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Clinical feature - Review

Recent advances in early esophageal cancer: diagnosis and treatment based on endoscopy

& ORCID Icon
Pages 665-673 | Received 09 Mar 2021, Accepted 21 May 2021, Published online: 01 Jun 2021

References

  • Fitzmaurice C, Allen C, Barber RM, et al. Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted Life-years for 32 cancer groups, 1990 to 2015: a systematic analysis for the global burden of disease study. JAMA Oncol. 2017 Apr 1 3;(4)524–548.
  • Spechler SJ, Souza RF. Barrett’s esophagus. N Engl J Med. 2014 Aug 28; 371(9):836–845.
  • Coleman HG, Xie SH, Lagergren J. The epidemiology of esophageal adenocarcinoma. Gastroenterology. 2018 Jan;154(2):390–405.
  • Lagergren J, Lagergren P. Recent developments in esophageal adenocarcinoma. CA Cancer J Clin. 2013 Jul-Aug;63(4):232–248.
  • Edgren G, Adami HO, Weiderpass E, et al. A global assessment of the oesophageal adenocarcinoma epidemic. Gut. 2013 Oct;62(10):1406–1414.
  • Abnet CC, Arnold M, Wei WQ. Epidemiology of Esophageal Squamous Cell Carcinoma. Gastroenterology. 2018 Jan;154(2):360–373.
  • Prabhu A, Obi KO, Rubenstein JH. The synergistic effects of alcohol and tobacco consumption on the risk of esophageal squamous cell carcinoma: a meta-analysis. Am J Gastroenterol. 2014 Jun;109(6):822–827.
  • Codipilly DC, Qin Y, Dawsey SM, et al. Screening for esophageal squamous cell carcinoma: recent advances. Gastrointest Endosc. 2018 Sep;88(3):413–426.
  • Fan J, Liu Z, Mao X, et al. Global trends in the incidence and mortality of esophageal cancer from 1990 to 2017. Cancer Med. 2020 Aug 4;9(18):e03338.
  • Uhlenhopp DJ, Then EO, Sunkara T, et al. Epidemiology of esophageal cancer: update in global trends, etiology and risk factors. Clin J Gastroenterol. 2020 Dec;13(6):1010–1021.
  • Lopes AB, Fagundes RB. Esophageal squamous cell carcinoma - precursor lesions and early diagnosis. World J Gastrointest Endosc. 2012 Jan 16;4(1):9–16.
  • Sun F, Yuan P, Chen T, et al. Efficacy and complication of endoscopic submucosal dissection for superficial esophageal carcinoma: a systematic review and meta-analysis. J Cardiothorac Surg. 2014 May;9(1):78.
  • Shaheen NJ, Falk GW, Iyer PG, et al. ACG Clinical Guideline: diagnosis and Management of Barrett’s Esophagus. Am J Gastroenterol. 2016 Jan;111(1):30–50. quiz 51.
  • Fitzgerald RC, di Pietro M, Ragunath K, et al. British Society of Gastroenterology guidelines on the diagnosis and management of Barrett’s oesophagus. Gut. 2014 Jan;63(1):7–42.
  • Qumseya B, Sultan S, Bain P, et al. ASGE guideline on screening and surveillance of Barrett’s esophagus. Gastrointest Endosc. 2019 Sep;90(3):335–359.e2.
  • Chen Y, Chen X, Yu H, et al. Oral Microbiota as Promising Diagnostic Biomarkers for Gastrointestinal Cancer: a Systematic Review. Onco Targets Ther. 2019;12:11131–11144.
  • Xu YW, Peng YH, Xu LY, et al. Autoantibodies: potential clinical applications in early detection of esophageal squamous cell carcinoma and esophagogastric junction adenocarcinoma. World J Gastroenterol. 2019 Sep 14;25(34):5049–5068.
  • Zhang Y, Li J, Wang L, et al. Clinical significance of detecting circulating tumor cells in patients with esophageal squamous cell carcinoma by EpCAM‑independent enrichment and immunostaining‑fluorescence in situ hybridization. Mol Med Rep. 2019 Aug;20(2):1551–1560.
  • Sudo K, Kato K, Matsuzaki J, et al. Development and Validation of an Esophageal Squamous Cell Carcinoma Detection Model by Large-Scale MicroRNA Profiling. JAMA Network Open. 2019 May 3;2(5):e194573.
  • Liu H, Zhang Q, Lou Q, et al. Differential Analysis of lncRNA, miRNA and mRNA Expression Profiles and the Prognostic Value of lncRNA in Esophageal Cancer. Pathol Oncol Res. 2020 Apr;26(2):1029–1039.
  • Li D, Zhang L, Liu Y, et al. Specific DNA methylation markers in the diagnosis and prognosis of esophageal cancer. Aging (Albany NY). 2019 Dec 13;11(23):11640–11658.
  • Lin DC, Wang MR, Koeffler HP. Genomic and epigenomic aberrations in esophageal squamous cell carcinoma and implications for patients. Gastroenterology. 2018 Jan;154(2):374–389.
  • Iyer PG, Kaul V. Barrett Esophagus. Mayo Clinic proceedings. 2019 Sep;94(9):1888–1901
  • Draganov PV, Wang AY, Othman MO, et al. AGA institute clinical practice update: endoscopic submucosal dissection in the united states. Clin Gastroenterol Hepatol. 2019 Jan;17(1):16–25.e1.
  • Sharma P, Shaheen NJ, Katzka D, et al. AGA clinical practice update on endoscopic treatment of barrett’s esophagus with dysplasia and/or early cancer: expert Review. Gastroenterology. 2020 Feb;158(3):760–769.
  • Rodríguez de Santiago E, Hernanz N, Marcos-Prieto HM, et al. Rate of missed oesophageal cancer at routine endoscopy and survival outcomes: a multicentric cohort study. United European Gastroenterol J. 2019 Mar 7;7(2):189–198.
  • Ishihara R, Goda K, Oyama T. Endoscopic diagnosis and treatment of esophageal adenocarcinoma: introduction of Japan Esophageal Society classification of Barrett’s esophagus. J Gastroenterol. 2019 Jan;54(1):1–9.
  • The Paris endoscopic classification of superficial neoplastic lesions: esophagus, stomach, and colon: November 30 to December 1, 2002. Gastrointest Endosc. 2003 Dec;58(6):S3–43.
  • Peters FP, Brakenhoff KP, Curvers WL, et al. Histologic evaluation of resection specimens obtained at 293 endoscopic resections in Barrett’s esophagus. Gastrointest Endosc. 2008 Apr;67(4):604–609.
  • Pech O, Gossner L, Manner H, et al. Prospective evaluation of the macroscopic types and location of early Barrett’s neoplasia in 380 lesions. Endoscopy. 2007 Jul;39(7):588–593.
  • Spataro J, Zfass AM, Schubert M, et al. Early Esophageal Cancer: a Gastroenterologist’s Disease. Dig Dis Sci. 2019 Nov;64(11):3048–3058.
  • Puli SR, Reddy JB, Bechtold ML, et al. Staging accuracy of esophageal cancer by endoscopic ultrasound: a meta-analysis and systematic review. World J Gastroenterol. 2008 Mar 14;14(10):1479–1490.
  • May A, Günter E, Roth F, et al. Accuracy of staging in early oesophageal cancer using high resolution endoscopy and high resolution endosonography: a comparative, prospective, and blinded trial. Gut. 2004 May;53(5):634–640.
  • Chiu PWY, Uedo N, Singh R, et al. An Asian consensus on standards of diagnostic upper endoscopy for neoplasia. Gut. 2019 Feb;68(2):186–197.
  • Hashimoto CL, Iriya K, Baba ER, et al. Lugol’s dye spray chromoendoscopy establishes early diagnosis of esophageal cancer in patients with primary head and neck cancer. Am J Gastroenterol. 2005 Feb;100(2):275–282.
  • Muto M, Hironaka S, Nakane M, et al. Association of multiple Lugol-voiding lesions with synchronous and metachronous esophageal squamous cell carcinoma in patients with head and neck cancer. Gastrointest Endosc. 2002 Oct;56(4):517–521.
  • Katada C, Yokoyama T, Yano T, et al. Alcohol consumption and multiple dysplastic lesions increase risk of squamous cell carcinoma in the esophagus, head, and neck. Gastroenterology. 2016 Nov;151(5):860–869.e7.
  • Liu M, Liu Z, Liu F, et al. Absence of Iodine Staining Associates With Progression of Esophageal Lesions in a Prospective Endoscopic Surveillance Study in China. Clin Gastroenterol Hepatol. 2020 Jun;18(7):1626–1635.e7.
  • Liu M, Zhou R, Guo C, et al. Size of Lugol-unstained lesions as a predictor for risk of progression in premalignant lesions of the esophagus. Gastrointest Endosc. 2021 May;93(5):1065–1073.e3
  • Singh R, Yeap SP. Endoscopic imaging in Barrett’s esophagus. Expert Rev Gastroenterol Hepatol. 2015 Apr;9(4):475–485.
  • Horwhat JD, Maydonovitch CL, Ramos F, et al. A randomized comparison of methylene blue-directed biopsy versus conventional four-quadrant biopsy for the detection of intestinal metaplasia and dysplasia in patients with long-segment Barrett’s esophagus. Am J Gastroenterol. 2008 Mar;103(3):546–554.
  • Song J, Zhang J, Wang J, et al. Meta-analysis of the effects of endoscopy with narrow band imaging in detecting dysplasia in Barrett’s esophagus. Dis Esophagus. 2015 Aug-Sep;28(6):560–566.
  • Morita FH, Bernardo WM, Ide E, et al. Narrow band imaging versus lugol chromoendoscopy to diagnose squamous cell carcinoma of the esophagus: a systematic review and meta-analysis. BMC Cancer. 2017 Jan 13;17(1):54.
  • Nagai K, Ishihara R, Ishiguro S, et al. Endoscopic optical diagnosis provides high diagnostic accuracy of esophageal squamous cell carcinoma. BMC Gastroenterol. 2014 Aug;9(14):141.
  • Hoffman A, Korczynski O, Tresch A, et al. Acetic acid compared with i-scan imaging for detecting Barrett’s esophagus: a randomized, comparative trial. Gastrointest Endosc. 2014 Jan;79(1):46–54.
  • Kodashima S, Fujishiro M. Novel image-enhanced endoscopy with i-scan technology. World J Gastroenterol. 2010 Mar 7;16(9):1043–1049.
  • Lipman G, Bisschops R, Sehgal V, et al. Systematic assessment with I-SCAN magnification endoscopy and acetic acid improves dysplasia detection in patients with Barrett’s esophagus. Endoscopy. 2017 Dec;49(12):1219–1228.
  • Bi Y, Min M, Zhang F, et al. The characteristics of blue laser imaging and the application in diagnosis of early digestive tract cancer. Technol Cancer Res Treat. 2019 1;Jan(18):1533033819825877.
  • Diao W, Huang X, Shen L, et al. Diagnostic ability of blue laser imaging combined with magnifying endoscopy for early esophageal cancer. Dig Liver Dis. 2018 Oct;50(10):1035–1040.
  • Ueda T, Dohi O, Naito Y, et al. Diagnostic performance of magnifying blue laser imaging versus magnifying narrow-band imaging for identifying the depth of invasion of superficial esophageal squamous cell carcinoma. Dis Esophagus. 2021 Mar 8;34(3): 10.1093/dote/doaa078.
  • Struyvenberg MR, De Groof AJ, Kahn A, et al. Multicenter study on the diagnostic performance of multiframe volumetric laser endomicroscopy targets for Barrett’s esophagus neoplasia with histopathology correlation. Dis Esophagus. 2020 7; 33(12):Dec.
  • Wolfsen HC, Sharma P, Wallace MB, et al. Safety and feasibility of volumetric laser endomicroscopy in patients with Barrett’s esophagus (with videos). Gastrointest Endosc. 2015 Oct;82(4):631–640.
  • Swager AF, de Groof AJ, Meijer SL, et al. Feasibility of laser marking in Barrett’s esophagus with volumetric laser endomicroscopy: first-in-man pilot study. Gastrointest Endosc. 2017 Sep;86(3):464–472.
  • Bergholt MS, Zheng W, Ho KY, et al. Fiberoptic confocal raman spectroscopy for real-time in vivo diagnosis of dysplasia in Barrett’s esophagus. Gastroenterology. 2014 Jan;146(1):27–32.
  • Canto MI, Anandasabapathy S, Brugge W, et al. In vivo endomicroscopy improves detection of Barrett’s esophagus-related neoplasia: a multicenter international randomized controlled trial (with video). Gastrointest Endosc. 2014 Feb;79(2):211–221.
  • Shah T, Lippman R, Kohli D, et al. Accuracy of probe-based confocal laser endomicroscopy (pCLE) compared to random biopsies during endoscopic surveillance of Barrett’s esophagus. Endosc Int Open. 2018 Apr;6(4):E414–e420.
  • Bajbouj M, Vieth M, Rösch T, et al. Probe-based confocal laser endomicroscopy compared with standard four-quadrant biopsy for evaluation of neoplasia in Barrett’s esophagus. Endoscopy. 2010 Jun;42(6):435–440.
  • Luo H, Xu G, Li C, et al. Real-time artificial intelligence for detection of upper gastrointestinal cancer by endoscopy: a multicentre, case-control, diagnostic study. Lancet Oncol. 2019 Dec;20(12):1645–1654.
  • Zhao YY, Xue DX, Wang YL, et al. Computer-assisted diagnosis of early esophageal squamous cell carcinoma using narrow-band imaging magnifying endoscopy. Endoscopy. 2019 Apr;51(4):333–341.
  • Everson M, Herrera L, Li W, et al. Artificial intelligence for the real-time classification of intrapapillary capillary loop patterns in the endoscopic diagnosis of early oesophageal squamous cell carcinoma: a proof-of-concept study. United European Gastroenterol J. 2019 Mar;7(2):297–306.
  • Tomita N, Abdollahi B, Wei J, et al. Attention-based deep neural networks for detection of cancerous and precancerous esophagus tissue on histopathological slides. JAMA Network Open. 2019 Nov 1;2(11):e1914645.
  • Vennalaganti PR, Kaul V, Wang KK, et al. Increased detection of Barrett’s esophagus-associated neoplasia using wide-area trans-epithelial sampling: a multicenter, prospective, randomized trial. Gastrointest Endosc. 2018 Feb;87(2):348–355.
  • Jisu H, Bo-Yong P, Hyunjin P. Convolutional neural network classifier for distinguishing Barrett's esophagus and neoplasia endomicroscopy images. Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society Annual International Conference,Jeju, Korea (South). Jul;2017:2892–2895
  • De Groof J, van der Sommen F, van der Putten J, et al. The Argos project: the development of a computer-aided detection system to improve detection of Barrett’s neoplasia on white light endoscopy. United European Gastroenterol J. 2019 May;7(4):538–547.
  • De Groof AJ, Struyvenberg MR, van der Putten J, et al. Deep-learning system detects neoplasia in patients with barrett’s esophagus with higher accuracy than endoscopists in a multistep training and validation study with benchmarking. Gastroenterology. 2020;158(4):915–929.e4.
  • Cai SL, Li B, Tan WM, et al. Using a deep learning system in endoscopy for screening of early esophageal squamous cell carcinoma (with video). Gastrointest Endosc. 2019 Nov;90(5):745–753.e2.
  • Hashimoto R, Requa J, Dao T, et al. Artificial intelligence using convolutional neural networks for real-time detection of early esophageal neoplasia in Barrett’s esophagus (with video). Gastrointest Endosc. 2020 Jun;91(6):1264–1271.e1.
  • Yang XX, Zhen L, Shao XJ, et al. Real-time artificial intelligence for endoscopic diagnosis of early esophageal squamous cell cancer (with video). Digestive Endosc. 2020 Dec 4;10.1111/den.13908
  • Pennathur A, Farkas A, Krasinskas AM, et al. Esophagectomy for T1 esophageal cancer: outcomes in 100 patients and implications for endoscopic therapy. Ann Thorac Surg. 2009 Apr;87(4):1048–1055. discussion 1054-5.
  • Pech O, May A, Manner H, et al. Long-term efficacy and safety of endoscopic resection for patients with mucosal adenocarcinoma of the esophagus. Gastroenterology. 2014 Mar;146(3):652–660.e1.
  • Pouw RE, Seewald S, Gondrie JJ, et al. Stepwise radical endoscopic resection for eradication of Barrett’s oesophagus with early neoplasia in a cohort of 169 patients. Gut. 2010 Sep;59(9):1169–1177.
  • Wani S, Drahos J, Cook MB, et al. Comparison of endoscopic therapies and surgical resection in patients with early esophageal cancer: a population-based study. Gastrointest Endosc. 2014 Feb;79(2):224–232.e1.
  • Schölvinck D, Künzli H, Meijer S, et al. Management of patients with T1b esophageal adenocarcinoma: a retrospective cohort study on patient management and risk of metastatic disease. Surg Endosc. 2016 Sep;30(9):4102–4113.
  • Park JM, Huo SM, Lee HH, et al. Longer Observation Time Increases Proportion of Neoplasms Detected by Esophagogastroduodenoscopy. Gastroenterology. 2017 Aug;153(2):460–469.e1.
  • Parasa S, Desai M, Vittal A, et al. Estimating neoplasia detection rate (NDR) in patients with Barrett’s oesophagus based on index endoscopy: a systematic review and meta-analysis. Gut. 2019 Dec;68(12):2122–2128.
  • Byrne MF, Chapados N, Soudan F, et al. Real-time differentiation of adenomatous and hyperplastic diminutive colorectal polyps during analysis of unaltered videos of standard colonoscopy using a deep learning model. Gut. 2019 Jan;68(1):94–100.
  • Park CH, Yang DH, Kim JW, et al. Clinical Practice Guideline for Endoscopic Resection of Early Gastrointestinal Cancer. Clin Endosc. 2020 Mar;53(2):142–166.
  • Ngamruengphong S, Wolfsen HC, Wallace MB. Survival of patients with superficial esophageal adenocarcinoma after endoscopic treatment vs surgery. Clin Gastroenterol Hepatol. 2013 Nov;11(11):1424–1429.e2. quiz e81.
  • Probst A, Aust D, Märkl B, et al. Early esophageal cancer in Europe: endoscopic treatment by endoscopic submucosal dissection. Endoscopy. 2015 Feb;47(2):113–121.
  • Isomoto H, Yamaguchi N, Minami H, et al. Management of complications associated with endoscopic submucosal dissection/endoscopic mucosal resection for esophageal cancer. Digestive Endosc. 2013 Mar;25(Suppl 1):29–38.
  • Prasad GA, Wu TT, Wigle DA, et al. Endoscopic and surgical treatment of mucosal (T1a) esophageal adenocarcinoma in Barrett’s esophagus. Gastroenterology. 2009 Sep;137(3):815–823.
  • Wang GQ, Abnet CC, Shen Q, et al. Histological precursors of oesophageal squamous cell carcinoma: results from a 13 year prospective follow up study in a high risk population. Gut. 2005 Feb;54(2):187–192.
  • Wei WQ, Hao CQ, Guan CT, et al. Esophageal Histological Precursor Lesions and Subsequent 8.5-Year Cancer Risk in a Population-Based Prospective Study in China. Am J Gastroenterol. 2020 Jul;115(7):1036–1044.
  • Hofstetter WL. Salvage esophagectomy. J Thorac Dis. 2014 May 6;6 Suppl 3(Suppl3):S341–9.
  • Ashok A, Niyogi D, Ranganathan P, et al. The enhanced recovery after surgery (ERAS) protocol to promote recovery following esophageal cancer resection. Surg Today. 2020 Apr;50(4):323–334.
  • Update on the paris classification of superficial neoplastic lesions in the digestive tract. Endoscopy. 2005Jun;37(6):570–578.
  • Malik S, Sharma G, Sanaka MR, et al. Role of endoscopic therapy in early esophageal cancer. World J Gastroenterol. 2018 Sep 21;24(35):3965–3973.
  • Araki K, Ohno S, Egashira A, et al. Pathologic features of superficial esophageal squamous cell carcinoma with lymph node and distal metastasis. Cancer. 2002 Jan 15;94(2):570–575.
  • Yoshii T, Ohkawa S, Tamai S, et al. Clinical outcome of endoscopic mucosal resection for esophageal squamous cell cancer invading muscularis mucosa and submucosal layer. Dis Esophagus. 2013 Jul;26(5):496–502.
  • Ajani JA, D’Amico TA, Bentrem DJ, et al. Esophageal and Esophagogastric Junction Cancers, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2019 Jul 1;17(7):855–883.
  • Terheggen G, Horn EM, Vieth M, et al. A randomised trial of endoscopic submucosal dissection versus endoscopic mucosal resection for early Barrett’s neoplasia. Gut. 2017 May;66(5):783–793.
  • Pimentel-Nunes P, Dinis-Ribeiro M, Ponchon T, et al. Endoscopic submucosal dissection: european Society of Gastrointestinal Endoscopy (ESGE) Guideline. Endoscopy. 2015 Sep;47(9):829–854.
  • Yang D, Coman RM, Kahaleh M, et al. Endoscopic submucosal dissection for Barrett’s early neoplasia: a multicenter study in the United States. Gastrointest Endosc. 2017 Oct;86(4):600–607.
  • Alvarez Herrero L, Pouw RE, van Vilsteren FG, et al. Safety and efficacy of multiband mucosectomy in 1060 resections in Barrett’s esophagus. Endoscopy. 2011 Mar;43(3):177–183.
  • May A, Gossner L, Behrens A, et al. A prospective randomized trial of two different endoscopic resection techniques for early stage cancer of the esophagus. Gastrointest Endosc. 2003 Aug;58(2):167–175.
  • Pouw RE, van Vilsteren FG, Peters FP, et al. Randomized trial on endoscopic resection-cap versus multiband mucosectomy for piecemeal endoscopic resection of early Barrett’s neoplasia. Gastrointest Endosc. 2011 Jul;74(1):35–43.
  • Zhang YM, Boerwinkel DF, Qin X, et al. A randomized trial comparing multiband mucosectomy and cap-assisted endoscopic resection for endoscopic piecemeal resection of early squamous neoplasia of the esophagus. Endoscopy. 2016 Apr;48(4):330–338.
  • Berger A, Rahmi G, Perrod G, et al. Long-term follow-up after endoscopic resection for superficial esophageal squamous cell carcinoma: a multicenter Western study. Endoscopy. 2019 Apr;51(4):298–306.
  • Spechler SJ, Sharma P, Souza RF, et al. American Gastroenterological Association medical position statement on the management of Barrett’s esophagus. Gastroenterology. 2011 Mar;140(3):1084–1091.
  • AJ S, JL A, Cl L, et al. Radiofrequency ablation is associated with decreased neoplastic progression in patients with barrett’s esophagus and confirmed low-grade dysplasia. Gastroenterology. 2015 Sep;149(3):567–76.e3. . quiz e13-4.
  • Phoa KN, Rosmolen WD, Weusten B, et al. The cost-effectiveness of radiofrequency ablation for Barrett’s esophagus with low-grade dysplasia: results from a randomized controlled trial (SURF trial). Gastrointest Endosc. 2017 Jul;86(1):120–129.e2.
  • Hur C, Choi SE, Rubenstein JH, et al. The cost effectiveness of radiofrequency ablation for Barrett’s esophagus. Gastroenterology. 2012 Sep;143(3):567–575.
  • Bhat S, Coleman HG, Yousef F, et al. Risk of malignant progression in Barrett’s esophagus patients: results from a large population-based study. J Natl Cancer Inst. 2011 Jul 6;103(13):1049–1057.
  • Hamade N, Vennelaganti S, Parasa S, et al. Lower annual rate of progression of short-segment vs long-segment barrett’s esophagus to esophageal adenocarcinoma. Clin Gastroenterol Hepatol. 2019 Apr;17(5):864–868.
  • He S, Bergman J, Zhang Y, et al. Endoscopic radiofrequency ablation for early esophageal squamous cell neoplasia: report of safety and effectiveness from a large prospective trial. Endoscopy. 2015 May;47(5):398–408.
  • Wang WL, Chang IW, Chang CY, et al. Circumferential balloon-based radiofrequency ablation for ultralong and extensive flat esophageal squamous neoplasia. Gastrointest Endosc. 2014 Dec;80(6):1185–1189.
  • Peerally MF, Bhandari P, Ragunath K, et al. Radiofrequency ablation compared with argon plasma coagulation after endoscopic resection of high-grade dysplasia or stage T1 adenocarcinoma in Barrett’s esophagus: a randomized pilot study (BRIDE). Gastrointest Endosc. 2019 Apr;89(4):680–689.
  • Lal P, Thota PN. Cryotherapy in the management of premalignant and malignant conditions of the esophagus. World J Gastroenterol. 2018 Nov 21;24(43):4862–4869.
  • Pacifico RJ, Wang KK, Wongkeesong LM, et al. Combined endoscopic mucosal resection and photodynamic therapy versus esophagectomy for management of early adenocarcinoma in Barrett’s esophagus. Clin Gastroenterol Hepatol. 2003 Jul;1(4):252–257.
  • di Pietro M, Mi C, Rc F. Endoscopic Management of Early Adenocarcinoma and Squamous Cell Carcinoma of the Esophagus: screening, Diagnosis, and Therapy. Gastroenterology. 2018 Jan;154(2):421–436.
  • Ono S, Fujishiro M, Niimi K, et al. Long-term outcomes of endoscopic submucosal dissection for superficial esophageal squamous cell neoplasms. Gastrointest Endosc. 2009 Nov;70(5):860–866.
  • Chevaux JB, Piessevaux H, Jouret-Mourin A, et al. Clinical outcome in patients treated with endoscopic submucosal dissection for superficial Barrett’s neoplasia. Endoscopy. 2015 Feb;47(2):103–112.
  • Ono S, Fujishiro M, Niimi K, et al. Predictors of postoperative stricture after esophageal endoscopic submucosal dissection for superficial squamous cell neoplasms. Endoscopy. 2009 Aug;41(8):661–665.
  • Miwata T, Oka S, Tanaka S, et al. Risk factors for esophageal stenosis after entire circumferential endoscopic submucosal dissection for superficial esophageal squamous cell carcinoma. Surg Endosc. 2016 Sep;30(9):4049–4056.
  • Wen J, Lu Z, Liu Q. Prevention and treatment of esophageal stenosis after endoscopic submucosal dissection for early esophageal cancer. Gastroenterol Res Pract. 2014;2014:457101.
  • Chadwick G, Groene O, Markar SR, et al. Systematic review comparing radiofrequency ablation and complete endoscopic resection in treating dysplastic Barrett’s esophagus: a critical assessment of histologic outcomes and adverse events. Gastrointest Endosc. 2014 May;79(5):718–731.e3.
  • Tomizawa Y, Konda VJA, Coronel E, et al. Efficacy, durability, and safety of complete endoscopic mucosal resection of barrett esophagus: a systematic review and meta-analysis. J Clin Gastroenterol. 2018 Mar;52(3):210–216.
  • Qumseya BJ, Wani S, Desai M, et al. Adverse events after radiofrequency ablation in patients with barrett’s esophagus: a systematic review and meta-analysis. Clinical gastroenterology and hepatology:the official clinical practice journal of the American Gastroenterological Association. 2016 Aug;14(8):1086–1095.e6.
  • Desai M, Saligram S, Gupta N, et al. Efficacy and safety outcomes of multimodal endoscopic eradication therapy in Barrett’s esophagus-related neoplasia: a systematic review and pooled analysis. Gastrointest Endosc. 2017 Mar;85(3):482–495.e4.
  • Wang H, Shuai Q, Tang J, et al. Local Thymosin β4 gel injection prevents esophageal stricture after circumferential endoscopic submucosal dissection in a porcine model. Dig Dis. 2019;37(2):87–92.
  • Tang J, Ye S, Ji X, et al. Deployment of carboxymethyl cellulose sheets to prevent esophageal stricture after full circumferential endoscopic submucosal dissection: a porcine model. Digestive Endosc. 2018 Sep;30(5):608–615.
  • Kim YJ, Park JC, Chung H, et al. Polyglycolic acid sheet application to prevent esophageal stricture after endoscopic submucosal dissection for recurrent esophageal cancer. Endoscopy. 2016;48(S 01):E319–e320.
  • Shi KD, Ji F. Prophylactic stenting for esophageal stricture prevention after endoscopic submucosal dissection. World J Gastroenterol. 2017 Feb 14;23(6):931–934.
  • Kataoka Y, Tsuji Y, Sakaguchi Y, et al. Preventing esophageal stricture after endoscopic submucosal dissection: steroid injection and shielding with polyglycolic acid sheets and fibrin glue. Endoscopy. 2015;47(Suppl S 01):E473–4.
  • Sakaguchi Y, Tsuji Y, Fujishiro M, et al. Triamcinolone injection and shielding with polyglycolic acid sheets and fibrin glue for postoperative stricture prevention after esophageal endoscopic resection: a pilot study. Am J Gastroenterol. 2016 Apr;111(4):581–583.
  • Ohki T, Yamato M, Ota M, et al. Prevention of esophageal stricture after endoscopic submucosal dissection using tissue-engineered cell sheets. Gastroenterology. 2012 Sep;143(3):582–588.e2.
  • Liao Z, Liao G, Yang X, et al. Transplantation of autologous esophageal mucosa to prevent stricture after circumferential endoscopic submucosal dissection of early esophageal cancer (with video). Gastrointest Endosc. 2018 Sep;88(3):543–546.
  • He K, Zhao L, Bu S, et al. Endoscopic mucosal autograft for treating esophageal caustic strictures: preliminary human experience. Endoscopy. 2018 Oct;50(10):1017–1021.
  • Hochberger J, Koehler P, Wedi E, et al. Transplantation of mucosa from stomach to esophagus to prevent stricture after circumferential endoscopic submucosal dissection of early squamous cell. Gastroenterology. 2014 Apr;146(4):906–909.
  • Chai N, Zou J, Linghu E, et al. Autologous skin-grafting surgery to prevent esophageal stenosis after complete circular endoscopic submucosal tunnel dissection for superficial esophageal neoplasms. Am J Gastroenterol. 2019 May;114(5):822–825.
  • Lagergren J, Smyth E, Cunningham D, et al. Oesophageal cancer. Lancet. 2017 Nov 25;390(10110):2383–2396.
  • Eguchi T, Nakanishi Y, Shimoda T, et al. Histopathological criteria for additional treatment after endoscopic mucosal resection for esophageal cancer: analysis of 464 surgically resected cases. Mod Pathol. 2006 Mar;19(3):475–480.
  • Higuchi K, Tanabe S, Koizumi W, et al. Expansion of the indications for endoscopic mucosal resection in patients with superficial esophageal carcinoma. Endoscopy. 2007 Jan;39(1):36–40.
  • Miura A, Momma K, Yoshida M. Endoscopic resection for T1a-MM and T1b-SM1 squamous cell carcinoma of the esophagus. Clin J Gastroenterol. 2009 Aug;2(4):252–256.
  • Tsou YK, Lee CH, Le PH, et al. Adjuvant therapy for pT1a-m3/pT1b esophageal squamous cell carcinoma after endoscopic resection: esophagectomy or chemoradiotherapy? A critical review. Crit Rev Oncol Hematol. 2020 Mar;147:102883.
  • Kam TY, Kountouri M, Roth A, et al. Endoscopic resection with adjuvant chemo-radiotherapy for superficial esophageal squamous cell carcinoma: a critical review. Crit Rev Oncol Hematol. 2018 Apr;124:61–65.

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