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Clinical features - Original research

Association between ivy leaves dry extract EA 575 prescriptions and antibiotic use, sick leave duration, and repeated infections in adult patients

ORCID Icon, , , ORCID Icon & ORCID Icon
Pages 333-340 | Received 16 Nov 2021, Accepted 03 Dec 2021, Published online: 02 Jan 2022

References

  • Allan GM, Arroll B. Prevention and treatment of the common cold: making sense of the evidence. CMAJ. 2014 Feb 18;186(3):190–199.
  • Eckel N, Sarganas G, Wolf IK, et al. Pharmacoepidemiology of common colds and upper respiratory tract infections in children and adolescents in Germany. BMC Pharmacol Toxicol. 2014 Aug 9;15(1):44.
  • German College of General Practitioners and Family Physicians, DEGAM-Leitlinie Nr. 11: Akuter und chronischer Husten. DEGAM 2021.
  • Altiner A, Bell J, Duerden M, et al. More action, less resistance: report of the 2014 Summit of the Global Respiratory Infection Partnership. Int J Pharm Pract. 2015;23(5):370–377.
  • Köchling A, Löffler C, Reinsch S, et al. Reduction of antibiotic prescriptions for acute respiratory tract infections in primary care: a systematic review. Implement Sci. 2018 Mar 20; 13(1):47.
  • European Centre for Disease Prevention and Control (ECDC), European Food Safety Authority (EFSA) and European Medicines Agency (EMA). Third joint inter-agency report on integrated analysis of consumption of antimicrobial agents and occurrence of antimicrobial resistance in bacteria from humans and food-producing animals in the EU/EEA, JIACRA III. 2016–2018. Stockholm, Parma, Amsterdam: ECDC, EFSA, EMA; 2021. https://doi.org/10.2900/056892
  • Raal A, Volmer D, Sõukand R, Hratkevitš S, and Kalle R. Complementary Treatment of the Common Cold and Flu with Medicinal Plants – Results from Two Samples of Pharmacy Customers in Estonia. PLoS One. 2013; 8(3): e58642.
  • Mousa HA-L. Prevention and treatment of influenza, influenza-like illness, and common cold by herbal, complementary, and natural therapies. J Evid Based Complementary Altern Med. 2017;22(1):166–174.
  • Lang C, Röttger-Lüer P, Staiger C. A valuable option for the treatment of respiratory diseases: review on the clinical evidence of the ivy leaves dry extract EA 575®. Planta Med. 2015 Aug;81(12/13):968–974.
  • Kardos P, Dinh QT, Fuchs KH, Gillissen A, Klimek L, Koehler M, Sitter H, and Worth H. Guidelines of the German Respiratory Society for Diagnosis and Treatment of Adults Suffering from Acute, Subacute and Chronic Cough. Pneumologie. 2019 Mar;73(3):143–180
  • Schaefer A, Kehr MS, Giannetti BM, et al. A randomized, controlled, double-blind, multi-center trial to evaluate the efficacy and safety of a liquid containing ivy leaves dry extract (EA 575®) vs. placebo in the treatment of adults with acute cough. Pharmazie. 2016 Sep 1;71(9):504–509.
  • Schaefer A, Ludwig F, Giannetti BM, et al. Efficacy of two dosing schemes of a liquid containing EA 575 versus placebo in the treatment of acute bronchitis in adults. ERJ Open Res. 2019 Dec 8;5(4):00019–2019.
  • Fazio S, Pouso J, Dolinsky D, Fernandez A, Hernandez M, Clavier G, and Hecker M. Tolerance, safety and efficacy of Hedera helix extract in inflammatory bronchial diseases under clinical practice conditions: a prospective, open, multicentre postmarketing study in 9657 patients. Phytomedicine 2009 Jan;16(1):17–24
  • Martin D, Konrad M, Adarkwah CC, et al. Reduced antibiotic use after initial treatment of acute respiratory infections with phytopharmaceuticals – a retrospective cohort study. Postgrad Med. 2020 Jun;132(5):412–418.
  • Becher H, Kostev K, Schröder-Bernhardi D. Validity and representativeness of the ”Disease Analyzer” patient database for use in pharmacoepidemiological and pharmacoeconomic studies. Int J Clin Pharmacol Ther. 2009 Oct;47(10):617–626.
  • Rathmann W, Bongaerts B, Carius H-J, et al. Basic characteristics and representativeness of the German disease analyzer database. Int J Clin Pharmacol Ther. 2018 Oct;56(10):459–466.
  • Quan H, Li B, Couris CM, Fushimi K, Graham P, Hider P, Januel JM, and Sundararajan V. Updating and validating the Charlson comorbidity index and score for risk adjustment in hospital discharge abstracts using data from 6 countries. American Journal of Epidemiology 2011;173(6):676–682.
  • Kern WV, and Kostev K. Prevalence of and Factors Associated with Antibiotic Prescriptions in Patients with Acute Lower and Upper Respiratory Tract Infections-A Case-Control Study. Antibiotics (Basel). 2021 Apr 16;10(4):455
  • Zweigner J, Meyer E, Gastmeier P, et al. Rate of antibiotic prescriptions in German outpatient care – are the guidelines followed or are they still exceeded? GMS Hyg Infect Control. 2018;13:Doc04. Published 2018 Mar 13.
  • Höller M, Steindl H, Abramov-Sommariva D, Wagenlehner F, Naber KG, and Kostev K. Treatment of Urinary Tract Infections with Canephron® in Germany: A Retrospective Database Analysis. Antibiotics (Basel). 2021 Jun 8;10(6):685
  • Benoun JM, Labuda JC, and McSorley SJ. Collateral Damage: Detrimental Effect of Antibiotics on the Development of Protective Immune Memory. mBio. 2016;7(6):e01520–16
  • Sierocinski E, Holzinger F, Chenot JF. Ivy leaf (Hedera helix) for acute upper respiratory tract infections: an updated systematic review. Eur J Clin Pharmacol. 2021;77(8):1113–1122.