94
Views
2
CrossRef citations to date
0
Altmetric
ORIGINAL ARTICLE

Obesity and the clinical use of serum GGT activity as a marker of heavy drinking

, , , , &
Pages 480-488 | Received 27 Sep 2006, Accepted 28 Nov 2006, Published online: 08 Jul 2009

References

  • Zein M., Discombe G. Serum gamma‐glutamyl transpeptidase as a diagnostic aid. Lancet 1970; 2: 748–50
  • Whitfield J. B. Gamma glutamyl transferase. Crit Rev Clin Lab Sci 2001; 38: 263–355
  • Niemelä O. Biomarkers in alcoholism. Clin Chim Acta 2007; 377: 39–49
  • Bagrel A., d'Houtaud A., Gueguen R., Siest G. Relations between reported alcohol consumption and certain biological variables in an “unselected” population. Clin Chem 1979; 25: 1242–6
  • Chick J., Kreitman N., Plant M. Mean cell volume and gamma‐glutamyl‐transpeptidase as markers of drinking in working men. Lancet 1981; 1: 1249–51
  • Papoz L., Warnet J. M., Pequignot G., Eschwege E., Claude J. R., Schwartz D. Alcohol consumption in a healthy population. Relationship to gamma‐glutamyl transferase activity and mean corpuscular volume. J Am Med Assoc 1981; 245: 1748–51
  • Anton R. F., Lieber C., Tabakoff B. Carbohydrate‐deficient transferrin and gamma‐glutamyltransferase for the detection and monitoring of alcohol use: results from a multisite study. Alcohol Clin Exp Res 2002; 26: 1215–22
  • Conigrave K. M., Davies P., Haber P., Whitfield J. B. Traditional markers of excessive alcohol use. Addiction 2003; 98 Suppl 2: 31–43
  • Hietala J., Puukka K., Koivisto H., Anttila P., Niemelä O. Serum gamma‐glutamyl transferase in alcoholics, moderate drinkers and abstainers: effect on GT reference intervals at population level. Alcohol Alcohol 2005; 40: 511–14
  • Daeppen J. B., Smith T. L., Schuckit M. A. Influence of age and body mass index on gamma‐glutamyltransferase activity: a 15‐year follow‐up evaluation in a community sample. Alcohol Clin Exp Res 1998; 22: 941–4
  • Lawlor D. A., Sattar N., Smith G. D., Ebrahim S. The associations of physical activity and adiposity with alanine aminotransferase and gamma‐glutamyltransferase. Am J Epidemiol 2005; 161: 1081–8
  • Colicchio P., Tarantino G., Del Genio F., Sorrentino P., Saldalamacchia G., Finelli C., et al. Non‐alcoholic fatty liver disease in young adult severely obese non‐diabetic patients in south Italy. Ann Nutr Metab 2005; 49: 289–95
  • Lam G. M., Mobarhan S. Central obesity and elevated liver enzymes. Nutr Rev 2004; 62: 394–9
  • Peters T. J., Cook C. C. Obesity as a cause of “false‐positive” alcohol misuse laboratory investigations. Addict Biol 2002; 7: 443–6
  • Puukka K., Hietala J., Koivisto H., Anttila P., Bloigu R., Niemelä O. Additive effects of moderate drinking and obesity on serum gamma‐glutamyl transferase activity. Am J Clin Nutr 2006; 83: 1351–4
  • Conway B., Rene A. Obesity as a disease: no lightweight matter. Obes Rev 2004; 5: 145–51
  • Felding P., Rustad P., Mårtensson A., Kairisto V., Franzson L., Hyltoft Petersen P., et al. Reference individuals, blood collection, treatment of samples and descriptive data from the questionnaire in the Nordic Reference Interval Project 2000. Scand J Clin Lab Invest 2004; 64: 327–42
  • Horn P. S., Pesce A. J. Reference intervals: an update. Clin Chim Acta 2003; 334: 5–23
  • Room R., Babor T., Rehm J. Alcohol and public health. Lancet 2005; 365: 519–30
  • Diehl A. M. Obesity and alcoholic liver disease. Alcohol 2004; 34: 81–7
  • Rohrer J. E., Rohland B. M., Denison A., Way A. Frequency of alcohol use and obesity in community medicine patients. BMC Fam Pract 2005; 6: 17
  • Seitz H. K. Additive effects of moderate drinking and obesity on serum gamma‐glutamyl transferase. Am J Clin Nutr 2006; 83: 1252–3
  • Stranges S., Dorn J. M., Muti P., Freudenheim J. L., Farinaro E., Russell M., et al. Body fat distribution, relative weight, and liver enzyme levels: a population‐based study. Hepatology 2004; 39: 754–63
  • Van Hoek B. Non‐alcoholic fatty liver disease: a brief review. Scand J Gastroenterol 2004; 241: 56–9
  • Nakanishi N., Nishina K., Li W., Sato M., Suzuki K., Tatara K. Serum gamma‐glutamyltransferase and development of impaired fasting glucose or type 2 diabetes in middle‐aged Japanese men. J Intern Med 2003; 254: 287–95
  • Lee D. H., Ha M. H., Kam S., Chun B., Lee J., Song K., et al. A strong secular trend in serum gamma‐glutamyltransferase from 1996 to 2003 among South Korean men. Am J Epidemiol 2006; 163: 57–65
  • Stromme J. H., Rustad P., Steensland H., Theodorsen L., Urdal P. Reference intervals for eight enzymes in blood of adult females and males measured in accordance with the International Federation of Clinical Chemistry reference system at 37 degrees C: part of the Nordic Reference Interval Project. Scand J Clin Lab Invest 2004; 64: 371–84
  • Kornhuber J., Kornhuber H. H., Backhaus B., Kornhuber A., Kaiserauer C., Wanner W. The normal values of gamma‐glutamyltransferase are falsely defined up to now: on the diagnosis of hypertension, obesity and diabetes with reference to normal consumption of alcohol. Versicherungsmedizin 1989; 41: 78–81
  • Lee D. H., Blomhoff R., Jacobs D. R, Jr. Is serum gamma glutamyltransferase a marker of oxidative stress?. Free Radic Res 2004; 38: 535–9
  • Furukawa S., Fujita T., Shimabukuro M., Iwaki M., Yamada Y., Nakajima Y., et al. Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest 2004; 114: 1752–61
  • Puukka K., Hietala J., Koivisto H., Anttila P., Bloigu R., Niemelä O. Age‐related changes on serum GGT activity and the assessment of ethanol intake. Alcohol Alcohol 2006; 41: 522–7
  • Stranges S., Trevisan M., Dorn J. M., Dmochowski J., Donahue R. P. Body fat distribution, liver enzymes, and risk of hypertension: evidence from the Western New York Study. Hypertension 2005; 46: 1186–93
  • Klatsky A. L., Morton C., Udaltsova N., Friedman G. D. Coffee, cirrhosis, and transaminase enzymes. Arch Intern Med 2006; 166: 1190–5
  • Speisky H., Shackel N., Varghese G., Wade D., Israel Y. Role of hepatic gamma‐glutamyltransferase in the degradation of circulating glutathione: studies in the intact guinea pig perfused liver. Hepatology 1990; 11: 843–9

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.