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EDITORIAL

Desaturase expression in human cells: A new biomarker for fatty acid status?

Pages 577-579 | Published online: 08 Jul 2009

References

  • Slagsvold J. E., Thorstensen K., Kvitland M., Mack M., Bjerve K. S. Regulation of desaturase expression in HL60 cells. Scand J Clin Lab Invest 2007; 67: XXX–X
  • Fuhrman B. J., Barba M., Krogh V., Micheli A., Pala V., Lauria R., et al. Erythrocyte membrane phospholipid composition as a biomarker of dietary fat. Ann Nutr Metab 2006; 50: 95–102
  • Warensjo E., Riserus U., Vessby B. Fatty acid composition of serum lipids predicts the development of the metabolic syndrome in men. Diabetologia 2005; 48: 1999–2005
  • Kolak M., Yki‐Jarvinen H., Kannisto K., Tiikkainen M., Hamsten A., Eriksson P., et al. Effects of chronic rosiglitazone therapy on gene expression in human adipose tissue in vivo in patients with type 2 diabetes. J Clin Endocrinol Metab 2006; 5: 000–0
  • Hulver M. W., Berggren J. R., Carper M. J., Miyazaki M., Ntambi J. M., Hoffman E. P., et al. Elevated stearoyl‐CoA desaturase‐1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans. Cell Metab 2005; 2: 251–61
  • Thijssen M. A., Malpuech‐Brugere C., Gregoire S., Chardigny J. M., Sebedio J. L., Mensink R. P. Effects of specific CLA isomers on plasma fatty acid profile and expression of desaturases in humans. Lipids 2005; 40: 137–45
  • Melin T., Nilsson A. Delta‐6‐desaturase and delta‐5‐desaturase in human Hep G2 cells are both fatty acid interconversion rate limiting and are upregulated under essential fatty acid deficient conditions. Prostaglandins Leukot Essent Fatty Acids 1997; 56: 437–42
  • Ntambi J. M. The regulation of stearoyl‐CoA desaturase (SCD). Prog Lipid Res 1995; 34: 139–50
  • Cho H. P., Nakamura M. T., Clarke S. D. Cloning, expression, and nutritional regulation of the mammalian Delta‐6 desaturase. J Biol Chem 1999; 274: 471–7
  • Cho H. P., Nakamura M., Clarke S. D. Cloning, expression, and fatty acid regulation of the human delta‐5 desaturase. J Biol Chem 1999; 274: 37335–9
  • Bene H., Lasky D., Ntambi J. M. Cloning and characterization of the human stearoyl‐CoA desaturase gene promoter: transcriptional activation by sterol regulatory element binding protein and repression by polyunsaturated fatty acids and cholesterol. Biochem Biophys Res Commun 2001; 284: 1194–8
  • Ntambi J. M. Regulation of stearoyl‐CoA desaturase by polyunsaturated fatty acids and cholesterol. J Lipid Res 1999; 40: 1549–58
  • Nakamura M. T., Nara T. Y. Essential fatty acid synthesis and its regulation in mammals. Prostaglandins Leukot Essent Fatty Acids 2003; 68: 145–50
  • Hannah V. C., Ou J., Luong A., Goldstein J. L., Brown M. S. Unsaturated fatty acids downregulate srebp isoforms 1a and 1c by two mechanisms in HEK‐293 cells. J Biol Chem 2001; 276: 4365–72
  • Xu J., Teran‐Garcia M., Park J. H., Nakamura M. T., Clarke S. D. Polyunsaturated fatty acids suppress hepatic sterol regulatory element‐binding protein‐1 expression by accelerating transcript decay. J Biol Chem 2001; 276: 9800–7
  • Xu J., Nakamura M. T., Cho H. P., Clarke S. D. Sterol regulatory element binding protein‐1 expression is suppressed by dietary polyunsaturated fatty acids. A mechanism for the coordinate suppression of lipogenic genes by polyunsaturated fats. J Biol Chem 1999; 274: 23577–83
  • Warensjo E., Ohrvall M., Vessby B. Fatty acid composition and estimated desaturase activities are associated with obesity and lifestyle variables in men and women. Nutr Metab Cardiovasc Dis 2006; 16: 128–36

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