A combined abnormality in heart rate variation and QT corrected interval is a strong predictor of cardiovascular death in type 1 diabetes

References

• Gale E. A. Type 1 diabetes in the young: the harvest of sorrow goes on. Diabetologia 2005; 48: 1435–8
   PubMed Web of Science ®Google Scholar
• Ewing D. J., Campbell I. W., Clarke B. F. Mortality in diabetic autonomic neuropathy. Lancet 1976; 1: 601–3
   PubMed Web of Science ®Google Scholar
• Sander G. E., Wilklow F. E., Giles T. D. Heart failure in diabetes mellitus: causal and treatment considerations. Minerva Cardioangiol 2004; 52: 491–503
   PubMedGoogle Scholar
• Suarez G. A., Clark V. M., Norell J. E., Kottke T. E., Callahan M. J., O'Brien P. C., et al. Sudden cardiac death in diabetes mellitus: risk factors in the Rochester diabetic neuropathy study. J Neurol Neurosurg Psychiatry 2005; 76: 240–5
   PubMed Web of Science ®Google Scholar
• Vinik A. I., Freeman R., Erbas T. Diabetic autonomic neuropathy. Semin Neurol 2003; 23: 365–72
   PubMed Web of Science ®Google Scholar
• Maser R. E., Mitchell B. D., Vinik A. I., Freeman R. The association between cardiovascular autonomic neuropathy and mortality in individuals with diabetes: a meta‐analysis. Diabetes Care 2003; 26: 1895–901
   PubMed Web of Science ®Google Scholar
• Wheeler S. G., Ahroni J. H., Boyko E. J. Prospective study of autonomic neuropathy as a predictor of mortality in patients with diabetes. Diabetes Res Clin Pract 2002; 58: 131–8
   PubMed Web of Science ®Google Scholar
• Gerritsen J., Dekker J. M., TenVoorde B. J., Kostense P. J., Heine R. J., Bouter L. M., et al. Impaired autonomic function is associated with increased mortality, especially in subjects with diabetes, hypertension, or a history of cardiovascular disease: the Hoorn Study. Diabetes Care 2001; 24: 1793–8
   PubMed Web of Science ®Google Scholar
• Veglio M., Sivieri R., Chinaglia A., Scaglione L., Cavallo‐Perin P. QT interval prolongation and mortality in type 1 diabetic patients: a 5‐year cohort prospective study. Neuropathy Study Group of the Italian Society of the Study of Diabetes, Piemonte Affiliate. Diabetes Care 2000; 23: 1381–3
   PubMed Web of Science ®Google Scholar
• Rossing P., Breum L., Major‐Pedersen A., Sato A., Winding H., Pietersen A., et al. Prolonged QTc interval predicts mortality in patients with Type 1 diabetes mellitus. Diabetic Med 2001; 18: 199–205
   PubMed Web of Science ®Google Scholar
• Okin P. M., Devereux R. B., Lee E. T., Galloway J. M., Howard B. V. Electrocardiographic repolarization complexity and abnormality predict all‐cause and cardiovascular mortality in diabetes: the strong heart study. Diabetes 2004; 53: 434–40
   PubMed Web of Science ®Google Scholar
• Rana B. S., Lim P. O., Naas A. A. O., Ogston S. A., Newton R. W., Jung R. T., et al. QT interval abnormalities are often present at diagnosis in diabetes and are better predictors of cardiac death than ankle brachial pressure index and autonomic function tests. Heart 2005; 91: 44–50
   PubMed Web of Science ®Google Scholar
• Whitsel E. A., Boyko E. J., Rautaharju P. M., Raghunathan T. E., Lin D., Pearce R. M., et al. Electrocardiographic QT interval prolongation and risk of primary cardiac arrest in diabetic patients. Diabetes Care 2005; 28: 2045–7
   PubMed Web of Science ®Google Scholar
• Hilsted J. Testing for autonomic neuropathy. Ann Clin Res 1984; 16: 128–35
   PubMedGoogle Scholar
• Elming H., Brendorp B., Kober L., Sahebzadah N., Torp‐Petersen C. QTc interval in the assessment of cardiac risk. Card Electrophysiol Rev 2002; 6: 289–94
   PubMedGoogle Scholar
• Malik M., Batchvarov V. N. Measurement, interpretation and clinical potential of QT dispersion. J Am Coll Cardiol 2000; 36: 1749–66
   PubMed Web of Science ®Google Scholar
• Tarnow L., Cambien F., Rossing P., Nielsen F. S., Hansen B. V., Lecerf L., et al. Insertion/deletion polymorphism in the angiotensin‐I‐converting enzyme gene is associated with coronary heart disease in IDDM patients with diabetic nephropathy. Diabetologia 1995; 38: 798–803
   PubMed Web of Science ®Google Scholar
• Tarnow L., Cambien F., Rossing P., Nielsen F. S., Hansen B. V., Lecerf L., et al. Lack of relationship between an insertion/deletion polymorphism in the angiotensin I‐converting enzyme gene and diabetic nephropathy and proliferative retinopathy in IDDM patients. Diabetes 1995; 44: 489–94
   PubMed Web of Science ®Google Scholar
• Tarnow L., Hildebrandt P., Hansen B. V., Borch‐Johnsen K., Parving H. H. Plasma N‐terminal pro‐brain natriuretic peptide as an independent predictor of mortality in diabetic nephropathy. Diabetologia 2005; 48: 149–55
   PubMed Web of Science ®Google Scholar
• Rose G., Blackburn H. Cardiovascular survey methods. Monogr Ser World Health Organ 1968; 56: 1–188
   PubMedGoogle Scholar
• Hilsted J., Jensen S. B. A simple test for autonomic neuropathy in juvenile diabetics. Acta Med Scand 1979; 205: 385–7
   PubMed Web of Science ®Google Scholar
• Ewing D. J., Martyn C. N., Young R. J., Clarke B. F. The value of cardiovascular autonomic function tests: 10 years experience in diabetes. Diabetes Care 1985; 8: 491–8
   PubMed Web of Science ®Google Scholar
• Elming H., Holm E., Jun L., Torp‐Pedersen C., Kober L., Kircshoff M., et al. The prognostic value of the QT interval and QT interval dispersion in all‐cause and cardiac mortality and morbidity in a population of Danish citizens. Eur Heart J 1998; 19: 1391–400
   PubMed Web of Science ®Google Scholar
• Hilsted J. Pathophysiology in diabetic autonomic neuropathy: cardiovascular, hormonal, and metabolic studies. Diabetes 1982; 31: 730–7
   PubMed Web of Science ®Google Scholar
• Ziegler D. Diabetic cardiovascular autonomic neuropathy: prognosis, diagnosis and treatment. Diabetes Metab Rev 1994; 10: 339–83
   PubMed Web of Science ®Google Scholar
• Suys B. E., Huybrechts S. J., De Wolf D., Op De Beeck L., Matthys D., Van Overmeire B., et al. QTc interval prolongation and QTc dispersion in children and adolescents with type 1 diabetes. J Pediatr 2002; 141: 59–63
   PubMed Web of Science ®Google Scholar
• Murphy N. P., Ford‐Adams M. E., Ong K. K., Harris N. D., Keane S. M., Davies C., et al. Prolonged cardiac repolarisation during spontaneous nocturnal hypoglycaemia in children and adolescents with type 1 diabetes. Diabetologia 2004; 47: 1940–7
   PubMed Web of Science ®Google Scholar
• Tentolouris N., Katsilambros N., Papazachos G., Papadogiannis D., Linos A., Stamboulis E., et al. Corrected QT interval in relation to the severity of diabetic autonomic neuropathy. Eur J Clin Invest 1997; 27: 1049–54
   PubMed Web of Science ®Google Scholar
• Veglio M., Borra M., Stevens L. K., Fuller J. H., Perin P. C. The relation between QTc interval prolongation and diabetic complications. The EURODIAB IDDM Complication Study Group. Diabetologia 1999; 42: 68–75
   PubMed Web of Science ®Google Scholar
• Whitsel E. A., Boyko E. J., Siscovick D. S. Reassessing the role of QTc in the diagnosis of autonomic failure among patients with diabetes: a meta‐analysis. Diabetes Care 2000; 23: 241–7
   PubMed Web of Science ®Google Scholar
• Astrup A. S., Tarnow L., Rossing P., Hansen B. V., Hilsted J., Parving H. H. Cardiac autonomic neuropathy predicts cardiovascular morbidity and mortality in type 1 diabetic patients with diabetic nephropathy. Diabetes Care 2006; 29: 334–9
   PubMed Web of Science ®Google Scholar