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Clinical Focus: Neurological and Psychiatric Disorders

Diagnosing and treating neurogenic orthostatic hypotension in primary care

, , , &
Pages 702-715 | Received 26 Mar 2015, Accepted 08 May 2015, Published online: 27 May 2015

References

  • Mathias CJ . To stand on one’s own legs. Clin Med JRCPL 2002;2:237–45
  • Sclater A , Alagiakrishnan K . Orthostatic hypotension. A primary care primer for assessment and treatment. Geriatrics 2004;59:22–7
  • Novak V , Novak P , Spies JM , Low PA . Autoregulation of cerebral blood flow in orthostatic hypotension. Stroke 1998;29:104–11
  • Horowitz DR , Kaufmann H . Autoregulatory cerebral vasodilation occurs during orthostatic hypotension in patients with primary autonomic failure. Clin Auton Res 2001;11:363–7
  • Freeman R . Clinical practice. Neurogenic orthostatic hypotension. N Engl J Med 2008;358:615–24
  • Kaufmann H . Consensus statement on the definition of orthostatic hypotension, pure autonomic failure and multiple system atrophy. Clin Auton Res 1996;6:125–6
  • Freeman R , Wieling W , Axelrod FB , Benditt DG , Benarroch E , Biaggioni I , et al. Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome. Clin Auton Res 2011;21:69–72
  • Goldstein DS , Sharabi Y . Neurogenic orthostatic hypotension. A pathophysiological approach. Circulation 2009;119:139–46
  • Graafmans WC , Ooms ME , Hofstee HM , Bezemer PD , Bouter LM , Lips P . Falls in the elderly: a prospective study of risk factors and risk profiles. Am J Epidemiol 1996;143:1129–36
  • Pathak A , Lapeyre-Mestre M , Montastruc JL , Senard JM . Heat-related morbidity in patients with orthostatic hypotension and primary autonomic failure. Mov Disord 2005;20:1213–19
  • Masaki KH , Schatz IJ , Burchfiel CM , Sharp DS , Chiu D , Foley D , Curb JD . Orthostatic hypotension predicts mortality in elderly men: the Honolulu Heart Program. Circulation 1998;98:2290–5
  • Rose KM , Eigenbrodt ML , Biga RL , Couper DJ , Light KC , Sharrett AR , Heiss G . Orthostatic hypotension predicts mortality in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) study. Circulation 2006;114:630–6
  • Low PA . Prevalence of orthostatic hypotension. Clin Auton Res 2008;18:8–13
  • Schroeder C , Jordan J , Kaufmann H . Management of neurogenic orthostatic hypotension in patients with autonomic failure. Drugs 2013;73:1267–9
  • Logan IC , Witham MD . Efficacy of treatments for orthostatic hypotension: a systematic review. Age Ageing 2012;41:587–94
  • Hillen ME , Wagner ML , Sage JI . “Subclinical” orthostatic hypotension is associated with dizziness in elderly patients with Parkinson disease. Arch Phys Med Rehabil 1996;77:710–12
  • Rutan GH , Hermanson B , Bild DE , Kittner SJ , LaBaw F , Tell GS . Orthostatic hypotension in older adults. The Cardiovascular Health Study. CHS Collaborative Research Group. Hypertension 1992;19:508–19
  • Poon IO , Braun U . High prevalence of orthostatic hypotension and its correlation with potentially causative medications among elderly veterans. J Clin Pharm Ther 2005;30:173–8
  • Hohler AD , Zuzuárregui JR , Katz DI , Katz DI , Depiero TJ , Hehl CL , et al. Differences in motor and cognitive function in patients with Parkinson’s disease with and without orthostatic hypotension. Int J Neurosci 2012;122:233–6
  • Allcock LM , Kenny RA , Mosimann UP , Tordoff S , Wesnes KA , Hildreth AJ , Burn DJ . Orthostatic hypotension in Parkinson’s disease: association with cognitive decline? Int J Geriatr Psychiatry 2006;21:778–83
  • Pilleri M , Facchini S , Gasparoli E , Biundo R , Bernardi L , Marchetti M , et al. Cognitive and MRI correlates of orthostatic hypotension in Parkinson’s disease. J Neurol 2013;260:253–9
  • Bae HJ , Lim JH , Cheon SM . Orthostatic hypotension and cognitive impairment in de novo patients with Parkinson’s disease. J Mov Disord 2014;7:102–4
  • Weisz N , Schandry R , Jacobs A , Mialet J , Duschek S . Early contingent negative variation of the EEG and attentional flexibility are reduced in hypotension. Int J Psychophysiol 2002;45:253–60
  • Duschek S , Matthias E , Schandry R . Essential hypotension is accompanied by deficits in attention and working memory. Behav Med 2005;30:149–58
  • Mehrabian S , Duron E , Labouree F , Rollot F , Bune A , Traykov L , Hanon O . Relationship between orthostatic hypotension and cognitive impairment in the elderly. J Neurol Sci 2010;299:45–8
  • Heims H , Critchley H , Martin N , Jager R , Mathias CJ , Copolotti L . Cognitive functioning in orthostatic hypotension due to pure autonomic failure. Clin Auton Res 2006;16:113–20
  • Oh YS , Kim JS , Lee KS . Orthostatic and supine blood pressures are associated with white matter hyperintensities in Parkinson disease. J Mov Disord 2013;6:23–7
  • Debette S , Markus HS . The clinical importance of white matter hyper- intensities on brain magnetic resonance imaging: systematic review and meta-analysis. BMJ 2010;341:c3666.
  • Lim TS , Lee PH , Kim HS , Yong SW . White matter hyperintensities in patients with multiple system atrophy. J Neurol 2009;256:1663–70
  • Umoto M , Miwa H , Ando R , Kajimoto Y , Kondo T . White matter hyperintensities in patients with multiple system atrophy. Parkinsonism Relat Disord 2012;18:17–20
  • Robertson D , Robertson RM . Causes of chronic orthostatic hypotension. Arch Intern Med 1994;154:1620–4
  • Kaufmann H , Biaggioni I . Autonomic failure in neurodegenerative disorders. Semin Neurol 2003;23:351–63
  • Marti MJ , Tolosa E , Campdelacreu J . Clinical overview of the synucleinopathies. Mov Disord 2003;18:S21–7
  • Velseboer DC , de Haan RJ , Wieling W , Goldstein DS , de Bie RM . Prevalence of orthostatic hypotension in Parkinson’s disease: a systematic review and meta-analysis. Parkinsonism Relat Disord 2011;17:724–9
  • Bonuccelli U , Lucetti C , Del DP , Ceravolo R , Gambaccini G , Bernardini S , et al. Orthostatic hypotension in de novo Parkinson disease. Arch Neurol 2003;60:1400–4
  • Matsui H , Nishinaka K , Oda M , Komatsu K , Kubori T , Udaka F . Does cardiac metaiodobenzylguanidine (MIBG) uptake in Parkinson’s disease correlate with major autonomic symptoms? Parkinsonism Relat Disord 2006;12:284–8
  • Thaisetthawatkul P , Boeve BF , Benarroch EE , Sandroni P , Ferman TJ , Petersen R , Low PA . Autonomic dysfunction in dementia with Lewy bodies. Neurology 2004;62:1804–9
  • Kollensperger M , Geser F , Ndayisaba JP , Boesch S , Seppi K , Ostergaard K , et al. Presentation, diagnosis, and management of multiple system atrophy in Europe: final analysis of the European multiple system atrophy registry. Mov Disord 2010;25:2604–12
  • Consensus statement on the definition of orthostatic hypotension, pure autonomic failure, and multiple system atrophy. The Consensus Committee of the American Autonomic Society and the American Academy of Neurology. Neurology 1996;46:1470
  • Smit AA , Halliwill JR , Low PA , Wieling W . Pathophysiological basis of orthostatic hypotension in autonomic failure. J Physiol 1999;519:1–10
  • Deidrich A , Biaggioni I . Segmental orthostatic fluid shifts. Clin Auton Res 2004;14:146–7
  • Zaidi A , Benitez D , Gaydecki PA , Vohra A , Fitzpatrick AP . Haemodynamic effects of increasing angle of head up tilt. Heart 2000;83:181–4
  • Kirchheim HR . Systemic arterial baroreceptor reflexes. Physiol Rev 1976;56:100–77
  • Eckberg DL , Rea RF , Andersson OK , Hedner T , Pernow J , Lundberg JM , Wallin BG . Baroreflex modulation of sympathetic activity and sympathetic neurotransmitters in humans. Acta Physiol Scand 1988;133:221–31
  • Imrich R , Eldadah BA , Bentho O , Pechnik S , Sharabi Y , Holmes C , et al. Functional effects of cardiac sympathetic denervation in neurogenic orthostatic hypotension. Parkinsonism Relat Disord 2009;15:122–7
  • Fu Q , Verheyden B , Wieling W , Levine BD . Cardiac output and sympathetic vasoconstrictor responses during upright tilt to presyncope in healthy humans. J Physiol 2012;590:1839–48
  • Stewart JM . Mechanisms of sympathetic regulation in orthostatic intolerance. J Appl Physiol (1985) 2012;113:1659–68
  • Ziegler MG , Lake CR , Kopin IJ . The sympathetic-nervous-system defect in primary orthostatic hypotension. N Engl J Med 1977;296:293–7
  • Goldstein DS , Holmes C , Li ST , Bruce S , Metman LV , Cannon RO 3rd . Cardiac sympathetic denervation in Parkinson disease. Ann Intern Med 2000;133:338–47
  • Goldstein DS . Cardiac denervation in patients with Parkinson disease. Cleve Clin J Med 2007;74:S91–4
  • Ziemssen T , Reichmann H . Cardiovascular autonomic dysfunction in Parkinson’s disease. J Neurol Sci 2010;289:74–80
  • Jain S , Goldstein DS . Cardiovascular dysautonomia in Parkinson disease: from pathophysiology to pathogenesis. Neurobiol Dis 2012;46:572–80
  • Wang N , Gibbons CH , Lafo J , Freeman R . α-Synuclein in cutaneous autonomic nerves. Neurology 2013;81:1604–10
  • Robertson D , Haile V , Perry SE , Robertson RM , Phillips JA 3rd , Biaggioni I . Dopamine beta-hydroxylase deficiency. A genetic disorder of cardiovascular regulation. Hypertension 1991;18:1–8
  • Kaufmann H . L-Dihydroxyphenylserine (droxidopa): a new therapy for neurogenic orthostatic hypotension. Clin Auton Res 2008;18:19–24
  • Noack C , Schroeder C , Heusser K , Lipp A . Cardiovascular effects of levodopa in Parkinson’s disease. Parkinsonism Relat Disord 2014;20:815–18
  • Witjas T , Kaphan E , Azulay JP , Blin O , Ceccaldi M , Pouget J , et al. Nonmotor fluctuations in Parkinson’s disease: frequent and disabling. Neurology 2002;59:408–13
  • Verbaan D , Marinus J , Visser M , van Rooden SM , Stiggelbout AM , van Hilten JJ . Patient-reported autonomic symptoms in Parkinson disease. Neurology 2007;69:333–41
  • Chaudhuri KR , Odin P , Antonini A , Martinez-Martin P . Parkinson’s disease: the non-motor issues. Parkinsonism Relat Disord 2011;17:717–23
  • Berganzo K , Tijero B , Somme JH , Llorens V , Sánchez-Manso JC , Low D , et al. SCOPA-AUT scale in different parkinsonisms and its correlation with (123) I-MIBG cardiac scintigraphy. Parkinsonism Relat Disord 2012;18:45–8
  • Kaufmann H , Goldstein DS . Autonomic dysfunction in Parkinson disease. Handb Clin Neurol 2013;117:259–78
  • Goldstein DS . Dysautonomia in Parkinson disease. Compr Physiol 2014;4:805–26
  • Goldstein DS , Sewell L , Sharabi Y . Autonomic dysfunction in PD: a window to early detection? J Neurol Sci 2011;310:118–22
  • Siderowf A , Lang AE . Premotor Parkinson’s disease: concepts and definitions. Mov Disord 2012;27:608–16
  • Berg D , Postuma RB , Bloem B , Chan P , Dubois B , Gasser T , et al. Time to redefine PD? Introductory statement of the MDS Task Force on the definition of Parkinson’s disease. Mov Disord 2014;29:454–62
  • Kaufmann H , Nahm K , Purohit D , Wolfe D . Autonomic failure as the initial presentation of Parkinson disease and dementia with Lewy bodies. Neurology 2004;63:1093–5
  • Bloch A , Probst A , Bissig H , Adams H , Tolnay M . Alpha-synuclein pathology of the spinal and peripheral autonomic nervous system in neurologically unimpaired elderly subjects. Neuropathol Appl Neurobiol 2006;32:284–95
  • Goldstein DS , Sharabi Y , Karp BI , Bentho O , Saleem A , Pacak K , Eisenhofer G . Cardiac sympathetic denervation preceding motor signs in Parkinson disease. Clin Auton Res 2007;17:118–21
  • Braak H , Del Tredici K . Invited article: nervous system pathology in sporadic Parkinson disease. Neurology 2008;70:1916–25
  • Goldstein DS , Holmes C , Sewell L , Park MY , Sharabi Y . Sympathetic noradrenergic before striatal dopaminergic denervation: relevance to Braak staging of synucleinopathy. Clin Auton Res 2012;22:57–61
  • Tsukamoto T , Kitano Y , Kuno S . Blood pressure fluctuation and hypertension in patients with Parkinson’s disease. Brain Behav 2013;3:710–14
  • Calne DB , Brennan J , Spiers AS , Stern GM . Hypotension caused by L-dopa. Br Med J 1970;1:474–5
  • Durrieu G , Senard JM , Tran MA , Rascol A , Montastruc JL . Effects of levodopa and bromocriptine on blood pressure and plasma catecholamines in parkinsonians. Clin Neuropharmacol 1991;14:84–90
  • Hoehn MM . Levodopa-induced postural hypotension. Treatment with fludrocortisone. Arch Neurol 1975;32:50–1
  • Low PA . Autonomic neuropathies. Curr Opin Neurol 2002;15:605–9
  • Beitzke M , Pfister P , Fortin J , Skrabal F . Autonomic dysfunction and hemodynamics in vitamin B12 deficiency. Auton Neurosci 2002;97:45–54
  • Reynolds EH . The neurology of folic acid deficiency. Handb Clin Neurol 2014;120:927–43
  • Ghavanini AA , Kimpinski K . Revisiting the evidence for neuropathy caused by pyridoxine deficiency and excess. J Clin Neuromuscul Dis 2014;16:25–31
  • Woimant F , Trocello JM . Disorders of heavy metals. Handb Clin Neurol 2014;120:851–64
  • Moore A , Ryan J , Watts M , Pillay I , Clinch D , Lyons D . Orthostatic tolerance in older patients with vitamin B12 deficiency before and after vitamin B12 replacement. Clin Auton Res 2004;14:67–71
  • Kobal SL , Paran E , Jamali A , Mizrahi S , Siegel RJ , Leor J . Pheochromocytoma: cyclic attacks of hypertension alternating with hypotension. Nat Clin Pract Cardiovasc Med 2008;5:53–7
  • Salyers WJ , Vega KJ , Munoz JC , Trotman BW , Tanev SS . Neuroendocrine tumors of the gastrointestinal tract: case reports and literature review. World J Gastrointest Oncol 2014;6:301–10
  • Braik T , Evans AT , Telfer M , McDunn S . Paraneoplastic neurological syndromes: unusual presentations of cancer. A practical review. Am J Med Sci 2010;340:301–8
  • Hajjar I . Postural blood pressure changes and orthostatic hypotension in the elderly patient: impact of antihypertensive medications. Drugs Aging 2005;22:55–68
  • Verwoert GC , Mattace-Raso FU , Hofman A , Heeringa J , Stricker BH , Breteler MM , Witteman JC . Orthostatic hypotension and risk of cardiovascular disease in elderly people: the Rotterdam study. J Am Geriatr Soc 2008;56:1816–20
  • Fedorowski A , Burri P , Melander O . Orthostatic hypotension in genetically related hypertensive and normotensive individuals. J Hypertens 2009;27:976–82
  • Fedorowski A , Stavenow L , Hedblad B , Berglund G , Nilsson PM , Melander O . Orthostatic hypotension predicts all-cause mortality and coronary events in middle-aged individuals (The Malmo Preventive Project). Eur Heart J 2010;31:85–91
  • Kamaruzzaman S , Watt H , Carson C , Ebrahim S . The association between orthostatic hypotension and medication use in the British Women’s Heart and Health Study. Age Ageing 2010;39:51–6
  • Feldstein C , Weder AB . Orthostatic hypotension: a common, serious and underrecognized problem in hospitalized patients. J Am Soc Hypertens 2012;6:27–39
  • Plaschke M , Trenkwalder P , Dahlheim H , Lechner C , Trenkwalder C . Twenty-four-hour blood pressure profile and blood pressure responses to head-up tilt tests in Parkinson’s disease and multiple system atrophy. J Hypertens 1998;16:1433–41
  • Goldstein DS , Pechnik S , Holmes C , Eldadah B , Sharabi Y . Association between supine hypertension and orthostatic hypotension in autonomic failure. Hypertension 2003;42:136–42
  • Kaku M , Simpson DM . HIV neuropathy. Curr Opin HIV AIDS 2014;9:521–6
  • Bilgrami M , O’Keefe P . Neurologic diseases in HIV-infected patients. Handb Clin Neurol 2014;121:1321–44
  • Namme Luma H , Doualla MS , Choukem SP , Temfack E , Ashuntantang G , Achu Joko H , Koulla-Shiro S . Adverse drug reactions of highly active antiretroviral therapy (HAART) in HIV infected patients at the General Hospital, Douala, Cameroon: a cross sectional study. Pan Afr Med J 2012;12:87
  • Robinson-Papp J , Sharma S , Simpson DM , Morgello S . Autonomic dysfunction is common in HIV and associated with distal symmetric polyneuropathy. J Neurovirol 2013;19:172–80
  • van Lieshout JJ , ten Harkel AD , Wieling W . Fludrocortisone and sleeping in the head-up position limit the postural decrease in cardiac output in autonomic failure. Clin Auton Res 2000;10:35–42
  • Gupta D , Nair MD . Neurogenic orthostatic hypotension: chasing “the fall.”. Postgrad Med J 2008;84:6–14
  • Krediet CTP , van Lieshout JJ , Bogert LWJ , Immink RV , Kim YS , Wieling W . Leg crossing improves orthostatic tolerance in healthy subjects: a placebo-controlled crossover study. Am J Physiol Heart Circ Physiol 2006;291:H1768–72
  • Brignole M , Croci F , Menozzi C , Solano A , Donateo P , Oddone D , et al. Isometric arm counter-pressure maneuvers to abort impending vasovagal syncope. J Am Coll Cardiol 2002;40:2053–9
  • Senard JM , Chamontin B , Rascol A , Montastruc JL . Ambulatory blood pressure in patients with Parkinson’s disease without and with orthostatic hypotension. Clin Auton Res 1992;2:99–104
  • Ejaz AA , Sekhon IS , Munjal S . Characteristic findings on 24-h ambulatory blood pressure monitoring in a series of patients with Parkinson’s disease. Eur J Intern Med 2006;17:417–20
  • Freeman R . Treatment of orthostatic hypotension. Semin Neurol 2003;23:435–42
  • El-Sayed H , Hainsworth R . Salt supplement increases plasma volume and orthostatic tolerance in patients with unexplained syncope. Heart 1996;75:134–40
  • May M , Jordan J . The osmopressor response to water drinking. Am J Physiol Regul Integr Comp Physiol 2011;300:R40–6
  • Jordan J , Shannon JR , Black BK , Ali Y , Farley M , Costa F , et al. The pressor response to water drinking in humans: a sympathetic reflex? Circulation 2000;101:504–9
  • Shannon JR , Diedrich A , Biaggioni I , Tank J , Robertson RM , Robertson D , Jordan J . Water drinking as a treatment for orthostatic syndromes. Am J Med 2002;112:355–60
  • Deguchi K , Ikeda K , Sasaki I , Shimamura M , Urai Y , Tsukaguchi M , et al. Effects of daily water drinking on orthostatic and postprandial hypotension in patients with multiple system atrophy. J Neurol 2007;254:735–40
  • Smit AA , Wieling W , Fujimura J , Denq JC , Opfer-Gehrking TL , Akarriou M , et al. Use of lower abdominal compression to combat orthostatic hypotension in patients with autonomic dysfunction. Clin Auton Res 2004;14:167–75
  • Podoleanu C , Maggi R , Brignole M , Croci F , Incze A , Solano A , et al. Lower limb and abdominal compression bandages prevent progressive orthostatic hypotension in elderly persons: a randomized single-blind controlled study. J Am Coll Cardiol 2006;48:1425–32
  • Verhaeverbeke I , Mets T . Drug-induced orthostatic hypotension in the elderly: avoiding its onset. Drug Saf 1997;17:105–18
  • Jiang W , Davidson JR . Antidepressant therapy in patients with ischemic heart disease. Am Heart J 2005;150:871–81
  • Mussi CA , Ungar A , Salvioli G , Menozzi C , Bartoletti A , Giada F , et al. Orthostatic hypotension as cause of syncope in patients older than 65 years admitted to emergency departments for transient loss of consciousness. J Gerontol A Biol Sci Med Sci 2009;64:801–6
  • Mosnaim AD , Abiola R , Wolf ME , Perlmuter LC . Etiology and risk factors for developing orthostatic hypotension. Am J Ther 2010;17:86–91
  • Meredith PA . Is postural hypotension a real problem with antihypertensive medication? Cardiology 2001;96:19–24
  • Shibao C , Okamoto L , Biaggioni I . Pharmacotherapy of autonomic failure. Pharmacol Ther 2012;134:279–86
  • Biaggioni I , Onrot J , Stewart CK , Robertson D . The potent pressor effect of phenylpropanolamine in patients with autonomic impairment. JAMA 1987;258:236–9
  • Jordan J , Shannon JR , Biaggioni I , Norman R , Black BK , Robertson D . Contrasting actions of pressor agents in severe autonomic failure. Am J Med 1998;105:116–24
  • Biaggioni I , Freeman R , Mathias CJ , Low P , Hewitt LA , Kaufmann H ; Droxidopa 302 Investigators . Randomized withdrawal study of patients with symptomatic neurogenic orthostatic hypotension responsive to droxidopa. Hypertension 2015;65:101–7
  • Ben-Dov IZ , Kark JD , Ben-Ishay D , Mekler J , Ben-Arie L , Bursztyn M . Predictors of all-cause mortality in clinical ambulatory monitoring: unique aspects of blood pressure during sleep. Hypertension 2007;49:1235–41
  • Fagard RH , Celis H , Thijs L , Staessen JA , Clement DL , De Buyzere ML , De Bacquer DA . Daytime and nighttime blood pressure as predictors of death and cause-specific cardiovascular events in hypertension. Hypertension 2008;51:55–61
  • Hermida RC , Ayala DE , Fernández JR , Mojón A . Sleep-time blood pressure: prognostic value and relevance as a therapeutic target for cardiovascular risk reduction. Chronobiol Int 2013;30:68–86
  • Seppi K , Weintraub D , Coelho M , Perez-Lloret S , Fox SH , Katzenschlager R , et al. The Movement Disorder Society evidence-based medicine review update: treatments for the non-motor symptoms of Parkinson’s disease. Mov Disord 2011;26:S42–80
  • Hussain RM , McIntosh SJ , Lawson J , Kenny RA . Fludrocortisone in the treatment of hypotensive disorders in the elderly. Heart 1996;76:507–9
  • Husebye ES , Allolio B , Arlt W , Badenhoop K , Bensing S , Betterle C , et al. Consensus statement on the diagnosis, treatment and follow-up of patients with primary adrenal insufficiency. J Intern Med 2014;275:104–15
  • Chobanian AV , Volicer L , Tifft CP , Gavras H , Liang CS , Faxon D . Mineralocorticoid-induced hypertension in patients with orthostatic hypotension. N Engl J Med 1979;301:68–73
  • Campbell IW , Ewing DJ , Clarke BF . 9-Alpha-fluorohydrocortisone in the treatment of postural hypotension in diabetic autonomic neuropathy. Diabetes 1975;24:381–4
  • Volk W , Stoll KD . Double-blind study on the therapy of postural hypotension in psychotic patients under psychotropic medication. Arzneimittelforschung 1976;26:1188–9
  • Zesiewicz TA , Sullivan KL , Arnulf I , Chaudhuri KR , Morgan JC , Gronseth GS , et al. Practice parameter: treatment of nonmotor symptoms of Parkinson disease: report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2010;74:924–31
  • Pittner H , Stormann H , Enzenhofer R . Pharmacodynamic actions of midodrine, a new alpha-adrenergic stimulating agent, and its main metabolite, ST 1059. Arzneimittelforschung 1976;26:2145–54
  • Kaufmann H , Saadia D , Voustianiouk A . Midodrine in neurally mediated syncope: a double-blind, randomized, crossover study. Ann Neurol 2002;52:342–5
  • Jankovic J , Gilden JL , Hiner BC , Kaufmann H , Brown DC , Coghlan CH , et al. Neurogenic orthostatic hypotension: a double-blind, placebo-controlled study with midodrine. Am J Med 1993;95:38–48
  • Low PA , Gilden JL , Freeman R , Sheng KN McEligott MA . Efficacy of midodrine vs placebo in neurogenic orthostatic hypotension. A randomized, double-blind multicenter study. Midodrine Study Group. JAMA 1997;277:1046–51
  • Izcovich A , González Malla C , Manzotti M , Catalano HN , Guyatt G . Midodrine for orthostatic hypotension and recurrent reflex syncope: a systematic review. Neurology 2014;83:1170–7
  • Biaggioni I , Robertson D . Endogenous restoration of noradrenaline by precursor therapy in dopamine-beta-hydroxylase deficiency. Lancet 1987;2:1170–2
  • Kaufmann H , Saadia D , Voustianiouk A , Goldstein DS , Holmes C , Yahr MD , et al. Norepinephrine precursor therapy in neurogenic orthostatic hypotension. Circulation 2003;108:724–8
  • Freeman R , Landsberg L , Young J . The treatment of neurogenic orthostatic hypotension with 3,4-DL-threo-dihydroxyphenylserine. A randomized, placebo-controlled, crossover trial. Neurology 1999;53:2151–7
  • Kaufmann H , Freeman R , Biaggioni I , Low P , Pedder S , Hewitt LA , et al. Droxidopa for neurogenic orthostatic hypotension: a randomized, placebo-controlled, phase 3 trial. Neurology 2014;83:328–35
  • Kaufmann H , Malamut R , Norcliffe-Kaufmann L , Rosa K , Freeman R . The Orthostatic Hypotension Questionnaire (OHQ): validation of a novel symptom assessment scale. Clin Auton Res 2012;22:79–90
  • Hauser RA , Hewitt LA , Isaacson S . Droxidopa in patients with neurogenic orthostatic hypotension associated with Parkinson’s disease (NOH306A). J Parkinsons Dis 2014;4:57–65
  • Hauser RA , Isaacson S , Lisk JP , Hewitt LA , Rowse G . Droxidopa for the short-term treatment of symptomatic neurogenic orthostatic hypotension in Parkinson’s disease (nOH306B). Mov Disord 2015;30(5):646–54
  • Singer W , Opfer-Gehrking TL , McPhee BR , Hilz MJ , Bharucha AE , Low PA . Acetylcholinesterase inhibition: a novel approach in the treatment of neurogenic orthostatic hypotension. J Neurol Neurosurg Psychiatry 2003;74:1294–8
  • Singer W , Sandroni P , Opfer-Gehrking TL , Suarez GA , Klein CM , Hines S , et al. Pyridostigmine treatment trial in neurogenic orthostatic hypotension. Arch Neurol 2006;63:513–18
  • Abate G , Polimeni RM , Cuccurullo F , Puddu P , Lenzi S . Effects of indomethacin on postural hypotension in Parkinsonism. Br Med J 1979;2:1466–8
  • Schoffer KL , Henderson RD , O’Maley K , O’Sullivan JD . Nonpharmacological treatment, fludrocortisone, and domperidone for orthostatic hypotension in Parkinson’s disease. Mov Disord 2007;22:1543–9
  • Hoeldtke RD , Streeten DH . Treatment of orthostatic hypotension with erythropoietin. N Engl J Med 1993;329:611–15
  • Kawakami K , Abe H , Harayama N , Nakashima Y . Successful treatment of severe orthostatic hypotension with erythropoietin. Pacing Clin Electrophysiol 2003;26:105–7
  • Kaufmann H , Oribe E , Miller M , Knott P , Wiltshire-Clement M , Yahr MD . Hypotension-induced vasopressin release distinguishes between pure autonomic failure and multiple system atrophy with autonomic failure. Neurology 1992;42:590–3
  • Mathias CJ , Fosbraey P , da Costa DF , Thornley A , Bannister R . The effect of desmopressin on nocturnal polyuria, overnight weight loss, and morning postural hypotension in patients with autonomic failure. Br Med J (Clin Res Ed) 1986;293:353–4
  • Hoeldtke RD , Davis KM , Joseph J , Gonzales R , Panidis IP , Friedman AC . Hemodynamic effects of octreotide in patients with autonomic neuropathy. Circulation 1991;84:168–76
  • Hoeldtke RD , Horvath GG , Bryner KD , Hobbs GR . Treatment of orthostatic hypotension with midodrine and octreotide. J Clin Endocrinol Metab 1998;83:339–43
  • Muth HH , Jansen W . Dihydroergot plus in the long-term therapy of orthostatic hypotonic dysregulation in older patients. Fortschr Med 1980;98:1571–4
  • Hoeldtke RD , Cavanaugh ST , Hughes JD , Polansky M . Treatment of orthostatic hypotension with dihydroergotamine and caffeine. Ann Intern Med 1986;105:168–73
  • Fouad-Tarazi FM , Okabe M , Goren H . Alpha sympathomimetic treatment of autonomic insufficiency with orthostatic hypotension. Am J Med 1995;99:604–10
  • Pohl K , Kriech W . Therapy of orthostatic disorders of cardiovascular regulation: placebo controlled double-blind study with oxilofrine. Fortschr Med 1991;109:685–8
  • Senard JM , Rascol O , Durrieu G , Tran MA , Berlan M , Rascol A , Montastruc JL . Effects of yohimbine on plasma catecholamine levels in orthostatic hypotension related to Parkinson disease or multiple system atrophy. Clin Neuropharmacol 1993;16:70–6
  • Shibao C , Okamoto LE , Gamboa A , Yu C , Diedrich A , Raj SR , et al. Comparative efficacy of yohimbine against pyridostigmine for the treatment of orthostatic hypotension in autonomic failure. Hypertension 2010;56:847–51
  • Victor RG , Talman WT . Comparative effects of clonidine and dihydroergotamine on venomotor tone and orthostatic tolerance in patients with severe hypoadrenergic orthostatic hypotension. Am J Med 2002;112:361–8
  • Shibao C , Gamboa A , Abraham R , Raj SR , Diedrich A , Black B , et al. Clonidine for the treatment of supine hypertension and pressure natriuresis in autonomic failure. Hypertension 2006;47:522–6
  • Shibao C , Raj SR , Gamboa A , Diedrich A , Choi L , Black BK , et al. Norepinephrine transporter blockade with atomoxetine induces hypertension in patients with impaired autonomic function. Hypertension 2007;50:47–53
  • Gangavati A , Hajjar I , Quach L , Jones RN , Kiely DK , Gagnon P , Lipsitz LA . Hypertension, orthostatic hypotension, and the risk of falls in a community-dwelling elderly population: the maintenance of balance, independent living, intellect, and zest in the elderly of Boston study. J Am Geriatr Soc 2011;59:383–9
  • Shibao C , Lipsitz LA , Biaggioni I . ASH position paper: evaluation and treatment of orthostatic hypotension. J Clin Hypertens (Greenwich) 2013;15:147–53
  • Sharabi Y , Goldstein DS . Mechanisms of orthostatic hypotension and supine hypertension in Parkinson disease. J Neurol Sci 2011;310:123–8

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