Effects of growth hormone replacement on cortisol metabolism in hypopituitary patients treated with cortisone acetate

REFERENCES

• Stewart PM. 11 beta-Hydroxysteroid dehydrogen-ase: implications for clinical medicine. Clin Endocrinol 1996; 44: 493–9.
   PubMed Web of Science ®Google Scholar
• White PC, Mune T, Agarwal AK. 11 beta-Hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess. Endocr Rev 1997; 18: 135–56.
   Google Scholar
• Rusvai E, Naray-Fejes Toth A. A new isoform of 11 beta-hydroxysteroid dehydrogenase in aldos-terone target cells. J Biol Chem 1993; 268: 10717–20.
   PubMed Web of Science ®Google Scholar
• Stewart PM, Murry BA, Mason JI. Human kidney 11 beta-hydroxysteroid dehydrogenase is a high affinity nicotinamide adenine dinucleotide-dependent enzyme and differs from the cloned type I isoform. J Clin Endocrinol Metab 1994; 79: 480–4.
   Google Scholar
• Lakshmi V, Monder C. Purification and charac-terization of the corticosteroid 11fl-dehydrogenase component of the rat liver 11fl-hydroxysteroid dehydrogenase complex. Endocrinology 1988; 123: 2390–8.
   PubMed Web of Science ®Google Scholar
• Agarwal AK, Tusie Luna MT, Monder C, White PC. Expression of 11 beta-hydroxysteroiddehydro-genase using recombinant vaccinia virus. Mol Endocrinol 1990; 4: 1827–32.
   PubMed Web of Science ®Google Scholar
• Walker BR, Campbell JC, Fraser R, Stewart PM, Edwards CR. Mineralocorticoid excess and inhi-bition of 11 beta-hydroxysteroid dehydrogenase in patients with ectopic ACTH syndrome. Clin Endocrinol 1992; 37: 483–92.
   Google Scholar
• Jamieson PM, Chapman KE, Edwards CR, Seckl JR. 11 beta-hydroxysteroid dehydrogenase is an exclusive 11 beta- reductase in primary cultures of rat hepatocytes: effect of physicochemical and hor-monal manipulations. Endocrinology 1995; 136: 4754–61.
   PubMed Web of Science ®Google Scholar
• Tannin GM, Agarwal AK, Monder C, New MI, White PC. The human gene for 11 beta-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization. J Biol Chem 1991;266: 16653–8.
   Google Scholar
• Ulick S, Levine LS, Gunczler P, Zanconato G, Ramirez LC, Rauh W, et al. A syndrome of apparent mineralocorticoid excess associated with defects in the peripheral metabolism of cortisol. J Clin Endocrinol Metab 1979; 49: 757–64.
   PubMed Web of Science ®Google Scholar
• Palermo M, Shackleton CH, Mantero F, Stewart PM. Urinary free cortisone and the assessment of 11 beta-hydroxysteroid dehydrogenase activity in man. Clin Endocrinol 1996; 45: 605–11.
   PubMed Web of Science ®Google Scholar
• Best R, Walker BR. Additional value of measure-ment of urinary cortisone and unconjugated cor-tisol metabolites in assessing the activity of 11 beta-hydroxysteroid dehydrogenase in vivo. Clin Endocrinol 1997; 47: 231–6.
   PubMedGoogle Scholar
• De Boer H, Blok GT, Van der Veen EA. Clinical aspects of growth hormone deficiency in adults. Endocr Rev 1995; 16: 63–86.
   Google Scholar
• Carroll PV, Christ ER, Bengtsson BA, Carlsson L, Christiansen JS, Clemmons D, et al. Growth hor-mone deficiency in adulthood and the effects of growth hormone replacement: a review. Growth Hormone Research Society Scientific Committee. J Clin Endocrinol Metab 1998; 83: 382–95.
   PubMedGoogle Scholar
• Low SC, Chapman KE, Edwards CR, Wells T, Robinson IC, Seckl JR. Sexual dimorphism of hepatic 11 beta-hydroxysteroid dehydrogenase in the rat: the role of growth hormone patterns. J Endocrinol 1994; 143: 541–8.
   PubMedGoogle Scholar
• Albiston AL, Smith RE, Krozowski ZS. Sex- and tissue- specific regulation of 11 beta-hydroxysteroid dehydrogenase mRNA. Mol Cell Endocrinol 1995; 109: 183–8.
   Google Scholar
• Liu YJ, Nakagawa Y, Nasuda K, Saegusa H, Igarashi Y. Effect of growth hormone, insulin and dexamethasone on 11 beta-hydroxysteroid dehydrogenase activity on a primary culture of rat hepatocytes. Life Sci 1996; 59: 227–34.
   Google Scholar
• Moore JS, Monson JP, Kaltsas G, Putignano P, Wood PJ, Sheppard MC, et al. Modulation of 11beta-hydroxysteroid dehydrogenase isoenzymes by growth hormone and insulin-like growth factor: in vivo and in vitro studies. J Clin Endocrinol Metab 1999; 84: 4172–7.
   PubMed Web of Science ®Google Scholar
• Weaver JU, Thaventhiran L, Noonan K, Burrin JM, Taylor NF, Norman MR, et al. The effect of growth hormone replacement on cortisol metab-olism and glucocorticoid sensitivity in hypopituit-ary adults. Clin Endocrinol 1994; 41: 639–48.
   PubMed Web of Science ®Google Scholar
• Gelding SV, Taylor NF, Wood PJ, Noonan K, Weaver JU, Wood DF, et al. The effect of growth hormone replacement therapy on cortisol-cortisone interconversion in hypopituitary adults: evidence for growth hormone modulation of extrarenal 11 beta-hydroxysteroid dehydrogenase activity. Clin Endocrinol 1998; 48: 153–62.
   PubMed Web of Science ®Google Scholar
• Walker BR, Andrew R, MacLeod KM, Padfield PL. Growth hormone replacement inhibits renal and hepatic 11 beta-hydroxysteroid dehydrogen-ases in ACTH-deficient patients. Clin Endocrinol 1998; 49: 257–63.
   Google Scholar
• Dullaart RPF, Pasterkamp SH, Beentjes JAM, Sluiter WJ. Evaluation of adrenal function in patients with hypothalamic and pituitary disorders: comparison of serum cortisol, urinary free cortisol and the human-corticotrophin releasing hormone test with the insulin tolerance test. Clin Endocrinol 1999; 50: 465–71.
   Google Scholar
• Beentjes JAM, Tjeerdsma G, Sluiter WJ, Dullaart RPF. Divergence between growth hormone responses to insulin-induced hypoglycaemia and growth hormone-releasing hormone in patients with non-functioning pituitary macroadenomas and hyperprolactinaemia. Clin Endocrinol 1996; 45: 391–8.
   Google Scholar
• Growth Hormone Research Society. Consensus guidelines for the diagnosis and treatment of adults with growth hormone deficiency: summary state-ment of the Growth Hormone Research Society Workshop on adult growth hormone deficiency. J Clin Endocrinol Metab 1998; 83: 379–81.
   PubMed Web of Science ®Google Scholar
• Beentjes JAM, Van Gorkom BAP, Sluiter WJ, Dullaart RPF. One year growth hormone replace-ment therapy does not alter colonic epithelial cell proliferation in growth hormone deficient adults. Clin Endocrinol 2000; 52: 457–63.
   Google Scholar
• Lukaski HC, Johnson PE, Bolonchuk WW, Lykken GI. Assessment of fat-free mass using bioelectrical impedance measurements of the human body. Am J Clin Nutr 1985; 41: 810–7.
   PubMed Web of Science ®Google Scholar
• Wolthers BG, De Vries U, Volmer M, Nagel GT. Detection of 3 beta-hydroxysteroid dehydrogenase deficiency in a newborn by means of urinary steroid analysis. Clin Chim Acta 1987; 169: 109–16.
   Google Scholar
• Zumoff B, Fukushima DK, Hellman L. Intercomparison of four methods for measuring cortisol production. J Clin Endocrinol Metab 1974; 38: 169–75.
   Google Scholar
• Pratt JJ, Boonman R, Woldring MG, Donker AJ. Special problems in the radioimmunoassay of plasma aldosterone without prior extraction and purification. Clin Chim Acta 1978; 84: 329–37.
   Google Scholar
• Kerstens MN, Riemens SC, Sluiter WJ, Pratt JJ, Wolthers BG, Dullaart RPF. Lack of relationship between 11fl-hydroxysteroid dehydrogenase setpo-int and insulin sensitivity in the basal state and after 24h of insulin infusion in healthy subjects and type 2 diabetic patients. Clin Endocrinol 2000; 52: 403–11.
   PubMed Web of Science ®Google Scholar
• Esteban NV, Loughlin T, Yergey AL, Zawadzki JK, Booth JD, Winterer JC, et al. Daily cortisol production rate in man determined by stable iso-tope dilution/mass spectrometry. J Clin Endocrinol Metab 1991; 72: 39–45.
   PubMed Web of Science ®Google Scholar
• Kraan GP, Dullaart RPF, Pratt JJ, Wolthers BG, Drayer NM, De Bruin R. The daily cortisol pro-duction reinvestigated in healthy men. The serum and urinary cortisol production rates are not sig-nificantly different. J Clin Endocrinol Metab 1998; 83: 1247–52.
   Google Scholar
• Stewart PM, Boulton A, Kumar S, Clark PM, Shackleton CH. Cortisol metabolism in human obesity: impaired cortisone—cortisol conversion in subjects with central adiposity. J Clin Endocrinol Metab 1999; 84: 1022–7.
   Google Scholar
• Rodriguez Arnao J, Perry L, Besser GM, Ross RJ. Growth hormone treatment in hypopituitary GH deficient adults reduces circulating cortisol levels during hydrocortisone replacement therapy. Clin Endocrinol 1996; 45: 33–7.
   Google Scholar