Frequency and outcomes of maternal thyroid function abnormalities in early pregnancy

References

• Jolving LR, Nielsen J, Kesmodel US, et al. Prevalence of maternal chronic diseases during pregnancy—a nationwide population based study from 1989 to 2013. Acta Obstet Gynecol Scand. 2016;95:1295–1304.
   PubMed Web of Science ®Google Scholar
• Effraimidis G, Wiersinga WM. Mechanisms in endocrinology: autoimmune thyroid disease: old and new players. Eur J Endocrinol. 2014;170:R241–R252.
   PubMed Web of Science ®Google Scholar
• Carle A, Laurberg P, Pedersen IB, et al. Epidemiology of subtypes of hypothyroidism in Denmark. Eur J Endocrinol. 2006;154:21–28.
   PubMed Web of Science ®Google Scholar
• Carle A, Pedersen IB, Knudsen N, et al. Epidemiology of subtypes of hyperthyroidism in Denmark: a population-based study. Eur J Endocrinol. 2011;164:801–809.
   PubMed Web of Science ®Google Scholar
• Ross DS, Burch HB, Cooper DS, et al. 2016 American Thyroid Association Guidelines for diagnosis and management of hyperthyroidism and other causes of thyrotoxicosis. Thyroid. 2016;26:1343–1421.
   PubMed Web of Science ®Google Scholar
• Alexander EK, Pearce EN, Brent GA, et al. 2017 Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and the postpartum. Thyroid. 2017;27:315–389.
   PubMed Web of Science ®Google Scholar
• Laurberg P, Andersen SL. Endocrinology in pregnancy: pregnancy and the incidence, diagnosing and therapy of Graves' disease. Eur J Endocrinol. 2016;175:R219–R230.
   PubMed Web of Science ®Google Scholar
• Bernal J. Thyroid hormone regulated genes in cerebral cortex development. J Endocrinol. 2017;232:R83–R97.
   PubMed Web of Science ®Google Scholar
• Morreale de Escobar G, Obregón MJ, Escobar del Rey F. Is neuropsychological development related to maternal hypothyroidism or to maternal hypothyroxinemia? J Clin Endocrinol Metab. 2000;85:3975–3987.
   PubMed Web of Science ®Google Scholar
• Andersen SL, Carle A, Karmisholt J, et al. Mechanisms in endocrinology: neurodevelopmental disorders in children born to mothers with thyroid dysfunction: evidence of fetal programming? Eur J Endocrinol. 2017;177:R27–R36.
   PubMed Web of Science ®Google Scholar
• Haddow JE, Palomaki GE, Allan WC, et al. Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. N Engl J Med. 1999;341:549–555.
   PubMed Web of Science ®Google Scholar
• Pop VJ, Kuijpens JL, van Baar AL, et al. Low maternal free thyroxine concentrations during early pregnancy are associated with impaired psychomotor development in infancy. Clin Endocrinol (Oxf). 1999;50:149–155.
   PubMed Web of Science ®Google Scholar
• Glinoer D. The systematic screening and management of hypothyroidism and hyperthyroidism during pregnancy. Trends Endocrinol Metab. 1998;9:403–411.
   PubMed Web of Science ®Google Scholar
• Korevaar TI, Muetzel R, Medici M, et al. Association of maternal thyroid function during early pregnancy with offspring IQ and brain morphology in childhood: a population-based prospective cohort study. Lancet Diabetes Endocrinol. 2016;4:35–43.
   PubMed Web of Science ®Google Scholar
• Lazarus JH, Bestwick JP, Channon S, et al. Antenatal thyroid screening and childhood cognitive function. N Engl J Med. 2012;366:493–501.
   PubMed Web of Science ®Google Scholar
• Casey BM, Thom EA, Peaceman AM, et al. Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Treatment of subclinical hypothyroidism or hypothyroxinemia in pregnancy. N Engl J Med. 2017;376:815–825.
   PubMed Web of Science ®Google Scholar
• Cooper DS, Pearce EN. Subclinical hypothyroidism and hypothyroxinemia in pregnancy – still no answers. N Engl J Med. 2017;376:876–877.
   PubMed Web of Science ®Google Scholar
• Andersen SL, Olsen J, Laurberg P. Foetal programming by maternal thyroid disease. Clin Endocrinol (Oxf). 2015;83:751–758.
   PubMed Web of Science ®Google Scholar
• Barker DJ, Winter PD, Osmond C, et al. Weight in infancy and death from ischaemic heart disease. Lancet. 1989;2:577–580.
   PubMed Web of Science ®Google Scholar
• Hales CN, Barker DJ, Clark PM, et al. Fetal and infant growth and impaired glucose tolerance at age 64. BMJ. 1991;303:1019–1022.
   PubMed Web of Science ®Google Scholar
• Bianco AC, Salvatore D, Gereben B, et al. Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. Endocr Rev. 2002;23:38–89.
   PubMed Web of Science ®Google Scholar
• Ahmed OM, Abd El-Tawab SM, Ahmed RG. Effects of experimentally induced maternal hypothyroidism and hyperthyroidism on the development of rat offspring: I. The development of the thyroid hormones-neurotransmitters and adenosinergic system interactions. Int J Dev Neurosci. 2010;28:437–454.
   PubMed Web of Science ®Google Scholar
• Pharoah PO, Buttfield IH, Hetzel BS. Neurological damage to the fetus resulting from severe iodine deficiency during pregnancy. Lancet. 1971;1:308–310.
   PubMed Web of Science ®Google Scholar
• Laurberg P, Cerqueira C, Ovesen L, et al. Iodine intake as a determinant of thyroid disorders in populations. Best Pract Res Clin Endocrinol Metab. 2010;24:13–27.
   PubMed Web of Science ®Google Scholar
• Jepsen P, Johnsen SP, Gillman MW, et al. Interpretation of observational studies. Heart. 2004;90:956–960.
   PubMed Web of Science ®Google Scholar
• Olsen J, Bronnum-Hansen H, Gissler M, et al. High-throughput epidemiology: combining existing data from the Nordic countries in health-related collaborative research. Scand J Public Health. 2010;38:777–779.
   PubMed Web of Science ®Google Scholar
• Andersen SL, Olsen J, Carle A, et al. Hyperthyroidism incidence fluctuates widely in and around pregnancy and is at variance with some other autoimmune diseases: a Danish Population-Based Study. J Clin Endocrinol Metab. 2015;100:1164–1171.
   PubMed Web of Science ®Google Scholar
• Andersen SL, Carle A, Olsen J, et al. Hypothyroidism incidence in and around pregnancy: a Danish nationwide study. Eur J Endocrinol. 2016;175:387–393.
   PubMed Web of Science ®Google Scholar
• Weetman AP. The immunology of pregnancy. Thyroid. 1999;9:643–646.
   PubMed Web of Science ®Google Scholar
• Amino N, Tada H, Hidaka Y. Postpartum autoimmune thyroid syndrome: a model of aggravation of autoimmune disease. Thyroid. 1999;9:705–713.
   PubMed Web of Science ®Google Scholar
• Cooper DS, Laurberg P. Hyperthyroidism in pregnancy. Lancet Diabetes Endocrinol. 2013;1:238–249.
   PubMed Web of Science ®Google Scholar
• Amino N, Tanizawa O, Mori H, et al. Aggravation of thyrotoxicosis in early pregnancy and after delivery in Graves' disease. J Clin Endocrinol Metab. 1982;55:108–112.
   PubMed Web of Science ®Google Scholar
• Andersen SL, Laurberg P, Wu CS, et al. Maternal thyroid dysfunction and risk of seizure in the child: a Danish nationwide cohort study. J Pregnancy. 2013;636705.
   PubMedGoogle Scholar
• Andersen SL, Laurberg P, Wu CS, et al. Attention deficit hyperactivity disorder and autism spectrum disorder in children born to mothers with thyroid dysfunction: a Danish nationwide cohort study. BJOG. 2014;121:1365–1374.
   PubMed Web of Science ®Google Scholar
• Burrow GN, Fisher DA, Larsen PR. Maternal and fetal thyroid function. N Engl J Med. 1994;331:1072–1078.
   PubMed Web of Science ®Google Scholar
• Korevaar TI, Steegers EA, de Rijke YB, et al. Reference ranges and determinants of total hCG levels during pregnancy: the Generation R Study. Eur J Epidemiol. 2015;30:1057–1066.
   PubMed Web of Science ®Google Scholar
• Hershman JM. Physiological and pathological aspects of the effect of human chorionic gonadotropin on the thyroid. Best Pract Res Clin Endocrinol Metab. 2004;18:249–265.
   PubMed Web of Science ®Google Scholar
• Huang SA, Dorfman DM, Genest DR, et al. Type 3 iodothyronine deiodinase is highly expressed in the human uteroplacental unit and in fetal epithelium. J Clin Endocrinol Metab. 2003;88:1384–1388.
   PubMed Web of Science ®Google Scholar
• Laurberg P, Andersen SL, Pedersen IB, et al. Screening for overt thyroid disease in early pregnancy may be preferable to searching for small aberrations in thyroid function tests. Clin Endocrinol. 2013;79:297–304.
   PubMed Web of Science ®Google Scholar
• Andersen SL, Laurberg P. Thyroidea funktionsanalyser i Danmark. DSKB-Nyt. 2016;2:28–30.
   Google Scholar
• Faix JD. Principles and pitfalls of free hormone measurements. Best Pract Res Clin Endocrinol Metab. 2013;27:631–645.
   PubMed Web of Science ®Google Scholar
• Welsh KJ, Soldin SJ. Diagnosis of endocrine disease: how reliable are free thyroid and total T3 hormone assays? Eur J Endocrinol. 2016;175:R255–R263.
   PubMed Web of Science ®Google Scholar
• Lee RH, Spencer CA, Mestman JH, et al. Free T4 immunoassays are flawed during pregnancy. Am J Obstet Gynecol. 2009;200:1–6.
   PubMed Web of Science ®Google Scholar
• Bliddal S, Feldt-Rasmussen U, Boas M, et al. Gestational age-specific reference ranges from different laboratories misclassify pregnant women's thyroid status: comparison of two longitudinal prospective cohort studies. Eur J Endocrinol. 2014;170:329–339.
   PubMed Web of Science ®Google Scholar
• Pedersen IB, Knudsen N, Jorgensen T, et al. Thyroid peroxidase and thyroglobulin autoantibodies in a large survey of populations with mild and moderate iodine deficiency. Clin Endocrinol. 2003;58:36–42.
   PubMed Web of Science ®Google Scholar
• Dashe JS, Casey BM, Wells CE, et al. Thyroid-stimulating hormone in singleton and twin pregnancy: importance of gestational age-specific reference ranges. Obstet Gynecol. 2005;106:753–757.
   PubMed Web of Science ®Google Scholar
• Stricker R, Echenard M, Eberhart R, et al. Evaluation of maternal thyroid function during pregnancy: the importance of using gestational age-specific reference intervals. Eur J Endocrinol. 2007;157:509–514.
   PubMed Web of Science ®Google Scholar
• Mannisto T, Surcel HM, Ruokonen A, et al. Early pregnancy reference intervals of thyroid hormone concentrations in a thyroid antibody-negative pregnant population. Thyroid. 2011;21:291–298.
   PubMed Web of Science ®Google Scholar
• Shen FX, Xie ZW, Lu SM, et al. Gestational thyroid reference intervals in antibody-negative Chinese women. Clin Biochem. 2014;47:673–675.
   PubMed Web of Science ®Google Scholar
• Li C, Shan Z, Mao J, et al. Assessment of thyroid function during first-trimester pregnancy: what is the rational upper limit of serum TSH during the first trimester in Chinese pregnant women? J Clin Endocrinol Metab. 2014;99:73–79.
   PubMed Web of Science ®Google Scholar
• Laurberg P, Andersen SL, Hindersson P, et al. Dynamics and predictors of serum TSH and fT4 reference limits in early pregnancy: a study within the Danish National Birth Cohort. J Clin Endocrinol Metab. 2016;101:2484–2492.
   PubMed Web of Science ®Google Scholar
• Liu J, Yu X, Xia M, et al. Development of gestation-specific reference intervals for thyroid hormones in normal pregnant Northeast Chinese women: what is the rational division of gestation stages for establishing reference intervals for pregnancy women? Clin Biochem. 2017;50:309–317.
   PubMed Web of Science ®Google Scholar
• Olsen J, Melbye M, Olsen SF, et al. The Danish National Birth Cohort-its background, structure and aim. Scand J Public Health. 2001;29:300–307.
   PubMed Web of Science ®Google Scholar
• Mannisto T, Surcel HM, Bloigu A, et al. The effect of freezing, thawing, and short- and long-term storage on serum thyrotropin, thyroid hormones, and thyroid autoantibodies: implications for analyzing samples stored in serum banks. Clin Chem. 2007;53:1986–1987.
   PubMed Web of Science ®Google Scholar
• Mannisto T, Suvanto E, Surcel HM, et al. Thyroid hormones are stable even during prolonged frozen storage. Clin Chem Lab Med. 2010;48:1669–1670. Author reply 1671–1672.
   PubMed Web of Science ®Google Scholar
• Andersen SL, Olsen J. Early pregnancy thyroid function test abnormalities in Biobank sera from women clinically diagnosed with thyroid dysfunction before or after pregnancy. Thyroid. 2017;27:451–459.
   PubMed Web of Science ®Google Scholar
• Thapar A, Cooper M, Rutter M. Neurodevelopmental disorders. Lancet Psychiatry. 2017;4:339–346.
   PubMed Web of Science ®Google Scholar
• Andersen SL, Andersen S, Vestergaard P, et al. Maternal thyroid function in early pregnancy and child neurodevelopmental disorders: a Danish nationwide case-cohort study. Thyroid. 2018;28:537–546.
   Web of Science ®Google Scholar
• Bachmann CJ, Wijlaars LP, Kalverdijk LJ, et al. Trends in ADHD medication use in children and adolescents in five western countries, 2005–2012. Eur Neuropsychopharmacol. 2017;27:484–493.
   PubMed Web of Science ®Google Scholar
• Krassas GE, Poppe K, Glinoer D. Thyroid function and human reproductive health. Endocr Rev. 2010;31:702–755.
   PubMed Web of Science ®Google Scholar
• Hvidtjorn D, Grove J, Schendel D, et al. Risk of autism spectrum disorders in children born after assisted conception: a population-based follow-up study. J Epidemiol Community Health. 2011;65:497–502.
   PubMed Web of Science ®Google Scholar
• Sandin S, Nygren KG, Iliadou A, et al. Autism and mental retardation among offspring born after in vitro fertilization. JAMA. 2013;310:75–84.
   PubMed Web of Science ®Google Scholar
• Kettner LO, Kesmodel US, Ramlau-Hansen CH, et al. Fertility treatment and childhood epilepsy: a nationwide cohort study. Epidemiology. 2017;28:412–418.
   PubMed Web of Science ®Google Scholar
• Kesmodel US, Underbjerg M, Kilburn TR, et al. Lifestyle during pregnancy: neurodevelopmental effects at 5 years of age. The design and implementation of a prospective follow-up study. Scand J Public Health. 2010;38:208–219.
   PubMed Web of Science ®Google Scholar
• Andersen SL, Andersen S, Liew Z, et al. Maternal thyroid function in early pregnancy and neuropsychological performance of the child at 5 years of age. J Clin Endocrinol Metab. 2018;103:660–670.
   PubMed Web of Science ®Google Scholar
• Auso E, Lavado-Autric R, Cuevas E, et al. A moderate and transient deficiency of maternal thyroid function at the beginning of fetal neocorticogenesis alters neuronal migration. Endocrinology. 2004;145:4037–4047.
   PubMed Web of Science ®Google Scholar
• Gilbert ME, Ramos RL, McCloskey DP, et al. Subcortical band heterotopia in rat offspring following maternal hypothyroxinaemia: structural and functional characteristics. J Neuroendocrinol. 2014;26:528–541.
   PubMed Web of Science ®Google Scholar
• Brown AS, Surcel HM, Hinkka-Yli-Salomaki S, et al. Maternal thyroid autoantibody and elevated risk of autism in a national birth cohort. Prog Neuropsychopharmacol Biol Psychiatry. 2015;57:86–92.
   PubMed Web of Science ®Google Scholar
• Chen SW, Zhong XS, Jiang LN, et al. Maternal autoimmune diseases and the risk of autism spectrum disorders in offspring: a systematic review and meta-analysis. Behav Brain Res. 2016;296:61–69.
   PubMed Web of Science ®Google Scholar
• Modesto T, Tiemeier H, Peeters RP, et al. Maternal mild thyroid hormone insufficiency in early pregnancy and attention-deficit/hyperactivity disorder symptoms in children. JAMA Pediatr. 2015;169:838–845.
   PubMed Web of Science ®Google Scholar
• Pakkila F, Mannisto T, Pouta A, et al. The impact of gestational thyroid hormone concentrations on ADHD symptoms of the child. J Clin Endocrinol Metab. 2014;99:E1–E8.
   PubMed Web of Science ®Google Scholar
• Ghassabian A, Bongers-Schokking JJ, de Rijke YB, et al. Maternal thyroid autoimmunity during pregnancy and the risk of attention deficit/hyperactivity problems in children: the Generation R Study. Thyroid. 2012;22:178–186.
   PubMed Web of Science ®Google Scholar
• Oostenbroek MHW, Kersten RHJ, Tros B, et al. Maternal hypothyroxinaemia in early pregnancy and problem behavior in 5-year-old offspring. Psychoneuroendocrinology. 2017;81:29–35.
   PubMed Web of Science ®Google Scholar
• Andersen SL, Olsen J, Wu CS, et al. Birth defects after early pregnancy use of antithyroid drugs: a Danish nationwide study. J Clin Endocrinol Metab. 2013;98:4373–4381.
   PubMed Web of Science ®Google Scholar
• Andersen SL, Lonn S, Vestergaard P, et al. Birth defects after use of antithyroid drugs in early pregnancy: a Swedish nationwide study. Eur J Endocrinol. 2017;177:369–378.
   PubMed Web of Science ®Google Scholar