67
Views
9
CrossRef citations to date
0
Altmetric
ORIGINAL ARTICLE

High‐dose, short‐term, anti‐inflammatory treatment with dexamethasone reduces growth and augments the effects of 5‐fluorouracil on dimethyl‐α‐benzanthracene‐induced mammary tumors in rats

, , , , &
Pages 477-486 | Received 31 Jan 2006, Accepted 04 Apr 2006, Published online: 08 Jul 2009

References

  • Jain R. K. Transport of molecules in the tumor interstitium: a review. Cancer Res 1987; 47: 3039–51
  • Wiig H., Tveit E., Hultborn R., Reed R., Weiss L. Interstitial fluid pressure in DMBA‐induced rat mammary tumors. Scand J Clin Lab Invest 1982; 42: 159–64
  • Heldin C‐H., Rubin K., Pietras K., Østman A. High interstitial fluid pressure: an obstacle in cancer therapy. Nature Rev 2004; 4: 808–13
  • Rubin K., Sjoquist M., Gustafsson A. M., Isaksson B., Salvessen G., Reed R. K. Lowering of tumoral interstitial fluid pressure by prostaglandin E(1) is paralleled by an increased uptake of (51)Cr‐EDTA. Int J Cancer 2000; 1: 636–43
  • Salnikov A. V., Iversen V. V., Koisti M., Sundberg C., Johansson L., Stuhr L. B., et al. Lowering of tumor interstitial fluid pressure specifically augments efficiency of chemotherapy. Faseb Journal 2003; 17: 1756–8
  • Pietras K., Østman A., Sjøquist M., Buchdunger E., Reed R. K., Heldin C. H., et al. Inhibition of platelet‐derived growth factor receptor reduces interstitial hypertension and increases transcapillary transport in tumors. Cancer Res 2001; 61: 2929–34
  • Pietras K., Rubin K., Sjøblom T., Buchdunger E., Sjøquist M., Heldin C. H., et al. Inhibition of PDGF receptor signalling in tumor stroma enhances antitumor effect of chemotherapy. Cancer Res 2002; 62: 5476–84
  • Shapiro W. R., Posner J. B. Corticosteroid hormones. Effects in an experimental brain tumor. Arch Neurol 1974; 30: 217–21
  • Kristjansen P. E. G., Boucher Y., Jain R. K. Dexamethasone reduces the interstitial fluid pressure in a human colon adenocarcinoma xenograft. Cancer Res 1993; 53: 4764–6
  • Hofmann J., Kaiser U., Maasberg M., Havemann K. Glucocorticoid receptors and growth inhibitory effects of dexamethasone in human lung cancer cell lines. Eur J Cancer 1995; 31: 2053–8
  • Denis M. G., Chadeneau C., Blanchardie P., Lustenberger P. Biological effects of glucocorticoid hormones on two rat colon adenocarcinoma cell lines. J Steroid Biochem Mol Biol 1992; 41: 739–45
  • Distelhorst G. W. Glucocorticosteroids induce DNA fragmentation in human lymphoid leukemia cells. Blood 1988; 72: 1305–9
  • Fadnes H. O., Reed R. K., Aukland K. Interstitial fluid pressure in rats measured with a modified wick technique. Microvasc Res 1977; 14: 27–36
  • Sundberg C., Ivarsson M., Gerdin B., Rubin K. Pericytes as collagen‐producing cells in excessive dermal scarring. Lab Invest 1996; 74: 52–466
  • Aukland K., Reed R. K. Interstitial‐lymphatic mechanisms in the control of extracellular fluid volume [review]. Physiol Rev 1993; 73: 1–78
  • Berg A., Ekwall A. K., Rubin K., Stjernschantz, Reed R. K. Effect of PGE1, PGI2 and PGF2α analogs on collagen gel compaction in vitro and interstitial pressure in vivo. Am J Physiol 1998; 274: 663–71
  • Kristensen C. A., Nozue M., Boucher Y., Jain R. K. Reduction of interstitial fluid pressure after TNF‐α treatment of three human melanoma xenografts. Br J Cancer 1996; 74: 533–6
  • Lee I., Boucher Y., Jain R. K. Nicotinamide can lower tumor interstitial fluid pressure: mechanistic and therapeutic implications. Cancer Res 1992; 52: 3237–40
  • Lee C. G., Heijn M., di Tomaso E., Griffon‐Etienne G., Ancukiewicz M., Koike C., et al. Anti‐vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions. Cancer Res 2000; 60: 5565–70
  • Lammerts E., Roswall P., Sundberg C., Gotwals P. J., Koteliansky V. E., Reed R. K., et al. Interference with TGF‐beta 1 and ‐beta3 in tumor stroma lowers tumor interstitial fluid pressure independently of growth in experimental carcinoma. Int J Cancer 2002; 102: 453–462
  • Salnikov A. V., Roswall P., Sunberg C., Gardner H., Heldin N‐E., Rubin K. Inhibition of TGF‐β modulates macrophages and vessel maturation in parallel to a lowering of interstitial fluid pressure in experimental carcinoma. Lab Invest 2005; 85: 512–21
  • Rippe B., Haraldsson B. Transport of macromolecules across microvascular walls: the two‐pore theory. Physiology Rev 1994; 74: 163–219
  • Jain R. K. Normalizing tumor vasculature with anti‐angiogenic therapy: a new paradigm for combination therapy. Nat Med 2001; 7: 987–9
  • Kawashima H., Ogose A., Hayami T., Yamagiwa H., Hatano H., Hotta T., et al. Effect of dexamethasone on growth inhibition and chondrogenic maturation of human chondrosarcoma. J Orthop Sci 2003; 8: 341–5
  • Kudawara I., Ueda T., Yoshikawa H., Miyama T., Yamamoto T., Nishizawa Y. In vivo inhibition of tumour growth by dexamethasone in murine osteosarcomas. Eur J Cancer 2001; 37: 1703–8
  • Tobelem G. Endothelial cell growth: biology and pharmacology in relation to angiogenesis. Blood Coagul Fibrinolysis 1990; 1: 703–5
  • Nishimura K., Nonomura N., Satoh E., Harada Y., Nakayama M., Tokizare T., et al. Potential mechanism for the effects of dexamethasone on growth of androgen‐independent prostate cancer. J Natl Cancer Inst 2001; 22: 1739–46
  • Yu W. D., McElwain M. C., Modzelewski R. A., Russell D. M., Smith D. C., Trump D. L., et al. Enhancement of 1,25‐dihydroxyvitamin D3‐mediated antitumor activity with dexamethasone. J Natl Cancer Inst. (Bethesda) 1998; 90: 134–41
  • Oikarinen A., Autio P. New aspects of the mechanism of corticosteroid‐induced dermal atrophy. Clin Exp Dermatol 1991; 16: 416–9
  • Bouma‐ter Steege J. C., Baeten C. I., Thijssen V. L., Satijn S. A., Verhoeven I. C., Hillen H. F., et al. Angiogenic profile of breast carcinoma determines leukocyte infiltration. Clin Cancer Res 2004; 10: 7171–8
  • Badie B., Schartner J. M., Paul J., Bartley B. A., Vorpahl J., Preston J. K. Dexamethasone‐induced abolition of the inflammatory response in an experimental glioma model: a flow cytometry study. J Neurosurg 2000; 93: 634–9
  • Nupponen I., Repo H., Kari A., Pohjavuori M., Andersson S. Early dexamethasone decreases expression of activation markers on neutrophils and monocytes in preterm infants. Acta Paediatr 2002; 9: 1200–7
  • Walsh C. J., Wyffels J. T., Bodine A. B., Luer C. A. Dexamethasone‐induced apoptosis in immune cells from peripheral circulation and lymphomyeloid tissues of juvenile clearnose skates, Raja eglanteria. Dev Comp Immunol 2002; 26: 623–33
  • Li H‐P., He G‐J., Yi X‐H., Paplan A. P. The influence of dexamethasone on the proliferation and apoptosis of pulmonary inflammatory cells in bleomycin‐induced pulmonary fibrosis in rats. Respirology 2004; 9: 25–32
  • Lin E. Y., Pollard J. W. Macrophages: modulators of breast cancer progression. Novartis Found Symp 2004; 256: 158–68

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.