Integrase inhibitor-based regimens are related to favorable systemic inflammatory index and platecrit scores in people living with HIV (PLWH) up to 2 years

References

• Bonou M, Kapelios CJ, Protogerou AD, et al. Cardiac adiposity as a modulator of cardiovascular disease in HIV. HIV Med. 2021;22(10):879–891.
   PubMed Web of Science ®Google Scholar
• Yang X, Su B, Zhang X, et al. Incomplete immune reconstitution in HIV/AIDS patients on antiretroviral therapy: challenges of immunological non-responders. J Leukoc Biol. 2020;107(4):597–612.
   PubMed Web of Science ®Google Scholar
• Hileman CO, Funderburg NT. Inflammation, immune activation, and antiretroviral therapy in HIV. Curr HIV/AIDS Rep. 2017;14(3):93–100.
   PubMed Web of Science ®Google Scholar
• Longenecker CT, Sullivan C, Baker JV. Immune activation and cardiovascular disease in chronic HIV infection. Curr Opin HIV AIDS. 2016;11(2):216–225.
   PubMed Web of Science ®Google Scholar
• McGinty T, Mirmonsef, P., Mallon, P., et al. Does systemic inflammation and immune activation contribute to fracture risk in HIV? Curr Opin HIV AIDS. 2016;11(3):1202–1210.
   Web of Science ®Google Scholar
• Appay V, Kelleher AD. Immune activation and immune aging in HIV infection. Curr Opin HIV AIDS. 2016;11(2):242–249.
   PubMed Web of Science ®Google Scholar
• Qian S, Chen, X., Wu, T., et al. The accumulation of plasma acylcarnitines are associated with poor immune recovery in HIV-infected individuals. BMC Infect Dis. 2021;21(1):808.
   PubMed Web of Science ®Google Scholar
• Saracino A, Bruno G, Scudeller L, et al. Chronic inflammation in a long-term cohort of HIV-infected patients according to the normalization of the CD4: CD8 ratio. AIDS Res Hum Retroviruses. 2014;30(12):1178–1184.
   PubMed Web of Science ®Google Scholar
• Hu B, Yang, X. R., Xu, Y., et al. Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma. Clin Cancer Res. 2014;20(23):1176–1191.
   Web of Science ®Google Scholar
• Raffetti E, Donato, F., Casari, S., et al. Systemic inflammation-based scores and mortality for all causes in HIV-infected patients: a MASTER cohort study. BMC infect dis. 2017;17(1):1–9.
   PubMed Web of Science ®Google Scholar
• Mena Á, Meijide H, Vázquez P, et al. HIV increases mean platelet volume during asymptomatic HIV infection in treatment-naive patients. J Acquir Immune Defic Syndr. 2011;57(5):e112–3.
   PubMed Web of Science ®Google Scholar
• Mese T, Guven B, Yilmazer MM, et al. Platelet activation markers in children with congenital heart disease associated with pulmonary arterial hypertension. Congenit Heart Dis. 2018;13(4):506–511.
   PubMed Web of Science ®Google Scholar
• Collaboration ATC. Life expectancy of individuals on combination antiretroviral therapy in high-income countries: a collaborative analysis of 14 cohort studies. Lancet. 2008;372(9635):293–299.
   PubMed Web of Science ®Google Scholar
• Kurtul A, Ornek E. Platelet to lymphocyte ratio in cardiovascular diseases: a systematic review. Angiology. 2019;70(9):802–818.
   PubMed Web of Science ®Google Scholar
• UNAIDS. Seizing the moment: tackling entrenched inequalities to end epidemics. 2020. Geneva Switzerland: UNAIDS.
   Google Scholar
• Deeks SG. HIV infection, inflammation, immunosenescence, and aging. Annu Rev Med. 2011;62(1):141–155.
   PubMed Web of Science ®Google Scholar
• Hsue PY, Waters DD. HIV infection and coronary heart disease: mechanisms and management. Nat Rev Cardiol. 2019;16(12):745–759.
   PubMed Web of Science ®Google Scholar
• da Mata GFD, Fernandes DE, Luciano EDP, et al. Inflammation and kidney involvement in human viral diseases caused by SARS-CoV-2, HIV, HCV and HBV. J Venom Anim Toxins Incl Trop Dis. 2021;27:e20200154.
   PubMed Web of Science ®Google Scholar
• Chamroonkul N, Bansal MB. HIV and the liver. Nat Rev Gastroenterol Hepatol. 2019;16(1):1–2.
   PubMed Web of Science ®Google Scholar
• Smail RC, Brew BJ. HIV-associated neurocognitive disorder. Handb Clin Neurol. 2018;152:75–97.
   PubMedGoogle Scholar
• Noubissi EC, Katte JC, Sobngwi E. Diabetes and HIV. Curr Diab Rep. 2018;18(11):125.
   PubMed Web of Science ®Google Scholar
• Houssein M,Inkaya, A. Ç., Balci, C., et al. Frailty and sarcopenia among Turkish people aged 40 and above living with HIV. HIV Med. 2022.
   PubMed Web of Science ®Google Scholar
• Tunjungputri RN, Van Der Ven AJ, Schonsberg A, et al. Reduced platelet hyperreactivity and platelet-monocyte aggregation in HIV-infected individuals receiving a raltegravir-based regimen. Aids. 2014;28(14):2091–2096.
   PubMed Web of Science ®Google Scholar
• Madzime M, Rossouw, T. M., Theron, A. J., et al. Interactions of HIV and antiretroviral therapy with neutrophils and platelets. Front Immunol. 2021;12:634386.
   PubMed Web of Science ®Google Scholar
• Celık T, Balta S, Demır M, et al. Predictive value of admission red cell distribution width-platelet ratio for no-reflow phenomenon in acute ST segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Cardiol J. 2016;23(1):84–92.
   PubMed Web of Science ®Google Scholar
• Uğur M, Ayhan E, Bozbay M, et al. The independent assocıatıon of plateletcrıt wıth long-term outcomes in patıents undergoıng prımary percutaneous coronary interventıon. J Crit Care. 2014;29(6):978–981.
   PubMed Web of Science ®Google Scholar
• Yan Q, Ertao Z, Zhimei Z, et al. Systemic immune-inflammation index (SII): a more promising inflammation-based prognostic marker for patients with synchronic colorectal peritoneal carcinomatosis. J Cancer. 2020;11(18):5264–5272.
   PubMed Web of Science ®Google Scholar
• Zhang X, Ding R, Li H, et al. An association between inflammation and cerebral venous thrombosis: a retrospective study. J Stroke Cerebrovasc Dis. 2021;30(11):106084.
   PubMed Web of Science ®Google Scholar
• Castanheira FVS, Kubes P. Neutrophils and NETs in modulating acute and chronic inflammation. Blood. 2019;133(20):2178–2185.
   PubMed Web of Science ®Google Scholar
• Moore DK, Loxton AG. Regulatory B lymphocytes: development and modulation of the host immune response during disease. Immunotherapy. 2019;11(8):691–704.
   PubMed Web of Science ®Google Scholar
• Bianconi V, Schiaroli, E., Mannarino, M. R., et al. The association between neutrophil to lymphocyte ratio and endothelial dysfunction in people living with HIV on stable antiretroviral therapy. Expert Rev Anti Infect Ther. 2022;20(1):113–120.
   PubMed Web of Science ®Google Scholar
• Teperman J, Carruthers D, Guo Y, et al. Relationship between neutrophil-lymphocyte ratio and severity of lower extremity peripheral artery disease. Int J Cardiol. 2017;228:201–204.
   PubMed Web of Science ®Google Scholar
• Cole JW, Pinto AN, Hebel JR, et al. Acquired immunodeficiency syndrome and the risk of stroke. Stroke. 2004;35(1):51–56.
   PubMed Web of Science ®Google Scholar
• Group DADS. Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patients enrolled in the D: a: d study: a multi-cohort collaboration. Lancet. 2008;371(9622):1417–1426.
   PubMed Web of Science ®Google Scholar
• Satchell CS, O’Halloran JA, Cotter AG, et al. Increased platelet reactivity in HIV-1–infected patients receiving abacavir-containing antiretroviral therapy. J Infect Dis. 2011;204(8):1202–1210.
   PubMed Web of Science ®Google Scholar
• van der Heijden WA, van de Wijer L, Jaeger M, et al. Long-term treated HIV infection is associated with platelet mitochondrial dysfunction. Sci Rep. 2021;11(1):1–12.
   PubMed Web of Science ®Google Scholar
• Hadigan C,Guven, B., Yilmazer, M. M., et al. Platelet activation markers in children with congenital heart disease associated with pulmonary arterial hypertension. Congenital Heart Disease. 2001;32(1):130–139.
   Google Scholar
• Triant VA, Lee H, Hadigan C, et al. Increased acute myocardial infarction rates and cardiovascular risk factors among patients with human immunodeficiency virus disease. J Clin Endocrinol Metab. 2007;92(7):2506–2512.
   PubMed Web of Science ®Google Scholar
• Srinivasa S, Grinspoon SK. Metabolic and body composition effects of newer antiretrovirals in HIV-infected patients. Eur J Endocrinol. 2014;170(5):R185–202.
   PubMed Web of Science ®Google Scholar
• Taramasso L, Tatarelli P, Ricci E, et al. Improvement of lipid profile after switching from efavirenz or ritonavir-boosted protease inhibitors to rilpivirine or once-daily integrase inhibitors: results from a large observational cohort study (SCOLTA). BMC Infect Dis. 2018;18(1):357.
   PubMed Web of Science ®Google Scholar
• Verboeket SO, Wit FW, Verheij E, et al. Human Immunodeficiency Virus (HIV)-negative men who have sex with men have higher CD8+ T-cell counts and lower CD4+/CD8+ T-cell ratios compared with HIV-negative heterosexual men. J Infect Dis. 2021;224(7):1187–1197.
   PubMed Web of Science ®Google Scholar
• Serrano-Villar S, Pérez-Elías MJ, Dronda F, et al. Increased risk of serious non-AIDS-related events in HIV-infected subjects on antiretroviral therapy associated with a low CD4/CD8 ratio. PLoS One. 2014;9(1):e85798.
   PubMed Web of Science ®Google Scholar
• Dutta A, Uno H, Lorenz DR, et al. Low T-cell subsets prior to development of virus-associated cancer in HIV-seronegative men who have sex with men. Cancer Causes Control. 2018;29(11):1131–1142.
   PubMed Web of Science ®Google Scholar
• Lee GC, Restrepo MI, Harper N, et al. Immunologic resilience and COVID-19 survival advantage. J Allergy Clin Immunol. 2021;148(5):1176–1191.
   PubMed Web of Science ®Google Scholar
• Erdinc FS, Dokuzoguz B, Unal S, et al. Temporal trends in the epidemiology of HIV in Turkey. Curr HIV Res. 2020;18(4):258–266.
   PubMed Web of Science ®Google Scholar