The pathogenesis of autoimmune diseases

REFERENCES

• Pincus T, Marcum SB, Callahan LF. Longterm drug therapy for rheumatoid arthritis in seven rheumatology private practices: II. Second line drugs and prednisone. J Rheumatol 1992; 19:1885–94.
   Google Scholar
• Geiler T, Kriegsmann J, Keyszer GM, Gay RE, Gay S. A new model for rheumatoid arthritis generated by engraftment of rheumatoid syno-vial tissue and normal human cartilage into SOD mice. Arthritis Rheum 1994; 37:1664–71.
   Google Scholar
• Neidhart M, Rethage J, Kuchen S, Kunzler P, Crowl RM, Billingham ME, Gay RE, Gay S. Retrotransposable Li elements expressed in rheumatoid arthritis synovial tissue: association with genomic DNA hypomethylation and influence on gene expression. Arthritis Rheum 2000; 43:2634–47.
   PubMed Web of Science ®Google Scholar
• Akbar AN, Borthwick N, Salmon M, Gombert W, Bofill M, Shamsadeen N, Pilling D, Pett S, Grundy JE, Janossy G. The significance of low bc1-2 expression by CD45R0 T cells in normal individuals and patients with acute viral infec-tions. The role of apoptosis in T cell memory. J Exp Med 1993; 178:427–38.
   PubMed Web of Science ®Google Scholar
• Lorenz H-M. Biological agents: a novel ap-proach to the therapy of rheumatoid arthritis. Exp Opin Invest Drugs 2000; 9:1479–90.
   PubMed Web of Science ®Google Scholar
• Kalden JR, Winkler T, Herrmann M, Krapf F. Pathogenesis of systemic lupus erythematosus. Rheumatol Int 1991; 11:95–100.
   PubMed Web of Science ®Google Scholar
• Mysler E, Bini P, Drappa J, Ramos P, Friedman SM, Krammer PH, Elkon KB. The apoptosis-1/Fas protein in human systemic lupus erythe-matosus. J Clin Invest 1994; 93:1029–34.
   Google Scholar
• Rosen A, Casciola-Rosen L, Ahearn J. Novel packages of viral and self-antigens are generated during apoptosis. J Exp Med 1995; 181:1557–61.
   PubMed Web of Science ®Google Scholar
• Lorenz H-M, Grünke M, Hieronymus T, Herrmann M, Kiihnel A, Manger B, Kalden JR. In vitro apoptosis and expression of apoptosis-related molecules in lymphocytes from patients with different autoimmune diseases. Arthritis Rheum 1997; 40:306–17.
   PubMed Web of Science ®Google Scholar
• Krieg AM. CpG DNA: a pathogenic factor in systemic lupus erythematosus? J Clin Immunol 1995; 15:284–92.
   PubMed Web of Science ®Google Scholar
• Lorenz H-M, Hieronymus T, Grünke M, Blank N, Rascu A, Winkler S, Geiler T, Kalden JR. Decreased rescue from apoptosis through 7c-chain cytokine signaling in PHA lymphoblasts deriving from SLE patients with with high in-flammatory activity. Arthritis Rheum 1998; 41:S68.
   Google Scholar
• Herrmann M, Voll RE, Zoller OM, Hagenhofer M, Ponner BB, Kalden JR. Impaired phagocyto-sis of apoptotic material by monocyte-derived macrophages from patients with systemic lupus erythematosus. Arthritis Rheum 1998; 41:1241–50.
   PubMed Web of Science ®Google Scholar
• Perniok A, Wedekind F, Herrmann M, Specker C, Schneider M. High levels of circulating early apoptotic peripheral blood mononuclear cells in systemic lupus erythematosus. Lupus 1998; 7:113–8.
   Google Scholar
• Voll R, Roth E, Girkontaite I, Fehr H, Herrmann M, Lorenz H-M, Kalden JR. Histone-specific Th0 and Thl clones derived from systemic lupus erythematosus patients induce double-stranded DNA antibody production. Arthritis Rheum 1997; 40:2162–9.
   Google Scholar
• Utz PJ, Hottelet M, Schur PH, Anderson P. Proteins phosphorylated during stress-induced apoptosis are common targets for autoantibody production in patients with systemic lupus ery-thematosus. J Exp Med 1997; 185:843–54.
   PubMed Web of Science ®Google Scholar
• Schellekens GA, de Jong BA, van den Hoogen FH, van de Putte LB, van Venrooij WJ. Citrul-line is an essential constituent of antigenic de-terminants recognized by rheumatoid arthritis-specific autoantibodies. J Clin Invest 1998; 101:273–81.
   PubMed Web of Science ®Google Scholar
• Rosen A, Casciola-Rosen L, Wigley F. Role of metal-catalyzed oxidation reactions in the early pathogenesis of scleroderma. Curr Opin Rheu-matol 1997; 9:538–43.
   PubMedGoogle Scholar
• Enestrom S, Hultman P. Does amalgam affect the immune system? A controversial issue. Int Arch Allergy Immunol 1995; 106:180–203.
   PubMed Web of Science ®Google Scholar
• Melino G, Piacentini M. 'Tissue' transglutami-nase in cell death: a downstream or a multifunc-tional upstream effector? FEBS Lett 1998; 430:59–63.
   Google Scholar
• Utz PJ, Hottelet M, van Venrooij WJ, Anderson P. Association of phosphorylated serine/arginine (SR) splicing factors with the Ul-small ribonu-cleoprotein (snRNP) autoantigen complex ac-companies apoptotic cell death. J Exp Med 1998; 187:547–60.
   PubMed Web of Science ®Google Scholar
• Utz PJ, Anderson P. Posttranslational protein modifications, apoptosis, and the bypass of tol-erance to autoantigens. Arthritis Rheum 1998; 41:1152–60.
   PubMed Web of Science ®Google Scholar
• Casciola-Rosen L, Andrade F, Ulanet D, Wong WB, Rosen A. Cleavage by granzyme B is strongly predictive of auto antigen status: impli-cations for initiation of autoimmunity. J Exp Med 1999; 190:815–26.
   Google Scholar
• Datta SK, Patel H, Berry D. Induction of a cati-onic shift in IgG anti-DNA autoantibodies. Role of T helper cells with classical and novel phe-notypes in three murine models of lupus nephri-tis. J Exp Med 1987; 165:1252–68.
   Google Scholar
• Naiki M, Chiang BL, Cawley D, Ansari A, Rozzo SJ, Kotzin BL, Zlotnik A, Gershwin ME. Generation and characterization of cloned T helper cell lines for anti-DNA responses in NZB.H-2bm12 mice. J Immunol 1992; 149:4109–15.
   Google Scholar
• Suzuki N, Harada T, Mizushima Y, Sakane T. Possible pathogenic role of cationic anti-DNA autoantibodies in the development of nephritis in patients with systemic lupus erythematosus. J Immunol 1993; 151:1128–36.
   PubMed Web of Science ®Google Scholar
• Raz E, Ben-Bassat H, Davidi T, Shlomai Z, Ei-lat D. Cross-reactions of anti-DNA autoanti-bodies with cell surface proteins. Eur J Immunol 1993; 23:383–90.
   PubMed Web of Science ®Google Scholar
• Ehrenstein MR, Katz DR, Griffiths MH, Pa-padaki L, Winkler TH, Kalden JR, Isenberg DA. Human IgG anti-DNA antibodies deposit in kid-neys and induce proteinuria in SCID mice. Kid-ney Int 1995; 48:705–11.
   Google Scholar
• Belmont HM, Abramson SB, Lie JT. Pathology and pathogenesis of vascular injury in systemic lupus erythematosus. Interactions of inflamma-tory cells and activated endothelium. Arthritis Rheum 1996; 39:9–22.
   Google Scholar
• Manger K, Repp R, Spriewald BM, Rascu A, Geiger A, Wassmuth R, Westerdaal NA, Wentz B, Manger B, Kalden JR, van de Winkel JG. Fcgamma receptor Ha polymorphism in Cauca-sian patients with systemic lupus erythematosus: association with clinical symptoms. Arthritis Rheum 1998; 41:1181–9.
   Google Scholar
• Bennett RM KB, Merritt MJ. DNA receptor dysfunction in systemic lupus erythematosus and kindred disorders. Induction by anti-DNA antibodies, antihistone antibodies, and antire-ceptor antibodies. J Exp Med 1987; 166:850–63.
   Google Scholar
• Frank MM, Hamburger MI, Lawley TJ, Kim-berly RP, Plotz PH. Fc-receptor dysfunction in lupus. N Engl J Med 1979; 300:1487.
   PubMed Web of Science ®Google Scholar
• Taylor RP, Horgan C, Buschbacher R, Brunner CM, Hess CE, O'Brien WM, Wanebo HJ. De-creased complement mediated binding of anti-body/3H-d5DNA immune complexes to the red blood cells of patients with systemic lupus ery-thematosus, rheumatoid arthritis, and hemato-logic malignancies. Arthritis Rheum 1983; 26:736–44.
   Google Scholar
• Walport MJ. Complement. Second of two parts. N Engl J Med 2001; 344:1140–4.
   PubMed Web of Science ®Google Scholar
• Amoura Z, Koutouzov S, Chabre H, Cacoub P, Amoura I, Musset L, Bach JF, Piette JC. Pres-ence of antinucleosome autoantibodies in a re-stricted set of connective tissue diseases: antinu-cleo some antibodies of the IgG3 subclass are markers of renal pathogenicity in systemic lupus erythematosus. Arthritis Rheum 2000; 43:76–84.
   PubMed Web of Science ®Google Scholar