69
Views
10
CrossRef citations to date
0
Altmetric
Original Article

Normal serum pepsinogen I levels in adults: A population‐based study with special reference to Helicobacter pylori infection and parietal cell antibodies

, , , , , , & show all
Pages 291-300 | Received 03 May 2004, Accepted 26 Jan 2005, Published online: 08 Jul 2009

References

  • Samloff IM, Liebmann WM, Panitch NM. Serum group I pepsinogens by radioimmunoassay in control subjects and patients with peptic ulcer. Gastroenterology 1975;69:83–90.
  • Plebani M. Pepsinogens in health and disease. Grit Rev Clin Lab Sci 1993;30:273–328.
  • Gritti I, Banfi G, Roi GS. Pepsinogens: pharmacology, pathophysiology and exercise. Pharmacol Res 2000;41:265–81.
  • Kekki M, Samloff IM, Vans K, Ihamäki T. Serum pepsinogen I and serum gastrin in the screening of severe atrophic corpus gastritis. Scand J Gastroenterol 1991;Suppl 186:109–16.
  • Samloff IM, Vans K, Ihamäki T, Siurala M, Rotter JI. Relationships among serum pepsinogen I, serum pepsinogen II, and gastric mucosal histology. A study in relatives of patients with pernicious anemia. Gastroenterology 1982;83:204–9.
  • Burman P, Karlsson FA, Loof L, Axelsson CK, Szesci PB, Borch K. H+,K—ATPase antibodies in autoimmune gastritis: observations on the development of pernicious anemia. Scand J Gastroenterol 1991;26:207–14.
  • Oksanen A, Sipponen P, Karttunen R, Miettinen A, Veijola L, Sarna S, et al. Atrophic gastritis and Helicobacter pylori infection in outpatients referred for gastroscopy. Gut 2000;46:460–3.
  • Knight T, Greaves S, Wilson A, Hengels K, Newell D, Corlett M, et al. Variability in serum pepsinogen levels in an asymptomatic population. Eur J Gastroenterol Hepatol 1995;7:647–54.
  • Plebani M, Di Mario F, Stanghellini V, Delle Fave G. Serological tests to monitor treatment of Helicobacter pylori. Lancet 1992;4:51–2.
  • Hunter FM, Correa P, Fontharn E, Ruiz B, Sobhan M, Samloff IM. Serum pepsinogens as markers of response to therapy for Helicobacter pylori gastritis. Dig Dis Sci 1993;38:2081–6.
  • Mossi S, Meyer-Wyss B, Renner EL, Merki HS, Gamboni G, Berlinger C. Influence of Helicobacter pylori, sex, and age on serum gastrin and pepsinogen concentrations in subjects without symptoms and patients with duodenal ulcers. Gut 1993;34:752–6.
  • Pals G, Dbfize J, Pronk JC, Frants RR, Eriksson AW, Westerveld BD, et al. Relations between serum pepsinogen levels, pepsinogen phenotypes, ABO blood groups and sex in blood donors. Ann Human Biol 1985;12:403–11.
  • Axelsson CK, Szecsi PB, Nielsen MD. Group I pepsinogens in serum. I. Normal range, age and sex relation, diurnal rhythm, seasonal variation, and distribution in ABO blood groups. Scand J Gastroenterol 1984;19:1114–8.
  • Veenendaal RA, Biemond I, Pena AS, van Duijn W, Kreuning J, Lamers CB. Influence of age and Helicobacter pylori infection on serum pepsinogens in healthy blood transfusion donors. Gut 1992;33:452–5.
  • Kosunen TU, Aromaa A, Knekt P, Salomaa A, Rautelin H, Lohi P, et al. Helicobacter antibodies in 1973 and 1994 in the adult population of Vammala, Finland. Epidemiol Infect 1997;119:29–34.
  • Kurki P, Linder E, Miettinen A, Alfthan O, Heikkinen A, Pasternack A. Tissue antibodies in malignant and benign urogenital disease. Int J Cancer 1977;19:332–6.
  • SPSS for Windows 11.5 software package. SPSS Inc., Chicago, IL, USA.
  • Kosunen TU, Höök J, Rautelin HI, Myllylä G. Age dependent increase of Campylobacter pylori antibodies in blood donors. Scand J Gastroenterol 1989;24:110–4.
  • Megraud F. Epidemiology of Helicobacter pylori infection. Gastroenterol Chin North Am 1993;22:73–88.
  • Valle J, Kekki M, Sipponen P, Ihamäki T, Siurala M. Long-term course and consequences of Helicobacter pylori gastritis. Scand J Gastroenterol 1996;31:546–50.
  • Kuipers EJ, Appelmelk BJ. Helicobacter pylori and atrophic gastritis. Biomed Pharmacother 1997;51:150–5.
  • Kokkola A, Kosunen TU, Puolakkainen P, Sipponen P, Härkönen M, Laxbn F, et al. Spontaneous disappearance of Helicobacter pylori antibodies in patients with advanced atrophic corpus gastritis. APMIS 2003;111:619–24.
  • Stolte M, Baumann K, Bethke B, Ritter M, Lauer E, Eidt H. Active autoimmune gastritis without total atrophy of the glands. Z Gastroenterol 1992;30:729–35.
  • Ban-Hock T, van Driel AR, Gleeson PA. Pernicious anemia. N Engl J Med 1997;337:1441–8.
  • Vans O, Valle J, Siurala M. Is Helicobacter pylori involved in the pathogesis of the gastritis characteristic of pernicious anaemia? Scand J Gastroenterol 1993;28:705–8.
  • Ito M, Haruma K, Kaya S, Kamada T, Kim S, Sasaki A, et al. Role of anti-parietal cell antibody in Helicobacter pylori-associated atrophic gastritis: evaluation in a country of high prevalence of atrophic gastritis. Scand J Gastroenterol 2002;37:287–93.
  • Henegham MA, McCarthy CF, Moran AP. Relationship of blood group determinants on Helicobacter pylori lipopolysaccharide with host Lewis phenotype and inflammatory response. Infect Immun 2000;68:937–41.
  • Nomura AMY, Stemmermann GN, Samloff IM. Serum pepsinogen I as predictor of stomach cancer. Ann Intern Med 1980;93:537–40.
  • Aromaa A, Kosunen TU, Knekt P, Maatela J, Teppo L, Heinonen OP, et al. Circulating anti -Helicobacter pylori IgA antibodies and low serum pepsinogen I level are associated with increased risk of gastric cancer. Am J Epidemiol 1996;144:142–9.
  • Broutet N, Plebani M, Sakarovitch C, Sipponen P, Megraud F and the Eurohepygast Study Group. Pepsinogen A, pepsinogen C, and gastrin as markers of atrophic chronic gastritis in European dyspeptics. Br J Cancer 2003;88:1239–47.
  • Väänänen H, Vauhkonen M, Helske T, Kääridinen I, Rasmussen M, Tunturi-Hihnala H, et al. Non-endoscopic diagnosis of atrophic gastritis with a blood test. Correlation between gastric histology and serum levels of gastrin-17 and pepsinogen I: a multicentre study. Eur J Gastroenterol Hepatol 2003;15: 885–91.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.