398
Views
6
CrossRef citations to date
0
Altmetric
Original Article

Relative effects of plasma, fibrinogen concentrate, and factor XIII on ROTEM coagulation profiles in an in vitro model of massive transfusion in trauma

, , , &
Pages 397-405 | Received 12 Feb 2016, Accepted 07 May 2017, Published online: 20 Jun 2017

References

  • Gruen RL, Brohi K, Schreiber M, Balogh ZJ, Pitt V, Narayan M, Maier RV. Haemorrhage control in severely injured patients. Lancet 2012;380:1099–108.
  • Brohi K, Cohen MJ, Davenport RA. Acute coagulopathy of trauma: mechanism, identification and effect. Curr Opin Crit Care 2007;13:680–5.
  • Cap A, Hunt B, Beckers SK, Brokmann JC, Rossaint R, Harrois A, Hamada SR, Duranteau J, Campion EM, Mackersie RC, Theusinger OM, Stein P, Spahn DR. Acute traumatic coagulopathy. Curr Opin Crit Care 2014;20:620–5.
  • Cardenas JC, Wade CE, Holcomb JB. Mechanisms of trauma-induced coagulopathy. Curr Opin Hematol 2014;21:404–9.
  • Rossaint R, Bouillon B, Cerny V, Coats TJ, Duranteau J, Fernández-Mondéjar E, Filipescu D, Hunt BJ, Komadina R, Nardi G, Neugebauer EAM, Ozier Y, Riddez L, Schultz A, Vincent J-L, Spahn DR. The European guideline on management of major bleeding and coagulopathy following trauma: fourth edition. Crit Care 2016;20:1.
  • Johansson PI, Stensballe J, Oliveri R, Wade CE, Ostrowski SR, Holcomb JB. How I treat patients with massive hemorrhage. Blood 2014;124:3052–8.
  • Waters JH. Role of the massive transfusion protocol in the management of haemorrhagic shock. Br J Anaesth 2014;113:ii3–8.
  • Holcomb JB, Tilley BC, Baraniuk S, Fox EE, Wade CE, Podbielski JM, del Junco DJ, Brasel KJ, Bulger EM, Callcut RA, Cohen MJ, Cotton BA, Fabian TC, Inaba K, Kerby JD, Muskat P, O’Keeffe T, Rizoli S, Robinson BRH, Scalea TM, Schreiber MA, Stein DM, Weinberg JA, Callum JL, Hess JR, Matijevic N, Miller CN, Pittet J, Hoyt DB, Pearson GD, Leroux B, van Belle G. Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma. JAMA 2015;313:471.
  • Chowdhury P, Saayman AG, Paulus U, Findlay GP, Collins PW. Efficacy of standard dose and 30 mL/kg fresh frozen plasma in correcting laboratory parameters of haemostasis in critically ill patients. Br J Haematol 2004;125:69–73.
  • Rahe-Meyer N, Sørensen B. For: fibrinogen concentrate for management of bleeding. J Thromb Haemost 2011;9:1–5.
  • Tobin JM, Tanaka KA, Smith CE. Factor concentrates in trauma. Curr Opin Anaesthesiol 2015;28:217–26.
  • Schlimp CJ, Voelckel W, Inaba K, Maegele M, Schöchl H. Impact of fibrinogen concentrate alone or with prothrombin complex concentrate (+/− fresh frozen plasma) on plasma fibrinogen level and fibrin-based clot strength (FIBTEM) in major trauma: a retrospective study. Scand J Trauma Resusc Emerg Med 2013;21:74.
  • Schlimp CJ, Schochl H. The role of fibrinogen in trauma-induced coagulopathy. Hamostaseologie 2014;34:29–39.
  • Theusinger OM, Baulig W, Seifert B, Müller SM, Mariotti S, Spahn DR. Changes in coagulation in standard laboratory tests and ROTEM in trauma patients between on-scene and arrival in the emergency department. Anesth Analg 2015;120:627–35.
  • Ostrowski SR, Sørensen A, Larsen CF, Johansson PI. Thrombelastography and biomarker profiles in acute coagulopathy of trauma: a prospective study. Scand J Trauma Resusc Emerg Med 2011;19:64.
  • Hethershaw EL, Cilia La Corte AL, Duval C, Ali M, Grant PJ, Ariëns RAS, Philippou H. The effect of blood coagulation factor XIII on fibrin clot structure and fibrinolysis. J Thromb Haemost 2014;12:197–205.
  • Winstedt D, Tynngård N, Olanders K, Schött U. Free oscillation rheometry monitoring of haemodilution and hypothermia and correction with fibrinogen and factor XIII concentrates. Scand J Trauma Resusc Emerg Med 2013;21:20.
  • Winstedt D, Thomas OD, Nilsson F, Olanders K, Schött U. Correction of hypothermic and dilutional coagulopathy with concentrates of fibrinogen and factor XIII: an in vitro study with ROTEM. Scand J Trauma Resusc Emerg Med 2014;22:73.
  • Haas T, Fries D, Velik-Salchner C, Reif C, Klingler A, Innerhofer P. The in vitro effects of fibrinogen concentrate, factor XIII and fresh frozen plasma on impaired clot formation after 60% dilution. Anesth Analg 2008;106:1360–5.
  • Schochl H, Schlimp CJ. Trauma bleeding management: the concept of goal-directed primary care. Anesth Analg 2014;119:1064–73.
  • Gaarder C, Naess PA, Frischknecht Christensen E, Hakala P, Handolin L, Heier HE, Ivancev K, Johansson P, Leppäniemi A, Lippert F, Lossius HM, Opdahl H, Pillgram-Larsen J, Røise O, Skaga NO, Søreide E, Stensballe J, Tønnessen E, Töttermann A, Ortenwall P, Östlund A. Scandinavian guidelines – “The massively bleeding patient.” Scand J Surg 2008;97:15–36.
  • Whiting D, Dinardo JA. TEG and ROTEM: technology and clinical applications. Am J Hematol 2014;89:228–32.
  • Lang T, Bauters A, Braun SL, Pötzsch B, von Pape K-W, Kolde H-J, Lakner M. Multi-centre investigation on reference ranges for ROTEM thromboelastometry. Blood Coagul Fibrinolysis 2005;16:301–10.
  • Bolliger D, Szlam F, Molinaro RJ, Rahe-Meyer N, Levy JH, Tanaka KA. Finding the optimal concentration range for fibrinogen replacement after severe haemodilution: An in vitro model. Br J Anaesth 2009;102:793–9.
  • Bates D, Maechler M, Bolker B, Walker S, Christensen RHB, Singmann H, Dai B, Grothendieck G. lme4: Linear Mixed-Effects Models using “Eigen” and S4. 2015; Available from: http://cran. r-project.org/package=lme4.
  • Hothorn T, Bretz F, Westfall P, Heiberger RM. Multcomp: Simultaneous inference in general parametric models. Biometrical J 2008;50:346–63.
  • Aubron C, Reade MC, Fraser JF, Cooper DJ. Efficacy and safety of fibrinogen concentrate in trauma patients – a systematic review. J Crit Care 2014;29:471.e11–17.
  • Armand R, Hess JR. Treating coagulopathy in trauma patients. Transfus Med Rev 2003;17:223–31.
  • Ponschab M, Schöchl H, Gabriel C, Süssner S, Cadamuro J, Haschke-Becher E, Gratz J, Zipperle J, Redl H, Schlimp CJ. Haemostatic profile of reconstituted blood in a proposed 1:1:1 ratio of packed red blood cells, platelet concentrate and four different plasma preparations. Anaesthesia 2015;70:528–36.
  • Rourke C, Curry N, Khan S, Taylor R, Raza I, Davenport R, Stanworth S, Brohi K. Fibrinogen levels during trauma hemorrhage, response to replacement therapy, and association with patient outcomes. J Thromb Haemost 2012;10:1342–51.
  • Caballo C, Escolar G, Diaz-Ricart M, Lopez-Viólchez I, Lozano M, Cid J, Pino M, Beltrán J, Basora M, Pereira A, Galan AM. Impact of experimental haemodilution on platelet function, thrombin generation and clot firmness: effects of different coagulation factor concentrates. Blood Transfus 2013;11:391–9.
  • Schlimp CJ, Cadamuro J, Solomon C, Redl H, Schöchl H. The effect of fibrinogen concentrate and factor XIII on thromboelastometry in 33% diluted blood with albumin, gelatine, hydroxyethyl starch or saline in vitro. Blood Transfus 2013;11:510–17.
  • Fries D, Innerhofer P, Reif C, Streif W, Klingler A, Schobersberger W, Velik-Salchner C, Friesenecker B. The effect of fibrinogen substitution on reversal of dilutional coagulopathy: An in vitro model. Anesth Analg 2006;102:347–51.
  • Fenger-Eriksen C, Anker-Møller E, Heslop J, Ingerslev J, Sørensen B. Thrombelastographic whole blood clot formation after ex vivo addition of plasma substitutes: Improvements of the induced coagulopathy with fibrinogen concentrate. Br J Anaesth 2005;94:324–9.
  • Shams Hakimi C, Fagerberg Blixter I, Hansson EC, Hesse C, Wallén H, Jeppsson A. Effects of fibrinogen and platelet supplementation on clot formation and platelet aggregation in blood samples from cardiac surgery patients. Thromb Res 2014;134:895–900.
  • Schafer N, Driessen A, Bauerfeind U, Frohlich M, Ofir J, Sturmer EK, Maegele M. In vitro effects of different sources of fibrinogen supplementation on clot initiation and stability in a model of dilutional coagulopathy. Transfus Med 2016;26:373–80.
  • Olde Engberink RHG, Kuiper GJAJM, Wetzels RJH, Nelemans PJ, Lance MD, Beckers EAM, Henskens YMC. Rapid and correct prediction of thrombocytopenia and hypofibrinogenemia with rotational thromboelastometry in cardiac surgery. J Cardiothorac Vasc Anesth 2014;28:210–16.
  • Ponschab M, Voelckel W, Pavelka M, Schlimp CJ, Schöchl H. Effect of coagulation factor concentrate administration on ROTEM® parameters in major trauma. Scand J Trauma Resusc Emerg Med 2015;23:84.
  • Rosenthal C, Rau J, Volk T, Sander M, Ziemer S, Heymann CVON. High-dose fibrinogen versus a clinically recommended dose of fresh frozen plasma for reversal of dilutional coagulopathy in an in vitro model of severe hemodilution. Minerva Anestesiol 2014;80:894–903.
  • Theusinger OM, Schröder CM, Eismon J, Emmert MY, Seifert B, Spahn DR, Baulig W. The influence of laboratory coagulation tests and clotting factor levels on rotation thromboelastometry (ROTEM(R)) during major surgery with hemorrhage. Anesth Analg 2013;117:314–21.
  • Schmidt DE, Holmström M, Majeed A, Näslin D, Wallén H, Ågren A. Detection of elevated INR by thromboelastometry and thromboelastography in warfarin treated patients and healthy controls. Thromb Res 2015;135:1007–11.
  • Theusinger OM, Baulig W, Asmis LM, Seifert B, Spahn DR. In vitro factor XIII supplementation increases clot firmness in rotation thromboelastometry (ROTEM). Thromb Haemost 2010;104:385–91.
  • Kind SL, Spahn-Nett GH, Emmert MY, Eismon J, Seifert B, Spahn DR, Theusinger OM. Is dilutional coagulopathy induced by different colloids reversible by replacement of fibrinogen and factor XIII concentrates? Anesth Analg 2013;117:1063–71.
  • Schroeder V, Kohler HP. Thrombelastographic studies on factor XIII. Thromb Haemost 2010;104:1277–9.
  • Muszbek L, Bagoly Z, Cairo A, Peyvandi F. Novel aspects of factor XIII deficiency. Curr Opin Hematol 2011;18:366–72.
  • Shenkman B, Livnat T, Lubetsky A, Tamarin I, Budnik I, Einav Y, Martinowitz U. The in-vitro effect of fibrinogen, factor XIII and thrombin-activatable fibrinolysis inhibitor on clot formation and susceptibility to tissue plasminogen activator-induced fibrinolysis in hemodilution model. Blood Coagul Fibrinolysis 2012;23:370–8.
  • Tauber H, Innerhofer P, Breitkopf R, Westermann I, Beer R, El222Attal R, Strasak A, Mittermayr M. Prevalence and impact of abnormal ROTEM? Assays in severe blunt trauma: Results of the “Diagnosis and Treatment of Trauma-Induced Coagulopathy (DIA-TRE-TIC) study.” Br J Anaesth 2011;107:378–87.
  • Da Luz LT, Nascimento B, Shankarakutty AK, Rizoli S, Adhikari NK. Effect of thromboelastography (TEG) and rotational thromboelastometry (ROTEM) on diagnosis of coagulopathy, transfusion guidance and mortality in trauma: descriptive systematic review. Crit Care 2014;18:518.
  • Inaba K, Rizoli S, Veigas PV, Callum J, Davenport R, Hess J, Maegele M. 2014 Consensus conference on viscoelastic test-based transfusion guidelines for early trauma resuscitation. J Trauma Acute Care Surg 2015;78:1220–9.
  • Moore HB, Moore EE, Gonzalez E, Chapman MP, Chin TL, Silliman CC, Banerjee A, Sauaia A. Hyperfibrinolysis, physiologic fibrinolysis, and fibrinolysis shutdown: the spectrum of postinjury fibrinolysis and relevance to antifibrinolytic therapy. J Trauma Acute Care Surg 2014;77:811–17.
  • Moore HB, Moore EE, Liras IN, Gonzalez E, Harvin JA, Holcomb JB, Sauaia A, Cotton BA. Acute fibrinolysis shutdown after injury occurs frequently and increases mortality: a multicenter evaluation of 2540 severely injured patients. J Am Coll Surg 2016;222:347–55.
  • Roberts I. Fibrinolytic shutdown: fascinating theory but randomized controlled trial data are needed. Transfusion 2016;56:S115–S18.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.