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Respiratory

Efficacy and effectiveness of the herbal medicinal product BNO 1016 in the management of acute rhinosinusitis in the context of antibiotic stewardship

ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon
Pages 607-614 | Received 02 Feb 2023, Accepted 05 Jul 2023, Published online: 25 Jul 2023

References

  • Fokkens WJ, Lund VJ, Hopkins C, et al. European position paper on rhinosinusitis and nasal polyps 2020. Rhinology. 2020 Feb 20;58(Suppl S29):1–464.
  • Jaume F, Alobid I, Mullol J, et al. Direct costs of acute rhinosinusitis in Spain: a Prospective and Observational Study (PROSINUS). J Investig Allergol Clin Immunol. 2021 Dec 21;31(6):481–488.
  • Orlandi RR, Kingdom TT, Smith TL, et al. International consensus statement on allergy and rhinology: rhinosinusitis 2021. Int Forum Allergy Rhinol. 2021 Mar;11(3):213–739.
  • Stjarne P, Odeback P, Stallberg B, et al. High costs and burden of illness in acute rhinosinusitis: real-life treatment patterns and outcomes in Swedish primary care. Prim Care Respir J. 2012 Jun;21(2):174–179.
  • Jaume F, Quinto L, Alobid I, et al. Overuse of diagnostic tools and medications in acute rhinosinusitis in Spain: a population-based study (the PROSINUS study). BMJ Open. 2018 Jan 31;8(1):e018788.
  • Ventola CL. The antibiotic resistance crisis: part 1: causes and threats. P T. 2015 Apr;40(4):277–283.
  • Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e.V., Deutsche Gesellschaft für Allgemeinmedizin und Familienmedizin e.V. Rhinosinusitis, 2k-Leitlinie, AWMF-Register-Nr. 017/049 und p. 053–012. 2017.
  • Kreindler JL, Chen B, Kreitman Y, et al. The novel dry extract BNO 1011 stimulates chloride transport and ciliary beat frequency in human respiratory epithelial cultures. Am J Rhinol Allergy. 2012;26(6):439–443. doi: 10.2500/ajra.2012.26.3821
  • Zhang S, Skinner D, Hicks SB, et al. Sinupret activates CFTR and TMEM16A-dependent transepithelial chloride transport and improves indicators of mucociliary clearance. PLoS One. 2014;9(8):e104090. doi: 10.1371/journal.pone.0104090
  • Cho DY, Skinner D, Mackey C, et al. Herbal dry extract BNO 1011 improves clinical and mucociliary parameters in a rabbit model of chronic rhinosinusitis. Int Forum Allergy Rhinol. 2019 Jun;9(6):629–637.
  • Workman AD, Maina IW, Triantafillou V, et al. Effects of BNO 1016 on ciliary transport velocity and cell culture surface liquid height of sinonasal epithelial cultures. Clin Phytosci. 2021;7(1): doi: 10.1186/s40816-021-00276-2
  • Rossi A, Dehm F, Kiesselbach C, et al. The novel Sinupret® dry extract exhibits anti-inflammatory effectiveness in vivo. Fitoterapia. 2012 Jun;83(4):715–720.
  • Zupanets IA, Shebeko SK, Popovych VI, et al. Study of the anti-inflammatory effect of the combined extract BNO 1016 in a leukotriene-dependent in vivo inflammation model. Clin Phytosci. 2020;6(1). doi: 10.1186/s40816-020-0153-8
  • Glatthaar-Saalmüller B, Rauchhaus U, Rode S, et al. Antiviral activity in vitro of two preparations of the herbal medicinal product Sinupret® against viruses causing respiratory infections. Phytomedicine. 2011;19(1):1–7. doi: 10.1016/j.phymed.2011.10.010
  • Tran HTT, Peterburs P, Seibel J, et al. In vitro screening of herbal medicinal products for their supportive curing potential in the context of SARS-CoV-2. Evid Based Complement Alternat Med. 2022;2022:1–9. doi: 10.1155/2022/8038195
  • Cochrane A. Effectiveness and efficiency: random reflections on health services. The Nuffield Provincial Hospitals Trust, London, UK; 1972.
  • Haynes B. Can it work? Does it work? Is it worth it? BMJ. 1999;319(7211):652–653. doi: 10.1136/bmj.319.7211.652
  • Sherman RE, Anderson SA, Dal Pan GJ, et al. Real-world evidence — what is it and what can it tell us? N Engl J Med. 2016;375(23):2293–2297. doi: 10.1056/NEJMsb1609216
  • Concato J, Corrigan-Curay J. Real-World Evidence — Where are we now? N Engl J Med. 2022;386(18):1680–1682. doi: 10.1056/NEJMp2200089
  • Jund R, Mondigler M, Stammer H, et al. Herbal drug BNO 1016 is safe and effective in the treatment of acute viral rhinosinusitis. Acta Otolaryngol. 2015;135(1):42–50. doi: 10.3109/00016489.2014.952047
  • Meltzer EO, Bachert C, Staudinger H. Treating acute rhinosinusitis: comparing efficacy and safety of mometasone furoate nasal spray, amoxicillin, and placebo. J Allergy Clin Immunol. 2005 Dec;116(6):1289–1295. doi: 10.1016/j.jaci.2005.08.044
  • Jund R, Mondigler M, Steindl H, et al. Clinical efficacy of a dry extract of five herbal drugs in acute viral rhinosinusitis. Rhinology. 2012 Dec;50(4):417–426.
  • Rathmann W, Bongaerts B, Carius H-J, et al. Basic characteristics and representativeness of the German disease analyzer database. Int J Clin Pharm Therap. 2018;56(10):459–466. doi: 10.5414/CP203320
  • DeBoer DL, Kwon E. Acute sinusitis. StatPearls. Treasure Island (FL): StatPearls Publishing Copyright© 2022. Florida, USA: StatPearls Publishing LLC; 2022.
  • Hopkins C, Surda P, Walker A, et al. EPOS 4 Patients. Rhinology. 2021 Oct 29:1–57. doi: 10.4193/Rhin20.950
  • Wiebringhaus R, Haubner F. Acute Rhinosinusitis - an update on therapy. MMW Fortschr Med. 2022 Mar;164(5):40–43. doi: 10.1007/s15006-022-0777-3
  • Bittner CB, Plach M, Steindl H, et al. Prevalence of antibiotic prescription in patients with acute rhinosinusitis treated by general practitioners and otolaryngologists in Germany- A retrospective cohort study. Antibiotics (Basel). 2022 Nov 9;11(11):1576.
  • Pouwels KB, Dolk FCK, Smith DRM, et al. Actual versus ‘ideal’ antibiotic prescribing for common conditions in English primary care. J Antimicrob Chemother. 2018 Feb 1;73(suppl_2):19–26.
  • Schwartz KL, Langford BJ, Daneman N, et al. Unnecessary antibiotic prescribing in a Canadian primary care setting: a descriptive analysis using routinely collected electronic medical record data. CMAJ Open. 2020 Apr;8(2):E360–e369.
  • Havers FP, Hicks LA, Chung JR, et al. Outpatient antibiotic prescribing for acute respiratory infections during influenza seasons. JAMA Netw Open. 2018 Jun 1;1(2):e180243.
  • Truitt KN, Brown T, Lee JY, et al. Appropriateness of antibiotic prescribing for acute sinusitis in primary care: a cross-sectional study. Clin Infect Dis. 2021 Jan 27;72(2):311–314.
  • Smith SS, Caliendo A, Cheng BT, et al. Patient perspectives on the drivers and deterrents of antibiotic treatment of acute rhinosinusitis: a qualitative study. J Gen Intern Med. 2023 Feb;38(3):683–690.
  • Martin D, Konrad M, Adarkwah CC, et al. Reduced antibiotic use after initial treatment of acute respiratory infections with phytopharmaceuticals- a retrospective cohort study. Postgrad Med. 2020 Jun;132(5):412–418.
  • Bachert C. Evidence-based management of acute rhinosinusitis with herbal products. Clin Phytosci. 2020;6(1). doi: 10.1186/s40816-020-00231-7
  • Dejaco D, Bocian-Sobkowska J, Szymanski W, et al. Tavipec in acute rhinosinusitis: a multi-centre, doubleblind, randomized, placebo-controlled, clinical trial. Rhinology. 2019 Oct 1;57(5):367–374.
  • European Commission. EU Guidelines for the prudent use of antimicrobials in human health. Off J Eur Union 2017 [1 Jul 2017];C212:1–12.
  • Davies J, Davies D. Origins and evolution of antibiotic resistance. Microbiol Mol Biol Rev. 2010;74(3):417–433. doi: 10.1128/MMBR.00016-10
  • Collaborators EAR. The burden of bacterial antimicrobial resistance in the WHO European region in 2019: a cross-country systematic analysis. Lancet Public Health. 2022 Nov;7(11):e897–e913. doi: 10.1016/S2468-2667(22)00225-0
  • Nausch B, Bittner CB, Höller M, et al. Contribution of symptomatic, herbal treatment options to antibiotic stewardship and microbiotic health. Antibiotics (Basel). 2022 Sep 29;11(10). doi: 10.3390/antibiotics11101331
  • Lange K, Buerger M, Stallmach A, et al. Effects of antibiotics on gut microbiota. Dig Dis. 2016;34(3):260–268. doi: 10.1159/000443360