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Clinical Focus: Gastroenterology, Hepatology & Nephrology - Review

Evaluation and treatment of hypernatremia: a practical guide for physicians

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Pages 299-306 | Received 31 Oct 2015, Accepted 25 Jan 2016, Published online: 23 Feb 2016

References

  • Liamis G, Tsimihodimos V, Doumas M, et al. Clinical and laboratory characteristics of hypernatraemia in an internal medicine clinic. Nephrol Dial Transplant. 2008;23:136–143.
  • Lindner G, Funk GC. Hypernatremia in critically ill patients. J Crit Care. 2013;28:216:e11–e20.
  • Hoorn EJ, Betjes MG, Weigel J, et al. Hypernatraemia in critically ill patients: too little water and too much salt. Nephrol Dial Transplant. 2008;23:1562–1568.
  • Shah MK, Workeneh B, Taffet GE. Hypernatremia in the geriatric population. Clin Interv Aging. 2014;9:1987–1992.
  • Liamis G, Rodenburg EM, Hofman A, et al. Electrolyte disorders in community subjects: prevalence and risk factors. Am J Med. 2013;126:256–263.
  • Bataille S, Baralla C, Torro D, et al. Undercorrection of hypernatremia is frequent and associated with mortality. BMC Nephrol. 2014;15:37.
  • Kovacs L, Robertson GL. Disorders of water balance-hyponatraemia and hypernatraemia. Baillieres Clin Endocrinol Metab. 1992;6:107–127.
  • Edelman IS, Leibman J, O’meara MP, et al. Interrelations between serum sodium concentration, serum osmolarity and total exchangeable sodium, total exchangeable potassium and total body water. J Clin Invest. 1958;37:1236–1256.
  • Danziger J, Zeidel ML. Osmotic homeostasis. Clin J Am Soc Nephrol. 2015;10:852–862.
  • Rose B, Post T. Clinical physiology of acid-base and electrolyte disorders. 5th ed. New York (NY): McGraw-Hill; 2001.
  • Liamis G, Milionis HJ, Elisaf M. A review of drug-induced hypernatraemia. NDT Plus. 2009;2:339–346.
  • Robertson GL, Aycinena P, Zerbe RL. Neurogenic disorders of osmoregulation. Am J Med. 1982;72:339–353.
  • Kenney WL, Chiu P. Influence of age on thirst and fluid intake. Med Sci Sports Exerc. 2001;33:1524–1532.
  • Phillips PA, Bretherton M, Johnston CI, et al. Reduced osmotic thirst in healthy elderly men. Am J Physiol. 1991;261:R166–71.
  • Stachenfeld NS, DiPietro L, Nadel ER, et al. Mechanism of attenuated thirst in aging: role of central volume receptors. Am J Physiol. 1997;272:R148–57.
  • Sterns RH. Disorders of plasma sodium-causes, consequences, and correction. N Engl J Med. 2015;372:55–65.
  • Harring TR, Deal NS, Kuo DC. Disorders of sodium and water balance. Emerg Med Clin North Am. 2014;32:379–401.
  • Maggs FG. The management of patients presenting with hypernatraemia: is aggressive management appropriate? Clin Med. 2014;14:260–263.
  • van der Helm-van Mil AH, van Vugt JP, Lammers GJ, et al. Hypernatremia from a hunger strike as a cause of osmotic myelinolysis. Neurology. 2005;64:574–575.
  • Liamis G, Kalogirou M, Saugos V, et al. Therapeutic approach in patients with dysnatraemias. Nephrol Dial Transplant. 2006;21:1564–1569.
  • Overgaard-Steensen C, Ring T. Clinical review: practical approach to hyponatraemia and hypernatraemia in critically ill patients. Crit Care. 2013;17:206.
  • Popli S, Tzamaloukas AH, Ing TS. Osmotic diuresis-induced hypernatremia: better explained by solute-free water clearance or electrolyte-free water clearance? Int Urol Nephrol. 2014;46:207–210.
  • Braun MM, Barstow CH, Pyzocha NJ. Diagnosis and management of sodium disorders: hyponatremia and hypernatremia. Am Fam Physician. 2015;91:299–307.
  • Al-Absi A, Gosmanova EO, Wall BM. A clinical approach to the treatment of chronic hypernatremia. Am J Kidney Dis. 2012;60:1032–1038.
  • Liamis G, Liberopoulos E, Barkas F, et al. Spurious electrolyte disorders: a diagnostic challenge for clinicians. Am J Nephrol. 2013;38:50–57.
  • Fortgens P, Pillay TS. Pseudohyponatremia revisited: a modern-day pitfall. Arch Pathol Lab Med. 2011;135:516–519.
  • Dimeski G, Morgan TJ, Presneill JJ, et al. Disagreement between ion selective electrode direct and indirect sodium measurements: estimation of the problem in a tertiary referral hospital. J Crit Care. 2012;27:326 e9–16.
  • Goldwasser P, Ayoub I, Barth RH. Pseudohypernatremia and pseudohyponatremia: a linear correction. Nephrol Dial Transplant. 2015;30:252–257.
  • Spasovski G, Vanholder R, Allolio B, et al. Clinical practice guideline on diagnosis and treatment of hyponatraemia. Eur J Endocrinol. 2014;170:G1–47.
  • Turchin A, Seifter JL, Seely EW. Clinical problem-solving. Mind the gap. N Engl J Med. 2003;349:1465–1469.
  • Filippatos T, Liamis G, Christopoulou F, et al. Ten common pitfalls in the evaluation of patients with hyponatremia. Eur J Internal Med. 2015. doi:10.1016/j.ejim.2015.11.022.
  • Sarahian S, Pouria MM, Ing TS, et al. Hypervolemic hypernatremia is the most common type of hypernatremia in the intensive care unit. Int Urol Nephrol. 2015;47:1817–1821.
  • Volume depletion in adults. [ cited 2015 Sep 23]. http://bestpractice.bmj.com/best-practice/monograph/937/diagnosis/step-by-step.html.
  • Carlotti AP, Bohn D, Mallie JP, et al. Tonicity balance, and not electrolyte-free water calculations, more accurately guides therapy for acute changes in natremia. Intensive Care Med. 2001;27:921–924.
  • Saifan C, Nasr R, Mehta S, et al. Diabetes Insipidus: A challenging diagnosis with new drug therapies. ISRN Nephrol. 2013;2013:7.
  • Adrogué HJ, Madias NE. Hypernatremia. N Engl J Med. 2000;342:1493–1499.
  • Bodonyi-Kovacs G, Lecker SH. Electrolyte-free water clearance: a key to the diagnosis of hypernatremia in resolving acute renal failure. Clin Exp Nephrol. 2008;12:74–78.
  • Lindner G, Schwarz C. Electrolyte-free water clearance versus modified electrolyte-free water clearance: do the results justify the effort? Nephron Physiol. 2012;120:p1–5.
  • Lindner G, Schwarz C, Funk GC. Osmotic diuresis due to urea as the cause of hypernatraemia in critically ill patients. Nephrol Dial Transplant. 2012;27:962–967.
  • Khositseth S, Uawithya P, Somparn P, et al. Autophagic degradation of aquaporin-2 is an early event in hypokalemia-induced nephrogenic diabetes insipidus. Sci Rep. 2015;5:18311.
  • Amlal H, Krane CM, Chen Q, et al. Early polyuria and urinary concentrating defect in potassium deprivation. Am J Physiol Renal Physiol. 2000;279:F655–63.
  • Gregoire JR. Adjustment of the osmostat in primary aldosteronism. Mayo Clin Proc. 1994;69:1108–1110.
  • Severs D, Rookmaaker MB, Hoorn EJ. Intravenous solutions in the care of patients with volume depletion and electrolyte abnormalities. Am J Kidney Dis. 2015;66:147–153.
  • Verbalis JG. Brain volume regulation in response to changes in osmolality. Neuroscience. 2010;168:862–870.
  • Agrawal V, Agarwal M, Joshi SR, et al. Hyponatremia and hypernatremia: disorders of water balance. J Assoc Physicians India. 2008;56:956–964.
  • Cox P. Insensible water loss and its assessment in adult patients: a review. Acta Anaesthesiol Scand. 1987;31:771–776.
  • Frost P. Intravenous fluid therapy in adult inpatients. BMJ. 2015;350:g7620.
  • Khanna A. Acquired nephrogenic diabetes insipidus. Semin Nephrol. 2006;26:244–248.
  • Adrogué HJ, Madias NE. Aiding fluid prescription for the dysnatremias. Intensive Care Med. 1997;23:309–316.
  • Liamis G, Filippatos TD, Elisaf MS. Correction of hypovolemia with crystalloid fluids: individualizing infusion therapy. Postgrad Med. 2015;127:405–412.
  • Liamis G, Kalaitzidis R, Elisaf M. Hypernatremia during correction of hypercalcemia. Nephron. 2000;86:358.
  • Milionis HJ, Liamis G, Elisaf MS. Hypernatremia in hospitalized patients: a sequel of inadvertent fluid administration. Arch Intern Med. 2000;160:1541–1542.
  • Kahn T. Hypernatremia with edema. Arch Intern Med. 1999;159:93–98.

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