Metformin has no major effects on glucose homeostasis in pregnant women with PCOS: results of a randomized double‐blind study

References

• Ehrmann D. A. Polycystic ovary syndrome. N Engl J Med 2005; 352: 223–36
   Google Scholar
• Diamanti‐Kandarakis E., Kouli C. R., Bergiele A. T., Filandra F. A., Tsianateli T. C., Spina G. G., et al. A survey of the polycystic ovary syndrome in the Greek island of Lesbos: hormonal and metabolic profile. J Clin Endocrinol Metab 1999; 84: 4006–11
   PubMed Web of Science ®Google Scholar
• Asuncion M., Calvo R. M., San Millan J. L., Sancho J., Avila S., Escobar‐Morreale H. F. A prospective study of the prevalence of the polycystic ovary syndrome in unselected Caucasian women from Spain. J Clin Endocrinol Metab 2000; 85: 2434–8
   PubMed Web of Science ®Google Scholar
• Radon P. A., McMahon M. J., Meyer W. R. Impaired glucose tolerance in pregnant women with polycystic ovary syndrome. Obstet Gynecol 1999; 94: 194–7
   PubMed Web of Science ®Google Scholar
• Mikola M., Hiilesmaa V., Halttunen M., Suhonen L., Tiitinen A. Obstetric outcome in women with polycystic ovarian syndrome. Hum Reprod 2001; 16: 226–9
   PubMed Web of Science ®Google Scholar
• Bjercke S., Dale P. O., Tanbo T., Storeng R., Ertzeid G., Abyholm T. Impact of insulin resistance on pregnancy complications and outcome in women with polycystic ovary syndrome. Gynecol Obstet Invest 2002; 54: 94–8
   PubMed Web of Science ®Google Scholar
• Glueck C. J., Wang P., Kobayashi S., Phillips H., Sieve‐Smith L. Metformin therapy throughout pregnancy reduces the development of gestational diabetes in women with polycystic ovary syndrome. Fertil Steril 2002; 77: 520–5
   PubMed Web of Science ®Google Scholar
• Vanky E., Salvesen K. A., Heimstad R., Fougner K. J., Romundstad P., Carlsen S. M. Metformin reduces pregnancy complications without affecting androgen levels in pregnant polycystic ovary syndrome women: results of a randomized study. Hum Reprod 2004; 19: 734–40
   PubMed Web of Science ®Google Scholar
• Velazquez E., Acosta A., Mendoza S. G. Menstrual cyclicity after metformin therapy in polycystic ovary syndrome. Obstet Gynecol 1997; 90: 392–5
   PubMed Web of Science ®Google Scholar
• Morin‐Papunen L. C., Koivunen R. M., Ruokonen A., Martikainen H. K. Metformin therapy improves the menstrual pattern with minimal endocrine and metabolic effects in women with polycystic ovary syndrome. Fertil Steril 1998; 69: 691–6
   PubMed Web of Science ®Google Scholar
• Moghetti P., Castello R., Negri C., Tosi F., Perrone F., Caputo M., et al. Metformin effects on clinical features, endocrine and metabolic profiles, and insulin sensitivity in polycystic ovary syndrome: a randomized, double‐blind, placebo‐controlled 6‐month trial, followed by open, long‐term clinical evaluation. J Clin Endocrinol Metab 2000; 85: 139–46
   PubMed Web of Science ®Google Scholar
• Pasquali R., Gambineri A., Biscotti D., Vicennati V., Gagliardi L., Colitta D., et al. Effect of long‐term treatment with metformin added to hypocaloric diet on body composition, fat distribution, and androgen and insulin levels in abdominally obese women with and without the polycystic ovary syndrome. J Clin Endocrinol Metab 2000; 85: 2767–74
   PubMed Web of Science ®Google Scholar
• Fleming R., Hopkinson Z. E., Wallace A. M., Greer I. A., Sattar N. Ovarian function and metabolic factors in women with oligomenorrhea treated with metformin in a randomized double blind placebo‐controlled trial. J Clin Endocrinol Metab 2002; 87: 569–74
   PubMed Web of Science ®Google Scholar
• Glueck C. J., Goldenberg N., Pranikoff J., Loftspring M., Sieve L., Wang P. Height, weight, and motor‐social development during the first 18 months of life in 126 infants born to 109 mothers with polycystic ovary syndrome who conceived on and continued metformin through pregnancy. Hum Reprod 2004; 19: 1323–30
   PubMed Web of Science ®Google Scholar
• Glueck C. J., Bornovali S., Pranikoff J., Goldenberg N., Dharashivkar S., Wang P. Metformin, pre‐eclampsia, and pregnancy outcomes in women with polycystic ovary syndrome. Diabet Med 2004; 21: 829–36
   PubMed Web of Science ®Google Scholar
• The Rotterdam ESHRE/ASRM‐Sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long‐term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 2004; 19: 41–7, and Fertil Steril 2004;81:9–25
   PubMed Web of Science ®Google Scholar
• Alberti K. G., Zimmet P. Z. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 1998; 15: 539–53
   PubMed Web of Science ®Google Scholar
• World Health Organization. Definition, diagnosis and classification of diabetes mellitus and its complications: Report of a WHO Consultation. Part 1. Diagnosis and classification of diabetes mellitus. WHO, Geneva 1999
   Google Scholar
• Matthews D. R., Hosker J. P., Rudenski A. S., Naylor B. A., Treacher D. F., Turner R. C. Homeostasis model assessment: insulin resistance and beta‐cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412–19
   PubMed Web of Science ®Google Scholar
• Buchanan T. A., Metzger B. E., Freinkel N., Bergman R. N. Insulin sensitivity and B‐cell responsiveness to glucose during late pregnancy in lean and moderately obese women with normal glucose tolerance or mild gestational diabetes. Am J Obstet Gynecol 1990; 162: 1008–14
   PubMed Web of Science ®Google Scholar
• Haffner S. M., Kennedy E., Gonzalez C., Stern M. P., Miettinen H. A prospective analysis of the HOMA model. The Mexico City Diabetes Study. Diabetes Care 1996; 19: 1138–41
   PubMed Web of Science ®Google Scholar
• Metzger B. E., Coustan D. R. Summary and recommendations of the Fourth International Workshop‐Conference on Gestational Diabetes Mellitus. The Organizing Committee. Diabetes Care 1998; 21((Suppl 2))B161–7
   PubMed Web of Science ®Google Scholar
• Jovanovic L., Pettitt D. J. Gestational diabetes mellitus. J Am Med Assoc 2001; 286: 2516–8
   PubMed Web of Science ®Google Scholar
• Carpenter M. W., Coustan D. R. Criteria for screening tests for gestational diabetes. Am J Obstet Gynecol 1982; 144: 768–73
   PubMed Web of Science ®Google Scholar
• American College of Obstetricians and Gynecologists. Clinical management guidelines for obstetrician‐gynecologists. Gestational diabetes. ACOG Practice Bulletin 30. Obstet Gynecol 2001; 98: 525–38
   PubMedGoogle Scholar
• Hanna F. W. F., Peters J. R. Screening for gestational diabetes; past, present and future. Diabet Med 2002; 19: 351–8
   PubMed Web of Science ®Google Scholar
• Agarwal M. M., Punnose J. Gestational diabetes: implications of variation in diagnostic criteria. Int J Gynecol Obstet 2002; 78: 45–6
   PubMed Web of Science ®Google Scholar
• Gestational diabetes mellitus. Position statement. American Diabetes Association. Diabetes Care 2004; 27((Suppl 1))S88–90
   PubMed Web of Science ®Google Scholar
• Ben‐Haroush A., Yogev Y., Hod M. Epidemiology of gestational diabetes mellitus and its association with Type 2 diabetes. Diabet Med 2004; 21: 103–13
   PubMed Web of Science ®Google Scholar