Diagnostic value of the mean corpuscular volume in the detection of vitamin B12 deficiency

REFERENCES

• Lindenbaum J, Healton EB, Savage DG, Brust JCM, Garrett TJ, Podell ER, et al. Neuropsychia-tric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis. N Engl J Med 1988; 318: 1720–8.
   PubMed Web of Science ®Google Scholar
• Carmel R. Pernicious anemia. The expected findings of very low serum cobalamin levels, anemia, and macrocytosis are often lacking. Arch Int Med 1988; 148: 1712–4.
   Google Scholar
• Thompson WG, Babitz L, Cassino C, Freedman M, Lipkin M. Evaluation of current criteria used to measure vitamin B12 levels. Am J Med 1987; 82: 291–4.
   Google Scholar
• Thompson WG, Cassino C, Babitz L, Meola T, Berman R, Lipkin M, et al. Hypersegmented neutrophils and vitamin B12 deficiency. Acta Haematol 1989; 81: 186–91.
   PubMed Web of Science ®Google Scholar
• Midgette AS, Stukel TA, Littenberg A. A meta-analytic method for summarizing diagnostic test performances. Med Decis Making 1993; 13: 253–7.
   PubMed Web of Science ®Google Scholar
• Irwig L, Macaskill P, Glasziou P, Fahey M. Meta-analytic methods for diagnostic test accuracy. J Clin Epimediol 1995; 48: 119–30.
   PubMed Web of Science ®Google Scholar
• Detsky AS, Naylor CD, O'Rourke K, McGeer AJ, L'Abbe A. Incorporating variations in the quality of individual randomized controlled trials into meta-analysis. J Clin Epidemiol 1992; 45: 255–65.
   Google Scholar
• Rutter CM, Gatsonis CA. Regression methods for meta analysis of a diagnostic test data. Acad Radiol 1995; 2: S48–56.
   PubMedGoogle Scholar
• Hunter R, Jones M, Jones TG, Matthews DM. Serum B12 and folate concentrations in mental patients. Br J Psychiatry 1967; 113: 1291–5.
   Web of Science ®Google Scholar
• Elsborg L, Lund V, Bastrup-Madsen P. Serum vitamin B12 levels in the aged. Acta Med Scand 1976; 200: 309–14.
   Google Scholar
• Garry PJ, Goodwin JS, Hunt WC. Folate and vitamin B12 status in a healthy elderly population. J Am Geriatr Soc 1984; 32: 719–26.
   Google Scholar
• Blundell EL, Matthews JH, Allen SM, Middleton AM, Morris JE, Wickramasinghe AS. Importance of low serum B12 and red cell folate concentra-tions in elderly hospital inpatients. J Clin Pathol 1985; 38: 1179–84.
   PubMed Web of Science ®Google Scholar
• Grinblat J, Marcus DL, Hernandez F, Freedman ML. Folate and vitamin B12 levels in the urban elderly population with chronic diseases: assess-ment of two laboratory folate assays. J Am Geriatr Soc 1986; 34: 627–32.
   PubMed Web of Science ®Google Scholar
• Nilsson-Ehle H, Landhal S, Lindstedt G, Netterblad L, Stockbruegger R, Westin J, et al. Low serum cobalamin levels in a population study of 70- and 75-year old subjects: gastrointestinal causes and hematological effects. Dig Dis Sci 1989; 34: 716–23.
   Google Scholar
• Bunting RW, Bitzer AM, Kenney RM, Ellman L. Prevalence of intrinsic factor antibodies and vitamin B12 malabsorption in older patients admitted to a rehabilitation hospital. J Am Geriatr Soc 1990; 38: 743–7.
   PubMed Web of Science ®Google Scholar
• Joosten E, Pelemans W, Hiele M, Goossens W. [Vitamin B12 (cobalamin) deficiency in the aged] Original Title: Vitamine B12 (cobalamine)-gebrek bij bejaarden. Ned Tijdschr Geneeskd 1990; 134: 652–6.
   PubMedGoogle Scholar
• Hanger HC, Sainsbury R, Gilchrist NL, Beard MEJ, Duncan JM. A community study of vitamin B12 and folate levels in the elderly. J Am Geriatr Soc 1991; 39: 1155–9.
   Google Scholar
• Pennypacker LC, Allen RH, Kelly JP, Matthews LM, Grigsby J, Kaye K, et al. High prevalence of cobalamin deficiency in elderly outpatients. J Am Geriatr Soc 1992; 40: 1197–204.
   PubMed Web of Science ®Google Scholar
• Yao Y, Yao SL, Yao SS, Yao G, Lou W. Prevalence of vitamin B12 deficiency among geriatric outpatients. J Fam Pract 1992; 35: 524–8.
   Google Scholar
• Norman EJ, Morrison JA. Screening elderly populations for cobalamin (vitamin B12) defi-ciency using the urinary MMA by gas chromato-graphy/mass spectrometry. Am J Med 1993; 94: 589— 94.
   PubMed Web of Science ®Google Scholar
• Brett AS, Roberts MS. Screening for vitamin B12 deficiency in psychiatric patients. J Gen Intern Med 1994; 9: 522–4.
   PubMed Web of Science ®Google Scholar
• Lindenbaum J, Rosenberg IH, Wilson PWF, Stabler SP, Allen RH. Prevalence of cobalamin deficiency in the Framingham elderly population. Am J Clin Nutrition 1994; 60: 2–11.
   Google Scholar
• Carmel R. Prevalence of undiagnosed pernicious anemia in the elderly. Arch Intern Med 1996; 156: 1097–2000.
   PubMedGoogle Scholar
• Griner PF, Oranburg PR. Predictive values of erythrocyte indices for tests of iron, folic acid, and vitamin B12 deficiency. Am J Clin Pathol 1978; 70: 748–52.
   PubMed Web of Science ®Google Scholar
• Jen P, Woo B, Rosenthal PE, Bunn F, Loscalzo A, Goldman L. The value of the peripheral blood smear in anemic inpatients. Arch Intern Med 1983; 143: 1120 — 5.
   PubMedGoogle Scholar
• Carmel R, Karnaze DS. Physician response to low serum cobalamin levels. Arch Int Med 1986; 146: 1161— 5.
   PubMedGoogle Scholar
• Moelby L, Rasmussen K, Jensen MK. The relationship between clinically confirmed cobala-min deficiency and serum methylmalonic acid. J Int Med 1990; 228: 373–8.
   Google Scholar
• Stabler SP, Allen RH, Savage DG, Lindenbaum J. Clinical spectrum and diagosis of cobalamin deficiency. Blood 1990; 76: 871–81.
   PubMed Web of Science ®Google Scholar
• Moelby L, Nielsen G, Rasmussen K, Jensen MK, Pedersen KO. Metabolic cobalamin deficiency in patients with low to low-normal plasma cobala-mins. Scand J Clin Lab Invest 1997; 57: 209— 15.
   Google Scholar
• Croft RF, Streeter AM, O'Neill BJ. Red cell indices in megaloblastosis and iron deficiency. Pathology 1974; 6: 107–17.
   Google Scholar
• Prentice AG, Evans IL. Megaloblastic anemia with normal mean cell volume. Lancet 1979; 1: 606 — 7.
   PubMed Web of Science ®Google Scholar
• Solanki DL, Jacobson RJ, Green R, McKibbon J, Berdoff R. Pernicious anemia in black: a study of 64 patients from Washington D.C. and Johannes-burg, South Africa. Am J Clin Pathol 1981; 75: 96 — 9.
   Google Scholar
• Norman EJ, Martelo OJ, Denton MD. Cobalamin (vitamin B12) deficiency detection by urinary methylmalonic acid quantitation. Blood 1982; 59: 1128–31.
   Google Scholar
• Saxena S, Weiner JM, Carmel R. Red blood cell distribution width in untreated pernicious anemia. Am J Clin Pathol 1988; 89: 660–3.
   Google Scholar
• Pruthi RK, Tefferi A. Pernicious anemia revisited. Mayo Clin Proc 1994; 69: 144–50.
   PubMed Web of Science ®Google Scholar
• Savage DG, Lindenbaum J, Stabler SP, Allen RH. Sensitivity of serum methylmalonic acid and total homocysteine determinations for diagnosing coba-lamin and folate deficiencies. Am J Med 1994; 96: 239–46.
   PubMed Web of Science ®Google Scholar
• Hattersley PG. Macrocytosis of the erythrocytes. A preliminary report. JAMA 1964; 189: 997–9.
   PubMed Web of Science ®Google Scholar
• McPhedran P, Branes MG, Weinstein JS, Robertson JS. Interpretation of electronically determined macrocytosis. Ann Intern Med 1973; 78: 677–83.
   PubMed Web of Science ®Google Scholar
• Davidson RJL, Hamilton PJ. High mean red cell volume: its incidence and significance in routine haematology. J Clin Pathol 1978; 31: 493–8.
   PubMed Web of Science ®Google Scholar
• Breedveld FC, Bieger R, Wermeskerken van RKA. The clinical significance of macrocytosis. Acta Med Scand 1981; 209: 319–22.
   PubMedGoogle Scholar
• Wymer A, Becker DM. Recognition and evalua-tion of red blood cell macrocytosis in the primary care setting. J Gen Intern Med 1990; 5: 192–7.
   PubMed Web of Science ®Google Scholar
• Stabler SP. Screening the older population for cobalamin (vitamin B12) deficiency. J Am Geriatr Soc 1995; 43: 1290–7.
   PubMed Web of Science ®Google Scholar
• McRae TD, Freedman ML. Why vitamin B12 deficiency should be managed aggressively. Ger-iatrics 1989; 44: 70–9.
   PubMed Web of Science ®Google Scholar
• Nieuwenhuizen C, Vreugdenhil G, van Eijk HG, Swaak AJ. [Rheumatoid arthritis and anemia; various aspects concerning prevalence, patho-genesis, diagnosis and therapy]. Original title: Reumatoide artritis en anemie; enkele aspecten betreffende prevalentie, pathogenese, diagnostiek en therapie. Ned Tijdschr Geneeskd 1992; 136: 864 — 8.
   Google Scholar
• Oscier DG, Hamblin TJ. Megaloblastosic anaemia with normal mean cell volume. Lancet 1979; 1: 389— 90.
   PubMed Web of Science ®Google Scholar
• Snow CF. Laboratory diagnosis of vitamin B12 and folate deficiency. Arch Int Med 1999; 159: 1289— 98.
   PubMedGoogle Scholar
• Chanarin I, Metz J. Diagnosis of cobalamin deficiency: the old and the new. Br J Hematol 1997; 97: 695–700.
   PubMed Web of Science ®Google Scholar