The reduced folate carrier (RFC1) 80G>A and folate hydrolase 1 (FOLH1) 1561C>T polymorphisms and the risk of colorectal cancer: A nested case‐referent study

References

• Sanjoaquin M. A., Allen N., Couto E., Roddam A. W., Key T. J. Folate intake and colorectal cancer risk: a meta‐analytical approach. Int J Cancer 2005; 113: 825–8
   PubMed Web of Science ®Google Scholar
• Zhang S. M., Moore S. C., Lin J., Cook N. R., Manson J. E., Lee I. M., et al. Folate, vitamin B6, multivitamin supplements, and colorectal cancer risk in women. Am J Epidemiol 2006; 163: 108–15
   PubMed Web of Science ®Google Scholar
• Larsson S. C., Giovannucci E., Wolk A. A prospective study of dietary folate intake and risk of colorectal cancer: modification by caffeine intake and cigarette smoking. Cancer Epidemiol Biomarkers Prev 2005; 14: 740–3
   PubMed Web of Science ®Google Scholar
• Wei E. K., Giovannucci E., Wu K., Rosner B., Fuchs C. S., Willett W. C., et al. Comparison of risk factors for colon and rectal cancer. Int J Cancer 2004; 108: 433–42
   PubMed Web of Science ®Google Scholar
• Giovannucci E., Stampfer M. J., Colditz G. A., Hunter D. J., Fuchs C., Rosner B. A., et al. Multivitamin use, folate, and colon cancer in women in the Nurses' Health Study. Ann Intern Med 1998; 129: 517–24
   PubMed Web of Science ®Google Scholar
• Konings E. J., Goldbohm R. A., Brants H. A., Saris W. H., van den Brandt P. A. Intake of dietary folate vitamers and risk of colorectal carcinoma: results from The Netherlands Cohort Study. Cancer 2002; 95: 1421–33
   PubMed Web of Science ®Google Scholar
• Su L. J., Arab L. Nutritional status of folate and colon cancer risk: evidence from NHANES I epidemiologic follow‐up study. Ann Epidemiol 2001; 11: 65–72
   PubMed Web of Science ®Google Scholar
• Kato I., Dnistrian A. M., Schwartz M., Toniolo P., Koenig K., Shore R. E., et al. Serum folate, homocysteine and colorectal cancer risk in women: a nested case‐control study. Br J Cancer 1999; 79: 1917–22
   PubMed Web of Science ®Google Scholar
• Glynn S. A., Albanes D., Pietinen P., Brown C. C., Rautalahti M., Tangrea J. A., et al. Colorectal cancer and folate status: a nested case‐control study among male smokers. Cancer Epidemiol Biomarkers Prev 1996; 5: 487–94
   PubMed Web of Science ®Google Scholar
• Ma J., Stampfer M. J., Giovannucci E., Artigas C., Hunter D. J., Fuchs C., et al. Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer. Cancer Res 1997; 57: 1098–102
   PubMed Web of Science ®Google Scholar
• Rossi E., Hung J., Beilby J. P., Knuiman M. W., Divitini M. L., Bartholomew H. Folate levels and cancer morbidity and mortality: prospective cohort study from Busselton, Western Australia. Ann Epidemiol 2006; 16: 206–12
   PubMed Web of Science ®Google Scholar
• Van Guelpen B., Hultdin J., Johansson I., Hallmans G., Stenling R., Riboli E., et al. Low folate levels may protect against colorectal cancer. Gut 2006; 55: 1461–6
   PubMed Web of Science ®Google Scholar
• Cole B. F., Baron J. A., Sandler R. S., Haile R. W., Ahnen D. J., Bresalier R. S., et al. Folic acid for the prevention of colorectal adenomas: a randomized clinical trial. J Am Med Assoc 2007; 297: 2351–9
   PubMed Web of Science ®Google Scholar
• Bonaa K. H., Njolstad I., Ueland P. M., Schirmer H., Tverdal A., Steigen T., et al. Homocysteine lowering and cardiovascular events after acute myocardial infarction. N Engl J Med 2006; 354: 1578–88
   PubMed Web of Science ®Google Scholar
• Lonn E., Yusuf S., Arnold M. J., Sheridan P., Pogue J., Micks M., et al. Homocysteine lowering with folic acid and B vitamins in vascular disease. N Engl J Med 2006; 354: 1567–77
   PubMed Web of Science ®Google Scholar
• Charles D., Ness A. R., Campbell D., Davey Smith G., Hall M. H. Taking folate in pregnancy and risk of maternal breast cancer. Br Med J 2004; 329: 1375–6
   PubMed Web of Science ®Google Scholar
• Kim Y. I. Will mandatory folic acid fortification prevent or promote cancer?. Am J Clin Nutr 2004; 80: 1123–8
   PubMed Web of Science ®Google Scholar
• Hustad S., Midttun O., Schneede J., Vollset S. E., Grotmol T., Ueland P. M. The methylenetetrahydrofolate reductase 677C–>T polymorphism as a modulator of a B vitamin network with major effects on homocysteine metabolism. Am J Hum Genet 2007; 80: 846–55
   PubMed Web of Science ®Google Scholar
• Ma D. W., Finnell R. H., Davidson L. A., Callaway E. S., Spiegelstein O., Piedrahita J. A., et al. Folate transport gene inactivation in mice increases sensitivity to colon carcinogenesis. Cancer Res 2005; 65: 887–97
   PubMed Web of Science ®Google Scholar
• Chango A., Emery‐Fillon N., de Courcy G. P., Lambert D., Pfister M., Rosenblatt D. S., et al. A polymorphism (80G‐>A) in the reduced folate carrier gene and its associations with folate status and homocysteinemia. Mol Genet Metab 2000; 70: 310–15
   PubMed Web of Science ®Google Scholar
• Whetstine J. R., Gifford A. J., Witt T., Liu X. Y., Flatley R. M., Norris M., et al. Single nucleotide polymorphisms in the human reduced folate carrier: characterization of a high‐frequency G/A variant at position 80 and transport properties of the His(27) and Arg(27) carriers. Clin Cancer Res 2001; 7: 3416–22
   PubMed Web of Science ®Google Scholar
• Devlin A. M., Clarke R., Birks J., Evans J. G., Halsted C. H. Interactions among polymorphisms in folate‐metabolizing genes and serum total homocysteine concentrations in a healthy elderly population. Am J Clin Nutr 2006; 83: 708–13
   PubMed Web of Science ®Google Scholar
• Dufficy L., Naumovski N., Ng X., Blades B., Yates Z., Travers C., et al. G80A reduced folate carrier SNP influences the absorption and cellular translocation of dietary folate and its association with blood pressure in an elderly population. Life Sci 2006; 79: 957–66
   PubMed Web of Science ®Google Scholar
• Yates Z., Lucock M. G80A reduced folate carrier SNP modulates cellular uptake of folate and affords protection against thrombosis via a non‐homocysteine related mechanism. Life Sci 2005; 77: 2735–42
   PubMed Web of Science ®Google Scholar
• Drogan D., Klipstein‐Grobusch K., Wans S., Luley C., Boeing H., Dierkes J. Plasma folate as marker of folate status in epidemiological studies: the European Investigation into Cancer and Nutrition (EPIC) – Potsdam study. Br J Nutr 2004; 92: 489–96
   PubMed Web of Science ®Google Scholar
• Relton C. L., Wilding C. S., Laffling A. J., Jonas P. A., Burgess T., Binks K., et al. Low erythrocyte folate status and polymorphic variation in folate‐related genes are associated with risk of neural tube defect pregnancy. Mol Genet Metab 2004; 81: 273–81
   PubMed Web of Science ®Google Scholar
• Morin I., Devlin A. M., Leclerc D., Sabbaghian N., Halsted C. H., Finnell R., et al. Evaluation of genetic variants in the reduced folate carrier and in glutamate carboxypeptidase II for spina bifida risk. Mol Genet Metab 2003; 79: 197–200
   PubMed Web of Science ®Google Scholar
• Winkelmayer W. C., Eberle C., Sunder‐Plassmann G., Fodinger M. Effects of the glutamate carboxypeptidase II (GCP2 1561C>T) and reduced folate carrier (RFC1 80G>A) allelic variants on folate and total homocysteine levels in kidney transplant patients. Kidney Int 2003; 63: 2280–5
   PubMed Web of Science ®Google Scholar
• Ulrich C. M., Curtin K., Potter J. D., Bigler J., Caan B., Slattery M. L. Polymorphisms in the reduced folate carrier, thymidylate synthase, or methionine synthase and risk of colon cancer. Cancer Epidemiol Biomarkers Prev 2005; 14: 2509–16
   PubMed Web of Science ®Google Scholar
• Devlin A. M., Ling E. H., Peerson J. M., Fernando S., Clarke R., Smith A. D., et al. Glutamate carboxypeptidase II: a polymorphism associated with lower levels of serum folate and hyperhomocysteinemia. Hum Mol Genet 2000; 9: 2837–44
   PubMed Web of Science ®Google Scholar
• Halsted C. H., Wong D. H., Peerson J. M., Warden C. H., Refsum H., Smith A. D., et al. Relations of glutamate carboxypeptidase II (GCPII) polymorphisms to folate and homocysteine concentrations and to scores of cognition, anxiety, and depression in a homogeneous Norwegian population: the Hordaland Homocysteine Study. Am J Clin Nutr 2007; 86: 514–21
   PubMed Web of Science ®Google Scholar
• Chen J., Kyte C., Valcin M., Chan W., Wetmur J. G., Selhub J., et al. Polymorphisms in the one‐carbon metabolic pathway, plasma folate levels and colorectal cancer in a prospective study. Int J Cancer 2004; 110: 617–20
   PubMed Web of Science ®Google Scholar
• Melse‐Boonstra A., Lievers K. J., Blom H. J., Verhoef P. Bioavailability of polyglutamyl folic acid relative to that of monoglutamyl folic acid in subjects with different genotypes of the glutamate carboxypeptidase II gene. Am J Clin Nutr 2004; 80: 700–4
   PubMed Web of Science ®Google Scholar
• Afman L. A., Trijbels F. J., Blom H. J. The H475Y polymorphism in the glutamate carboxypeptidase II gene increases plasma folate without affecting the risk for neural tube defects in humans. J Nutr 2003; 133: 75–7
   PubMed Web of Science ®Google Scholar
• Lievers K. J., Kluijtmans L. A., Boers G. H., Verhoef P., den Heijer M., Trijbels F. J., et al. Influence of a glutamate carboxypeptidase II (GCPII) polymorphism (1561C–>T) on plasma homocysteine, folate and vitamin B(12) levels and its relationship to cardiovascular disease risk. Atherosclerosis 2002; 164: 269–73
   PubMed Web of Science ®Google Scholar
• Vargas‐Martinez C., Ordovas J. M., Wilson P. W., Selhub J. The glutamate carboxypeptidase gene II (C>T) polymorphism does not affect folate status in the Framingham Offspring cohort. J Nutr 2002; 132: 1176–9
   PubMed Web of Science ®Google Scholar
• Koushik A., Kraft P., Fuchs C. S., Hankinson S. E., Willett W. C., Giovannucci E. L., et al. Nonsynonymous polymorphisms in genes in the one‐carbon metabolism pathway and associations with colorectal cancer. Cancer Epidemiol Biomarkers Prev 2006; 15: 2408–17
   PubMed Web of Science ®Google Scholar
• Hallmans G., Agren A., Johansson G., Johansson A., Stegmayr B., Jansson J. H., et al. Cardiovascular disease and diabetes in the Northern Sweden Health and Disease Study Cohort – evaluation of risk factors and their interactions. Scand J Public Health 2003; Suppl 61: 18–24
   Web of Science ®Google Scholar
• Wang L., Chen W., Wang J., Tan Y., Zhou Y., Ding W., et al. Reduced folate carrier gene G80A polymorphism is associated with an increased risk of gastroesophageal cancers in a Chinese population. Eur J Cancer 2006; 42: 3206–11
   PubMed Web of Science ®Google Scholar
• Gotze T., Rocken C., Rohl F. W., Wex T., Hoffmann J., Westphal S., et al. Gene polymorphisms of folate metabolizing enzymes and the risk of gastric cancer. Cancer Lett 2007; 251: 228–36
   PubMed Web of Science ®Google Scholar
• O'Keefe D. S., Heston W. D. Clearing up the confusion over the glutamate carboxypeptidase II gene. Am J Med Genet 2004; 130 A: 327–28, author reply 329–30
   Web of Science ®Google Scholar
• Vieira A. R., Devlin A. M. Glutamate carboxipeptidase II (GCPII) His475Tyr polymorphism and association studies. Am J Med Genet 2004; 130A: 329–30
   Web of Science ®Google Scholar
• Kim Y. I., Fawaz K., Knox T., Lee Y. M., Norton R., Arora S., et al. Colonic mucosal concentrations of folate correlate well with blood measurements of folate status in persons with colorectal polyps. Am J Clin Nutr 1998; 68: 866–72
   PubMed Web of Science ®Google Scholar
• Kim Y. I., Fawaz K., Knox T., Lee Y. M., Norton R., Libby E., et al. Colonic mucosal concentrations of folate are accurately predicted by blood measurements of folate status among individuals ingesting physiologic quantities of folate. Cancer Epidemiol Biomarkers Prev 2001; 10: 715–19
   PubMed Web of Science ®Google Scholar
• Agudo A., Slimani N., Ocke M. C., Naska A., Miller A. B., Kroke A., et al. Consumption of vegetables, fruit and other plant foods in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohorts from 10 European countries. Public Health Nutr 2002; 5: 1179–96
   PubMed Web of Science ®Google Scholar