534
Views
16
CrossRef citations to date
0
Altmetric
Original Article

Reference values for serum leptin in healthy non-obese children and adolescents

, , , , , , & show all
Pages 561-567 | Received 26 May 2016, Accepted 04 Jul 2016, Published online: 09 Aug 2016

References

  • Rosenbaum M, Leibel RL. 20 years of leptin: role of leptin in energy homeostasis in humans. J Endocrinol 2014;223:T83–96.
  • Park H-K, Ahima RS. Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism. Metab Clin Exp 2015;64:24–34.
  • Forbes S, Bui S, Robinson BR, Hochgeschwender U, Brennan MB. Integrated control of appetite and fat metabolism by the leptin-proopiomelanocortin pathway. Proc Natl Acad Sci USA 2001;98:4233–7.
  • Prieur X, Tung YCL, Griffin JL, Farooqi IS, O’Rahilly S, Coll AP. Leptin regulates peripheral lipid metabolism primarily through central effects on food intake. Endocrinology 2008;149:5432–9.
  • Friedman JM. A tale of two hormones. Nat Med 2010;16:1100–6.
  • Minokoshi Y, Kim Y-B, Peroni OD, Fryer LGD, Müller C, Carling D, Kahn BB. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 2002;415:339–43.
  • Donoso MA, Muñoz-Calvo MT, Barrios V, Garrido G, Hawkins F, Argente J. Increased circulating adiponectin levels and decreased leptin/soluble leptin receptor ratio throughout puberty in female ballet dancers: association with body composition and the delay in puberty. Eur J Endocrinol 2010;162:905–11.
  • Agarwal SK, Vogel K, Weitsman SR, Magoffin DA. Leptin antagonizes the insulin-like growth factor-I augmentation of steroidogenesis in granulosa and theca cells of the human ovary. J Clin Endocrinol Metab 1999;84:1072–6.
  • Matarese G, Procaccini C, De Rosa V, Horvath TL, La Cava A. Regulatory T cells in obesity: the leptin connection. Trends Mol Med 2010;16:247–56.
  • Sadaf Farooqi I, Matarese G, Lord GM, Keogh JM, Lawrence E, Agwu C, Sanna V, Jebb SA, Perna F, Fontana S, Lechler RI, Depaoli AM, O’Rahilly S. Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest 2002;110:1093–103.
  • Paz-Filho G, Mastronardi CA, Licinio J. Leptin treatment: facts and expectations. Metab Clin Exp 2015;64:146–56.
  • Zuo H, Shi Z, Yuan B, Dai Y, Wu G, Hussain A. Association between serum leptin concentrations and insulin resistance: a population-based study from China. PLoS One 2013;8:e54615.
  • Reinehr T, Kratzsch J, Kiess W, Andler W. Circulating soluble leptin receptor, leptin, and insulin resistance before and after weight loss in obese children. Int J Obes 2005;29:1230–5.
  • Lönnqvist F, Arner P, Nordfors L, Schalling M. Overexpression of the obese (ob) gene in adipose tissue of human obese subjects. Nat Med 1995;1:950–3.
  • Huang L, Wang Z, Li C. Modulation of circulating leptin levels by its soluble receptor. J Biol Chem 2001;276:6343–9.
  • Schaab M, Kratzsch J. The soluble leptin receptor. Best Pract Res Clin Endocrinol Metab 2015;29:661–70.
  • Lammert A, Kiess W, Bottner A, Glasow A, Kratzsch J. Soluble leptin receptor represents the main leptin binding activity in human blood. Biochem Biophys Res Commun 2001;283:982–8.
  • Yang G, Ge H, Boucher A, Yu X, Li C. Modulation of direct leptin signaling by soluble leptin receptor. Mol Endocrinol 2004;18:1354–62.
  • Kratzsch J, Lammert A, Bottner A, Seidel B, Mueller G, Thiery J, Hebebrand J, Kiess W. Circulating soluble leptin receptor and free leptin index during childhood, puberty, and adolescence. J Clin Endocrinol Metab 2002;87:4587–94.
  • Gonzaga NC, Medeiros CC, De Carvalho DF, Alves JG. Leptin and cardiometabolic risk factors in obese children and adolescents. J Paediatr Child Health 2014;50:707–12.
  • Yadav A, Kataria MA, Saini V, Yadav A. Role of leptin and adiponectin in insulin resistance. Clin Chim Acta 2013;417:80–4.
  • Huang K, Lin RCY, Kormas N, Lee L, Chen C, Gill TP, Caterson ID. Plasma leptin is associated with insulin resistance independent of age, body mass index, fat mass, lipids, and pubertal development in nondiabetic adolescents. Int J Obes Relat Metab Disord 2004;28:470–5.
  • Han JC, Lawlor DA, Kimm SYS. Childhood obesity. Lancet 2010;375:1737–48.
  • Erhardt E, Foraita R, Pigeot I, Barba G, Veidebaum T, Tornaritis M, Michels N, Eiben G, Ahrens W, Moreno LA, Kovács E, Molnár D. Reference values for leptin and adiponectin in children below the age of 10 based on the IDEFICS cohort. Int J Obes 2014;38:S32–S8.
  • Venner AA, Doyle-Baker PK, Lyon ME, Fung TS. A meta-analysis of leptin reference ranges in the healthy paediatric prepubertal population. Ann Clin Biochem 2009;46:65–72.
  • Barlow SE. Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report. Pediatrics 2007;120:S164–S92.
  • Cole TJ, Green PJ. Smoothing reference centile curves: the LMS method and penalized likelihood. Stat Med 1992;11:1305–19.
  • Nysom K, Mølgaard C, Hutchings B, Michaelsen KF. Body mass index of 0 to 45-y-old Danes: reference values and comparison with published European reference values. Int J Obes Relat Metab Disord 2001;25:177–84.
  • Marshall WA, Tanner JM. Variations in pattern of pubertal changes in girls. Arch Dis Child 1969;44:291–303.
  • Marshall WA, Tanner JM. Variations in the pattern of pubertal changes in boys. Arch Dis Child 1970;45:13–23.
  • van der Sluis IM, de Ridder MAJ, Boot AM, Krenning EP, de Muinck Keizer-Schrama SMPF. Reference data for bone density and body composition measured with dual energy x ray absorptiometry in white children and young adults. Arch Dis Child 2002;87:341–7.
  • Yannakoulia M, Yiannakouris N, Blüher S, Matalas AL, Klimis-Zacas D, Mantzoros CS. Body fat mass and macronutrient intake in relation to circulating soluble leptin receptor, free leptin index, adiponectin, and resistin concentrations in healthy humans. J Clin Endocrinol Metab 2003;88:1730–6.
  • Rigby RA, Stasinopoulos DM, Lane PW. Generalized additive models for location, scale and shape. Appl Stat 2005;54:507–54.
  • Uh H-W, Hartgers FC, Yazdanbakhsh M, Houwing-Duistermaat JJ. Evaluation of regression methods when immunological measurements are constrained by detection limits. BMC Immunol 2008;9:59.
  • Hornung RW, Reed LD. Estimation of average concentrations in the presence of nondetectable values. Appl Occup Environ Hyg 1990;5:46–51.
  • Andersen A, Benn CS, Jørgensen MJ, Ravn H. Censored correlated cytokine concentrations: multivariate tobit regression using clustered variance estimation. Stat Med 2013;32:2859–74.
  • Taylor PJ. Matrix effects: the Achilles heel of quantitative high-performance liquid chromatography-electrospray-tandem mass spectrometry. Clin Biochem 2005;38:328–34.
  • Van Eeckhaut A, Lanckmans K, Sarre S, Smolders I, Michotte Y. Validation of bioanalytical LC-MS/MS assays: evaluation of matrix effects. J Chromatogr B Analyt Technol Biomed Life Sci 2009;877:2198–207.
  • Sasse EA. Determination of reference intervals in the clinical laboratory using the proposed guideline National Committee for Clinical Laboratory Standards C28-P. Arch Pathol Lab Med 1992;116:710–13.
  • Quinton ND, Smith RF, Clayton PE, Gill MS, Shalet S, Justice SK, Simon SA, Walters S, Postel-Vinay MC, Blakemore AIF, Ross RJM. Leptin binding activity changes with age: the link between leptin and puberty. J Clin Endocrinol Metab 1999;84:2336–41.
  • Mantzoros CS, Flier JS, Rogol AD. A longitudinal assessment of hormonal and physical alterations during normal puberty in boys. V. Rising leptin levels may signal the onset of puberty. J Clin Endocrinol Metab 1997;82:1066–70.
  • Ankarberg-Lindgren C, Dahlgren J, Carlsson B, Rosberg S, Carlsson L, Wikland KA, Norjavaara E. Leptin levels show diurnal variation throughout puberty in healthy children, and follow a gender-specific pattern. Eur J Endocrinol 2001;145:43–51.
  • Nagy TR, Gower BA. Correlates of leptin concentration in the San Antonio heart study. Ann Epidemiol 1997;7:79–80.
  • Narayanan S. The preanalytic phase. An important component of laboratory medicine. Am J Clin Pathol 2000;113:429–52.
  • Saad MF, Riad-Gabriel MG, Khan A, Sharma A, Michael R, Jinagouda SD, Boyadjian R, Steil GM. Diurnal and ultradian rhythmicity of plasma leptin: effects of gender and adiposity. J Clin Endocrinol Metab 1998;83:453–9.
  • Sinha MK, Sturis J, Ohannesian J, Magosin S, Stephens T, Heiman ML, Polonsky KS, Caro JF. Ultradian oscillations of leptin secretion in humans. Biochem Biophys Res Commun 1996;228:733–8.
  • Licinio J, Negrao AB, Mantzoros C, Kaklamani V, Wong ML, Bongiorno PB, Negro PP, Mulla A, Veldhuis JD, Cearnal L, Flier JS, Gold PW. Sex differences in circulating human leptin pulse amplitude: clinical implications. J Clin Endocrinol Metab 1998;83:4140–7.
  • Wagner R, Oberste-Berghaus C, Herpertz S, Blum WF, Pelz B, Hebebrand J, Senf W, Mann K, Albers N. Time relationship between circadian variation of serum levels of leptin, insulin and cortisol in healthy subjects. Horm Res 2000;54:174–80.
  • Stakos DA, Papaioannou HI, Angelidou I, Mantadakis E, Paraskakis E, Tsigalou C, Chatzimichael A. Plasma leptin and adiponectin concentrations correlate with cardiometabolic risk and systemic inflammation in healthy, non-obese children. J Pediatr Endocrinol Metab 2014;27:221–8.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.