Preanalytical, analytical, and biological variation of blood plasma submicron particle levels measured with nanoparticle tracking analysis and tunable resistive pulse sensing

References

• Gaceb A, Martinez MC, Andriantsitohaina R. Extracellular vesicles: new players in cardiovascular diseases. Int J Biochem Cell Biol 2014;50:24–8.
   PubMed Web of Science ®Google Scholar
• Martins VR, Dias MS, Hainaut P. Tumor-cell-derived microvesicles as carriers of molecular information in cancer. Curr Opin Oncol 2013;25:66–75.
   PubMed Web of Science ®Google Scholar
• Raposo G, Stoorvogel W. Extracellular vesicles: exosomes, microvesicles, and friends. J Cell Biol 2013;200:373–83.
   PubMed Web of Science ®Google Scholar
• Arraud N, Linares R, Tan S, Gounou C, Pasquet JM, Mornet S, Brisson AR. Extracellular vesicles from blood plasma: determination of their morphology, size, phenotype and concentration. J Thromb Haemost 2014;12:614–27.
   PubMed Web of Science ®Google Scholar
• Witwer KW, Buzas EI, Bemis LT, Bora A, Lasser C, Lotvall J, Nolte-'T Hoen EN, Piper MG, Sivaraman S, Skog J, Thery C, Wauben MH, Hochberg F. Standardization of sample collection, isolation and analysis methods in extracellular vesicle research. J Extracell Vesicles 2013;2:20360–85.
   PubMedGoogle Scholar
• Freyssinet JM, Toti F. Membrane microparticle determination: at least seeing what’s being sized! J Thromb Haemost 2010;8:311–4.
   PubMed Web of Science ®Google Scholar
• Inglis HC, Danesh A, Shah A, Lacroix J, Spinella PC, Norris PJ. Techniques to improve detection and analysis of extracellular vesicles using flow cytometry. Cytometry A 2015;87:1052–63.
   PubMed Web of Science ®Google Scholar
• van der Pol E, Boing AN, Harrison P, Sturk A, Nieuwland R. Classification, functions, and clinical relevance of extracellular vesicles. Pharmacol Rev 2012;64:676–705.
   PubMed Web of Science ®Google Scholar
• Robert S, Lacroix R, Poncelet P, Harhouri K, Bouriche T, Judicone C, Wischhusen J, Arnaud L, Dignat-George F. High-sensitivity flow cytometry provides access to standardized measurement of small-size microparticles – brief report. Arterioscler Thromb Vasc Biol 2012;32:1054–8.
   PubMed Web of Science ®Google Scholar
• Nielsen MH, Beck-Nielsen H, Andersen MN, Handberg A. A flow cytometric method for characterization of circulating cell-derived microparticles in plasma. J Extracell Vesicles 2014;3:20795–807.
   PubMedGoogle Scholar
• Gardiner C, Ferreira YJ, Dragovic RA, Redman CW, Sargent IL. Extracellular vesicle sizing and enumeration by nanoparticle tracking analysis. J Extracell Vesicles 2013;2:19671–82.
   PubMedGoogle Scholar
• Dragovic RA, Southcombe JH, Tannetta DS, Redman CW, Sargent IL. Multicolor flow cytometry and nanoparticle tracking analysis of extracellular vesicles in the plasma of normal pregnant and pre-eclamptic women. Biol Reprod 2013;89:151.
   PubMed Web of Science ®Google Scholar
• de Vrij J, Maas SL, van Nispen M, Sena-Esteves M, Limpens RW, Koster AJ, Leenstra S, Lamfers ML, Broekman ML. Quantification of nanosized extracellular membrane vesicles with scanning ion occlusion sensing. Nanomedicine (Lond) 2013;8:1443–58.
   PubMed Web of Science ®Google Scholar
• Filipe V, Hawe A, Jiskoot W. Critical evaluation of nanoparticle tracking analysis (NTA) by NanoSight for the measurement of nanoparticles and protein aggregates. Pharm Res 2010;27:796–810.
   PubMed Web of Science ®Google Scholar
• Rhyner MN. The coulter principle for analysis of subvisible particles in protein formulations. Aaps J 2011;13:54–8.
   PubMed Web of Science ®Google Scholar
• Coumans FA, van der Pol E, Boing AN, Hajji N, Sturk G, van Leeuwen TG, Nieuwland R. Reproducible extracellular vesicle size and concentration determination with tunable resistive pulse sensing. J Extracell Vesicles 2014;3:25922.
   PubMedGoogle Scholar
• Yuana Y, Koning RI, Kuil ME, Rensen PC, Koster AJ, Bertina RM, Osanto S. Cryo-electron microscopy of extracellular vesicles in fresh plasma. J Extracell Vesicles 2013;2:21494–501.
   Google Scholar
• Wasan KM, Brocks DR, Lee SD, Sachs-Barrable K, Thornton SJ. Impact of lipoproteins on the biological activity and disposition of hydrophobic drugs: implications for drug discovery. Nat Rev Drug Discov 2008;7:84–99.
   PubMed Web of Science ®Google Scholar
• Yuana Y, Levels J, Grootemaat A, Sturk A, Nieuwland R. Co-isolation of extracellular vesicles and high-density lipoproteins using density gradient ultracentrifugation. J Extracell Vesicles 2014;3:23262–7.
   PubMedGoogle Scholar
• Böing AN, van der Pol E, Grootemaat AE, Coumans FA, Sturk A, Nieuwland R. Single-step isolation of extracellular vesicles by size-exclusion chromatography. J Extracell Vesicles 2014;3:23430–41.
   PubMedGoogle Scholar
• Davila M, Robles-Carrillo L, Unruh D, Huo Q, Gardiner C, Sargent IL, Adam M, Woodhams BJ, Francis JL, Bogdanov VY, Amirkhosravi A. Microparticle association and heterogeneity of tumor-derived tissue factor in plasma: is it important for coagulation activation? J Thromb Haemost 2014;12:186–96.
   PubMed Web of Science ®Google Scholar
• de Menezes-Neto A, Saez MJ, Lozano-Ramos I, Segui-Barber J, Martin-Jaular L, Ullate JM, Fernandez-Becerra C, Borras FE, Del Portillo HA. Size-exclusion chromatography as a stand-alone methodology identifies novel markers in mass spectrometry analyses of plasma-derived vesicles from healthy individuals. J Extracell Vesicles 2015;4:27378–92.
   PubMed Web of Science ®Google Scholar
• Kristensen AF, Pedersen S, Jørgensen MM, Stensballe A, Christiansen G, Nieuwland R, Kristensen SR. Characterization of extracellular vesicles isolated by size exclusion chromatography. J Extracell Vesicles 2014;3:143.
   Google Scholar
• Welton JL, Webber JP, Botos LA, Jones M, Clayton A. Ready-made chromatography columns for extracellular vesicle isolation from plasma. J Extracell Vesicles 2015;4:27269–78.
   PubMed Web of Science ®Google Scholar
• Lacroix R, Judicone C, Poncelet P, Robert S, Arnaud L, Sampol J. Impact of pre-analytical parameters on the measurement of circulating microparticles. J Thromb Haemost 2012;10:437–46.
   PubMed Web of Science ®Google Scholar
• Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972;18:499–502.
   PubMed Web of Science ®Google Scholar
• Lund SM, Stensballe A, Christiansen G, Nielsen MH, Kristensen SR. Pedersen S, Newly designed size exclusion chromatography columns for isolation and purification of extracellular vesicles in clinical samples. J Extracell Vesicles 2015;4:13.
   Google Scholar
• van der Pol E, Coumans FA, Grootemaat AE, Gardiner C, Sargent IL, Harrison P, Sturk A, van Leeuwen TG, Nieuwland R. Particle size distribution of exosomes and microvesicles determined by transmission electron microscopy, flow cytometry, nanoparticle tracking analysis, and resistive pulse sensing. J Thromb Haemost 2014;12:1182–92.
   PubMed Web of Science ®Google Scholar
• Dragovic RA, Gardiner C, Brooks AS, Tannetta DS, Ferguson DJ, Hole P, Carr B, Redman CW, Harris AL, Dobson PJ, Harrison P, Sargent IL. Sizing and phenotyping of cellular vesicles using nanoparticle tracking analysis. Nanomedicine 2011;7:780–8.
   PubMed Web of Science ®Google Scholar
• Roberts GS, Yu S, Zeng Q, Chan LC, Anderson W, Colby AH, Grinstaff MW, Reid S, Vogel R. Tunable pores for measuring concentrations of synthetic and biological nanoparticle dispersions. Biosens Bioelectron 2012;31:17–25.
   PubMed Web of Science ®Google Scholar
• Harrison P, Gardiner C. Invisible vesicles swarm within the iceberg. J Thromb Haemost 2012;10:916–8.
   PubMed Web of Science ®Google Scholar
• van der Pol E, van Gemert MJ, Sturk A, Nieuwland R, van Leeuwen TG. Single vs. swarm detection of microparticles and exosomes by flow cytometry. J Thromb Haemost 2012;10:919–30.
   PubMed Web of Science ®Google Scholar
• Ricos C, Alvarez V, Cava F, Garcia-Lario JV, Hernandez A, Jimenez CV, Minchinela J, Perich C, Simon M. Current databases on biological variation: pros, cons and progress. Scand J Clin Lab Invest 1999;59:491–500.
   PubMed Web of Science ®Google Scholar
• Nakajima K, Nakano T, Tokita Y, Nagamine T, Inazu A, Kobayashi J, Mabuchi H, Stanhope KL, Havel PJ, Okazaki M, Ai M, Tanaka A. Postprandial lipoprotein metabolism: VLDL vs chylomicrons. Clin Chim Acta 2011;412:1306–18.
   PubMed Web of Science ®Google Scholar
• Wojczynski MK, Glasser SP, Oberman A, Kabagambe EK, Hopkins PN, Tsai MY, Straka RJ, Ordovas JM, Arnett DK. High-fat meal effect on LDL, HDL, and VLDL particle size and number in the genetics of lipid-lowering drugs and diet network (GOLDN): an interventional study. Lipids Health Dis 2011;10:181–92.
   PubMed Web of Science ®Google Scholar
• Savorani F, Kristensen M, Larsen FH, Astrup A, Engelsen SB. High throughput prediction of chylomicron triglycerides in human plasma by nuclear magnetic resonance and chemometrics. Nutr Metab (Lond) 2010;7:43. 7075-7-43.
   PubMed Web of Science ®Google Scholar
• Mackness MI, Durrington PN. Lipoprotein separation and analysis for clinical studies. In: Converse CA, Skinner ER, editors. Lipoprotein research – a practical approach. 1st ed. London, UK: Oxford University Press 1992:1–42.
   Google Scholar
• Barter PJ, Ballantyne CM, Carmena R, Castro Cabezas M, Chapman MJ, Couture P, de Graaf J, Durrington PN, Faergeman O, Frohlich J, Furberg CD, Gagne C, Haffner SM, Humphries SE, Jungner I, Krauss RM, Kwiterovich P, Marcovina S, Packard CJ, Pearson TA, Reddy KS, Rosenson R, Sarrafzadegan N, Sniderman AD, Stalenhoef AF, Stein E, Talmud PJ, Tonkin AM, Walldius G, Williams KM. Apo B versus cholesterol in estimating cardiovascular risk and in guiding therapy: report of the thirty-person/ten-country panel. J Intern Med 2006;259:247–58.
   PubMed Web of Science ®Google Scholar
• Tushuizen ME, Nieuwland R, Scheffer PG, Sturk A, Heine RJ, Diamant M. Two consecutive high-fat meals affect endothelial-dependent vasodilation, oxidative stress and cellular microparticles in healthy men. J Thromb Haemost 2006;4:1003–10.
   PubMed Web of Science ®Google Scholar
• Tushuizen ME, Diamant M, Peypers EG, Hoek FJ, Heine RJ, Sturk A, Nieuwland R. Postprandial changes in the phospholipid composition of circulating microparticles are not associated with coagulation activation. Thromb Res 2012;130:115–21.
   PubMed Web of Science ®Google Scholar
• Ferreira AC, Peter AA, Mendez AJ, Jimenez JJ, Mauro LM, Chirinos JA, Ghany R, Virani S, Garcia S, Horstman LL, Purow J, Jy W, Ahn YS, de Marchena E. Postprandial hypertriglyceridemia increases circulating levels of endothelial cell microparticles. Circulation 2004;110:3599–603.
   PubMed Web of Science ®Google Scholar
• Jeppesen DK, Hvam ML, Primdahl-Bengtson B, Boysen AT, Whitehead B, Dyrskjot L, Orntoft TF, Howard KA, Ostenfeld MS. Comparative analysis of discrete exosome fractions obtained by differential centrifugation. J Extracell Vesicles 2014;3:25011–27.
   PubMedGoogle Scholar
• Nielsen T, Pedersen S, Hultcrantz M, Kristensen SR, Kristinsson S. Procoagulant extracellular vesicles in the patients with monoclonal gammopathy of undetermined significance and their impact on the thrombogenic profile. J Extracell Vesicles 2014;3:110.
   Google Scholar
• Pedersen S, Gezelius E, Kristensen A, Kristensen SR, Belting M. Procoagulant extracellular vesicles in patients with small cell lung carcinoma (SCLC) and their impact on the thrombogenic profile. J Extracell Vesicles 2015;3:166.
   Google Scholar
• Sokolova V, Ludwig AK, Hornung S, Rotan O, Horn PA, Epple M, Giebel B. Characterisation of exosomes derived from human cells by nanoparticle tracking analysis and scanning electron microscopy. Colloids Surf B Biointerfaces 2011;87:146–50.
   PubMed Web of Science ®Google Scholar
• Jayachandran M, Miller VM, Heit JA, Owen WG. Methodology for isolation, identification and characterization of microvesicles in peripheral blood. J Immunol Methods 2012;375:207–14.
   PubMed Web of Science ®Google Scholar