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Scandinavian Journal of Clinical and Laboratory Investigation Volume 80, 2020 - Issue 8
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Original Articles

Spectrophotometry of cerebrospinal fluid for xanthochromia is a sensitive and specific test for subarachnoid bleeding but adds little to computed tomography

Anders Berg Wulffa Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark;b Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, DenmarkCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-2175-8342
ORCID Icon,
Joan Lilja Sunnleyg Højgaardc Department of Neurology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
&
Linda Hilsteda Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
Pages 681-686 | Received 10 Dec 2019, Accepted 01 Nov 2020, Published online: 13 Nov 2020

References

  • Macdonald RL, Schweizer TA. Spontaneous subarachnoid haemorrhage. Lancet. 2017;389(10069):655–666.
  • Vermeulen M, Van Gijn J. The diagnosis of subarachnoid haemorrhage. J Neurol Neurosurg Psychiatry. 1990;53(5):365–372.
  • Edlow JA, Caplan LR. Avoiding pitfalls in the diagnosis of subarachnoid hemorrhage. N Engl J Med. 2000;342(1):29–36.
  • Van Der Wee N, Rinkel GJE, Hasan D, et al. Detection of subarachnoid haemorrhage on early CT: is lumbar puncture still needed after a negative scan? J Neurol Neurosurg Psychiatry. 1995;58(3):357–359.
  • van Gijn J, van Dongen KJ. The time course of aneurysmal haemorrhage on computed tomograms. Neuroradiology. 1982;23(3):153–156.
  • Watson MA, Scott MG. Clinical utility of biochemical analysis of cerebrospinal fluid. Clin Chem. 1995;41(3):343–360.
  • Wahlgren NG, Lindquist C. Haem derivatives in subdural haematomas. Acta Neurochir (Wien). 1988;95(3–4):109–113.
  • Wahlgren NG, Bergström K. Determination of haem derivatives in the cerebrospinal fluid-a semi-quantitative method. J Neurol Neurosurg Psychiatry. 1983;46(7):653–658.
  • Cruickshank A, Auld P, Beetham R, et al. Revised national guidelines for analysis of cerebrospinal fluid for bilirubin in suspected subarachnoid haemorrhage. Ann Clin Biochem. 2008;45(Pt 3):238–244.
  • Pyne-Geithman GJ, Morgan CJ, Wagner K, et al. Bilirubin production and oxidation in CSF of patients with cerebral vasospasm after subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2005;25(8):1070–1077.
  • Vermeulen M, Hasan D, Blijenberg BG, et al. Xanthochromia after subarachnoid haemorrhage needs no revisitation. J Neurol Neurosurg Psychiatry. 1989;52(7):826–828.
  • Brunt LK. Using hyperbilirubinaemia correction formula in assessment of CSF xanthochromia. Ann Clin Biochem. 2006;43(2):165–167.
  • Bakr A, Silva D, Cramb R, et al. Outcomes of CSF spectrophotometry in cases of suspected subarachnoid haemorrhage with negative CT: two years retrospective review in a Birmingham hospital. Br J Neurosurg. 2017;31(2):223–226.
  • Dubosh NM, Bellolio MF, Rabinstein AA, et al. Sensitivity of early brain computed tomography to exclude aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis. Stroke. 2016;47(3):750–755.
  • Perry JJ, Stiell IG, Sivilotti MLA, et al. Sensitivity of computed tomography performed within six hours of onset of headache for diagnosis of subarachnoid haemorrhage: prospective cohort study. BMJ. 2011;343:d4277
  • Backes D, Rinkel GJE, Kemperman H, et al. Time-dependent test characteristics of head computed tomography in patients suspected of nontraumatic subarachnoid hemorrhage. Stroke. 2012;43(8):2115–2119.
  • Sayer D, Bloom B, Fernando K, et al. An observational study of 2,248 patients presenting with headache, suggestive of subarachnoid hemorrhage, who received lumbar punctures following normal computed tomography of the head. Acad Emerg Med. 2015;22(11):1267–1273.
  • Godwin SA, Cherkas DS, Panagos PD, et al. Clinical policy: critical issues in the evaluation and management of adult patients presenting to the emergency department with acute headache. Ann Emerg Med. 2019;74(4):e41–e74.
  • Wright BLC, Lai JTF, Sinclair AJ. Cerebrospinal fluid and lumbar puncture: a practical review. J Neurol. 2012;259(8):1530–1545.
  • Ahmed F, Gibbons S, El-Kadiki A. CSF xanthochromia: correlation with brain imaging and its usefulness as an out-of-hours test. J Clin Pathol. 2014;67(8):736–738.
  • Ahmed F, Gibbons S. Comments on: analysis of cerebrospinal fluid for xanthochromia versus modern computed tomography scanners in the diagnosis of subarachnoid haemorrhage: experience at a tertiary trauma referral centre. Ann Clin Biochem. 2016;53(Pt 5):622–623.
  • Goyale A, O'Shea J, Marsden J, et al. Analysis of cerebrospinal fluid for xanthochromia versus modern computed tomography scanners in the diagnosis of subarachnoid haemorrhage: experience at a tertiary trauma referral centre. Ann Clin Biochem. 2016;53(Pt 1):150–154.

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