Internal dysregulation of the renin system in patients with stable liver cirrhosis

References

• EASL clinical practice guidelines on the management of ascites, spontaneous bacterial peritonitis, and hepatorenal syndrome in cirrhosis. J Hepatol 2010;53:397–417.
   PubMed Web of Science ®Google Scholar
• Mindikoglu AL, Weir MR. Current concepts in the diagnosis and classification of renal dysfunction in cirrhosis. Am J Nephrol 2013;38:345–54.
   PubMed Web of Science ®Google Scholar
• Moller SKA. Cardiorenal syndrome: a new entity. Front Gastrointest Res 2010;28:102–11.
   Google Scholar
• Dam FA, Schaffalitzky de Muckadell OB, Touborg LA. Incidence, etiology and mortality of cirrhosis: a population-based cohort study. Scand J Gastroenterol 2012;47:702–9.
   PubMed Web of Science ®Google Scholar
• Lefton HB, Rosa A, Cohen M. Diagnosis and epidemiology of cirrhosis. Med Clin North Am 2009;93:787–99.
   PubMed Web of Science ®Google Scholar
• Gentilini P, Romanelli RG, Laffi G, Barletta G, Del BR, Messeri G, La VG. Cardiovascular and renal function in normotensive and hypertensive patients with compensated cirrhosis: effects of posture. J Hepatol 1999;30:632–8.
   PubMed Web of Science ®Google Scholar
• Moller S, Bendtsen F, Henriksen JH. Determinants of the renin-angiotensin-aldosterone system in cirrhosis with special emphasis on the central blood volume. Scand J Gastroenterol 2006;41:451–8.
   PubMed Web of Science ®Google Scholar
• Nicholls KM, Shapiro MD, Kluge R, Chung HM, Bichet DG, Schrier RW. Sodium excretion in advanced cirrhosis: effect of expansion of central blood volume and suppression of plasma aldosterone. Hepatology 1986;6:235–8.
   PubMed Web of Science ®Google Scholar
• Bernardi M, Fornale L, Di MC, Trevisani F, Baraldini M, Gasbarrini A, De CC, Zaca F, Ligabue A, Colantoni A. Hyperdynamic circulation of advanced cirrhosis: a re-appraisal based on posture-induced changes in hemodynamics. J Hepatol 1995;22:309–18.
   PubMed Web of Science ®Google Scholar
• Wong F, Sniderman K, Blendis L. The renal sympathetic and renin-angiotensin response to lower body negative pressure in well-compensated cirrhosis. Gastroenterology 1998;115:397–405.
   PubMed Web of Science ®Google Scholar
• Bernardi M, Santini C, Trevisani F, Baraldini M, Ligabue A, Gasbarrini G. Renal function impairment induced by change in posture in patients with cirrhosis and ascites. Gut 1985;26:629–35.
   PubMed Web of Science ®Google Scholar
• Bernardi M, Trevisani F, Santini C, Zoli G, Baraldini M, Ligabue A, Gasbarrini G. Plasma norepinephrine, weak neurotransmitters, and renin activity during active tilting in liver cirrhosis: relationship with cardiovascular homeostasis and renal function. Hepatology 1983;3:56–64.
   PubMed Web of Science ®Google Scholar
• Bernardi M, Trevisani F, Fornale L, Di MC, Gasbarrini A, Baraldini M, Ligabue A, Gasbarrini G. Renal sodium handling in cirrhosis with ascites: mechanisms of impaired natriuretic response to reclining. J Hepatol 1994;21:1116–22.
   PubMed Web of Science ®Google Scholar
• Clemensen P, Christensen P, Norsk P, Gronlund J. A modified photo- and magnetoacoustic multigas analyzer applied in gas exchange measurements. J Appl Physiol 1994;76:2832–9.
   PubMed Web of Science ®Google Scholar
• Poulsen K, Jorgensen J. An easy radioimmunological microassay of renin activity, concentration and substrate in human and animal plasma and tissues based on angiotensin I trapping by antibody. J Clin Endocrinol Metab 1974;39:816–25.
   PubMed Web of Science ®Google Scholar
• Bie P, Damkjaer M. Renin secretion and total body sodium: pathways of integrative control. Clin Exp Pharmacol Physiol 2010;37:e34–42.
   PubMed Web of Science ®Google Scholar
• Friis UG, Madsen K, Stubbe J, Hansen PB, Svenningsen P, Bie P, Skott O, Jensen BL. Regulation of renin secretion by renal juxtaglomerular cells. Pflugers Arch 2013;465:25–37.
   PubMed Web of Science ®Google Scholar
• Bie P, Sandgaard NC. Determinants of the natriuresis after acute, slow sodium loading in conscious dogs. Am J Physiol Regul Integr Comp Physiol 2000;278:R1–10.
   PubMed Web of Science ®Google Scholar
• Child CG, Turcotte JG. Surgery and portal hypertension. Major Probl Clin Surg 1964;1:1–85.
   PubMedGoogle Scholar
• Kamath PS, Wiesner RH, Malinchoc M, Kremers W, Therneau TM, Kosberg CL, D'amico G, Dickson ER, Kim WR. A model to predict survival in patients with end-stage liver disease. Hepatology 2001;33:464–70.
   PubMed Web of Science ®Google Scholar
• Pugh RN, Murray-Lyon IM, Dawson JL, Pietroni MC, Williams R. Transection of the oesophagus for bleeding oesophageal varices. Br J Surg 1973;60:646–9.
   PubMed Web of Science ®Google Scholar
• Bernardi M, Di MC, Trevisani F, Fornale L, Andreone P, Cursaro C, Baraldini M, Ligabue A, Tame MR, Gasbarrini G. Renal sodium retention during upright posture in pre-ascitic cirrhosis. Gastroenterology 1993;105:188–93.
   PubMed Web of Science ®Google Scholar
• Moller S, Norgaard A, Henriksen JH, Frandsen E, Bendtsen F. Effects of tilting on central hemodynamics and homeostatic mechanisms in cirrhosis. Hepatology 2004;40:811–19.
   PubMed Web of Science ®Google Scholar
• Salo J, Guevara M, Fernandez-Esparrach G, Bataller R, Gines A, Jimenez W, Gines P, Rivera F, Arroyo V, Rodes J. Impairment of renal function during moderate physical exercise in cirrhotic patients with ascites: relationship with the activity of neurohormonal systems. Hepatology 1997;25:1338–42.
   PubMed Web of Science ®Google Scholar
• Castrop H, Hocherl K, Kurtz A, Schweda F, Todorov V, Wagner C. Physiology of kidney renin. Physiol Rev 2010;90:607–73.
   PubMed Web of Science ®Google Scholar
• Schweda F, Friis U, Wagner C, Skott O, Kurtz A. Renin release. Physiology (Bethesda) 2007;22:310–19.
   PubMed Web of Science ®Google Scholar
• Wagner C, Hinder M, Kramer BK, Kurtz A. Role of renal nerves in the stimulation of the renin system by reduced renal arterial pressure. Hypertension 1999;34:1101–5.
   PubMed Web of Science ®Google Scholar
• Sellars L, Shore AC, Mott V, Wilkinson R. The renin-angiotensin-aldosterone system in decompensated cirrhosis: its activity in relation to sodium balance. Q J Med 1985;56:485–96.
   PubMedGoogle Scholar
• Sansoe G, Silvano S, Mengozzi G, Todros L, Smedile A, Touscoz G, Rosina F, Rizzetto M. Inappropriately low angiotensin II generation: a factor determining reduced kidney function and survival in patients with decompensated cirrhosis. J Hepatol 2004;40:417–23.
   PubMed Web of Science ®Google Scholar
• Ayers CR. Plasma renin activity and renin-substrate concentration in patients with liver disease. Circ Res 1967;20:594–8.
   PubMed Web of Science ®Google Scholar
• Sernia C, Reid IA. Stimulation of angiotensinogen production: a dose-related effect of angiotensin II in the conscious dog. Am J Physiol 1980;239:E442–6.
   PubMed Web of Science ®Google Scholar
• Campbell DJ. Differential regulation of angiotensin peptides in plasma and kidney: effects of adrenalectomy and estrogen treatment. Clin Exp Hypertens 1997;19:687–98.
   PubMed Web of Science ®Google Scholar
• Clauser E, Bouhnik J, Jaramillo HN, Auzan C, Corvol P, Menard J. Angiotensinogen production and consumption in the adrenalectomized rat. Endocrinology 1985;116:274–80.
   PubMed Web of Science ®Google Scholar
• Evans DB, Cornette JC, Sharma SK. Effect of angiotensinogen concentration on renin activity following nephrectomy and adrenalectomy: implications in the activation of plasma prorenin. Clin Exp Hyperten 1990;12:1473–87.
   Web of Science ®Google Scholar
• Hilgenfeldt U, Schwind S, Muley T, Rubin I. Elevated des-AngI-angiotensinogen levels by nephrectomy and adrenalectomy. Clin Exp Hypertens 1996;18:675–89.
   PubMed Web of Science ®Google Scholar
• Medina-Campos ON, Pedraza-Chaverri J, Correa-Rotter R, Ibarra-Rubio ME. Regulation of hepatic angiotensinogen gene expression in nephrotic rats. Clin Exp Hyperten 1997;19:343–62.
   PubMed Web of Science ®Google Scholar
• Nieman LK. Dynamic evaluation of adrenal hypofunction. J Endocrinol Invest 2003;26:74–82.
   PubMedGoogle Scholar
• Hall JE. Control of sodium excretion by angiotensin II: intrarenal mechanisms and blood pressure regulation. Am J Physiol 1986;250:R960–72.
   PubMed Web of Science ®Google Scholar
• Raff H, Gehrand A, Bruder ED, Hoffman MJ, Engeland WC, Moreno C. Renin knockout rat: control of adrenal aldosterone and corticosterone synthesis in vitro and adrenal gene expression. Am J Physiol Regul Integr Comp Physiol 2015;308:R73–7.
   PubMed Web of Science ®Google Scholar
• DeClue JW, Guyton AC, Cowley AW Jr, Coleman TG, Norman RA Jr, McCaa RE. Subpressor angiotensin infusion, renal sodium handling, and salt-induced hypertension in the dog. Circ Res 1978;43:503–12.
   PubMed Web of Science ®Google Scholar
• Hall JE, Guyton AC, Smith MJ Jr, Coleman TG. Blood pressure and renal function during chronic changes in sodium intake: role of angiotensin. Am J Physiol 1980;239:F271–80.
   PubMed Web of Science ®Google Scholar
• Lumbers ER. Angiotensin and aldosterone. Regul Pept 1999;80:91–100.
   PubMed Web of Science ®Google Scholar
• Degoricija V, Zjacic-Rotkvic V, Marout J, Sefer S, Troskot B. Clinical and neurohumoral response to posture, physical exercise, and ascites treatment in Child-Pugh C liver cirrhosis: randomized prospective trial. Croat Med J 2003;44:178–86.
   PubMed Web of Science ®Google Scholar
• Jespersen B, Eiskjaer H, Jensen JD, Mogensen CE, Sorensen SS, Pedersen EB. Effects of high dose atrial natriuretic peptide on renal haemodynamics, sodium handling and hormones in cirrhotic patients with and without ascites. Scand J Clin Lab Invest 1995;55:273–87.
   PubMed Web of Science ®Google Scholar
• Bassett MH, White PC, Rainey WE. The regulation of aldosterone synthase expression. Mol Cell Endocrinol 2004;217:67–74.
   PubMed Web of Science ®Google Scholar
• Acevedo J, Fernandez J, Prado V, Silva A, Castro M, Pavesi M, Roca D, Jimenez W, Gines P, Arroyo V. Relative adrenal insufficiency in decompensated cirrhosis. relationship to short-term risk of severe sepsis, hepatorenal syndrome and death. Hepatology 2013;58:1757–65.
   PubMed Web of Science ®Google Scholar
• Fede G, Spadaro L, Tomaselli T, Privitera G, Germani G, Tsochatzis E, Thomas M, Bouloux PM, Burroughs AK, Purrello F. Adrenocortical dysfunction in liver disease: a systematic review. Hepatology 2012;55:1282–91.
   PubMed Web of Science ®Google Scholar
• Fede G, Spadaro L, Tomaselli T, Privitera G, Piro S, Rabuazzo AM, Sigalas A, Xirouchakis E, O'beirne J, Garcovich M, Tsochatzis E, Purrello F, Burroughs AK. Assessment of adrenocortical reserve in stable patients with cirrhosis. J Hepatol 2011;54:243–50.
   PubMed Web of Science ®Google Scholar
• O’beirne J, Holmes M, Agarwal B, Bouloux P, Shaw S, Patch D, Burroughs A. Adrenal insufficiency in liver disease: what is the evidence? J Hepatol 2007;47:418–23.
   PubMed Web of Science ®Google Scholar
• White PC. Disorders of aldosterone biosynthesis and action. N Engl J Med 1994;331:250–8.
   PubMed Web of Science ®Google Scholar
• Stadlbauer V, Wright GA, Banaji M, Mukhopadhya A, Mookerjee RP, Moore K, Jalan R. Relationship between activation of the sympathetic nervous system and renal blood flow autoregulation in cirrhosis. Gastroenterology 2008;134:111–19.
   PubMed Web of Science ®Google Scholar
• Andersen LJ, Jensen TU, Bestle MH, Bie P. Isotonic and hypertonic sodium loading in supine humans. Acta Physiol Scand 1999;166:23–30.
   PubMedGoogle Scholar
• Molstrom S, Larsen NH, Simonsen JA, Washington R, Bie P. Normotensive sodium loading in normal man: regulation of renin secretion during beta-receptor blockade. Am J Physiol Regul Integr Comp Physiol 2009;296:R436–45.
   PubMed Web of Science ®Google Scholar
• Wong F, Liu P, Blendis L. Sodium homeostasis with chronic sodium loading in pre-ascitic cirrhosis. Gut 2001;49:847–51.
   PubMed Web of Science ®Google Scholar
• Bernardi M, De PR, Trevisani F, Santini C, Capani F, Baraldini M, Gasbarrini G. Chronobiological study of factors affecting plasma aldosterone concentration in cirrhosis. Gastroenterology 1986;91:683–91.
   PubMed Web of Science ®Google Scholar
• Gerbes AL, Pilz A, Wernze H, Jungst D. Renal sodium handling and neurohumoral systems in patients with cirrhosis in sitting posture: effects of spironolactone and water immersion. Clin Investig 1993;71:894–7.
   PubMedGoogle Scholar
• Henriksen JH, Moller S, Ring-Larsen H, Christensen NJ. The sympathetic nervous system in liver disease. J Hepatol 1998;29:328–41.
   PubMed Web of Science ®Google Scholar
• Ring-Larsen H, Hesse B, Henriksen JH, Christensen NJ. Sympathetic nervous activity and renal and systemic hemodynamics in cirrhosis: plasma norepinephrine concentration, hepatic extraction, and renal release. Hepatology 1982;2:304–10.
   PubMed Web of Science ®Google Scholar
• Wong F, Bomzon A, Logan A, Blendis L. Effects of sodium status on the venous response to noradrenaline infusion in pre-ascitic cirrhosis. Clin Sci (Lond) 1995;88:525–31.
   PubMed Web of Science ®Google Scholar
• Esler MD, Hasking GJ, Willett IR, Leonard PW, Jennings GL. Noradrenaline release and sympathetic nervous system activity. J Hypertens 1985;3:117–29.
   PubMed Web of Science ®Google Scholar