Effects of selective and unselective endothelin‐receptor antagonists on prostacyclin synthase gene expression in experimental pulmonary hypertension

References

• D'Alonzo G., Barst R., Ayres S., Bergofsky E., Brundage B., Detre K. Survival in patients with primary pulmonary hypertension. Results from a national prospective registry. Ann Intern Med 1991; 115: 343–9
   PubMed Web of Science ®Google Scholar
• Christman B. W., McPherson C. D., Newman J. H., King G. A., Bernard G. R., Groves B. M. An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension. N Engl J Med 1992; 327: 70–5
   PubMed Web of Science ®Google Scholar
• Farber H. W., Loscalzo J. Pulmonary arterial hypertension. N Engl J Med 2004; 351: 1655–65
   PubMed Web of Science ®Google Scholar
• Seo B., Oemar B. S., Siebenmann R., von Segesser L., Luscher T. F. Both ETA and ETB receptors mediate contraction to endothelin‐1 in human blood vessels. Circulation 1994; 89: 1203–8
   PubMed Web of Science ®Google Scholar
• Zamora M., Dempsey E. C., Stelzner T. J. BQ123, an ETA receptor antagonist, inhibits endothelin‐1‐mediated proliferation of human pulmonary artery smooth muscle cells. Am J Respir Cell Mol Biol 1993; 429–33
   PubMed Web of Science ®Google Scholar
• Hirata Y., Emori T., Eguchi S., Kanno., Imai T., Ohta K. Endothelin receptor subtype B mediates synthesis of nitric oxide by cultured bovine endothelial cells. J Clin Invest 1993; 4: 1367–73
   Web of Science ®Google Scholar
• Lee S. H., Rubin L. J. Current treatment strategies for pulmonary arterial hypertension. J Intern Med 2005; 258: 199–215
   PubMed Web of Science ®Google Scholar
• Motte S., McEntee K., Naeije R. Endothelin receptor antagonists. Pharmacol Ther 2006; 110: 386–414
   PubMed Web of Science ®Google Scholar
• Galie N., Badesch D., Oudiz R., Simonneau G., McGoon M. D., Keogh A. M. Ambrisentan therapy for pulmonary arterial hypertension. J Am Coll Cardiol 2005; 46: 529–35
   PubMed Web of Science ®Google Scholar
• Rubin L. J., Badesch D. B., Barst R. J., Galie N., Black C. M., Keogh A. Bosentan therapy for pulmonary arterial hypertension. N Engl J Med 2002; 346: 896–903
   PubMed Web of Science ®Google Scholar
• Blumberg F. C., Wolf K., Sandner P., Lorenz C., Riegger G. A. J., Pfeifer M. The NO donor molsidomine reduces endothelin‐1 gene expression in chronic hypoxic rat lungs. Am J Physiol Lung Cell Mol Physiol 2001; 280: L258–63
   PubMed Web of Science ®Google Scholar
• Remmele W., Hildebrand U., Hienz H. A., Klein P. J., Vierbuchen M., Behnken LtJ. Comparative histological, histochemical, immunohistochemical and biochemical studies on oestrogen receptors, lectin receptors, and Barr bodies in human breast cancer. Virchows Arch 1986; 409: 127–47
   Web of Science ®Google Scholar
• Tuder R. M., Cool C. D., Geraci M. W., Wang J., Abman S. H., Wright L. Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary hypertension. Am J Respir Crit Care Med 1999; 159: 1925–32
   PubMed Web of Science ®Google Scholar
• Humbert M., Sitbon O., Simonneau G. Treatment of pulmonary arterial hypertension. N Engl J Med 2004; 351: 1425–36
   PubMed Web of Science ®Google Scholar
• Okahara K., Sun B., Kambayashi J. Upregulation of prostacyclin synthesis‐related gene expression by shear stress in vascular endothelial cells. Arterioscler Thromb Vasc Biol 1998; 18: 1922–6
   PubMed Web of Science ®Google Scholar
• Blumberg F. C., Lorenz C., Wolf K., Sandner P., Riegger G. A. J., Pfeifer M. Increased pulmonary prostacyclin synthesis in rats with chronic hypoxic pulmonary hypertension. Cardiovasc Res 2002; 55: 171–7
   PubMed Web of Science ®Google Scholar
• McLaughlin V. V., Shillington A., Rich S. Survival in primary pulmonary hypertension: the impact of epoprostenol therapy. Circulation 2002; 106: 1477–82
   PubMed Web of Science ®Google Scholar
• Olschewski H., Simonneau G., Galie N., Higenbottam T., Naeije R., Rubin L. J. Inhaled iloprost for severe pulmonary hypertension. N Engl J Med 2002; 347: 322–9
   PubMed Web of Science ®Google Scholar
• Hoshikawa Y., Voelkel N. T., Gesell T. L., Mark M. D., Morris K. G., Alger L. A. Prostacyclin receptor‐dependent modulation of pulmonary vascular remodeling. Am J Respir Crit Care Med 2001; 164: 314–18
   PubMed Web of Science ®Google Scholar
• Ivy D., McMurtry I. F., Colvin K., Imamura M., Oka M., Lee D. S. Development of occlusive neointimal lesions in distal pulmonary arteries of endothelin B receptor‐deficient rats: a new model of severe pulmonary arterial hypertension. Circulation 2005; 111: 2988–96
   PubMed Web of Science ®Google Scholar
• Ivy D., Yanagisawa M., Gariepy C. E., Gebb S. A., Colvin K. L., McMurtry I. F. Exaggerated hypoxic pulmonary hypertension in endothelin B receptor‐deficient rats. Am J Physiol Lung Cell Mol Physiol 2002; 282: L703–12
   PubMed Web of Science ®Google Scholar
• Bauer M., Wilkens H., Langer F., Schneider S. O., Lausberg H., Schafers H. J. Selective upregulation of endothelin B receptor gene expression in severe pulmonary hypertension. Circulation 2002; 105: 1034–6
   PubMed Web of Science ®Google Scholar
• Ivy D., Parker T. A., Abman S. H. Prolonged endothelin B receptor blockade causes pulmonary hypertension in the ovine fetus. Am J Physiol Lung Cell Mol Physiol 2000; 279: L758–65
   PubMed Web of Science ®Google Scholar
• Jasmin J. F., Lucas M., Cernacek P., Dupuis J. Effectiveness of a nonselective ET(A/B) and a selective ET(A) antagonist in rats with monocrotaline‐induced pulmonary hypertension. Circulation 2001; 103: 314–18
   PubMed Web of Science ®Google Scholar
• D'Orleans‐Juste P., Labonte J., Bkaily G., Choufani S., Plante M., Honore J. C. Function of the endothelin(B) receptor in cardiovascular physiology and pathophysiology. Pharmacol Ther 2002; 95: 221–38
   PubMed Web of Science ®Google Scholar
• Nishida M., Okada Y., Akiyoshi K., Eshiro K., Takaoka M., Gariepy C. E. Role of endothelin ETB receptor in the pathogenesis of monocrotaline‐induced pulmonary hypertension in rats. Eur J Pharmacol 2004; 496: 159–65
   PubMed Web of Science ®Google Scholar
• Soma S., Takahashi H., Muramatsu M., Oka M., Fukuchi Y. Localization and distribution of endothelin receptor subtypes in pulmonary vasculature of normal and hypoxia‐exposed rats. Am J Respir Cell Mol Biol 1999; 20: 620–30
   PubMed Web of Science ®Google Scholar
• Takahashi H., Soma S., Muramatsu M., Oka M., Ienaga H., Fukuchi Y. Discrepant distribution of big endothelin (ET)‐1 and ET receptors in the pulmonary artery. Eur Respir J 2001; 18: 5–14
   PubMed Web of Science ®Google Scholar
• Schiffrin E. L., Touyz R. M. Vascular biology of endothelin. J Cardiovasc Pharmacol 1998; 32(Suppl 3)S2–13
   PubMed Web of Science ®Google Scholar