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ORIGINAL ARTICLE

Fatty acid desaturase expression in human leucocytes correlates with plasma phospholipid fatty acid status

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Pages 496-504 | Received 03 Sep 2008, Published online: 26 Aug 2009

References

  • Zhang L, Ge L, Parimoo S, Stenn K, Prouty SM. Human stearoyl‐CoA desaturase: alternative transcripts generated from a single gene by usage of tandem polyadenylation sites. Biochem J 1999; 340: 255–64
  • Insull W, JrBartsch GE. Fatty acid composition of human adipose tissue related to age, sex, and race. Am J Clin Nutr 1967; 20: 13–23
  • Sprecher H. Metabolism of highly unsaturated n‐3 and n‐6 fatty acids. Biochim Biophys Acta 2000; 1486: 219–31
  • Ntambi JM, Miyazaki M, Dobrzyn A. Regulation of stearoyl‐CoA desaturase expression. Lipids 2004; 39: 1061–5
  • Sprecher H. Biochemistry of essential fatty acids. Prog Lipid Res 1981; 20: 13–22
  • Zhou L, Nilsson A. Sources of eicosanoid precursor fatty acid pools in tissues. J Lipid Res 2001; 42: 1521–42
  • Nakamura MT, Cho HP, Xu J, Tang Z, Clarke SD. Metabolism and functions of highly unsaturated fatty acids: an update. Lipids 2001; 36: 961–4
  • Nakamura MT, Nara TY. Structure, function, and dietary regulation of delta6, delta5, and delta9 desaturases. Annu Rev Nutr 2004; 24: 345–76
  • Zolfaghari R, Ross AC. Recent advances in molecular cloning of fatty acid desaturase genes and the regulation of their expression by dietary vitamin A and retinoic acid. Prostaglandins Leukot Essent Fatty Acids 2003; 68: 171–9
  • Nakamura MT, Phinney SD, Tang AB, Oberbauer AM, German JB, Murray JD. Increased hepatic delta 6‐desaturase activity with growth hormone expression in the MG101 transgenic mouse. Lipids 1996; 31: 139–43
  • Pigeon C, Legrand P, Leroyer P, Bouriel M, Turlin B, Brissot P, Loreal O. Stearoyl coenzyme A desaturase 1 expression and activity are increased in the liver during iron overload. Biochim Biophys Acta 2001; 1535: 275–84
  • Brenner RR. Nutritional and hormonal factors influencing desaturation of essential fatty acids. Prog Lipid Res 1981; 20: 41–7
  • Christiansen EN, Lund JS, Rortveit T, Rustan AC. Effect of dietary n‐3 and n‐6 fatty acids on fatty acid desaturation in rat liver. Biochim Biophys Acta 1991; 1082: 57–62
  • Lapillonne A, Clarke SD, Heird WC. Polyunsaturated fatty acids and gene expression. Curr Opin Clin Nutr Metab Care 2004; 7: 151–6
  • Grimaldi PA. Fatty acid regulation of gene expression. Curr Opin Clin Nutr Metab Care 2001; 4: 433–7
  • Ntambi JM, Bene H. Polyunsaturated fatty acid regulation of gene expression. J Mol Neurosci 2001; 16: 273–8
  • Finstad HS, Kolset SO, Holme JA, Wiger R, Farrants AK, Blomhoff R, Drevon CA. Effect of n‐3 and n‐6 fatty acids on proliferation and differentiation of promyelocytic leukemic HL‐60 cells. Blood 1994; 84: 3799–809
  • Moore S, Knudsen B, True LD, Hawley S, Etzioni R, Wade C, Gifford D, Coleman I, Nelson PS. Loss of stearoyl‐CoA desaturase expression is a frequent event in prostate carcinoma. Int J Cancer 2005; 114: 563–71
  • Lane JMR, Jiang WG. Expression of human delta‐6‐desaturase is associated with aggressiveness of human breast cancer. Int J Mol Med 2003; 12: 253–7
  • Slagsvold JE, Thorstensen K, Kvitland M, Mack M, Bjerve KS. Regulation of desaturase expression in HL60 cells. Scand J Clin Lab Invest 2007; 67: 632–42
  • Xiang M, Rahman MA, Ai H, Li X, Harbige LS. Diet and gene expression: Delta‐5 and Delta‐6 desaturases in healthy Chinese and European subjects. Ann Nutr Metab 2006; 50: 492–8
  • Cho HP, Nakamura M, Clarke SD. Cloning, expression, and fatty acid regulation of the human delta‐5 desaturase. J Biol Chem 1999; 274: 37335–9
  • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real‐time quantitative PCR and the 2(‐Delta Delta C(T)) method. Methods 2001; 25: 402–8
  • Bonaa KH, Bjerve KS, Straume B, Gram IT, Thelle D. Effect of eicosapentaenoic and docosahexaenoic acids on blood pressure in hypertension. A population‐based intervention trial from the Tromso study. N Engl J Med 1990; 322: 795–801
  • Grubb F. Procedures for detecting outlying observations in samples. Technometrics 1969; 11: 1–21
  • Krokan HE, Bjerve KS, Mork E. The enteral bioavailability of eicosapentaenoic acid and docosahexaenoic acid is as good from ethyl esters as from glyceryl esters in spite of lower hydrolytic rates by pancreatic lipase in vitro. Biochim Biophys Acta 1993; 1168: 59–67
  • Foulon T, Richard MJ, Payen N, Bourrain JL, Beani JC, Laporte F, Hadjian A. Effects of fish oil fatty acids on plasma lipids and lipoproteins and oxidant‐antioxidant imbalance in healthy subjects. Scand J Clin Lab Invest 1999; 59: 239–48
  • Jenkins DJ, Josse AR, Beyene J, Dorian P, Burr ML, LaBelle R, Kendall CW, Cunnane SC. Fish‐oil supplementation in patients with implantable cardioverter defibrillators: a meta‐analysis. Can Med Assoc J 2008; 178: 157–64

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