumann E, Kalousek DK, et al. Astrocytoma with a unique telomere association. Cancer Genet Cytogenet 1994; 76: 33-5.
  • Pandita TK, Hall EJ, Hei TK, et al. Chromosome end-to-end associations and telomerase activity during cancer progression in human cells after treatment with á-particles simulating radon progeny. Oncogene 1996; 13: 1423-30.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.