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Original

Insulin Resistance and Inflammation in the Early Phase of Type 2 Diabetes: Potential for Therapeutic Intervention

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Pages 30-40 | Published online: 08 Jul 2009

References

  • King H., Aubert R. E., Herman W. H. Global burden of diabetes, 1995–2025: prevalence, numerical estimates, and projections. Diabetes Care 1998; 21: 1414–1431
  • Isomaa B., Almgren P., Tuomi T. Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care 2001; 24: 683–689
  • Reaven G. M. Role of insulin resistance in human disease. Diabetes 1988; 37: 1595–1607
  • Kylin E. Studien über das Hypertonie‐Hyperglykamie‐Hyperurikamiesyndrom. Zentralblatt für Innere Medizin 1923; 44: 105–127
  • Bonora E., Kiechl S., Willeit J. Prevalence of insulin resistance in metabolic disorders: the Bruneck Study. Diabetes 1998; 47: 1643–1649
  • Hanson R. L., Imperatore G., Bennett P. H., Knowler W. C. Components of the “metabolic syndrome” and incidence of type 2 diabetes. Diabetes 2002; 51: 3120–3127
  • Pereira M. A., Kartashov A. I., Ebbeling C. B., Van horn L., Slattery M. L., Jacobs dr D. R Jr., Ludwig D. S. Fast‐food habits, weight gain, and insulin resistance (the CARDIA study): 15‐year prospective analysis. Lancet 2005; 365: 36–42
  • Dunstan D. W., Zimmet P. Z., Welborn T. A. The rising prevalence of diabetes and impaired glucose tolerance: the Australian Diabetes, Obesity and Lifestyle Study. Diabetes Care 2002; 25: 829–834
  • Accili D. Perspectives in Diabetes. The Struggle for Mastery in Insulin Action: From Triumvirate to Republic. Diabetes 2004; 53: 1633–1642
  • Pickup J. C., Mattock M. B., Chusney G. D., Burt D. NIDDM as a disease of the innate immune system: association of acute‐phase reactants and IL‐6 with metabolic syndrome X. Diabetologia 1997; 40: 1286–1292
  • Pradhan A. D., Manson J. E., Rifai N. C‐reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA 2001; 286: 327–334
  • Ridker P. M., Hennekens C. H., Buring J. E. C‐reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med 2000; 342: 836–843
  • Han T. S., Sattar N., Williams K. Prospective study of reactive protein in relation to the development of diabetes and metabolic syndrome in the Mexico City Diabetes Study. Diabetes Care 2002; 25: 2016–2021
  • Freeman D. J., Norrie J., Caslake M. J. C‐reactive protein is an independent predictor of risk for the development of diabetes in the West of Scotland Coronary Prevention Study. Diabetes 2002; 51: 1596–1600
  • Duncan B. B., Schmidt M. I., Pankow J. S. Low‐grade systemic inflammation and the development of type 2 diabetes. Diabetes 2003; 52: 1799–1805
  • Verma S., Kuliszewski M. A., Li S. H. C‐reactive protein attenuates endothelial progenitor cell survival, differentiation, and function. Circulation 2004; 109: 2058–2067
  • Ridker P. M., Wilson P. W., Grundy S. M. Should C‐reactive protein be added to metabolic syndrome and to assessment of global cardiovascular risk?. Circulation 2004; 109: 2818–2825
  • The Diabetes Prevention Program Research Group. Prevention of Type 2 Diabetes with Troglitazone in the Diabetes Prevention Program. Diabetes 2005; 54: 1150–1156
  • Schernthaner G. Cardiovascular mortality and morbidity in type‐2 diabetes mellitus. Diabetes Research and Clinical Practise 1996; 31 Suppl: S3–S13
  • Haffner S. M., Mykkanen L., Festa A. Insulin‐resistant prediabetic subjects have more atherogenic risk factors than insulin‐sensitive prediabetic subjects: implications for preventing coronary heart disease during the prediabetic state. Circulation 2000; 101: 975–980
  • Festa A., D'agostino r R Jr., Howard G. Chronic subclinical inflammation as part of the insulin resistance syndrome. Circulation 2000; 102: 42–47
  • Haffner S. M., Greenberg A. S., Weston W. M. Effect of rosiglitazone treatment on nontraditional markers of cardiovascular disease in patients with type 2 diabetes mellitus. Circulation 2002; 106: 679–684
  • Dandona P., Aljada A., Bandyopadhyay A. Inflammation: the link between insulin resistance, obesity and diabetes. Trends Immunol 2004; 25: 4–7
  • Fernandez‐real J. M., Ricart W. Insulin resistance and chronic cardiovascular inflammatory syndrome. Endocr Rev 2003; 24: 278–301
  • Sjöholm A., Nyström T. Endothelial inflammation in insulin resistance. Lancet 2005; 365: 610–612
  • Devaraj S., Rosenson R. S., Jialal I. Metabolic syndrome: an appraisal of the pro‐inflammatory and procoagulant status. Endocrinol Metab Clin North Am 2004; 33: 431–453
  • Trayhurn P., Wood I. S. Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr 2004; 92: 347–355
  • Ouchi N., Kihara S., Arita Y. Adiponectin, an adipocytederived plasma protein, inhibits endothelial NF‐kB signaling through a cAMP‐dependent pathway. Circulation 2000; 102: 1296–1301
  • Hotta K., Funahashi T., Arita Y. Plasma concentrations of a novel, adipose‐specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol 2000; 20: 1595–1599
  • Weyer C., Funahashi T., Tanaka S. Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab 2001; 86: 1930–1935
  • Duncan B. B., Schmidt M. I., Pankow J. S. Adiponectin and the development of type 2 diabetes: the Atherosclerosis Risk in Communities Study. Diabetes 2004; 53: 2473–2478
  • Lindsay R. S., Funahashi T., Hanson R. L. Adiponectin and development of type 2 diabetes in the Pima Indian population. Lancet 2002; 360: 57–58
  • Snehalatha C., Mukesh B., Simon M. Plasma adiponectin is an independent predictor of type 2 diabetes in Asian indians. Diabetes Care 2003; 26: 3226–3229
  • Spranger J., Kroke A., Mohlig M. Adiponectin and protection against type 2 diabetes mellitus. Lancet 2003; 361: 226–228
  • Krakoff J., Funahashi T., Stehouwer C. D. Inflammatory markers, adiponectin, and risk of type 2 diabetes in the Pima Indian. Diabetes Care 2003; 26: 1745–1751
  • Yu J. G., Javorschi S., Hevener A. L. The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects. Diabetes 2002; 51: 2968–2974
  • Kang E. S., Park S. Y., Kim H. J., Ahn C. W., Nam M., Cha B. S., Lim S. K., Kim K. R., Lee H. C. The influence of adiponectin gene polymorphism on the rosiglitazone response in patients with type 2 diabetes. Diabetes Care 2005; 28: 1139–1144
  • Debril M. B., Renaud J. P., Fajas L. The pleiotropic functions of peroxisome proliferator‐activated receptor. J Mol Med 2001; 79: 30–47
  • Desvergne B., Wahli W. Peroxisome proliferator‐activated receptors: nuclear control of metabolism. Endocr Rev 1999; 20: 649–688
  • Yoshimoto T., Naruse M., Nishikawa M. Antihypertensive and vasculo‐ and renoprotective effects of pioglitazone in genetically obese diabetic rats. Am J Physiol 1997; 272: E989–E996
  • Smith U. Thiazolidinedione‐induced effects beyond glycaemic control. Br J Diabetes Vasc Dis 2002; 2 (suppl 1): S24–S27
  • Bennett S. M., Agrawal A., Elasha H., Heise M., Jones N. P., Walker M., Wilding J. P. Rosiglitazone improves insulin sensitivity, glucose tolerance and ambulatory blood pressure in subjects with impaired glucose tolerance. Diabet Med. 2004; 21: 415–422
  • Chiquette E., Ramirez G., Defronzo R. A meta‐analysis comparing the effect of thiazolidinediones on cardiovascular risk factors. Arch Intern Med. 2004; 164: 2097–2104
  • Langenfeld M. R., Forst T., Hohberg C., Kann P., Lubben G., Konrad T., Fullert S. D., Sachara C., Pfutzner A. Pioglitazone decreases carotid intima‐media thickness independently of glycemic control in patients with type 2 diabetes mellitus: results from a controlled randomized study. Circulation 2005; 111: 2525–2531
  • Choi D., Kim S. K., Choi S. H., Ko Y. G., Ahn C. W., Jang Y., Lim S. K., Lee H. C., Cha B. S. Preventative effects of rosiglitazone on restenosis after coronary stent implantation in patients with type 2 diabetes. Diabetes Care 2004; 27: 2654–60
  • Reaven G. M. The Insulin Resistance Syndrome: Definition and Dietary Approaches to Treatment. Annu Rev Nutr 2005; 25: 17.1–17.16
  • Hu G., Jousilahti P., Barengo N. C., Qiao Q., Lakka T. A., Tuomilehto J. Physical activity, cardiovascular risk factors, and mortality among Finnish adults with diabetes. Diabetes Care 2005; 28: 799–805
  • Schernthaner G., Matthews D. R., Charbonnel B., Hanefeld M., Brunetti P. Efficacy and safety of pioglitazone versus metformin in patients with type 2 diabetes mellitus: a double‐blind, randomized trial. J Clin Endocrinol Metab 2004; 89: 6068–6076
  • Charbonnel B. H., Matthews D. R., Schernthaner G., Hanefeld M., Brunetti P. A long‐term comparison of pioglitazone and gliclazide in patients with Type 2 diabetes mellitus: a randomized, double‐blind, parallelgroup comparison trial. Diabet Med 2005; 22: 399–405
  • Hanefeld M., Brunetti P., Schernthaner G. H., Matthews D. R., Charbonnel B. H. One‐year glycemic control with a sulfonylurea plus pioglitazone versus a sulfonylurea plus metformin in patients with type 2 diabetes. Diabetes Care 2004; 27: 141–147
  • Matthews D. R., Charbonnel B. H., Hanefeld M., Brunetti P., Schernthaner G. Long‐term therapy with addition of pioglitazone to metformin compared with the addition of gliclazide to metformin in patients with type 2 diabetes: a randomized, comparative study. Diabetes Metab Res Rev 2005; 21: 167–174
  • Ceriello A., Johns D., Widel M., Eckland D. J., Gilmore K. J., Tan M. H. Comparison of effect of pioglitazone with metformin or sulfonylurea (monotherapy and combination therapy) on postload glycemia and composite insulin sensitivity index during an oral glucose tolerance test in patients with type 2 diabetes. Diabetes Care 2005; 28: 266–272
  • Miyazaki Y., Mahankali A., Matsuda M., Mahankali S., Hardies J., Cusi K., Mandarino L. J., Defronzo R. A. Effect of pioglitazone on abdominal fat distribution and insulin sensitivity in type 2 diabetic patients. J Clin Endocrinol Metab 2002; 87: 2784–2791
  • Bajaj M., Suraamornkul S., Pratipanawatr T., Hardies L. J., Pratipanawatr W., Glass L., Cersosimo E., Miyazaki Y., Defronzo R. A. Pioglitazone reduces hepatic fat content and augments splanchnic glucose uptake in patients with type 2 diabetes. Diabetes 2003; 52: 1364–1370
  • Tiikkainen M., Hakkinen A. M., Korsheninnikova E., Nyman T., Makimattila S., Yki‐jarvinen H. Effects of rosiglitazone and metformin on liver fat content, hepatic insulin resistance, insulin clearance, and gene expression in adipose tissue in patients with type 2 diabetes. Diabetes 2004; 53: 2169–2176
  • Retnakaran R., Hanley A. J., Raif N., Hirning C. R., Connelly P. W., Sermer M., Kahn S. E., Zinman B. Adiponectin and beta cell dysfunction in gestational diabetes: pathophysiological implications. Diabetologia 2005; 48: 993–1001
  • Charbonnel B., Schernthaner G., Brunetti P., Matthews D. R., Urquhart R., Tan M. H., Hanefeld M. Long‐term efficacy and tolerability of add‐on pioglitazone therapy to failing monotherapy compared with addition of gliclazide or metformin in patients with type 2 diabetes. Diabetologia, 2005 in press
  • Nesto R. W., Bell D., Bonow R. O., Fonseca V., Grundy S. M., Horton E. S., Le winter M., Porte D., Semenkovich C. F., Smith S., Young L. H., Kahn R. Thiazolidinedione use, fluid retention, and congestive heart failure: a consensus statement from the American Heart Association and American Diabetes Association. Diabetes Care 2004; 27: 256–263
  • Masoudi F. A., Inzucchi S. E., Wang Y., Havranek E. P., Foody J. M., Krumholz H. M. Thiazolidinediones, metformin, and outcomes in older patients with diabetes and heart failure: an observational study. Circulation 2005; 111: 583–590
  • Marchesini G., Bugianesi E., Forlani G., Cerrelli F., Lenzi M., Manini R. Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome. Hepatology 2003; 37: 917–923
  • Belcher G., Schernthaner G. Changes in liver tests during one‐year treatment of patients with type 2 diabetes with pioglitazone, metformin, or gliclazide. Diabetic Medicine, 2005 in press
  • Charbonnel B., Dormandy J., Erdmann E., Massi‐benedetti M., Skene A. PROactive Study Group. The prospective pioglitazone clinical trial in macrovascular events (PROactive): can pioglitazone reduce cardiovascular events in diabetes? Study design and baseline characteristics of 5238 patients. Diabetes Care 2004; 27: 1647–1653
  • Schernthaner G. Progress in the prevention of type 2 Diabetes. Wien.Klin.Wochenschr 2003; 115: 745–757
  • Pan X. R., Li G. W., Hu Y. H., Wang J. X., Yang W. Y., An Z. X., Hu Z. X., Lin J., Xiao J. Z., Cao H. B., Liu P. A., Jiang X. G., Jiang Y. Y., Wang J. P., Zheng H., Zhang H., Bennett P. H., Howard B. V. Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study. Diabetes Care 1997; 20: 537–544
  • Tuomilehto J., Lindström J., Eriksson J. G., Valle T. T., Hämäläinen H., Ilanne‐parikka P. Prevention of type‐2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 2001; 344: 1343–1350
  • Knowler W. C., Barrett‐connor E., Fowler S. E., Hamman R. F., Lachin J. M., Walker E. A. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002; 346: 393–403
  • Chiasson J. L., Josse R. G., Gomis R., Hanefeld M., Karasik A., Laakso M. Acarbose for prevention of type‐2 diabetes mellitus: the STOP‐NIDDM randomised trial. Lancet 2002; 359: 2072–2077
  • Hensrud D. D. Dietary treatment and long‐term weight loss and maintenance in type 2 diabetes. Obes Res 2001; Suppl 4: 348S–353S
  • Sjostrom L., Lindroos A. K., Peltonen M. Swedish Obese Subjects Study Scientific Group. Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N Engl J Med 2004; 351: 2683–2693
  • Buchwald H., Avidor Y., Braunwald E. Bariatric surgery: a systematic review and meta‐analysis. JAMA 2004; 292: 1724–1737
  • Kopp H. P., Kopp C. W., Festa A. Impact of weight loss on inflammatory proteins and their association with the insulin resistance syndrome in morbidly obese patients. Arterioscler Thromb Vasc Biol 2003; 23: 1042–7
  • Christou N. V., Sampalis J. S., Liberman M. Surgery decreases long‐term mortality, morbidity, and health care use in morbidly obese patients. Ann Surg 2004; 240: 416–23
  • Kopp C. W., Kopp H. P., Steiner S. Weight loss reduces tissue factor in morbidly obese patients. Obes Res 2003; 11: 950–956
  • Krzyzanowska K., Mittermayer F., Kopp H. P. Weight loss reduces circulating asymmetrical dimethylarginine concentrations in morbidly obese women. J Clin Endocrinol.Metab 2004; 89: 6277–6281
  • Kopp H. P., Spranger J., Möhlig M., Krzyzanowska K., Pfeiffer A. F. H. Schernthaner G Effect of weight loss on plasma levels of adiponectin in association with markers of chronic subclinical inflammation and the insulin resistance syndrome in obese subjects. Internat. J. Obes, 2005 in press

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