2,418
Views
5
CrossRef citations to date
0
Altmetric
Original Articles

Short-term effect of pharmacologically induced alterations in testosterone levels on common blood biomarkers in a controlled healthy human model

ORCID Icon, , , , , , , & show all
Pages 25-31 | Received 28 Jun 2019, Accepted 02 Nov 2019, Published online: 18 Nov 2019

References

  • Traish AM, Miner MM, Morgentaler A, et al. Testosterone deficiency. Am J Med. 2011;124(7):578–587.
  • Allan CA, McLachlan RI. Age-related changes in testosterone and the role of replacement therapy in older men. Clin Endocrinol (Oxf). 2004;60(6):653–670.
  • Miner M, Barkin J, Rosenberg MT. Testosterone deficiency: myth, facts, and controversy. Can J Urol. 2014;21:39–54.
  • Araujo AB, Wittert GA. Endocrinology of the aging male. Best Pract Res Clin Endocrinol Metab. 2011;25(2):303–319.
  • Travison TG, Araujo AB, O’Donnell AB, et al. A population-level decline in serum testosterone levels in American men. J Clin Endocrinol Metab. 2007;92(1):196–202.
  • Kloner RA, Carson C, Dobs A, et al. Testosterone and cardiovascular disease. J Am Coll Cardiol. 2016;67(5):545–557.
  • Ebrahimi F, Christ-Crain M. Metabolic syndrome and hypogonadism-two peas in a pod. Swiss Med Wkly. 2016;146:w14283.
  • Cheung KKT, Luk AOY, So WY, et al. Testosterone level in men with type 2 diabetes mellitus and related metabolic effects: a review of current evidence. J Diabetes Invest. 2015;6(2):112–123.
  • Zarotsky V, Huang MY, Carman W, et al. Systematic literature review of the risk factors, comorbidities, and consequences of hypogonadism in men. Andrology. 2014;2(6):819–834.
  • Bhasin S. A perspective on the evolving landscape in male reproductive medicine. J Clin Endocrinol Metab. 2016;101(3):827–836.
  • Mohamad NV, Soelaiman IN, Chin KY. A concise review of testosterone and bone health. Clin Interv Aging. 2016;11:1317–1324.
  • Gencer B, Mach F. Testosterone: a hormone preventing cardiovascular disease or a therapy increasing cardiovascular events? Eur Heart J. 2016;37(48):3569–3575.
  • Morgentaler A. Controversies and advances with testosterone therapy: a 40-year perspective. Urology. 2016;89:27–32.
  • Naderi S. Testosterone replacement therapy and the cardiovascular system. Curr Atheroscler Rep. 2016;18:1–6.
  • R Core Team. R: A language and environment for statistical computing. R Foundation for Statistical Computing [Internet]; 2016. Available from: https://www.r-project.org/
  • Shapiro SS, Wilk A. An analysis of variance test for normality (complete samples). Biometrika. 1965;52(3-4):591.
  • Bonferroni CE. Teoria statistica delle classi e calcolo delle probabilità. 8th ed. Pubblicazioni Del R Istituto Superiore di Scienze Economiche e Commerciali di Firenze. Libreria internazionale Seeber; 1936. p. 3–62.
  • Greenfield ML, Kuhn JE, Wojtys EM. A statistics primer. Confidence intervals. Am J Sports Med. 1998;26(1):145–149.
  • Lam T, Poljak A, McLean M, et al. Testosterone prevents protein loss via the hepatic urea cycle in human. Eur J Endocrinol. 2017;176(4):489–496.
  • Peskoe SB, Joshu CE, Rohrmann S, et al. Circulating total testosterone and PSA concentrations in a nationally representative sample of men without a diagnosis of prostate cancer. Prostate. 2015;75(11):1167.
  • Lu M, Lu Q, Zhang Y, et al. ApoB/apoA1 is an effective predictor of coronary heart disease risk in overweight and obesity. J Biomed Res. 2011;25(4):266–273.
  • Mody A, White D, Kanwal F, et al. Relevance of low testosterone to nonalcoholic fatty liver disease. Cardiovasc Endocrinol. 2015;4(3):83–89.
  • Simental-Mendía LE, Rodríguez-Morán M, Gómez-Díaz R, et al. Insulin resistance is associated with elevated transaminases and low aspartate aminotransferase/alanine aminotransferase ratio in young adults with normal weight. Eur J Gastroenterol Hepatol. 2017;29(4):435–440.
  • Bhasin S, Woodhouse L, Casaburi R, et al. Testosterone dose-response relationships in healthy young men. Am J Physiol Metab. 2001;281:E1172–E1181.
  • Rabiee A, Dwyer AA, Caronia LM, et al. Impact of acute biochemical castration on insulin sensitivity in healthy adult men. Endocr Res. 2010;35(2):71–84.
  • Host C, Gormsen LC, Hougaard DM, et al. Acute and short-term chronic testosterone fluctuation effects on glucose homeostasis, insulin sensitivity, and adiponectin: a randomized, double-blind, placebo-controlled, crossover study. J Clin Endocrinol Metab. 2014;99:1088–1096.
  • Thirumalai A, Rubinow KB, Cooper LA, et al. Dose-response effects of sex hormone concentrations on body composition and adipokines in medically castrated healthy men administered graded doses of testosterone gel. Clin Endocrinol. 2017;87(1):59–67.
  • Kelly DM, Jones TH. Testosterone: a metabolic hormone in health and disease. J Endocrinol. 2013;217(3):R25–R45.
  • Traish AM. Outcomes of testosterone therapy in men with testosterone deficiency (TD): part II. Steroids. 2014;88:117–126.