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Original Articles

Nutritional supplementation with megadoses of vitamin B6

Effective therapy, placebo, or potentiator of neuropathy?

Pages 113-116 | Published online: 16 May 2016

Key article

  • Schaumburg H, Kaplan J, Windebank A, et al. Sensory neuropathy from pyridoxine abuse: a new megavitamin syndrome. N Engl J Med 1983: 309(8): 445–8 (Reprint address: Herbert Schaumberg, MD, Albert Einstein College of Medicine, Bronx, NY 10461)

References

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  • Rosenberg L. Vitamin-dependent genetic disease. In: McKusick VA, Clayborne R, eds. Medical genetics. New York: HP Publishing, 1975: 73–8
  • Gordon R. Therapy developed for group of fatal genetic diseases. JAMA 1981: 245(9): 917
  • Branda RF, Arthur DC, Woods WG, et al. Folate metabolism and chromosomal stability in the fragile X syndrome. Am J Med 1984: 77(4): 602–11
  • Shinnar S, Singer HS. Cobalamin C mutation (methylmalonic aciduria and homocystinuria) in adolescence: a treatable cause of dementia and myelopathy. N Engl J Med 1984: 311(7): 451–4
  • Stoerner JW, Butler IJ, Morriss FJ Jr, et al. CSF neurotransmitter studies: an infant with ascorbic-responsive tyrosinemia. Am J Dis Child 1980: 134(5): 492–4
  • Theone J, Baker H, Yoshino M, et al. Biotin-responsive carboxylase deficiency associated with subnormal plasma and urinary biotin. N Engl J Med 1981: 304(14): 817–20
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  • Marshall CW. Vitamins and minerals: help or harm? Philadelphia: GF Stickley, 1983
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  • Goei G, Abraham GE. Effect of a nutritional supplement optivite, on symptoms of premenstrual tension. J Reprod Med 1983: 28(8): 527–31
  • Coleman M, Steinberg G, Tippett J. A preliminary study of the effect of pyridoxine administration in a subgroup of hyperkinetic children. Biol Psychiatry 1979: 14(5): 741–51
  • Haslam R, Dalby JT, Rademaker AW. Effects of megavitamin therapy on children with attention deficit disorder. Pediatrics 1984: 74(1): 103–11
  • Ellis J, Folkers K, Levy M, et al. Response of vitamin B6 deficiency and the carpal tunnel syndrome. Proc Natl Acad Sci USA 1982: 79(23): 7494–8
  • Adams PW, Rose DP, Folkard J, et al. Effect of pyridoxine hydrochloride (vitamin B6) upon depression associated with oral contraception. Lancet 1973: 1(Apr 28): 899–904
  • Collipp PJ, Goldzier S 3d, Weiss N, et al. Pyridoxine treatment of childhood bronchial asthma. Ann Allergy 1975: 35(2): 93–7
  • Rimland B, Callaway E, Dreyfus P. The effects of high doses of vitamin B6 on autistic children: a double-blind crossover study. Arch Gen Psych 1972: 2: 816–22
  • Brooks SC, D'Angelo L, Chalmeta A, et al. An unusual schizophrenic illness responsive to pyridoxine HCL(B6) subsequent to phenothiazine and butyrophenone toxicities. Biol Psychiatry 1983: 18(11): 1321–8
  • Is vitamin B6 an anti-thrombotic agent? (Editorial) Lancet 1981: 1(Jun 13): 1299–300
  • Will ET, Bijvoet OL. Primary oxalosis: clinical and biochemical response to high-dose pyridoxine therapy. Metabolism 1979: 28(5): 542–8
  • Gershoff SN, Prien EL. Effect of daily MgO and vitamin B6 administration to patients with recurring calcium oxalate kidney stones. Am J Clin Nutr 1967: 20(5): 393–9
  • Berger A, Schaumburg HH. Mere on neuropathy from pyridoxine abuse. (Letter) N Engl J Med 1984: 311(15): 986–7
  • Alhadeff L, Gualtieri CT, Lipton M. Toxic effects of water-soluble vitamins. Nutr Rev 1984: 42(2): 33–40

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