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Original Articles

Sublingual or Buccal Administration of Steroidal Hormones

Clinical Applications

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Pages 393-400 | Published online: 18 Apr 2016

Selected References Relating to Sublingual Therapy

Sublingual administration in general

  • Brunton, Robert Lauder: Pharmacology and Therapeutics, or Medicine Past and Present; the Gaulstonian Lectures delivered before the Royal College of Surgeons, London, 1877, Macmillan and Co.
  • Davis, David, and Ayman, David: Sublingual absorption of drugs: morphine. Arch. Int. Med. 41: 231–233 (February) 1928.
  • Walton, R. P.: Sublingual administration of drugs. J.A.M.A. 124: 138–143 (January 15) 1944.

Desoxycorticosterone Acetate

  • Anderson, Evelyn, Haymaker, Webb, and Henderson, Edward: Successful sublingual therapy in Addison's disease. J.A.M.A. 115: 2167–2168 (December 21) 1940.
  • Turnoff, David, and Rowntree, L. G.: Successful sublingual therapy in Addison's disease. J.A.M.A. 116: 2016 (May 3) 1941.
  • Anderson, Evelyn, Kinsell, Laurance, Daniels, Troy C., and Henderson, Edward: The intraoral administration of desoxycorticosterone acetate tablets in the treatment of Addison's disease. J. Clin. Endocrinol. 8: 884–886 (October) 1948; 9: 1324–1332 (December) 1949.

Progestins

  • Corner, George W., Jr.: The absorption of steroid hormones from the oral mucous membranes, with special reference to the sublingual administration of progesterone. Am. J. Obst. SC Gynec. 47: 670–677, 1944.
  • Greenblatt, Robert B.: Sublingual absorption of progesterone and anhydrohydroxyprogesterone. J. Clin. Endocrinol. 4: 156–158 (April) 1944.
  • Bickers, William: Progesterone: a comparison of intramuscular, oral and sublingual routes of administration. J. Clin. Endocrinol. 9: 736–742 (August) 1949.

Testosterone Compounds

  • Joel, C. A.: Clinical results obtained with sublingual administration of methyl testosterone. J. Clin. Endocrinol. 2: 116–119 (February) 1942.
  • Spence, A. W.: Sublingual administration of methyl testosterone. Brit. M. J. 1: 668 (May 30) 1942.
  • Lisser, H., Escamilla, R. F., and Curtis, L. E.: Testosterone therapy of male eunuchoids. III. Sublingual administration of testosterone compounds. J. Clin. Endocrinol. 2: 351–360 (June) 1942.
  • Lisser, H., and Escamilla, R. F.: Testosterone compounds in the male: clinical indications and methods of administration. Urol. & Cutan. Rev. 46: 87–93 (February) 1942.
  • Lisser, H., and Curtis, L. E.: Testosterone therapy of male eunuchoids. IV. Results from methyl testosterone linguets. J. Clin. Endocrinol. 3: 389–399 (July) 1943.
  • Lisser, H., and Curtis, L. E.: Treatment of posttraumatic Simmonds' disease with methyl testosterone linguets. J. Clin. Endocrinol. 5: 363–366 (November) 1945.
  • Dunn, C. W., and Hoffman, R. H.: Male hormone therapy. Clinics 5: 878–897 (December) 1946.
  • Finkler, Rita S.: Male hypogonadism treated by sublingual methyltestosterone. J. Clin. Endocrinol. 7: 293–302 (April) 1947.
  • Deamer, W. C.: Stimulation of growth in boys by sublingual (methyl) testosterone. Am. J. Dis. Child. 75: 850–859 (June) 1948.
  • Escamilla, R. F.: Treatment of preadolescent eunuchoidism with (methyl) testosterone linguets. Am. Practitioner 3: 425–427 (March) 1949.
  • Tyler, E. T.: Use and abuse of endocrine therapy in sterility. J.A.M.A. 139: 560–564 (February 26) 1949.
  • Escamilla, R. F., and Gordan, G. S.: Efficacy of testosterone compounds administered sublingually to hypogonadal men. J. Clin. Endocrinol. 10: 248–264 (February) 1950.

Estrogens

  • (Sublingual preparations of alpha-estradiol are available but have not been studied in this Clinic because economic advantages over orally potent agents in this group are not apparent.)
  • Salmon, U. J., and Geist, S. H.: Buccal administration of alpha-estradiol in propylene glycol. Proc. Soc. Exper. Biol. & Med. 45: 766–769 (December) 1940.
  • Hall, G. J.: Clinical experiences with sublingual administration of alpha-estradiol. J. Clin. Endocrinol. 2: 26–28 (January) 1942.

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