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Original Article

Reduced bone mass and increased bone turnover in postmenopausal women with epilepsy using antiepileptic drug monotherapy

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Pages 759-766 | Received 13 Mar 2008, Accepted 21 May 2008, Published online: 08 Jul 2009

References

  • Kruse R. Osteopathien bei antiepileptischer Langzeittherapie (Vorläufige Mitteilung). Monatsscr Kinderheilkd 1968; 116: 378–81
  • Richens A., Rowe D. J. F. Disturbances of calcium metabolism by anticonvulsant drugs. Br Med J 1970; 4: 73–6
  • Bouillon R., Reynaert J., Claes J. H., Lissens W., De Moor P. The effect of anticonvulsant therapy on serum levels of 25‐hydroxy‐vitamin D, calcium, and parathyroid hormone. J Clin Endocrinol Metab 1975; 41: 1130–5
  • Cummings S. R., Nevitt M. C., Browner W. S., Stone K., Fox K. M., Ensrud K. E., et al. Risk factors for hip fracture in white women. Study of osteoporotic fractures research group. N Engl J Med 1995; 332: 767–74
  • Sato Y., Kondo I., Ishida S., Motooka H., Takayama K., Tomita Y., et al. Decreased bone mass and increased bone turnover with valproate therapy in adults with epilepsy. Neurology 2001; 57: 445–9
  • Kulak C. A. M., Borba V. Z. C., Bilezikian J. P., Silvado C. E., De Paola L., Boguszewski C. L. Bone mineral density and serum levels of 25 OH vitamin D in chronic users of antiepileptic drugs. Arquivos de Neuro‐psiquiatria 2004; 62: 940–8
  • Petty S. J., O'Brien T. J., Wark J. D. Anti‐epilepic medication and bone health. Osteoporosis Int 2007; 18: 129–42
  • Gough H., Bissesar A., Goggin T., Higgins D., Baker M., Crowley M., et al. Factors associated with the biochemical changes in vitamin D and calcium metabolism in institutionalized patients with epilepsy. Irish J Med Sci 1986; 155: 181–9
  • Gough H., Goggin T., Bissesar A., Baker M., Crowley M., Callaghan N. A comparative study of the relative influence of different anticonvulsant drugs, UV exposure and diet on vitamin D and calcium metabolism in out‐patients with epilepsy. Q J Med 1986; 59: 569–77
  • Farhat G., Yamout B., Mikati M. A., Demirjian S., Sawaya R., El‐Hajj Fuleihan G. Effect of antiepileptic drugs on bone density in ambulatory patients. Neurology 2002; 58: 1348–53
  • Vestergaard P., Rejnmark L., Mosekilde L. Fracture risk associated with use of antiepileptic drugs. Epilepsia 2004; 45: 1330–7
  • Chung S., Ahn C. Effects of anti‐epileptic drug therapy on bone mineral density in ambulatory epileptic children. Brain Dev 1994; 16: 382–5
  • Verrotti A., Greco R., Morgese G., Chiarelli F. Increased bone turnover in epileptic patients treated with carbamazepine. Ann Neurol 2000; 47: 385–8
  • Nissen‐Meyer L. S., Jemtland R., Gautvik V. T., Pedersen M. E., Paro R., Fortunati D., et al. Osteopenia, decreased bone formation and impaired osteoblast development in Sox4 heterozygous mice. J Cell Sci 2007; 120: 2785–95
  • Hahn T. J., Birge S. J., Scharp C. R., Avioli L. V. Phenobarbital‐induced alterations in vitamin D metabolism. J Clin Invest 1972; 51: 741–8
  • Pento J. T., Glick S. M., Kagan A. Diphenylhydantoin inhibition of calcitonin secretion in the pig. Endocrinology 1973; 92: 330–3
  • Matheson R. T., Herbst J. J., Jubiz W., Freston J. W., Tolman K. G. Absorption and biotransformation of cholecalciferol in drug‐induced osteomalacia. J Clin Pharmacol 1976; 16: 426–32
  • Hoikka V., Alhava E. M., Karjalainen P., Keränen T., Savolainen K. E., Riekkinen P., et al. Carbamazepine and bone mineral metabolism. Acta Neurol Scand 1984; 70: 77–80
  • Weinstein R. S., Bryce G. F., Sappington L. J., King D. W., Gallagher B. B. Decreased serum ionized calcium and normal vitamin D metabolite levels with anticonvulsant drug treatment. J Clin Endocrinol Metab 1984; 58: 1003–9
  • Kruse K., Süss A., Büsse M., Schneider P. Monomeric serum calcitonin and bone turnover during anticonvulsant treatment and in congenital hypothyroidism. J Pediatr 1987; 111: 57–63
  • Välimäki M. J., Tiihonen M., Laitinen K., Tähtelä R., Kärkkäinen M., Lamberg‐Allardt C., et al. Bone mineral density measured by dual‐energy X‐ray absorptiometry and novel markers of bone formation and resorption in patients on antiepileptic drugs. J Bone Miner Res 1994; 9: 631–7
  • Feldkamp J., Becker A., Witte O. W., Scharff D., Scherbaum W. A. Long‐term anticonvulsant therapy leads to low bone mineral density – evidence for direct drug effects of phenytoin and carbamazepine on human osteoblast‐like cells. Exp Clin Endocrinol 2000; 108: 37–43
  • Andress D. L., Ozuna J., Tirschwell D., Grande L., Johnson M., Jacobson A. F., et al. Antiepileptic drug‐induced bone loss in young male patients who have seizures. Arch Neurol 2002; 59: 781–6
  • Petty S. J., Paton L. M., O'Brien T. J., Makovey J., Erbas B., Sambrook P., et al. Effect of antiepileptic medication on bone mineral measures. Neurology 2005; 65: 1358–63
  • Souverein P. C., Webb D. J., Weil J. G., Van Staa T. P., Egberts A. C. G. Use of antiepileptic drugs and risk of fractures: case‐control study among patients with epilepsy. Neurology 2006; 66: 1318–24
  • Stephen L. J., McLellan A. R., Harrison J. H., Shapiro D., Dominiczak M. H., Sills G. J., et al. Bone density and antiepileptic drugs: a case‐controlled study. Seizure 1999; 8: 339–42
  • Pack A. M., Olarte L. S., Morrell M. J., Flaster E., Resor S. R., Shane E. Bone mineral density in an outpatient population receiving enzyme‐inducing antiepileptic drugs. Epilepsy Behav 2003; 4: 169–74
  • Lofthus C. M., Osnes E. K., Falch J. A., Kaastad T. S., Kristiansen I. S., Nordsletten L., et al. Epidemiology of hip fractures in Oslo, Norway. Bone 2001; 29: 413–8
  • Ensrud K. E., Walczak T. S., Blackwell T., Ensrud E. R., Bowman P. J., Stone K. L. Antiepileptic drug use increases rates of bone loss in older women: a prospective study. Neurology 2004; 62: 2051–7
  • Godang K., Ueland T., Bollerslev J. Decreased bone area, bone mineral content, formative markers, and increased bone resorptive markers in endogenous Cushing's syndrome. Eur J Endocrinol 1999; 141: 126–31
  • Gjesdal C. G., Aanerud S. J., Haga H. J., Brun J. G., Tell G. S. Femoral and whole‐body bone mineral density in middle‐aged and older Norwegian men and women; suitability of the reference values. Osteoporosis Int 2004; 15: 525–34
  • Assessment of osteoporotic fracture risk and its role in screening for postmenopausal osteoporosis. 1994, WHO Technical Report Series. Geneva
  • Stögmann W. Störungen des Kalzium‐Phosphat‐Stoffwechsels durch Antikonvulsiva in Relation zu ihrer Serumkonzentration. Padiatr Padol 1979; 14: 89–95
  • O'Hare J. A., Duggan B., O'Driscoll D., Callaghan N. Biochemical evidence for osteomalacia with carbamazepine therapy. Acta Neurol Scand 1980; 62: 282–6
  • Pack A. M., Morrell M. J., Marcus R., Holloway L., Flaster E., Doñe S., et al. Bone mass and turnover in women with epilepsy on antiepileptic drug monotherapy. Ann Neurol 2005; 57: 252–7
  • Sheth R. D., Wesolowski C. A., Jacob J. C., Penney S., Hobbs G. R., Riggs J. E., et al. Effect of carbamazepine and valproate on bone mineral density. J Pediatr 1995; 127: 256–62
  • Li X., Breteler M. M., De Bruyne M. C., Meinardi H., Hauser W. A., Hofman A. Vascular determinants of epilepsy: the Rotterdam Study. Epilepsia 1997; 38: 1216–20
  • Klein P., Serje A., Pezzullo J. C. Premature ovarian failure in women with epilepsy. Epilepsia 2001; 42: 1584–9

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