Leptin levels are not affected by enalapril treatment after an uncomplicated myocardial infarction, but associate strongly with changes in fibrinolytic variables in men

References

• Jaganathan R, Ravindran R, Dhanasekaran S. Emerging role of adipocytokines in type 2 diabetes as mediators of insulin resistance and cardiovascular disease. Can J Diabetes. 2018;42(4):446–456.
   PubMed Web of Science ®Google Scholar
• Aldhahi W, Hamdy O. Adipokines, inflammation, and the endothelium in diabetes. Curr Diab Rep. 2003;3(4):293–298.
   PubMedGoogle Scholar
• Carrier N, Wang X, Sun L, et al. Sex-specific and estrous cycle-dependent antidepressant-like effects and hippocampal akt signaling of leptin. Endocrinology. 2015;156(10):3695–3705.
   PubMed Web of Science ®Google Scholar
• Belin de Chantemèle EJ. Sex differences in leptin control of cardiovascular function in health and metabolic diseases. Adv Exp Med Biol. 2017;1043:87–111.
   PubMedGoogle Scholar
• Tsai JP. The association of serum leptin levels with metabolic diseases. Tzu Chi Med J. 2017;29(4):192–196.
   Web of Science ®Google Scholar
• Faber DR, de Groot PG, Visseren FL. Role of adipose tissue in haemostasis, coagulation and fibrinolysis. Obes Rev. 2009;10(5):554–563.
   PubMed Web of Science ®Google Scholar
• Schäfer K, Konstantinides S. Adipokines and thrombosis. Clin Exp Pharmacol Physiol. 2011;38(12):864–871.
   PubMed Web of Science ®Google Scholar
• Hilzendeger AM, Morais RL, Todiras M, et al. Leptin regulates ACE activity in mice. J Mol Med. 2010;88(9):899–907.
   PubMed Web of Science ®Google Scholar
• Söderberg S, Olsson T, Eliasson M, et al. Plasma leptin levels are associated with abnormal fibrinolysis in men and postmenopausal women. J Intern Med. 1999;245(5):533–543.
   PubMed Web of Science ®Google Scholar
• Söderberg S, Stegmayr B, Stenlund H, et al. Leptin, but not adiponectin, predicts stroke in males. J Intern Med. 2004;256(2):128–136.
   PubMed Web of Science ®Google Scholar
• Söderberg S, Colquhoun D, Keech A, et al. Leptin, but not adiponectin, is a predictor of recurrent cardiovascular events in men: results from the LIPID study. Int J Obes. 2009;33(1):123–130.
   Web of Science ®Google Scholar
• Fox KM. Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study). Lancet. 2003;362(9386):782–788.
   PubMed Web of Science ®Google Scholar
• Sleight P, Yusuf S, Pogue J, et al. Blood-pressure reduction and cardiovascular risk in HOPE study. Lancet. 2001;358(9299):2130–2131.
   PubMed Web of Science ®Google Scholar
• Flather MD, Yusuf S, Køber L, et al. Long-term ACE-inhibitor therapy in patients with heart failure or left-ventricular dysfunction: a systematic overview of data from individual patients. ACE-Inhibitor Myocardial Infarction Collaborative Group. Lancet. 2000;355(9215):1575–1581.
   PubMed Web of Science ®Google Scholar
• Hilzendeger AM, Morgan DA, Brooks L, et al. A brain leptin-renin angiotensin system interaction in the regulation of sympathetic nerve activity. Am J Physiol Heart Circ Physiol. 2012;303(2):H197–206.
   PubMed Web of Science ®Google Scholar
• Boman KO, Jansson JH, Nyhlén KA, et al. Improved fibrinolysis after one year of treatment with enalapril in men and women with uncomplicated myocardial infarction. Thromb Haemost. 2002;87(2):311–316.
   PubMed Web of Science ®Google Scholar
• Bergsdorf N, Nilsson T, Wallén P. An enzyme linked immunosorbent assay for determination of tissue plasminogen activator applied to patients with thromboembolic disease. Thromb Haemost. 1983;50(3):740–744.
   PubMed Web of Science ®Google Scholar
• Cejka J. Enzyme immunoassay for factor VIII-related antigen. Clin Chem. 1982;28(6):1356–1358.
   PubMed Web of Science ®Google Scholar
• Shareware F. PS-power and sample size collection. Power and sample size calculation version 3.1.6, October 2018.
   Google Scholar
• Eriksson M, Johnson O, Boman K, et al. Improved fibrinolytic activity during exercise may be an effect of the adipocyte-derived hormones leptin and adiponectin. Thromb Res. 2008;122(5):701–708.
   PubMed Web of Science ®Google Scholar
• Couillard C, Mauriége P, Imbeault P, et al. Hyperleptinemia is more closely associated with adipose cell hypertrophy than with adipose tissue hyperplasia. Int J Obes. 2000;24(6):782–788.
   Web of Science ®Google Scholar
• Garaulet M, Pérex-Llamas F, Fuente T, et al. Anthropometric, computed tomography and fat cell data in an obese population: relationship with insulin, leptin, tumor necrosis factor-alpha, sex hormone-binding globulin and sex hormones. Eur J Endocrinol. 2000;143(5):657–666.
   PubMed Web of Science ®Google Scholar
• Meli R, Pacilio M, Raso GM, et al. Estrogen and raloxifene modulate leptin and its receptor in hypothalamus and adipose tissue from ovariectomized rats. Endocrinology. 2004;145(7):3115–3121.
   PubMed Web of Science ®Google Scholar
• Clegg DJ, Riedy CA, Smith KA, et al. Differential sensitivity to central leptin and insulin in male and female rats. Diabetes. 2003;52(3):682–687.
   PubMed Web of Science ®Google Scholar
• Wallace AM, McMahon AD, Packard CJ, et al. Plasma leptin and the risk of cardiovascular disease in the west of Scotland coronary prevention study (WOSCOPS). Circulation. 2001;104(25):3052–3056.
   PubMed Web of Science ®Google Scholar
• Beltowski J. Leptin and atherosclerosis. Atherosclerosis. 2006;189(1):47–60.
   PubMed Web of Science ®Google Scholar
• Singh P, Peterson TE, Barber KR, et al. Leptin upregulates the expression of plasminogen activator inhibitor-1 in human vascular endothelial cells. Biochem Biophys Res Commun. 2010;392(1):47–52.
   PubMed Web of Science ®Google Scholar
• Mea H. Leptin increases plasminogen activator inhibitor-1(PAI-1) production in human vascular smooth muscle cell. Diabetes. 1998;47:A118. Abstract 463.
   Web of Science ®Google Scholar
• Aprath-Husmann I, Röhrig K, Gottschling-Zeller H, et al. Effects of leptin on the differentiation and metabolism of human adipocytes. Int J Obes. 2001;25(10):1465–1470.
   Web of Science ®Google Scholar
• Bobbert P, Eisenreich A, Weithäuser A, et al. Leptin and resistin induce increased procoagulability in diabetes mellitus. Cytokine. 2011;56(2):332–337.
   PubMed Web of Science ®Google Scholar
• van Hinsbergh VW, Binnema D, Scheffer MA, et al. Production of plasminogen activators and inhibitor by serially propagated endothelial cells from adult human blood vessels. Arteriosclerosis. 1987;7(4):389–400.
   PubMedGoogle Scholar
• Sakamoto K, Sakamoto T, Ogawa H. Effects of metabolic risk factors on production of plasminogen activator inhibitor-1 and adiponectin by adipocytes. Circ J. 2008;72(5):844–846.
   PubMed Web of Science ®Google Scholar
• Huang W, Dedousis N, Bhatt BA, et al. Impaired activation of phosphatidylinositol 3-kinase by leptin is a novel mechanism of hepatic leptin resistance in diet-induced obesity. J Biol Chem. 2004;279(21):21695–21700.
   PubMed Web of Science ®Google Scholar
• Huang W, Dedousis N, Bandi A, et al. Liver triglyceride secretion and lipid oxidative metabolism are rapidly altered by leptin in vivo. Endocrinology. 2006;147(3):1480–1487.
   PubMed Web of Science ®Google Scholar
• Steinberg GR, Dyck DJ. Development of leptin resistance in rat soleus muscle in response to high-fat diets. Am J Physiol Endocrinol Metab. 2000;279(6):E1374–82.
   PubMed Web of Science ®Google Scholar
• Steinberg GR, Parolin ML, Heigenhauser GJ, et al. Leptin increases FA oxidation in lean but not obese human skeletal muscle: evidence of peripheral leptin resistance. Am J Physiol Endocrinol Metab. 2002;283(1):E187–92.
   PubMed Web of Science ®Google Scholar
• Bitkin EC, Boyraz M, Taşkin N, et al. Effects of ACE inhibitors on insulin resistance and lipid profile in children with metabolic syndrome. J Clin Res Pediatr Endocrinol. 2013;5(3):164–169.
   PubMed Web of Science ®Google Scholar
• Bełtowski J. Role of leptin in blood pressure regulation and arterial hypertension. J Hypertens. 2006;24(5):789–801.
   PubMed Web of Science ®Google Scholar
• Fortuño A, Rodriguez A, Gómez-Ambrosi J, et al. Leptin inhibits angiotensin II-induced intracellular calcium increase and vasoconstriction in the rat aorta. Endocrinology. 2002;143(9):3555–3560.
   PubMed Web of Science ®Google Scholar
• Werida R, Khairat I, Khedr L, et al. Comparative effects of enalapril versus perindopril on serum levels of leptin and adiponectin in hypertensive patients. Acta Cardiol. 2019;26:1–6.
   Google Scholar