1,494
Views
28
CrossRef citations to date
0
Altmetric
Clinical Features - Review

Health benefits of Lactobacillus rhamnosus GG and Bifidobacterium animalis subspecies lactis BB-12 in children

ORCID Icon & ORCID Icon
Pages 441-451 | Received 07 Sep 2019, Accepted 14 Feb 2020, Published online: 26 Feb 2020

References

  • Draper K, Ley C, Parsonnet J. A survey of probiotic use practices among patients at a tertiary medical centre. Benef Microbes. 2017;8(3):345–351. Epub 2017/ 04/14.
  • Dwyer J, Nahin RL, Rogers GT, et al. Prevalence and predictors of children’s dietary supplement use: the 2007 National Health Interview Survey. Am J Clin Nutr. 2013;97(6):1331–1337. Epub 2013/ 04/12.
  • Black LI, Clarke TC, Barnes PM, et al. Use of complementary health approaches among children aged 4–17 years in the United States: National Health Interview Survey, 2007–2012. Natl Health Stat Report. 2015;(78):1–19. Epub 2015/ 02/12.
  • Williams MD, Ha CY, Ciorba MA. Probiotics as therapy in gastroenterology: a study of physician opinions and recommendations. J Clin Gastroenterol. 2010;44(9):631–636. Epub 2010/ 03/11.
  • Cordina C, Shaikh I, Shrestha S, et al. Probiotics in the management of gastrointestinal disease: analysis of the attitudes and prescribing practices of gastroenterologists and surgeons. J Dig Dis. 2011;12(6):489–496. Epub 2011/ 11/29.
  • Draper K, Ley C, Parsonnet J. Probiotic guidelines and physician practice: a cross-sectional survey and overview of the literature. Benef Microbes. 2017;8(4):507–519. Epub 2017/ 06/18.
  • Abe AM, Gregory PJ, Hein DJ, et al. Survey and systematic literature review of probiotics stocked in academic medical centers within the United States. Hosp Pharm. 2013;48(10):834–847. Epub 2014/ 01/15.
  • Merenstein D, Murphy M, Fokar A, et al. Use of a fermented dairy probiotic drink containing Lactobacillus casei (DN-114 001) to decrease the rate of illness in kids: the DRINK study. A patient-oriented, double-blind, cluster-randomized, placebo-controlled, clinical trial. Eur J Clin Nutr. 2010;64(7):669–677. Epub 2010/ 05/21.
  • Sur D, Manna B, Niyogi SK, et al. Role of probiotic in preventing acute diarrhoea in children: a community-based, randomized, double-blind placebo-controlled field trial in an urban slum. Epidemiol Infect. 2011;139(6):919–926. Epub 2010/ 07/31.
  • Sweileh WM, Shraim NY, Al-Jabi SW, et al. Assessing worldwide research activity on probiotics in pediatrics using Scopus database: 1994–2014. World Allergy Organ J. 2016;9:25. Epub 2016/ 08/10.
  • Wolvers D, Antoine JM, Myllyluoma E, et al. Guidance for substantiating the evidence for beneficial effects of probiotics: prevention and management of infections by probiotics. J Nutr. 2010;140(3):698s–712s. Epub 2010/ 01/29.
  • Hempel S, Newberry SJ, Maher AR, et al. Probiotics for the prevention and treatment of antibiotic-associated diarrhea: a systematic review and meta-analysis. JAMA. 2012;307(18):1959–1969. Epub 2012/ 05/10.
  • Dalal R, McGee RG, Riordan SM, et al. Probiotics for people with hepatic encephalopathy. Cochrane Database Syst Rev. 2017;2:CD008716. Epub 2017/ 02/24.
  • Recine N, Palma E, Domenici L, et al. Restoring vaginal microbiota: biological control of bacterial vaginosis. A prospective case-control study using Lactobacillus rhamnosus BMX 54 as adjuvant treatment against bacterial vaginosis. Arch Gynecol Obstet. 2016;293(1):101–107. Epub 2015/ 07/06.
  • Shen NT, Maw A, Tmanova LL, et al. Timely use of probiotics in hospitalized adults prevents Clostridium difficile infection: A asystematic review with meta-regression analysis. Gastroenterology. 2017;152(8):1889–1900.e1889. Epub 2017/ 02/14.
  • Khalesi S, Bellissimo N, Vandelanotte C, et al. A review of probiotic supplementation in healthy adults: helpful or hype? Eur J Clin Nutr. 2019;73(1):24–37. Epub 2018/ 03/28.
  • Koretz RL. Probiotics in gastroenterology: how pro is the evidence in adults? Am J Gastroenterol. 2018;113(8):1125–1136. Epub 2018/ 06/20.
  • Palma E, Recine N, Domenici L, et al. Long-term Lactobacillus rhamnosus BMX 54 application to restore a balanced vaginal ecosystem: a promising solution against HPV-infection. BMC Infect Dis. 2018;18(1):13. Epub 2018/ 01/07.
  • Flach J, van der Waal MB, Kardinaal AFM, et al. Probiotic research priorities for the healthy adult population: a review on the health benefits of Lactobacillus rhamnosus GG and Bifidobacterium animalis subspecies lactic BB-12. Cogent Food Agric. 2018;4:1452839.
  • Di Cerbo A, Palmieri B. Review: the market of probiotics. Pak J Pharm Sci. 2015;28(6):2199–2206. Epub 2015/ 12/08.
  • Scourboutakos MJ, Franco-Arellano B, Murphy SA, et al. Mismatch between probiotic benefits in trials versus food products. Nutrients. 2017;9:4. Epub 2017/ 04/20.
  • Sanders ME, Guarner F, Guerrant R, et al. An update on the use and investigation of probiotics in health and disease. Gut. 2013;62(5):787–796. Epub 2013/ 03/12.
  • Guarino A, Ashkenazi S, Gendrel D, et al. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition/European Society for Pediatric Infectious Diseases evidence-based guidelines for the management of acute gastroenteritis in children in Europe: update 2014. J Pediatr Gastroenterol Nutr. 2014;59(1):132–152. Epub 2014/ 04/18.
  • Cruchet S, Furnes R, Maruy A, et al. The use of probiotics in pediatric gastroenterology: a review of the literature and recommendations by Latin-American experts. Paediatr Drugs. 2015;17(3):199–216. Epub 2015/ 03/25.
  • Lo Vecchio A, Dias JA, Berkley JA, et al. Comparison of recommendations in clinical practice guidelines for acute gastroenteritis in children. J Pediatr Gastroenterol Nutr. 2016;63(2):226–235. Epub 2016/ 02/03.
  • Cameron D, Hock QS, Kadim M, et al. Probiotics for gastrointestinal disorders: proposed recommendations for children of the Asia-Pacific region. World J Gastroenterol. 2017;23(45):7952–7964. Epub 2017/ 12/21.
  • Valdovinos MA, Montijo E, Abreu AT, et al. The Mexican consensus on probiotics in gastroenterology. Rev Gastroenterol Mex. 2017;82(2):156–178. Epub 2017/ 01/21.
  • Chen J, Wan CM, Gong ST, et al. Chinese clinical practice guidelines for acute infectious diarrhea in children. World J Pediatr. 2018;14(5):429–436. Epub 2018/ 10/01.
  • Hojsak I, Fabiano V, Pop TL, et al. Guidance on the use of probiotics in clinical practice in children with selected clinical conditions and in specific vulnerable groups. Acta Paediatr. 2018;107(6):927–937. Epub 2018/ 02/16.
  • Saxelin M. Probiotic formulations and applications, the current probiotics market, and changes in the marketplace: a European perspective. Clin Infect Dis. 2008;46(Suppl 2):S76–79. Discussion S144–151. Epub 2008/ 01/10.
  • Szajewska H, Chmielewska A. Growth of infants fed formula supplemented with Bifidobacterium lactis BB12 or Lactobacillus GG: a systematic review of randomized controlled trials. BMC Pediatr. 2013;13:185. Epub 2013/ 11/13.
  • Laursen RP, Hojsak I. Probiotics for respiratory tract infections in children attending day care centers-a systematic review. Eur J Pediatr. 2018;177(7):979–994. Epub 2018/ 05/13.
  • Florez ID, Veroniki AA, Al Khalifah R, et al. Comparative effectiveness and safety of interventions for acute diarrhea and gastroenteritis in children:   asystematic review and network meta-analysis. PLoS One. 2018;13(12):e0207701. Epub 2018/ 12/06.
  • Szajewska H, Kolodziej M, Gieruszczak-Bialek D, et al. Systematic review with meta-analysis: Lactobacillus rhamnosus GG for treating acute gastroenteritis in children - a 2019 update. Aliment Pharmacol Ther. 2019;49(11):1376–1384. Epub 2019/ 04/27.
  • McFarland LV. Deciphering meta-analytic results: a mini-review of probiotics for the prevention of paediatric antibiotic-associated diarrhoea and Clostridium difficile infections. Benef Microbes. 2015;6(2):189–194. Epub 2014/ 06/04.
  • Szajewska H, Kolodziej M. Systematic review with meta-analysis: Lactobacillus rhamnosus GG in the prevention of antibiotic-associated diarrhoea in children and adults. Aliment Pharmacol Ther. 2015;42(10):1149–1157. Epub 2015/ 09/15.
  • Szajewska H, Wanke M, Patro B. Meta-analysis: the effects of Lactobacillus rhamnosus GG supplementation for the prevention of healthcare-associated diarrhoea in children. Aliment Pharmacol Ther. 2011;34(9):1079–1087. Epub 2011/ 09/09.
  • Hojsak I, Szajewska H, Canani RB, et al. Probiotics for the prevention of nosocomial diarrhea in children. J Pediatr Gastroenterol Nutr. 2018;66(1):3–9. Epub 2017/ 06/03.
  • Horvath A, Dziechciarz P, Szajewska H. Meta-analysis: Lactobacillus rhamnosus GG for abdominal pain-related functional gastrointestinal disorders in childhood. Aliment Pharmacol Ther. 2011;33(12):1302–1310. Epub 2011/ 04/22.
  • Chouraqui JP, Van Egroo LD, Fichot MC. Acidified milk formula supplemented with Bifidobacterium lactis: impact on infant diarrhea in residential care settings. J Pediatr Gastroenterol Nutr. 2004;38(3):288–292. Epub 2004/ 04/13.
  • Weizman Z, Asli G, Alsheikh A. Effect of a probiotic infant formula on infections in child care centers: comparison of two probiotic agents. Pediatrics. 2005;115(1):5–9. Epub 2005/ 01/05.
  • Taipale T, Pienihakkinen K, Isolauri E, et al. Bifidobacterium animalis subsp. lactis BB-12 in reducing the risk of infections in infancy. Br J Nutr. 2011;105(3):409–416. Epub 2010/ 09/25.
  • Hojsak I, Mocic Pavic A, Kos T, et al. Bifidobacterium animalis subsp. lactis in prevention of common infections in healthy children attending day care centers - randomized, double blind, placebo-controlled study. Clin Nutr. 2016;35(3):587–591. Epub 2015/ 06/03.
  • Szajewska H, Skorka A, Ruszczynski M, et al. Meta-analysis: Lactobacillus GG for treating acute diarrhoea in children. Aliment Pharmacol Ther. 2007;25(8):871–881. Epub 2007/ 04/04.
  • Szajewska H, Skorka A, Ruszczynski M, et al. Meta-analysis: Lactobacillus GG for treating acute gastroenteritis in children–updated analysis of randomised controlled trials. Aliment Pharmacol Ther. 2013;38(5):467–476. Epub 2013/ 07/12.
  • Hojsak I, Snovak N, Abdovic S, et al. Lactobacillus GG in the prevention of gastrointestinal and respiratory tract infections in children who attend day care centers: a randomized, double-blind, placebo-controlled trial. Clin Nutr. 2010;29(3):312–316. Epub 2009/ 11/10.
  • Sindhu KN, Sowmyanarayanan TV, Paul A, et al. Immune response and intestinal permeability in children with acute gastroenteritis treated with Lactobacillus rhamnosus GG: a randomized, double-blind, placebo-controlled trial. Clin Infect Dis. 2014;58(8):1107–1115. Epub 2014/ 02/07.
  • Schnadower D, Tarr PI, Casper TC, et al. Lactobacillus rhamnosus GG versus placebo for acute gastroenteritis in children. N Engl J Med. 2018;379(21):2002–2014. Epub 2018/ 11/22.
  • Laursen RP, Larnkjaer A, Ritz C, et al. Probiotics and child care absence due to infections: arandomized controlled trial. Pediatrics. 2017;140:2. Epub 2017/ 07/05.
  • Rautava S, Salminen S, Isolauri E. Specific probiotics in reducing the risk of acute infections in infancy–a randomised, double-blind, placebo-controlled study. Br J Nutr. 2009;101(11):1722–1726. Epub 2008/ 11/07.
  • Taipale TJ, Pienihakkinen K, Isolauri E, et al. Bifidobacterium animalis subsp. lactis BB-12 in reducing the risk of infections in early childhood. Pediatr Res. 2016;79(1):65–69. Epub 2015/ 09/16.
  • Szajewska H, Guarino A, Hojsak I, et al. Use of probiotics for management of acute gastroenteritis: a position paper by the ESPGHAN Working Group for Probiotics and Prebiotics. J Pediatr Gastroenterol Nutr. 2014;58(4):531–539. Epub 2014/ 03/13.
  • Guarner F, Sanders ME, Eliakim R, et al. World Gastroenterology Organisation global guidelines: probiotics and prebiotics. Milwaukee (WI): World Gastroenterology Organisation; 2017.
  • Johnston BC, Supina AL, Vohra S. Probiotics for pediatric antibiotic-associated diarrhea: a meta-analysis of randomized placebo-controlled trials. CMAJ. 2006;175(4):377–383. Epub 2006/ 08/16.
  • Szajewska H, Ruszczynski M, Radzikowski A. Probiotics in the prevention of antibiotic-associated diarrhea in children: a meta-analysis of randomized controlled trials. J Pediatr. 2006;149(3):367–372. Epub 2006/ 08/31.
  • Arvola T, Laiho K, Torkkeli S, et al. Prophylactic Lactobacillus GG reduces antibiotic-associated diarrhea in children with respiratory infections: a randomized study. Pediatrics. 1999;104(5):e64. Epub 1999/ 11/05.
  • Szajewska H, Canani RB, Guarino A, et al. Probiotics for the prevention of antibiotic-associated diarrhea in children. J Pediatr Gastroenterol Nutr. 2016;62(3):495–506. Epub 2016/ 01/13.
  • Wojtyniak K, Szajewska H. Systematic review: probiotics for functional constipation in children. Eur J Pediatr. 2017;176(9):1155–1162. Epub 2017/ 08/02.
  • Wegh CAM, Benninga MA, Tabbers MM. Effectiveness of probiotics in children with functional abdominal pain disorders and functional constipation:   asystematic review. J Clin Gastroenterol. 2018;52(Suppl 1):S10–26. Epub 2018/ 05/22.
  • Kianifar H, Jafari SA, Kiani M, et al. Probiotic for irritable bowel syndrome in pediatric patients: a randomized controlled clinical trial. Electron Physician. 2015;7(5):1255–1260. Epub 2015/ 10/06.
  • Banaszkiewicz A, Szajewska H. Ineffectiveness of Lactobacillus GG as an adjunct to lactulose for the treatment of constipation in children: a double-blind, placebo-controlled randomized trial. J Pediatr. 2005;146(3):364–369.
  • Hojsak I, Tokic Pivac V, Mocic Pavic A, et al. Bifidobacterium animalis subsp. lactis fails to prevent common infections in hospitalized children: a randomized, double-blind, placebo-controlled study. Am J Clin Nutr. 2015;101(3):680–684. Epub 2015/ 03/04.
  • Hojsak I, Abdovic S, Szajewska H, et al. Lactobacillus GG in the prevention of nosocomial gastrointestinal and respiratory tract infections. Pediatrics. 2010;125(5):e1171–1177. Epub 2010/ 04/21.
  • Partty A, Luoto R, Kalliomaki M, et al. Effects of early prebiotic and probiotic supplementation on development of gut microbiota and fussing and crying in preterm infants: a randomized, double-blind, placebo-controlled trial. J Pediatr. 2013;163(5):1272–1277.e1271-1272. Epub 2013/ 08/07.
  • Luoto R, Laitinen K, Nermes M, et al. Impact of maternal probiotic-supplemented dietary counselling on pregnancy outcome and prenatal and postnatal growth: a double-blind, placebo-controlled study. Br J Nutr. 2010;103(12):1792–1799. Epub 2010/ 02/05.
  • Elias J, Bozzo P, Einarson A. Are probiotics safe for use during pregnancy and lactation? Can Fam Physician. 2011;57(3):299–301. Epub 2011/ 03/16.
  • Ho NT, Li F, Lee-Sarwar KA, et al. Meta-analysis of effects of exclusive breastfeeding on infant gut microbiota across populations. Nat Commun. 2018;9(1):4169. Epub 2018/ 10/12.
  • Guidelines for the evaluation of probiotics in food [Internet]. London, ON, Canada: Food and Agriculture Organization of the United Nations, Work Health Organization; 2002 [cited 2019 Jan 11]. Available from: https://www.who.int/foodsafety/fs_management/en/probiotic_guidelines.pdf
  • van den Nieuwboer M, Brummer RJ, Guarner F, et al. Safety of probiotics and synbiotics in children under 18 years of age. Benef Microbes. 2015;6(5):615–630. Epub 2015/ 03/27.
  • Tapiovaara L, Lehtoranta L, Poussa T, et al. Absence of adverse events in healthy individuals using probiotics–analysis of six randomised studies by one study group. Benef Microbes. 2016;7(2):161–169. Epub 2015/ 12/23.
  • Tan TP, Ba Z, Sanders ME, et al. Safety of Bifidobacterium animalis subsp. lactis (B. lactis) strain BB-12-supplemented yogurt in healthy children. J Pediatr Gastroenterol Nutr. 2017;64(2):302–309. Epub 2017/ 01/24.
  • Scalabrin D, Harris C, Johnston WH, et al. Long-term safety assessment in children who received hydrolyzed protein formulas with Lactobacillus rhamnosus GG: a 5-year follow-up. Eur J Pediatr. 2017;176(2):217–224. Epub 2016/ 12/16.
  • Dugoua JJ, Machado M, Zhu X, et al. Probiotic safety in pregnancy: a systematic review and meta-analysis of randomized controlled trials of Lactobacillus, Bifidobacterium, and Saccharomyces spp. J Obstet Gynaecol Can. 2009;31(6):542–552. Epub 2009/ 08/04.
  • Lundelin K, Poussa T, Salminen S, et al. Long-term safety and efficacy of perinatal probiotic intervention: evidence from a follow-up study of four randomized, double-blind, placebo-controlled trials. Pediatr Allergy Immunol. 2017;28(2):170–175. Epub 2016/ 10/26.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.