Low free triiodothyronine levels are associated with frail phenotype in hospitalized inpatients with cirrhosis

References

• Fried LP, Tangen CM, Walston J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56(3):M146–56.
   PubMed Web of Science ®Google Scholar
• Feng H, Wang X, Mao L, et al. Relationship between sarcopenia/myosteatosis and frailty in hospitalized patients with cirrhosis: a sex-stratified analysis. Ther Adv Chronic Dis. 2021;12:20406223211026996.
   Web of Science ®Google Scholar
• Cron DC, Friedman JF, Winder GS, et al. Depression and frailty in patients with end-stage liver disease referred for transplant evaluation. Am J Transplant. 2016;16(6):1805–1811.
   PubMed Web of Science ®Google Scholar
• Tapper EB, Konerman M, Murphy S, et al. Hepatic encephalopathy impacts the predictive value of the fried frailty index. Am J Transplant. 2018;18(10):2566–2570.
   PubMed Web of Science ®Google Scholar
• Roman E, Parramon M, Flavia M, et al. Frailty in outpatients with cirrhosis: a prospective observational study. Liver Int. 2021;41(2):357–368.
   PubMed Web of Science ®Google Scholar
• Deng LX, Bischoff KE, Kent DS, et al. Frailty is strongly associated with self-reported symptom burden among patients with cirrhosis. Eur J Gastroenterol Hepatol. 2021;33(1S):e395–e400.
   PubMed Web of Science ®Google Scholar
• Deng Y, Lin L, Hou L, et al. A self-reported frailty index predicts long-term mortality in hospitalized patients with cirrhosis. Ann Transl Med. 2020;8(19):1217.
   PubMed Web of Science ®Google Scholar
• Lai JC, Covinsky KE, Dodge JL, et al. Development of a novel frailty index to predict mortality in patients with end-stage liver disease. Hepatology. 2017;66(2):564–574.
   PubMed Web of Science ®Google Scholar
• Deng Y, Lin L, Fan X, et al. Incorporation of frailty estimated by gait speed within MELD-Na and the predictive potential for mortality in cirrhosis. Ther Adv Chronic Dis. 2020;11:2040622320922023.
   Web of Science ®Google Scholar
• Tandon P, Montano-Loza AJ, Lai JC, et al. Sarcopenia and frailty in decompensated cirrhosis. J Hepatol. 2021;75(Suppl 1):S147–S162.
   PubMed Web of Science ®Google Scholar
• Manka P, Bechmann L, Best J, et al. Low free triiodothyronine is associated with advanced fibrosis in patients at high risk for nonalcoholic steatohepatitis. Dig Dis Sci. 2019;64(8):2351–2358.
   PubMed Web of Science ®Google Scholar
• Kim D, Kim W, Joo SK, et al. Subclinical hypothyroidism and low-normal thyroid function are associated with nonalcoholic steatohepatitis and fibrosis. Clin Gastroenterol Hepatol. 2018;16(1):123–131 e1.
   PubMed Web of Science ®Google Scholar
• Punekar P, Sharma AK, Jain A. A study of thyroid dysfunction in cirrhosis of liver and correlation with severity of liver disease. Indian J Endocrinol Metab. 2018;22(5):645–650.
   PubMedGoogle Scholar
• Vincken S, Reynaert H, Schiettecatte J, et al. Liver cirrhosis and thyroid function: friend or foe? Acta Clin Belg. 2017;72(2):85–90.
   PubMed Web of Science ®Google Scholar
• Tas A, Koklu S, Beyazit Y, et al. Thyroid hormone levels predict mortality in intensive care patients with cirrhosis. Am J Med Sci. 2012;344(3):175–179.
   PubMed Web of Science ®Google Scholar
• Huang X, Jiang S, Fan X, et al. Low-free triiodothyronine is associated with poor prognosis of portal hypertension in cirrhosis. Eur J Gastroenterol Hepatol. 2020;32(10):1358–1363.
   PubMed Web of Science ®Google Scholar
• Bertoli A, Valentini A, Cianfarani MA, et al. Low FT3: a possible marker of frailty in the elderly. Clin Interv Aging. 2017;12:335–341.
   PubMed Web of Science ®Google Scholar
• Xiu S, Mu Z, Zhao L, et al. Low free triiodothyronine levels are associated with risk of frailty in older adults with type 2 diabetes mellitus. Exp Gerontol. 2020;138:111013.
   PubMed Web of Science ®Google Scholar
• Hui Y, Xu L, Wang X, et al. Association between sleep disturbance and multidimensional frailty assessed by frailty index in hospitalized cirrhosis. Eur J Gastroenterol Hepatol. 2021;33(1S):e727–e733.
   PubMed Web of Science ®Google Scholar
• Malik R, Hodgson H. The relationship between the thyroid gland and the liver. Qjm. 2002;95(9):559–569.
   PubMed Web of Science ®Google Scholar
• Pasqualetti G, Calsolaro V, Bernardini S, et al. Degree of peripheral thyroxin deiodination, frailty, and long-term survival in hospitalized older patients. J Clin Endocrinol Metab. 2018;103(5):1867–1876.
   PubMed Web of Science ®Google Scholar
• Fozouni L, Wang CW, Lai JC. Sex differences in the association between frailty and sarcopenia in patients with cirrhosis. Clin Transl Gastroenterol. 2019;10(12):e00102.
   PubMed Web of Science ®Google Scholar
• Souza NC, Gonzalez MC, Martucci RB, et al. Frailty is associated with myosteatosis in obese patients with colorectal cancer. Clin Nutr. 2020;39(2):484–491.
   PubMed Web of Science ®Google Scholar
• Hirota K, Kawaguchi T, Koya S, et al. Clinical utility of the liver frailty index for predicting muscle atrophy in chronic liver disease patients with hepatocellular carcinoma. Hepatol Res. 2020;50(3):330–341.
   PubMed Web of Science ®Google Scholar
• Bloise FF, Cordeiro A, Ortiga-Carvalho TM. Role of thyroid hormone in skeletal muscle physiology. J Endocrinol. 2018;236(1):R57–R68.
   PubMed Web of Science ®Google Scholar
• Samoylova ML, Covinsky KE, Haftek M, et al. Disability in patients with end-stage liver disease: results from the functional assessment in liver transplantation study. Liver Transpl. 2017;23(3):292–298.
   PubMed Web of Science ®Google Scholar
• Ando Y, Ishigami M, Ito T, et al. Sarcopenia impairs health-related quality of life in cirrhotic patients. Eur J Gastroenterol Hepatol. 2019;31(12):1550–1556.
   PubMed Web of Science ®Google Scholar
• Bonnefoy M, Berrut G, Lesourd B, et al. Frailty and nutrition: searching for evidence. J Nutr Health Aging. 2015;19(3):250–257.
   PubMed Web of Science ®Google Scholar
• Moura Neto A, Zantut-Wittmann DE. Abnormalities of thyroid hormone metabolism during systemic illness: the low T3 syndrome in different clinical settings. Int J Endocrinol. 2016;2016:2157583.
   PubMed Web of Science ®Google Scholar
• Boelen A, Schiphorst MC P-T, Wiersinga WM. Association between serum interleukin-6 and serum 3,5,3’-triiodothyronine in nonthyroidal illness. J Clin Endocrinol Metab. 1993;77(6):1695–1699.
   PubMed Web of Science ®Google Scholar
• Zoccali C, Mallamaci F, Tripepi G, et al. Low triiodothyronine and survival in end-stage renal disease. Kidney Int. 2006;70(3):523–528.
   PubMed Web of Science ®Google Scholar
• Soysal P, Stubbs B, Lucato P, et al. Inflammation and frailty in the elderly: a systematic review and meta-analysis. Ageing Res Rev. 2016;31:1–8.
   PubMed Web of Science ®Google Scholar
• Bunchorntavakul C, Reddy KR. Review article: malnutrition/sarcopenia and frailty in patients with cirrhosis. Aliment Pharmacol Ther. 2020;51(1):64–77.
   PubMed Web of Science ®Google Scholar
• Hui Y, Li N, Yu Z, et al. Health-related quality of life and its contributors according to a preference-based generic instrument in cirrhosis. Hepatol Commun. 2021;6(3):610–620.
   PubMed Web of Science ®Google Scholar
• Williams FR, Milliken D, Lai JC, et al. Assessment of the frail patient with end-stage liver disease: a practical overview of sarcopenia, physical function, and disability. Hepatol Commun. 2021;5(6):923–937.
   PubMed Web of Science ®Google Scholar
• Lai JC, Tandon P, Bernal W, et al. Malnutrition, frailty, and sarcopenia in patients with cirrhosis: 2021 practice guidance by the American association for the study of liver diseases. Hepatology. 2021;74(3):1611–1644.
   PubMed Web of Science ®Google Scholar
• Lai JC, Dodge JL, Kappus MR, et al. Changes in frailty are associated with waitlist mortality in patients with cirrhosis. J Hepatol. 2020;73(3):575–581.
   PubMed Web of Science ®Google Scholar
• Bertani L, Trico D, Pugliese D, et al. Serum triiodothyronine-to-thyroxine (T3/T4) ratio predicts therapeutic outcome to biological therapies in elderly IBD patients. Aliment Pharmacol Ther. 2021;53(2):273–280.
   PubMed Web of Science ®Google Scholar
• Shah S, Goldberg DS, Kaplan DE, et al. Patient frailty is independently associated with the risk of hospitalization for acute-on-chronic liver failure. Liver Transpl. 2021;27(1):16–26.
   PubMed Web of Science ®Google Scholar
• Louissaint J, Murphy SL, Sonnenday CJ, et al. Applying administrative data-based coding algorithms for frailty in patients with cirrhosis. Liver Transpl. 2021;27(10):1401–1411.
   PubMed Web of Science ®Google Scholar