Vitamin D deficiency, insulin resistance and thyroid dysfunction in obese patients: is inflammation the common link?

References

• Souberbielle JC, Body JJ, Lappe JM, et al. Vitamin D and musculoskeletal health, cardiovascular disease, autoimmunity, and cancer: recommendations for clinical practice. Autoimmune Rev. 2010;9:709–715.
   PubMed Web of Science ®Google Scholar
• Wang J, Lv S, Chen G, et al. Meta-analysis of the association between vitamin D and autoimmune thyroid disease. Nutrients. 2015;7:2485–2498.
   PubMed Web of Science ®Google Scholar
• Al-Shoumer KAS, Al-Essa TM. Is there a relationship between vitamin D with insulin resistance and diabetes mellitus? World J Diabetes. 2015;6:1057–1064.
   PubMed Web of Science ®Google Scholar
• Turer CB, Lin H, Flores G. Prevalence of vitamin D deficiency among overweight and obese US children. Pediatrics. 2013;131:e152–e161.
   PubMed Web of Science ®Google Scholar
• Nihan TCF, Isiksacan N, Kocamaz N, et al. The association among vitamin D, insulin resistance, and obesity in Turkish women. Shiraz E-Med J. 2017;18:e44925.
   Google Scholar
• Sung CC, Liao MT, Lu KC, et al. Role of vitamin D in insulin resistance. J Biomed Biotechnol. 2012;2012:1.
   PubMedGoogle Scholar
• Marques CDL, Dantas AT, Fragoso TS, et al. The importance of vitamin D levels in autoimmune diseases. Rev Bras Reumatol. 2010;50:67–80.
   PubMed Web of Science ®Google Scholar
• Kim D. The role of vitamin D in thyroid diseases. IJMS. 2017;18:1949.
   Google Scholar
• Rezzonico J, Rezzonico M, Pusiol E, et al. Introducing the thyroid gland as another victim of the insulin resistance syndrome. Thyroid. 2008;18:461.
   PubMed Web of Science ®Google Scholar
• Verma A, Jayaraman M, Kumar HK, et al. Hypothyroidism and obesity. Cause or effect? Saudi Med J. 2008;29:1135–1138.
   PubMed Web of Science ®Google Scholar
• Marzullo P, Minocci A, Tagliaferri MA, et al. Investigations of thyroid hormones and antibodies in obesity: leptin levels are associated with thyroid autoimmunity independent of bioanthropometric, hormonal, and weight-related determinants. J Clin Endocrinol Metab. 2010;95:3965–3972.
   PubMed Web of Science ®Google Scholar
• WHO. Obesity: preventing and managing the global epidemic. Report of a WHO Consultation. WHO Technical Report Series 894. Geneva: World Health Organization; 2011.
   Google Scholar
• Alberti KG, Eckel RH, Grundy SM, et al. Harmonizing the metabolic syndrome: a joint interim statement of the Internaţional Diabetes Federation task force on epidemiology and prevention; National Heart, Lung and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and Internaţional Association for the Study of Obesity. Circulation. 2009;120:1640–1645.
   PubMed Web of Science ®Google Scholar
• Beineke M. Marker for the diagnosis of insulin resistance. Labor Bioscientia. 2008;1:1–8.
   Google Scholar
• Kim SK1, Kim HJ, Hur KY, et al. Visceral fat thickness measured by ultrasonography can estimate not only visceral obesity but also risks of cardiovascular and metabolic diseases. Am J Clin Nutr. 2004;79:593–599.
   PubMed Web of Science ®Google Scholar
• Jäntschi L, Bolboacă SD. Exact probabilities and confidence limits for binomial samples: applied to the difference between two proportions. ScientificWorldJournal. 2010;10:865–878.
   PubMedGoogle Scholar
• Ye J. Mechanisms of insulin resistance in obesity. Front Med. 2013;7:14–24.
   PubMed Web of Science ®Google Scholar
• Castro AV, Kolka CM, Kim SP, et al. Obesity, insulin resistance and comorbidities? Mechanisms of association. Arq Bras Endocrinol Metabol. 2014;58:600–609.
   PubMedGoogle Scholar
• Vimaleswaran KS, Berry DJ, Lu C, et al. Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Med. 2013;10:e1001383.
   PubMed Web of Science ®Google Scholar
• Weisberg SP, McCann D, Desai M, et al. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest. 2003;112:1796–1808.
   PubMed Web of Science ®Google Scholar
• Torun E, Gonullu E, Ozgen I, et al. Vitamin D deficiency and insufficiency in obese children and adolescents and its relationship with insulin resistance. Int J Endocrinol. 2013;2013:631845.
   PubMedGoogle Scholar
• Alkharfy K, Al-Daghri N, Yakout S, et al. Influence of vitamin D treatment on transcriptional regulation of insulin-sensitive genes. Metab Syndr Relat Disord. 2013;11:283–288.
   PubMed Web of Science ®Google Scholar
• Ding C, Wilding JPH, Bing C. 1,25-Dihydroxyvitamin D3 protects against macrophage-induced activation of NFκB and MAPK signalling and chemokine release in human adipocytes. PLoS One. 2013;8:e61707.
   PubMed Web of Science ®Google Scholar
• Autier P, Boniol M, Pizot C, et al. Vitamin D: chasing a myth? Vitamin D status and ill health: a systematic review. Lancet Diabetes Endocrinol. 2014;2:76–89.
   PubMed Web of Science ®Google Scholar
• Merrill J, Minucci SB. Thyroid autoimmunity: an interplay of factors. Vitam Horm. 2018;106:129–145.
   PubMed Web of Science ®Google Scholar
• Artuković M, Ikić M, Kustelega J, et al. Influence of UV formatted: Swedish (Sweden) radiation on immunological system and occurrence of autoimmune diseases. Coll Antropol. 2010;34:175–178.
   PubMedGoogle Scholar
• De Pergola G, Ciampolillo A, Paolotti S, et al. Free triiodothyronine and thyroid stimulating hormone are directly associated with waist circumference, independently of insulin resistance, metabolic parameters and blood pressure in overweight and obese women. Clin Endocrinol (Oxf)). 2007;67:265–269.
   PubMed Web of Science ®Google Scholar
• Ortega FJ, Jilkova ZM, Moreno-Navarrete JM, et al. Type I iodothyronine 5'-deiodinase mRNA and activity is increased in adipose tissue of obese subjects . Int J Obes (Lond). 2012;36:320–324.
   PubMed Web of Science ®Google Scholar
• Vanderpump MPJ. The epidemiology of thyroid disease. Br Med Bull. 2011;99:39–51.
   PubMed Web of Science ®Google Scholar