Cyclosporin A pre‐incubation attenuates hypoxia/reoxygenation‐induced apoptosis in mesenchymal stem cells

References

• Makino S., Fukuda K., Miyoshi S., Konishi F., Kodama H., Pan J., et al. Cardiomyocytes can be generated from marrow stromal cells in vitro. J Clin Invest 1999; 103: 697–705
   PubMed Web of Science ®Google Scholar
• Kawada H., Fujita J., Kinjo K., Matsuzaki Y., Tsuma M., Miyatake H., et al. Nonhematopoietic mesenchymal stem cells can be mobilized and differentiated into cardiomyocytes after myocardial infarction. Blood 2004; 104: 3581–7
   PubMed Web of Science ®Google Scholar
• Toma C., Pittenger M. F., Cahill K. S., Byrne B. J., Kessler P. D. Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart. Circulation 2002; 105: 93–8
   PubMed Web of Science ®Google Scholar
• Geng Y. J. Molecular mechanisms for cardiovascular stem cell apoptosis and growth in the hearts with atherosclerotic coronary disease and ischemic heart failure. Ann NY Acad Sci 2003; 1010: 687–97
   PubMed Web of Science ®Google Scholar
• Zhu W., Chen J., Cong X., Hu S., Chen X. Hypoxia and serum deprivation‐induced apoptosis in mesenchymal stem cells. Stem Cells 2006; 24: 416–25
   PubMed Web of Science ®Google Scholar
• Walter D. H., Haendeler J., Galle J., Zeiher A. M., Dimmeler S. Cyclosporin A inhibits apoptosis of human endothelial cells by preventing release of cytochrome C from mitochondria. Circulation 1998; 98: 1153–7
   PubMed Web of Science ®Google Scholar
• Xie J. R., Yu L. N. Cardioprotective effects of cyclosporine A in an in vivo model of myocardial ischemia and reperfusion. Acta Anaesthesiol Scand 2007; 51: 909–13
   PubMed Web of Science ®Google Scholar
• Nicolli A., Basso E., Petronilli V., Wenger R. M., Bernardi P. Interactions of cyclophilin with the mitochondrial inner membrane and regulation of the permeability transition pore and cyclosporin A‐sensitive channel. J Biol Chem 1996; 271: 2185–92
   PubMed Web of Science ®Google Scholar
• Wilkins B. J., Dai Y‐S., Bueno O. F., Parsons S. A., Xu J., Plank D. M., et al. Molkentin. Calcineurin/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy. Circ Res 2004; 94: 110
   PubMed Web of Science ®Google Scholar
• Takadera T., Sakamoto Y., Hizume Y., Ohyashiki T. Cyclosporine A‐ and FK506‐induced apoptosis in PC12 cells. Cell Biol Toxicol 2007; 23: 355–60
   PubMedGoogle Scholar
• Zhang W., Liu H. T. MAPK signal pathways in the regulation of cell proliferation in mammalian cells. Cell Res 2002; 12: 9–18
   PubMed Web of Science ®Google Scholar
• Xie X. J., Wang J. A., Cao J., Zhang X. Differentiation of bone marrow mesenchymal stem cells induced by myocardial medium under hypoxic conditions. Acta Pharmacol Sin 2006; 27: 1153–8
   PubMedGoogle Scholar
• Ljubkovic M., Mio Y., Marinovic J., Stadnicka A., Warltier D. C., Bosnjak Z. J., et al. Isoflurane preconditioning uncouples mitochondria and protects against hypoxia‐reoxygenation. Am J Physiol Cell Physiol 2007; 292: C1583–90
   PubMedGoogle Scholar
• Suzuki K., Smolenski R. T., Jayakumar J., Murtuza B., Brand N. J., Yacoub M. H. Heat shock treatment enhances graft cell survival in skeletal myoblast transplantation to the heart. 2000; 102: III–216, Circulation
   Google Scholar
• Tang Y. L., Tang Y., Zhang Y. C., Qian K., Shen L., Phillips M. I. Improved graft mesenchymal stem cell survival in ischemic heart with a hypoxia‐regulated heme oxygenase‐1 vector. J Am Coll Cardiol 2005; 46: 1339–50
   PubMed Web of Science ®Google Scholar
• Gnecchi M., He H., Liang O. D., Melo L. G., Morello F., Mu H., et al. Paracrine action accounts for marked protection of ischemic heart by Akt‐modified mesenchymal stem cells. Nat Med 2005; 11: 367–8
   PubMed Web of Science ®Google Scholar
• Song H., Kwon K., Lim S., Kang S‐M., Ko Y‐G., Xu Z‐Z., et al. Transfection of mesenchymal stem cells with the FGF‐2 gene improves their survival under hypoxic conditions. Mol Cells 2005; 19: 402–7
   PubMed Web of Science ®Google Scholar
• Noiseux N., Gnecchi M., Lopez‐Ilasaca M., Zhang L., Solomon S. D., Deb A., et al. Mesenchymal stem cells overexpressing Akt dramatically repair infarcted myocardium and improve cardiac function despite infrequent cellular fusion or differentiation. Mol Ther 2006; 14: 840–50
   PubMed Web of Science ®Google Scholar
• Sartore S., Lenzi M., Angelini A., Chiavegato A., Gasparotto L., Coppi P., et al. Amniotic mesenchymal cells autotransplanted in a porcine model of cardiac ischemia do not differentiate to cardiogenic phenotypes. Eur J Cardiothorac Surg 2005; 28: 677–84
   PubMed Web of Science ®Google Scholar
• Connern C. P., Halestrap A. P. Purification and N‐terminal sequencing of peptidyl‐prolyl cis‐trans‐isomerase from rat liver mitochondrial matrix reveals the existence of a distinct mitochondrial cyclophilin. Biochem J 1992; 284: 381–5
   PubMedGoogle Scholar
• Marsden V. S., Ekert P. G., Van Delft M., Vaux D. L., Adams J. M., Strasser A. Bcl‐2‐regulated apoptosis and cytochrome c release can occur independently of both caspase‐2 and caspase‐9. J Cell Biol 2004; 165: 775–80
   PubMedGoogle Scholar
• Bulut S., Ozdemir B. H., Alaaddinoglu E. E., Oduncuoglu F. B., Bulut O. E., Demirhan B. Effect of cyclosporin A on apoptosis and expression of p53 and bcl‐2 proteins in the gingiva of renal transplant patients. J Periodontol 2005; 76: 691–5
   PubMed Web of Science ®Google Scholar
• Liu Q., Wilkins B. J., Lee Y. J., Ichijo H., Molkentin J. D. Direct interaction and reciprocal regulation between ASK1 and calcineurin‐NFAT control cardiomyocyte death and growth. Mol Cell Biol 2006; 26: 3785–97
   PubMed Web of Science ®Google Scholar
• Ciechomska I., Legat M., Golab J., Wesolowska A., Kurzaj Z., Mackiewicz A., et al. Cyclosporine A and its non‐immunosuppressive derivative NIM811 induce apoptosis of malignant melanoma cells in in vitro and in vivo studies. Int J Cancer 2005; 20;117: 59–67
   Google Scholar