Association between serum ferritin and bone turnover marker levels in type 2 diabetes mellitus patients with non-alcoholic fatty liver disease

References

• Sheka AC, Adeyi O, Thompson J, et al. Non-alcoholic steatohepatitis: a review. JAMA. 2020;323(12):1175–1183. doi: 10.1001/jama.2020.2298
   PubMed Web of Science ®Google Scholar
• Man S, Deng Y, Ma Y, et al. Prevalence of liver steatosis and fibrosis in the general population and various high-risk populations: a nationwide study with 5.7 million adults in China. Gastroenterology. 2023;165(4):1025–1040. doi: 10.1053/j.gastro.2023.05.053
   PubMed Web of Science ®Google Scholar
• Younossi ZM, Golabi P, de Avila L, et al. The global epidemiology of NAFLD and NASH in patients with type 2 diabetes: a systematic review and meta-analysis. J Hepatol. 2019;71(4):793–801. doi: 10.1016/j.jhep.2019.06.021
   PubMed Web of Science ®Google Scholar
• Saxena A, Wahi N, Kumar A, et al. Functional interactomes of genes showing association with type-2 diabetes and its intermediate phenotypic traits point towards adipo-centric mechanisms in its pathophysiology. Biomolecules. 2020;10(4):601. doi: 10.3390/biom10040601
   PubMed Web of Science ®Google Scholar
• Compston J. Type 2 diabetes mellitus and bone. J Intern Med. 2018;283(2):140–153. doi: 10.1111/joim.12725
   PubMed Web of Science ®Google Scholar
• Guo H, Wang C, Jiang B, et al. Association of insulin resistance and β-cell function with bone turnover biomarkers in dysglycemia patients. Front Endocrinol. 2021;12:554604. doi: 10.3389/fendo.2021.554604
   PubMed Web of Science ®Google Scholar
• Shen Z, Cen L, Chen X, et al. Increased risk of low bone mineral density in patients with non-alcoholic fatty liver disease: a cohort study. Eur J Endocrinol. 2020;182(2):157–164. doi: 10.1530/EJE-19-0699
   PubMed Web of Science ®Google Scholar
• Shang X, Zhang R, Wang X, et al. The relationship of hyperferritinemia to metabolism and chronic complications in type 2 diabetes. Diabetes Metab Syndr Obes. 2022;15:175–182. doi: 10.2147/DMSO.S348232
   PubMed Web of Science ®Google Scholar
• Pouwels S, Sakran N, Graham Y, et al. Non-alcoholic fatty liver disease (NAFLD): a review of pathophysiology, clinical management and effects of weight loss. BMC Endocr Disord. 2022;22(1):63. doi: 10.1186/s12902-022-00980-1
   PubMed Web of Science ®Google Scholar
• Balogh E, Tolnai E, Nagy BJ, et al. Iron overload inhibits osteogenic commitment and differentiation of mesenchymal stem cells via the induction of ferritin. Biochim Biophys Acta. 2016;1862(9):1640–1649. doi: 10.1016/j.bbadis.2016.06.003
   PubMed Web of Science ®Google Scholar
• Zhang H, Wang A, Shen G, et al. Hepcidin-induced reduction in iron content and PGC-1β expression negatively regulates osteoclast differentiation to play a protective role in postmenopausal osteoporosis. Aging (Albany NY). 2021;13(8):11296–11314. doi: 10.18632/aging.202817
   PubMedGoogle Scholar
• Schini M, Vilaca T, Gossiel F, et al. Bone turnover markers: basic biology to clinical applications. Endocr Rev. 2023 May 8;44(3):417–473. doi: 10.1210/endrev/bnac031
   PubMed Web of Science ®Google Scholar
• Song S, Guo Y, Yang Y, et al. Advances in pathogenesis and therapeutic strategies for osteoporosis. Pharmacol Ther. 2022;237:108168. doi: 10.1016/j.pharmthera.2022.108168
   PubMed Web of Science ®Google Scholar
• Picke AK, Campbell G, Napoli N, et al. Update on the impact of type 2 diabetes mellitus on bone metabolism and material properties. Endocr Connect. 2019;8(3):R55–R70. doi: 10.1530/EC-18-0456
   PubMed Web of Science ®Google Scholar
• Maagensen H, Junker AE, Jørgensen NR, et al. Bone turnover markers in patients with non-alcoholic fatty liver disease and/or type 2 diabetes during oral glucose and isoglycemic intravenous glucose. J Clin Endocrinol Metab. 2018;103(5):2042–2049. doi: 10.1210/jc.2018-00176
   PubMed Web of Science ®Google Scholar
• Díaz-López A, Iglesias-Vázquez L, Pallejà-Millán M, et al. Association between iron status and incident type 2 diabetes: a population-based cohort study. Nutrients. 2020;12(11):3249. doi: 10.3390/nu12113249
   PubMed Web of Science ®Google Scholar
• Wang Q, Zhu M, Li H, et al. Hyperferritinemia correlates to metabolic dysregulation and steatosis in Chinese biopsy-proven non-alcoholic fatty liver disease patients. Diabetes Metab Syndr Obes. 2022;15:1543–1552. doi: 10.2147/DMSO.S361187
   PubMed Web of Science ®Google Scholar
• Yan JX, Pan BJ, Zhao PP, et al. Serum ferritin is correlated with non-alcoholic fatty liver disease in middle-aged and older patients with type 2 diabetes. Endocr Connect. 2021;10(12):1560–1569. doi: 10.1530/EC-21-0367
   PubMed Web of Science ®Google Scholar
• Wang JW, Jin CH, Ke JF, et al. Serum iron is closely associated with metabolic dysfunction-associated fatty liver disease in type 2 diabetes: a real-world study. Front Endocrinol. 2022;13:942412. doi: 10.3389/fendo.2022.942412
   PubMedGoogle Scholar
• Sandnes M, Ulvik RJ, Vorland M, et al. Hyperferritinemia-A clinical overview. J Clin Med. 2021;10(9):2008. doi: 10.3390/jcm10092008
   PubMed Web of Science ®Google Scholar
• Muckenthaler MU, Rivella S, Hentze MW, et al. A red carpet for iron metabolism. Cell. 2017;168(3):344–361. doi: 10.1016/j.cell.2016.12.034
   PubMed Web of Science ®Google Scholar
• Qin Y, Huang Y, Li Y, et al. Association between systemic iron status and β-cell function and insulin sensitivity in patients with newly diagnosed type 2 diabetes. Front Endocrinol. 2023;14:1143919. doi: 10.3389/fendo.2023.1143919
   PubMed Web of Science ®Google Scholar
• Cullis JO, Fitzsimons EJ, Griffiths WJ, et al. British society for haematology. Investigation and management of a raised serum ferritin. Br J Haematol. 2018;181(3):331–340. doi: 10.1111/bjh.15166
   PubMed Web of Science ®Google Scholar
• Lee SLK, Wong RSM, Li CK, et al. Prevalence and risk factors of fractures in transfusion dependent thalassemia - a Hong Kong Chinese population cohort. Endocrinol Diabetes Metab. 2022;5(4):e340. doi: 10.1002/edm2.340
   PubMedGoogle Scholar
• Li C, Lingna F, Yanming H, et al. The correlation between iron accumulation and bone mineral density in patients with type 2 diabetes mellitus. Chin J Osteoporos. 2023;29(3):371–377.
   Google Scholar
• Cheng Q, Zhang X, Jiang J, et al. Postmenopausal iron overload exacerbated bone loss by promoting the degradation of type I collagen. Biomed Res Int. 2017;2017:1345193. doi: 10.1155/2017/1345193
   PubMed Web of Science ®Google Scholar
• Wang L, Fang B, Fujiwara T, et al. Deletion of ferroportin in murine myeloid cells increases iron accumulation and stimulates osteoclastogenesis in vitro and in vivo. J Biol Chem. 2018;293(24):9248–9264. doi: 10.1074/jbc.RA117.000834
   PubMed Web of Science ®Google Scholar
• Wolf M, Chertow GM, Macdougall IC, et al. Randomized trial of intravenous iron-induced hypophosphatemia. JCI Insight. 2018;3(23):e124486. doi: 10.1172/jci.insight.124486
   PubMed Web of Science ®Google Scholar
• Yang R, Chen J, Zhang J, et al. 1,25-dihydroxyvitamin D protects against age-related osteoporosis by a novel VDR-Ezh2-p16 signal axis. Aging Cell. 2020;19(2):e13095. doi: 10.1111/acel.13095
   PubMed Web of Science ®Google Scholar
• Ma J, Wang A, Zhang H, et al. Iron overload induced osteocytes apoptosis and led to bone loss in Hepcidin-/- mice through increasing sclerostin and RANKL/OPG. Bone. 2022;164:116511. doi: 10.1016/j.bone.2022.116511
   PubMed Web of Science ®Google Scholar
• Peng P, Xiao F, Gao S, et al. Association between serum ferritin and bone mineral density in US adults. J Orthop Surg Res. 2022;17(1):494. doi: 10.1186/s13018-022-03357-1
   PubMed Web of Science ®Google Scholar
• Choi KH, Lee JH, Lee DG. Sex-related differences in bone metabolism in osteoporosis observational study. Medicine (Baltimore). 2021;100(21):e26153. doi: 10.1097/MD.0000000000026153
   PubMed Web of Science ®Google Scholar
• Yu SJ, Yang Y, Zang JC, et al. Evaluation of serum 25-hydroxyvitamin D3 and bone mineral density in 268 patients with hip fractures. Orthop Surg. 2021;13(3):892–899. doi: 10.1111/os.12920
   PubMed Web of Science ®Google Scholar
• Buettmann EG, Goldscheitter GM, Hoppock GA, et al. Similarities between disuse and age-induced bone loss. J Bone Miner Res. 2022;37(8):1417–1434. doi: 10.1002/jbmr.4643
   PubMed Web of Science ®Google Scholar
• Almeida M, Laurent MR, Dubois V, et al. Estrogens and androgens in skeletal physiology and pathophysiology. Physiol Rev. 2017;97(1):135–187. doi: 10.1152/physrev.00033.2015
   PubMed Web of Science ®Google Scholar
• Wang X, Chen B, Sun J, et al. Iron-induced oxidative stress stimulates osteoclast differentiation via NF-κB signaling pathway in mouse model. Metabolism. 2018;83:167–176. doi: 10.1016/j.metabol.2018.01.005
   PubMed Web of Science ®Google Scholar