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Research Article

Cytokeratin-positive cells in preoperative peripheral blood and bone marrow aspirates of patients with colorectal cancer

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Pages 49-57 | Published online: 08 Jul 2009

  • Butler TP, Gullino PM. Quantitation of cell shedding into efferent blood of mammary adenocarcinoma. Cancer Res 1975; 35: 512-6.
  • Paget S. The distribution of secondary growths in cancer of the breast. 1889 [classical article]. Cancer Metastasis Rev 1989; 8: 98-101.
  • Price JE, Carr D, Tarin D. Spontaneous and induced metastasis of naturally occurring tumors in mice: analysis of cell shedding into the blood. J Natl Cancer Inst 1984; 73: 1319-26.
  • Juacaba SF, Horak E, Price JE, Tarin D. Tumor cell dissemination patterns and metastasis of murine mammary carcinoma. Cancer Res 1989; 49: 570-5.
  • Leinung S, Wurl P, Weiss CL, Roder I, Schonfelder M. Cytokeratin-positive cells in bone marrow in comparison with other prognostic factors in colon carcinoma. Langenbecks Arch Surg 2000; 385: 337-43.
  • Lindemann F, Schlimok G, Dirschedl P, Witte J, Riethmuller G. Prognostic significance of micrometastatic tumour cells in bone marrow of colorectal cancer patients. Lancet 1992; 340(8821): 685-9.
  • Braun S, Pantel K, Muller P, Janni W, Hepp F, Kentenich CR, Gastroph S, Wischnik A, Dimpfl T, Kindermann G, Riethmuller G, Schlimok G. Cytokeratin-positive cells in the bone marrow and survival of patients with stage I, II, or III breast cancer [see comments]. N Engl J Med 2000; 342: 525-33.
  • Molino A, Pelosi G, Turazza M, Sperotto L, Bonetti A, Nortilli R, Fattovich G, Alaimo C, Piubello Q, Pavanel F, Micciolo R, Cetto GL. Bone marrow micrometastases in 109 breast cancer patients: correlations with clinical and pathological features and prognosis. Breast Cancer Res Treat 1997; 42: 23-30.
  • Sloane JP, Ormerod MG, Neville AM. Potential pathological application of immunocytochemical methods to the detection of micrometastases. Cancer Res 1980; 40: 3079-82.
  • Schlimok G, Funke I, Holzmann B, Gottlinger G, Schmidt G, Hauser H, Swierkot S, Warnecke HH, Schneider B, Koprowski H. Micrometastatic cancer cells in bone marrow: in vitro detection with anti-cytokeratin and in vivo labeling with anti-17-1 A monoclonal antibodies. Proc Natl Acad Sei USA 1987; 84: 8672-6.
  • WyId DK, Selby P, Perren TJ, Jonas SK, AllenMersh TG, Wheeldon J, Burchill SA. Detection of colorectal cancer cells in peripheral blood by reverse-transcriptase polymerase chain reaction for cytokeratin 20. Int J Cancer 1998; 79: 288-93.
  • Schlimok G, Funke I, Bock B, Schweiberer B, Witte J, Riethmuller G. Epithelial tumor cells in bone marrow of patients with colorectal cancer: immunocytochemical detection, phenotypic characterization, and prognostic significance. J CHn Oncol 1990; 8: 831-7.
  • Borgen E, Beiske K, Trachsel S, Nesland JM, Kvalheim G, Herstad TK, Schlichting E, Qvist H, Naume B. Immunocytochemical detection of isolated epithelial cells in bone marrow: non-specific staining and contribution by plasma cells directly reactive to alkaline phosphatase. J Pathol 1998; 185: 427-34.
  • Lagrange M, Ferrero JM, Lagrange JL, Machiavello JC, Monticelli J, Bayle C, Creisson A, Namer M, Thyss A, Bourcier C, Gioanni J, Schneider M. Non-specifically labelled cells that simulate bone marrow metastases in patients with non-metastatic breast cancer. J Clin Pathol 1997; 50:206-11.
  • Werther K, Normark M, Hansen BF, Brunner N, Nielsen HJ. The use of the CELLection kit in the isolation of carcinoma cells from mononuclear cell suspensions. J Immunol Methods 2000; 238: 133-41.
  • Latza U, Niedobitek G, Schwarting R, Nekarda H, Stein H. Ber-EP4: new monoclonal antibody which distinguishes epithelia from mesothelial. J CHn Pathol 1990; 43: 213-9.
  • Mignatti P, Rifkin DB. Biology and biochemistry of proteinases in tumor invasion. Physiol Rev 1993; 73: 161-95.
  • Dano K, Romer J, Nielsen BS, Bjom S, Pyke C, Rygaard J, Lund LR. Cancer invasion and tissue remodeling-cooperation of protease systems and cell types. APMIS 1999; 107: 120-7.
  • Cohen RL, Xi XP, Crowley CW, Lucas BK, Levinson AD, Shuman MA. Effects of urokinase receptor occupancy on plasm in generation and proteolysis of basement membrane by human tumor cells. Blood 1991; 78: 479-87.
  • Reiter LS, Kruithof EK, Cajot JF, Sordat B. The role of the urokinase receptor in extracellular matrix degradation by HT29 human colon carcinoma cells. Int J Cancer 1993; 53: 444-50.
  • Grondahl-Hansen J, Peters HA, van Putten WL, Look MP, Pappot H, Ronne E, Dano K, Klijn JG, Brunner N, Foekens JA. Prognostic significance of the receptor for urokinase plasminogen activator in breast cancer. Clin Cancer Res 1995; 1: 1079-87.
  • Stephens RW, Nielsen HJ, Christensen IJ, Thorlacius-Ussing O, Sorensen S, Dano K, Brunner N. Plasma urokinase receptor levels in patients with colorectal cancer relationship to prognosis. J Natl Cancer Inst 1999; 91: 869-74.
  • Heiss MM, Allgayer H, Gruetzner KU, Funke I, Babic R, Jauch KW, Schildberg FW. Individual development and uPA-receptor expression of disseminated tumour cells in bone marrow: a reference to early systemic disease in solid cancer. Nat Med 1995; 1: 1035-9.
  • Werther K, Normark M, Hansen BF, Nielsen HJ. Immunoglobulin and enzyme-conjugated dextran polymers enhance u-PAR staining intensity of carcinoma cells in peripheral blood smears. J Histochem Cytochem 1999; 47: 959-64.
  • Ford TC, Lai T, Symes MO. Morphological and functional characteristics of mouse mammary carcinoma cells separated on Nycodenz columns. Br J Exp Pathol 1987; 68: 453-60.
  • Klein E, Vanky F, GaIiH U, Vose BM, Fopp M. Separation and characteristics of tumor-infiltrating lymphocytes in man. Contemp Top Immunobiol 1980; 10: 79-107.
  • Kasper M, Stosiek P, Typlt H, Rarsten U. Histological evaluation of three new monoclonal anti-cytokeratin antibodies. 1. Normal tissues. Eur J Cancer CHn Oncol 1987; 23: 137-47.
  • Groom AC, MacDonald IC, Schmidt EE, Morris VL, Chambers AF. Tumour metastasis to the liver. and the roles of proteinases and adhesion molecules: new concepts from in vivo videomicroscopy. Can J Gastroenterol 1999; 13: 733-43.
  • Luzzi KJ, MacDonald IC, Schmidt EE, Kerkvliet N, Morris VL, Chambers AF, Groom AC. Multistep nature of metastatic inefficiency: dormancy of solitary cells after successful extravasation and limited survival of early micrometastases. Am J Pathol 1998; 153: 865-73.
  • Ohtani H, Pyke C, Dano K, Nagura H. Expression of urokinase receptor in various stromal-cell populations in human colon cancer immunoelectron microscopical analysis. Int J Cancer 1995; 62: 691-6.
  • Ossowski L, Aguirre-Ghiso JA. Urokinase receptor and integrin partnership: coordination of signaling for cell adhesion, migration and growth. Curr Opin Cell Biol 2000; 12: 613-20.
  • Janni W, Gastroph S, Hepp F, Kentenidi C, Rjosk D, Schindlbeck C, Dimpfl T, Sommer H, Braun S. Prognostic significance of an increased number of micrometastatic tumor cells in the bone marrow of patients with first recurrence of breast carcinoma. Cancer 2000; 88: 2252-9.

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