Recent advances in clinical diagnosis and treatment of male factor infertility

References

• Sciarra J. Infertility: an international health problem. Int J Gynecol Obstet. 1994;46:155–163.
   PubMed Web of Science ®Google Scholar
• Infecundity, infertility, and childlessness in developing countries. DHS Comparative Reports No 9. Calverton, Maryland, USA: ORC Macro and the World Health Organization; 2004. World Health Organization.
   Google Scholar
• Brugh VM, Lipshultz LI. Male factor infertility. Med Clin North Am. 2004;88:367–385.
   PubMed Web of Science ®Google Scholar
• Aston KI, Conrad DF. A review of genome-wide approaches to study the genetic basis for spermatogenic defects. Methods Mol Biol. 2013;927:397–410.
   PubMedGoogle Scholar
• Campbell MF, Wein AJ, Kavoussi LR. (Eds.). Campbell-walsh-wein urology. 2007. Philadelphia: W.B. Saunders.
   Google Scholar
• Ferlin A, Raicu F, Gatta V, et al. Male infertility: role of genetic background. Reprod Biomed Online. 2007;14:734–745.
   PubMed Web of Science ®Google Scholar
• Gorelick JI, Goldstein M. Loss of fertility in men with varicocele. Fertil Steril. 1993;59:613–616.
   PubMed Web of Science ®Google Scholar
• Abdel-Meguid TA, Al-Sayyad A, Tayib A, et al. Does varicocele repair improve male infertility? An evidence-based perspective from a randomized, controlled trial. Eur Urol. 2011;59:455–461.
   PubMed Web of Science ®Google Scholar
• Asafu-Adjei D, Judge C, Deibert CM, et al. Systematic review of the impact of varicocele grade on response to surgical management. J Urol. 2020;203:48–56.
   PubMed Web of Science ®Google Scholar
• Palmer NO, Bakos HW, Fullston T, et al. Impact of obesity on male fertility, sperm function and molecular composition. Spermatogenesis. 2012;2:253–263.
   PubMedGoogle Scholar
• Mitchell M, Fullston T, Palmer NO, et al. The effect of paternal obesity in mice on reproductive and metabolic fitness of F1 male offspring. Reprod Fertil Dev. 2010;22:21.
   PubMed Web of Science ®Google Scholar
• Fullston T, Palmer NO, Owens JA, et al. Diet-induced paternal obesity in the absence of diabetes diminishes the reproductive health of two subsequent generations of mice. Hum Reprod. 2012;27:1391–1400.
   PubMed Web of Science ®Google Scholar
• Ng S-F, Lin RCY, Laybutt DR, et al. Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring. Nature. 2010;467:963–966.
   PubMed Web of Science ®Google Scholar
• Bundhun PK, Janoo G, Bhurtu A, et al. Tobacco smoking and semen quality in infertile males: a systematic review and meta-analysis. BMC Public Health. 2019;19:36.
   PubMed Web of Science ®Google Scholar
• Gunes S, Metin Mahmutoglu A, Arslan MA, et al. Smoking-induced genetic and epigenetic alterations in infertile men. Andrologia. 2018;50:e13124.
   PubMed Web of Science ®Google Scholar
• Subirán N, Casis L, Irazusta J. Regulation of male fertility by the opioid system. Mol Med. 2011;17:846–853.
   PubMed Web of Science ®Google Scholar
• World Health Organization Department of Reproductive Health and Research. WHO laboratory manual for the examination and processing of human semen, fifth edition. WHO; 2010 [cited 2020 Jun]. Available from: http://www.who.int/reproductivehealth/publications/infertility/9789241547789/en/. .
   Google Scholar
• Elzanaty S, Malm J. Comparison of semen parameters in samples collected by masturbation at a clinic and at home. Fertil Steril. 2008;89:1718–1722.
   PubMed Web of Science ®Google Scholar
• Shimomura Y, Shin T, Osaka A, et al. Comparison between semen parameters in specimens collected early in the morning and in the evening. Syst Biol Reprod Med. 2020;66:147–150.
   PubMed Web of Science ®Google Scholar
• Cooper TG, Noonan E, von Eckardstein S, et al. World health organization reference values for human semen characteristics*‡. Hum Reprod Update. 2010;16:231–245.
   PubMed Web of Science ®Google Scholar
• Engel KM, Grunewald S, Schiller J, et al. Automated semen analysis by SQA vision® versus the manual approach—A prospective double-blind study. Andrologia. 2019;51:e13149.
   PubMed Web of Science ®Google Scholar
• Agarwal A, Henkel R, Huang C, et al. Automation of human semen analysis using a novel artificial intelligence optical microscopic technology. Andrologia. 2019Dec;51(11):e13440. DOI:10.1111/and.13440. Epub 2019 Oct 4.
   Web of Science ®Google Scholar
• Thirumalaraju P, Bormann CL, Kanakasabapathy M, et al. Automated sperm morpshology testing using artificial intelligence. Fertil Steril. 2018;110:e432.
   Web of Science ®Google Scholar
• Coppola MA, Klotz KL, Kim K-A, et al. SpermCheck® fertility, an immunodiagnostic home test that detects normozoospermia and severe oligozoospermia. Hum Reprod. 2010;25:853–861.
   PubMed Web of Science ®Google Scholar
• Fredriksen LL, Epperson J, Hong K, et al. Design and validation of the trak® volume cup - a dual purpose semen collection and volume measurement device for diagnosing hypospermia. Fertil Steril. 2018;110:e275.
   Web of Science ®Google Scholar
• Yu S, Rubin M, Geevarughese S, et al. Emerging technologies for home-based semen analysis. Andrology. 2018;6(1):10–19.
   PubMed Web of Science ®Google Scholar
• Yoon YE, Kim TY, Shin TE, et al. Validation of SwimCountTM, a novel home-based device that detects progressively motile spermatozoa: correlation with world health organization 5th semen analysis. World J Men's Health. 2020;38:191–197.
   PubMedGoogle Scholar
• Agarwal A, Panner Selvam MK, Sharma R, et al. Home sperm testing device versus laboratory sperm quality analyzer: comparison of motile sperm concentration. Fertil Steril. 2018;110(7):1277–1284.
   PubMed Web of Science ®Google Scholar
• Cheon WH, Park HJ, Park MJ, et al. Validation of a smartphone-based, computer-assisted sperm analysis system compared with laboratory-based manual microscopic semen analysis and computer-assisted semen analysis. Investig Clin Urol. 2019;60:380.
   PubMed Web of Science ®Google Scholar
• Dohle G, COLPI G, HARGREAVE T, et al. EAU Guidelines on Male Infertility. Eur Urol. 2005;48:703–711.
   PubMed Web of Science ®Google Scholar
• Jarow J, Sigman M, Peter NK, et al. The optimal evaluation of the infertile male: AUA best practice statement. 2010.
   Google Scholar
• Practice committee of the American society for reproductive medicine. Diagnostic evaluation of the infertile male: a committee opinion. Fertil Steril. 2015;103:e18–25.
   PubMed Web of Science ®Google Scholar
• Kohn TP, Kohn JR, Owen RC, et al. The prevalence of Y-chromosome microdeletions in oligozoospermic men: a systematic review and meta-analysis of European and North American studies. Eur Urol. 2019;76:626–636.
   PubMed Web of Science ®Google Scholar
• Pelzman DL, Hwang K. Genetic testing for men with infertility: techniques and indications. Transl Androl Urol. 2020. DOI:10.21037/tau-19-725.
   Web of Science ®Google Scholar
• Ha N-T, Freytag S, Bickeboeller H. Coverage and efficiency in current SNP chips. Eur J Hum Genet. 2014;22:1124–1130.
   PubMed Web of Science ®Google Scholar
• Koscinski I, ElInati E, Fossard C, et al. DPY19L2 deletion as a major cause of globozoospermia. Am J Hum Genet. 2011;88:344–350.
   PubMed Web of Science ®Google Scholar
• Patel B, Parets S, Akana M, et al. Comprehensive genetic testing for female and male infertility using next-generation sequencing. J Assist Reprod Genet. 2018;35:1489–1496.
   PubMed Web of Science ®Google Scholar
• Nsota Mbango J-F, Coutton C, Arnoult C, et al. Genetic causes of male infertility: snapshot on morphological abnormalities of the sperm flagellum. Basic Clin Androl. 2019;29:2.
   PubMed Web of Science ®Google Scholar
• James E, Jenkins TG. Epigenetics, infertility, and cancer: future directions. Fertil Steril. 2018;109:27–32.
   PubMed Web of Science ®Google Scholar
• Jenkins TG, Aston KI, James ER, et al. Sperm epigenetics in the study of male fertility, offspring health, and potential clinical applications. Syst Biol Reprod Med. 2017;63:69–76.
   PubMed Web of Science ®Google Scholar
• Aston KI, Uren PJ, Jenkins TG, et al. Aberrant sperm DNA methylation predicts male fertility status and embryo quality. Fertil Steril. 2015;104(1388–1397):e1–5.
   PubMed Web of Science ®Google Scholar
• Urdinguio RG, Bayón GF, Dmitrijeva M, et al. Aberrant DNA methylation patterns of spermatozoa in men with unexplained infertility. Hum Reprod. 2015;30:1014–1028.
   PubMed Web of Science ®Google Scholar
• Schon SB, Luense LJ, Wang X, et al. Histone modification signatures in human sperm distinguish clinical abnormalities. J Assist Reprod Genet. 2019;36:267–275.
   PubMed Web of Science ®Google Scholar
• Steilmann C, Cavalcanti MCO, Bartkuhn M, et al. The interaction of modified histones with the bromodomain testis-specific (BRDT) gene and its mRNA level in sperm of fertile donors and subfertile men. Reproduction. 2010;140:435–443.
   PubMed Web of Science ®Google Scholar
• Wu W, Hu Z, Qin Y, et al. Seminal plasma microRNAs: potential biomarkers for spermatogenesis status. Mol Hum Reprod. 2012;18:489–497.
   PubMed Web of Science ®Google Scholar
• Bonache S, Mata A, Ramos MD, et al. Sperm gene expression profile is related to pregnancy rate after insemination and is predictive of low fecundity in normozoospermic men. Hum Reprod. 2012;27:1556–1567.
   PubMed Web of Science ®Google Scholar
• García-Herrero S, Meseguer M, Martínez-Conejero JA, et al. The transcriptome of spermatozoa used in homologous intrauterine insemination varies considerably between samples that achieve pregnancy and those that do not. Fertil Steril. 2010;94:1360–1373.
   PubMed Web of Science ®Google Scholar
• Schagdarsurengin U, Steger K. Epigenetics in male reproduction: effect of paternal diet on sperm quality and offspring health. Nat Rev Urol. 2016;13:584–595.
   PubMed Web of Science ®Google Scholar
• Sakkas D, Alvarez JG. Sperm DNA fragmentation: mechanisms of origin, impact on reproductive outcome, and analysis. Fertil Steril. 2010;93:1027–1036.
   PubMed Web of Science ®Google Scholar
• O’Flaherty C, Hales BF, Chan P, et al. Impact of chemotherapeutics and advanced testicular cancer or Hodgkin lymphoma on sperm deoxyribonucleic acid integrity. Fertil Steril. 2010;94:1374–1379.
   PubMed Web of Science ®Google Scholar
• IRVINE DS, Twigg JP, Gordon EL, et al. DNA integrity in human spermatozoa: relationships with semen quality. J Andrology. 2000;21:33–44.
   PubMedGoogle Scholar
• Sugihara A, Van Avermaete F, Roelant E, et al. The role of sperm DNA fragmentation testing in predicting intra-uterine insemination outcome: A systematic review and meta-analysis. Eur J Obstetrics Gynecol Reprod Biol. 2020;244:8–15.
   PubMed Web of Science ®Google Scholar
• Chen Q, Zhao J-Y, Xue X, et al. The association between sperm DNA fragmentation and reproductive outcomes following intrauterine insemination, a meta analysis. Reprod Toxicol. 2019;86:50–55.
   PubMed Web of Science ®Google Scholar
• Cissen M, Wely MV, Scholten I, et al. Measuring sperm DNA fragmentation and clinical outcomes of medically assisted reproduction: a systematic review and meta-analysis. PLoS ONE. 2016;11:e0165125.
   PubMed Web of Science ®Google Scholar
• Simon L, Castillo J, Oliva R, et al. Relationships between human sperm protamines, DNA damage and assisted reproduction outcomes. Reprod Biomed Online. 2011;23:724–734.
   PubMed Web of Science ®Google Scholar
• Li Z, Wang L, Cai J, et al. Correlation of sperm DNA damage with IVF and ICSI outcomes: a systematic review and meta-analysis. J Assist Reprod Genet. 2006;23:367–376.
   PubMed Web of Science ®Google Scholar
• Evenson DP. Utility of the sperm chromatin structure assay as a diagnostic and prognostic tool in the human fertility clinic. Hum Reprod. 1999;14:1039–1049.
   PubMed Web of Science ®Google Scholar
• Gorczyca W, Gong J, Darzynkiewicz Z. Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays. Cancer Res. 1993;53:1945–1951.
   PubMed Web of Science ®Google Scholar
• Singh NP, McCoy MT, Tice RR, et al. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res. 1988;175:184–191.
   PubMed Web of Science ®Google Scholar
• Majzoub A, Esteves S, Gosálvez J, et al. Specialized sperm function tests in varicocele and the future of andrology laboratory. Asian J Androl. 2016;18:205.
   PubMed Web of Science ®Google Scholar
• Varghese AC, Fischer-Hammadeh C, Hammadeh ME. Acridine orange test for assessment of human sperm DNA integrity. In: Zini A, Agarwal A, editors. Sperm Chromatin. Springer: New York. 2011. p. 189–199. doi:10.1007/978-1-4419-6857-9_13.
   Google Scholar
• Majzoub A, Agarwal A, Esteves S. The clinical utility of sperm DNA fragmentation: a survey based study of fertility specialists. Fertil Steril. 2017;108:e138.
   Web of Science ®Google Scholar
• Esteves SC, Roque M, Bradley CK, et al. Reproductive outcomes of testicular versus ejaculated sperm for intracytoplasmic sperm injection among men with high levels of DNA fragmentation in semen: systematic review and meta-analysis. Fertil Steril. 2017;108(456–467):e1.
   PubMed Web of Science ®Google Scholar
• Sigman M. Testicular versus ejaculated sperm should be used for intracytoplasmic sperm injection (ICSI) in cases of infertility associated with sperm DNA fragmentation | opinion: no. Int Braz J Urol. 2018;44: 676–679.
   PubMed Web of Science ®Google Scholar
• Agarwal A, Cho C-L, Majzoub A, et al. The society for translational medicine: clinical practice guidelines for sperm DNA fragmentation testing in male infertility. Transl Androl Urol. 2017;6: S720–S733.
   PubMed Web of Science ®Google Scholar
• Samantha P, Jeffrey G, Michael T, et al. The clinical utility of sperm DNA integrity testing: a guideline. Fertil Steril. 2013;99:673–677.
   PubMed Web of Science ®Google Scholar
• Jungwirth A, Giwercman A, Tournaye H, et al. European Association of Urology Working Group on Male Infertility. European Association of Urology guidelines on Male Infertility: the 2012 update. Eur Urol. 2012 Aug;62(2):324–332. DOI:10.1016/j.eururo.2012.04.048. Epub 2012 May 3.
   Google Scholar
• Agarwal A, Hamada A, Esteves SC. Insight into oxidative stress in varicocele-associated male infertility: part 1. Nat Rev Urol. 2012;9:678–690.
   PubMed Web of Science ®Google Scholar
• Dubin L, Amelar RD. Varicocele size and results of varicocelectomy in selected subfertile men with varicocele*. Fertil Steril. 1970;21:606–609.
   PubMed Web of Science ®Google Scholar
• Practice Committee of the American Society for Reproductive Medicine; Society for Male Reproduction and Urology. Report on varicocele and infertility: a committee opinion. Fertil Steril. 2014 Dec;102(6):1556–1560. DOI:10.1016/j.fertnstert.2014.10.007. Epub 2014 Nov 25. PMID:25458620.
   Google Scholar
• Kroese ACJ, de Lange NM, Collins J, et al. Surgery or embolization for varicoceles in subfertile men. Cochrane Database Syst Rev. 2012;10:CD000479.
   PubMed Web of Science ®Google Scholar
• Kirby EW, Wiener LE, Rajanahally S, et al. Undergoing varicocele repair before assisted reproduction improves pregnancy rate and live birth rate in azoospermic and oligospermic men with a varicocele: a systematic review and meta-analysis. Fertil Steril. 2016;106:1338–1343.
   PubMed Web of Science ®Google Scholar
• Dubin JM, Greer AB, Kohn TP, et al. Men with severe oligospermia appear to benefit from varicocele repair: a cost-effectiveness analysis of assisted reproductive technology. Urology. 2018;111:99–103.
   PubMed Web of Science ®Google Scholar
• Çayan S, Erdemir F, Özbey ISA, et al. Can varicocelectomy significantly change the way couples use assisted reproductive technologies? J Urol. 2002;167(4):1749–1752.
   PubMed Web of Science ®Google Scholar
• Marc G, Gilbert Bruce R, Dicker Adam P, et al. Microsurgical inguinal varicocelectomy with delivery of the testis: an artery and lymphatic sparing technique. J Urol. 1992;148:1808–1811.
   PubMed Web of Science ®Google Scholar
• Marmar JL, Kim Y. Subinguinal microsurgical varicocelectomy: a technical critique and statistical analysis of semen and pregnancy data. J Urol. 1994;152:1127–1132.
   PubMed Web of Science ®Google Scholar
• Guo L, Sun W, Shao G, et al. Outcomes of microscopic subinguinal varicocelectomy with and without the assistance of doppler ultrasound: a randomized clinical trial. Urology. 2015;86:922–928.
   PubMed Web of Science ®Google Scholar
• McCullough A, Elebyjian L, Ellen J, et al. A retrospective review of single-institution outcomes with robotic-assisted microsurgical varicocelectomy. Asian J Androl. 2018;20:189.
   PubMed Web of Science ®Google Scholar
• Coward RM, Mills JN. A step-by-step guide to office-based sperm retrieval for obstructive azoospermia. Transl Andro Urol. 2017;6:730–744.
   PubMed Web of Science ®Google Scholar
• Alom M, et al. Office-based andrology and male infertility procedures—a cost-effective alternative. Transl Androl Urol. 2017;6(4):761–772. DOI:10.21037/tau.2017.07.34. PMID:28904909.
   Web of Science ®Google Scholar
• Walker* K, Smith J. Mp39-04 feasibility study of video telehealth clinic visits in urology. J Urol. 2019;201:e545–e545.
   Web of Science ®Google Scholar
• Eisenberg M, Lathi RB, Baker VL, et al. Frequency of the male infertility evaluation: data from the national survey of family growth. J Urol. 2013;189:1030–1034. DOI:10.1016/j.juro.2012.08.239. Epub 2012 Sep 23.
   PubMed Web of Science ®Google Scholar