89
Views
6
CrossRef citations to date
0
Altmetric
INVITED REVIEWS

Update on amyloid‐β homeostasis markers for sporadic Alzheimer's disease

Pages 18-21 | Received 06 Aug 2008, Accepted 12 Nov 2008, Published online: 08 Jul 2009

References

  • Blennow K., de Leon M. J., Zetterberg H. Alzheimer's disease. Lancet 2006; 368: 387–403
  • De Strooper B. Aph‐1, Pen‐2, and Nicastrin with Presenilin generate an active gamma‐Secretase complex. Neuron 2003; 38: 9–12
  • Hussain I., Powell D., Howlett D. R., Tew D. G., Meek T. D., Chapman C., et al. Identification of a novel aspartic protease (Asp 2) as beta‐secretase. Mol Cell Neurosci 1999; 14: 419–27
  • Sinha S., Anderson J. P., Barbour R., Basi G. S., Caccavello R., Davis D., et al. Purification and cloning of amyloid precursor protein beta‐secretase from human brain. Nature 1999; 402: 537–40
  • Vassar R., Bennett B. D., Babu‐Khan S., Kahn S., Mendiaz E. A., Denis P., et al. Beta‐secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 1999; 286: 735–41
  • Yan R., Bienkowski M. J., Shuck M. E., Miao H., Tory M. C., Pauley A. M., et al. Membrane‐anchored aspartyl protease with Alzheimer's disease beta‐secretase activity. Nature 1999; 402: 533–7
  • Blennow K., Hampel H. CSF markers for incipient Alzheimer's disease. Lancet Neurol 2003; 2: 605–13
  • Fukumoto H., Cheung B. S., Hyman B. T., Irizarry M. C. Beta‐secretase protein and activity are increased in the neocortex in Alzheimer disease. Arch Neurol 2002; 59: 1381–9
  • Johnston J. A., Liu W. W., Todd S. A., Coulson D. T., Murphy S., Irvine G. B., et al. Expression and activity of beta‐site amyloid precursor protein cleaving enzyme in Alzheimer's disease. Biochem Soc Trans 2005; 33: 1096–100
  • Holsinger R. M., Lee J. S., Boyd A., Masters C. L., Collins S. J. CSF BACE1 activity is increased in CJD and Alzheimer disease versus corrected] other dementias. Neurology 2006; 67: 710–12
  • Holsinger R. M., McLean C. A., Collins S. J., Masters C. L., Evin G. Increased beta‐Secretase activity in cerebrospinal fluid of Alzheimer's disease subjects. Ann Neurol 2004; 55: 898–9
  • Verheijen J. H., Huisman L. G., van Lent N., Neumann U., Paganetti P., Hack C. E., et al. Detection of a soluble form of BACE‐1 in human cerebrospinal fluid by a sensitive activity assay. Clin Chem 2006; 52: 1168–74
  • Zhong Z., Ewers M., Teipel S., Burger K., Wallin A., Blennow K., et al. Levels of beta‐secretase (BACE1) in cerebrospinal fluid as a predictor of risk in mild cognitive impairment. Arch Gen Psychiatry 2007; 64: 718–26
  • Zetterberg H., Andreasson U., Hansson O., Wu G., Sankaranarayanan S., Andersson ME., et al. Elevated cerebrospinal fluid BACE1 activity in incipient Alzheimer disease. Arch Neurol 2008; 65: 1102–7
  • Seubert P., Vigo‐Pelfrey C., Esch F., Lee M., Dovey H., Davis D., et al. Isolation and quantification of soluble Alzheimer's beta‐peptide from biological fluids. Nature 1992; 359: 325–7
  • Hock C., Golombowski S., Muller‐Spahn F., Naser W., Beyreuther K., Monning U., et al. Cerebrospinal fluid levels of amyloid precursor protein and amyloid beta‐peptide in Alzheimer's disease and major depression – inverse correlation with dementia severity. Eur Neurol 1998; 39: 111–18
  • Palmert M. R., Usiak M., Mayeux R., Raskind M., Tourtellotte W. W., Younkin S. G. Soluble derivatives of the beta amyloid protein precursor in cerebrospinal fluid: alterations in normal aging and in Alzheimer's disease. Neurology 1990; 40: 1028–34
  • Prior R., Monning U., Schreiter‐Gasser U., Weidemann A., Blennow K., Gottfries C. G., et al. Quantitative changes in the amyloid beta A4 precursor protein in Alzheimer cerebrospinal fluid. Neurosci Lett 1991; 124: 69–73
  • Van Nostrand W. E., Wagner S. L., Shankle W. R., Farrow J. S., Dick M., Rozemuller J. M., et al. Decreased levels of soluble amyloid beta‐protein precursor in cerebrospinal fluid of live Alzheimer disease patients. Proc Natl Acad Sci USA 1992; 89: 2551–5
  • Lannfelt L., Basun H., Wahlund L. O., Rowe B. A., Wagner S. L. Decreased alpha‐secretase‐cleaved amyloid precursor protein as a diagnostic marker for Alzheimer's disease. Nat Med 1995; 1: 829–32
  • Olsson A., Hoglund K., Sjogren M., Andreasen N., Minthon L., Lannfelt L., et al. Measurement of alpha‐ and beta‐secretase cleaved amyloid precursor protein in cerebrospinal fluid from Alzheimer patients. Exp Neurol 2003; 183: 74–80
  • Sennvik K., Fastbom J., Blomberg M., Wahlund L. O., Winblad B., Benedikz E. Levels of alpha‐ and beta‐secretase cleaved amyloid precursor protein in the cerebrospinal fluid of Alzheimer's disease patients. Neurosci Lett 2000; 278: 169–72
  • Vigo‐Pelfrey C., Lee D., Keim P., Lieberburg I., Schenk D. B. Characterization of beta‐amyloid peptide from human cerebrospinal fluid. J Neurochem 1993; 61: 1965–8
  • Wiltfang J., Esselmann H., Bibl M., Smirnov A., Otto M., Paul S., et al. Highly conserved and disease‐specific patterns of carboxyterminally truncated Abeta peptides 1–37/38/39 in addition to 1–40/42 in Alzheimer's disease and in patients with chronic neuroinflammation. J Neurochem 2002; 81: 481–96
  • Hoglund K., Hansson O., Buchhave P., Zetterberg H., Lewczuk P., Londos E., et al. Prediction of Alzheimer's disease using a CSF pattern of C‐terminally truncated beta‐amyloid peptides. Neurodegener Dis. 2008, In press
  • Mehta P. D., Pirttila T., Mehta S. P., Sersen E. A., Aisen P. S., Wisniewski H. M. Plasma and cerebrospinal fluid levels of amyloid beta proteins 1–40 and 1–42 in Alzheimer disease. Arch Neurol 2000; 57: 100–5
  • Schoonenboom N. S., Mulder C., Van Kamp G. J., Mehta S. P., Scheltens P., Blankenstein M. A., et al. Amyloid beta 38, 40, and 42 species in cerebrospinal fluid: more of the same?. Ann Neurol 2005; 58: 139–42
  • Hansson O., Zetterberg H., Buchhave P., Andreasson U., Londos E., Minthon L., et al. Prediction of Alzheimer's disease using the CSF Abeta42/Abeta40 ratio in patients with mild cognitive impairment. Dement Geriatr Cogn Disord 2007; 23: 316–20
  • Simonsen A. H., Hansson S. F., Ruetschi U., McGuire J., Podust V. N., Davies H. A., et al. Amyloid beta1–40 quantification in CSF: comparison between chromatographic and immunochemical methods. Dement Geriatr Cogn Disord 2007; 23: 246–50
  • Sergeant N., Bombois S., Ghestem A., Drobecq H., Kostanjevecki V., Missiaen C., et al. Truncated beta‐amyloid peptide species in pre‐clinical Alzheimer's disease as new targets for the vaccination approach. J Neurochem 2003; 85: 1581–91
  • Casas C., Sergeant N., Itier J. M., Blanchard V., Wirths O., van der Kolk N., et al. Massive CA1/2 neuronal loss with intraneuronal and N‐terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model. Am J Pathol 2004; 165: 1289–300
  • Vanderstichele H., De Meyer G., Andreasen N., Kostanjevecki V., Wallin A., Olsson A., et al. Amino‐truncated {beta}‐amyloid42 peptides in cerebrospinal fluid and prediction of progression of mild cognitive impairment. Clin Chem 2005; 51: 1650–60
  • Portelius E., Westman‐Brinkmalm A., Zetterberg H., Blennow K. Determination of beta‐amyloid peptide signatures in cerebrospinal fluid using immunoprecipitation‐mass spectrometry. J Proteome Res 2006; 5: 1010–16
  • Portelius E., Zetterberg H., Andreasson U., Brinkmalm G., Andreasen N., Wallin A., et al. An Alzheimer's disease‐specific beta‐amyloid fragment signature in cerebrospinal fluid. Neurosci Lett 2006; 409: 215–19
  • Portelius E., Tran A. J., Andreasson U., Persson R., Brinkmalm G., Zetterberg H., et al. Characterization of amyloid beta peptides in cerebrospinal fluid by an automated immunoprecipitation procedure followed by mass spectrometry. J Proteome Res. 2007, In press
  • Bateman R. J., Munsell L. Y., Morris J. C., Swarm R., Yarasheski K. E., Holtzman D. M. Human amyloid‐beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo. Nat Med 2006; 12: 856–61

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.