Advanced search
Publication Cover
Scandinavian Journal of Clinical and Laboratory Investigation Volume 78, 2018 - Issue 7-8
Submit an article Journal homepage
212
Views
4
CrossRef citations to date
0
Altmetric
Articles

Falsely high HbA1c value due to a novel α1-globin gene mutation: Hb shantou [α127(H10)Lys > Glu; HBA1: c.382 A > G]

Anping XuDepartment of Laboratory Medicine, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China; ORCID Iconhttp://orcid.org/0000-0002-9827-7272
ORCID Icon,
Jie LeiDepartment of Laboratory Medicine, Maternity and Child Healthcare Hospital of Nanshan District, Shenzhen, China
,
Jie LiDepartment of Laboratory Medicine, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China;
,
Weidong ChenDepartment of Laboratory Medicine, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China;
,
Yu ZhouDepartment of Laboratory Medicine, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China;
,
Ruoyang ZhengDepartment of Laboratory Medicine, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China;
&
Ling JiDepartment of Laboratory Medicine, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China; Correspondence[email protected]
 show all
Pages 621-625 | Received 19 Jul 2018, Accepted 29 Sep 2018, Published online: 30 Oct 2018

References

  • Miedema K. Standardization of HbA1c and optimal range of monitoring. Scand J Clin Lab Invest Suppl. 2005;240:61–72.
  • Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993;29:977–986.
  • American Diabetes Association. Standards of medical care in diabetes-2011. Diabetes Care. 2011;34:S11–S61.
  • International Expert Committee. International Expert Committee report on the role of the A1c assay in the diagnosis of diabetes. Diabetes Care. 2009;32:1327–1334.
  • Little RR, La'ulu SL, Hanson SE, et al. Effects of 49 different rare Hb variants on HbA1c measurement in eight methods. J Diabetes Sci Technol. 2015;9:849–856.
  • Wang Y, Zhang P, Zhou H, et al. Effect of Hb Shuangfeng on HbA1c results. Scand J Clin Lab Invest. 2017;77:394–396.
  • Silva MR, Sendin SM, Velloso-Rodrigues C, et al. Unstable hemoglobin rush [beta 101(G3) Glu > Gln, HBB:c.304G > C] in a Brazilian family with moderate hemolytic anemia. Ann Hematol. 2012;91:1091–1096.
  • Cai WJ, Xie XM, Zhang YL, et al. A new hemoglobin variant: Hb Henan [β90(F6)Glu → Gln; HBB: c.271G < C]. Hemoglobin. 2014;38:127–129.
  • Weatherall DJ, Clegg JB. Inherited haemoglobin disorders: an increasing global health problem. Bull World Health Organ. 2001;79:704–712.
  • Giardine B, Borg J, Viennas E, et al. Updates of the HbVar database of human hemoglobin variants and thalassemia mutations. Nucl Acids Res. 2014;42:D1063–D1069. http://globin.cse.psu.edu).
  • Vella F, Galbraith P, Wilson JB, et al. Hemoglobin St. Claude or alpha2-127(H10)Lys leads to Thr-beta2. Biochim Biophys Acta. 1974;365:318–322.
  • Perutz M. Stereochemistry of cooperative effects in hemoglobin: hem–hem interaction and the problem of allostery. Nature. 1970;228:726–734.
  • Lee ST, Weykamp CW, Lee YW, et al. Effects of 7 hemoglobin variants on the measurement of glycohemoglobin by 14 analytical methods. Clin Chem. 2007;53:2202–2205.
  • Klingenberg O, Furuset T, Hestbråten CR, et al. HbA1c analysis by capillary electrophoresis - comparison with chromatography and an immunological method. Scand J Clin Lab Invest. 2017;77:458–464.
  • Khashoggi H, Pignalosa S, Russo C, et al. New HPLC instrument performance evaluation in HbA1c determination and comparison with capillary electrophoresis. Scand J Clin Lab Invest. 2018;11:1–5.
  • Little RR, Vesper H, Rohlfing CL, et al. Validation by a mass spectrometric reference method of use of boronate affinity chromatography to measure glycohemoglobin in the presence of hemoglobin S and C traits. Clin Chem. 2004;51:264–265.
  • Lenters-Westra E, Strunk A, Campbell P, et al. Can the Afinion HbA1c point-of-care instrument be an alternative method for the Tosoh G8 in the case of Hb-Tacoma? Scand J Clin Lab Invest. 2017;77:2–7.
  • Miyashita T, Sugiyama T, Yamadate S, et al. Study of a newly developed high-performance liquid chromatography analyzer for glycosylated hemoglobin measurements in blood containing hemoglobin variants in the Japanese population. Ann Clin Biochem. 2014;51:591–601.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.