Endogenous anti-streptavidin antibodies causing erroneous laboratory results more common than anticipated

References

• Faix JD. Principles and pitfalls of free hormone measurements. Best Pract Res Clin Endocrinol Metab. 2013;27(5):631–645.
   PubMed Web of Science ®Google Scholar
• Koulouri O, Moran C, Halsall D, et al. Pitfalls in the measurement and interpretation of thyroid function tests. Best Pract Res Clin Endocrinol Metab. 2013;27(6):745–762.
   PubMed Web of Science ®Google Scholar
• Piketty ML, Polak M, Flechtner I, et al. False biochemical diagnosis of hyperthyroidism in streptavidin-biotin-based immunoassays: the problem of biotin intake and related interferences. Clin Chem Lab Med. 2017;55(6):780–788.
   PubMed Web of Science ®Google Scholar
• Package Insert, Elecsys FT3 III Immunoassay [cited 2020 July 12]. http://labogids.sintmaria.be/sites/default/files/files/ft3_iii_2017-03_v2.pdf
   Google Scholar
• Trambas C, Lu Z, Yen T, et al. Characterization of the scope and magnitude of biotin interference in susceptible Roche Elecsys competitive and sandwich immunoassays. Ann Clin Biochem. 2018;55(2):205–215.
   PubMed Web of Science ®Google Scholar
• Ando T, Yasui J, Inokuchi N, et al. Non-specific activities against ruthenium crosslinker as a new cause of assay interference in an electrochemilluminescent immunoassay. Intern Med. 2007;46(15):1225–1229.
   PubMed Web of Science ®Google Scholar
• Bolstad N, Warren DJ, Bjerner J, et al. Heterophilic antibody interference in commercial immunoassays; a screening study using paired native and pre-blocked sera. Clin Chem Lab Med. 2011;49(12):2001–2006.
   PubMed Web of Science ®Google Scholar
• Favresse J, Burlacu MC, Maiter D, et al. Interferences with thyroid function immunoassays: clinical implications and detection algorithm. Endocr Rev. 2018;39(5):830–850.
   PubMed Web of Science ®Google Scholar
• Ismail AA. Interference from endogenous antibodies in automated immunoassays: what laboratorians need to know. J Clin Pathol. 2009;62(8):673–678.
   PubMed Web of Science ®Google Scholar
• Berth M, Willaert S, De Ridder C. Anti-streptavidin IgG antibody interference in anti-cyclic citrullinated peptide (CCP) IgG antibody assays is a rare but important cause of false-positive anti-CCP results. Clin Chem Lab Med. 2018;56(8):1263–1268.
   PubMed Web of Science ®Google Scholar
• Verougstraete N, Berth M, Vaneechoutte M, et al. Interference of anti-streptavidin antibodies in immunoassays: a very rare phenomenon or a more common finding? Clin Chem Lab Med. 2020;58(10):1673–1680.
   PubMed Web of Science ®Google Scholar
• Minkovsky A, Lee MN, Dowlatshahi M, et al. High-dose biotin treatment for secondary progressive multiple sclerosis may interfere with thyroid assays. AACE Clin Case Rep. 2016;2:370–373.
   Google Scholar
• Elston MS, Sehgal S, Du Toit S, et al. Factitious Graves’ disease due to biotin immunoassay interference-A case and review of the literature. J Clin Endocrinol Metab. 2016;101(9):3251–3255.
   PubMed Web of Science ®Google Scholar
• Tabarki B, Al-Hashem A, Alfadhel M, et al. Biotin-thiamineresponsive basal ganglia disease. In: Adam MP, Ardinger HH, Pagon RA, editors. GeneReviews®. Seattle (WA): University of Washington; 2013, p. 1–12.
   Google Scholar
• Buijs MM, Gorgels JP, Endert E. Interference by antiruthenium antibodies in the Roche thyroid-stimulating hormone assay. Ann Clin Biochem. 2011;48(3):276–281.
   PubMed Web of Science ®Google Scholar
• Ohba K, Noh JY, Unno T, et al. Falsely elevated thyroid hormone levels caused by anti-ruthenium interference in the Elecsys assay resembling the syndrome of inappropriate secretion of thyrotropin. Endocr J. 2012;59(8):663–667.
   PubMed Web of Science ®Google Scholar
• Rodriguez-Borja E, Barba-Serrano E, Alfayate-Guerra R, et al. The unfinished story of interference in thyroid hormones with Roche immunoassays: when prewashing procedures matter. Clin Chem Lab Med. 2017;55:175–177.
   Web of Science ®Google Scholar
• Heil WEV. Reference ranges for adults and children: pre-analytical considerations [Internet]. Mannheim (Germany): Roche Diagnostics GmbH; 2008 [cited 2020 June 11]. https://diagnostics.roche.com/cz/cs/home.html#selectProfile
   Google Scholar
• Lam L, Kyle CV. A simple method to detect biotin interference on immunoassays. Clin Chem Lab Med. 2017;55:104–106.
   Web of Science ®Google Scholar
• Piketty ML, Prie D, Sedel F, et al. High-dose biotin therapy leading to false biochemical endocrine profiles: validation of a simple method to overcome biotin interference. Clin Chem Lab Med. 2017;55(6):817–825.
   PubMed Web of Science ®Google Scholar
• Trambas C, Lu Z, Yen T, et al. Depletion of biotin using streptavidin-coated microparticles: a validated solution to the problem of biotin interference in streptavidin-biotin immunoassays. Ann Clin Biochem. 2018;55(2):216–226.
   PubMed Web of Science ®Google Scholar
• Frame IJ, Joshi PH, Mwangi C, et al. Susceptibility of cardiac troponin assays to biotin interference. Am J Clin Pathol. 2019;151(5):486–493.
   PubMed Web of Science ®Google Scholar
• Li D, Radulescu A, Shrestha RT, et al. Association of biotin ingestion with performance of hormone and nonhormone assays in healthy adults. JAMA. 2017;318(12):1150–1160.
   PubMed Web of Science ®Google Scholar
• Mrosewski I, Urbank M, Stauch T, et al. Interference from high-dose biotin intake in immunoassays for potentially time-critical analytes by Roche: evaluation of a countermeasure for worst-case scenarios. Arch Pathol Lab Med. 2020;144(9):1108–1117.
   PubMed Web of Science ®Google Scholar
• Nguyen KQN, Langevin R, Fankhauser K, et al. Assessment of risk for interference by circulating biotin in samples received for high sensitivity troponin-T, thyrotropin, and for prostate specific antigen testing by immunoassays. Clin Lab. 2020;66:149–153.
   Web of Science ®Google Scholar
• Bayart JL, Favresse J, Melnik E, et al. Erroneous thyroid and steroid hormones profile due to anti-streptavidin antibodies. Clin Chem Lab Med. 2019;57:255–258.
   Web of Science ®Google Scholar
• Favresse J, Lardinois B, Nassogne MC, et al. Anti-streptavidin antibodies mimicking heterophilic antibodies in thyroid function tests. Clin Chem Lab Med. 2018;56:160–163.
   Web of Science ®Google Scholar
• Harsch IA, Konturek PC, Boer K, et al. Implausible elevation of peripheral thyroid hormones during therapy with a protein supplement. Clin Chem Lab Med. 2017;55:197–198.
   Web of Science ®Google Scholar
• Lam L, Bagg W, Smith G, et al. Apparent hyperthyroidism caused by biotin-like interference from IgM anti-streptavidin antibodies. Thyroid. 2018;28(8):1063–1067.
   PubMed Web of Science ®Google Scholar
• Peltier L, Massart C, Moineau MP, et al. Anti-streptavidin interferences in Roche thyroid immunoassays: a case report. Clin Chem Lab Med. 2016;54:11–14.
   Web of Science ®Google Scholar
• Rulander NJ, Cardamone D, Senior M, et al. Interference from anti-streptavidin antibody. Arch Pathol Lab Med. 2013;137(8):1141–1146.
   PubMed Web of Science ®Google Scholar
• Wouters Y, Oosterbos J, Reynaert N, et al. Alarmed by misleading interference in free T3 and free T4 assays: a new case of anti-streptavidin antibodies. Clin Chem Lab Med. 2020;58:69–71.
   PubMed Web of Science ®Google Scholar
• Sapin R, Agin A, Gasser F. Efficacy of a new blocker against anti-ruthenium antibody interference in the Elecsys free triiodothyronine assay. Clin Chem Lab Med. 2007;45(3):416–418.
   PubMed Web of Science ®Google Scholar
• Heijboer AC, Ijzerman RG, Bouman AA, et al. Two cases of antiruthenium antibody interference in modular free thyroxine assay. Ann Clin Biochem. 2009;46(3):263–264.
   PubMed Web of Science ®Google Scholar
• Suarez Rivero R, Ponce Lorenzo F, Diaz Torres J, et al. Falsely elevated thyroid-stimulating hormone value due to anti-ruthenium antibodies in a patient with primary hypothyroidism: a case report. Clin Chem Lab Med. 2017;55:273–275.
   Web of Science ®Google Scholar
• Zaninotto M, Tognon C, Venturini R, et al. Interference in thyroid hormones with Roche immunoassays: an unfinished story. Clin Chem Lab Med. 2014;52:269–270.
   Web of Science ®Google Scholar
• Gessl A, Blueml S, Bieglmayer C, et al. Anti-ruthenium antibodies mimic macro-TSH in electrochemiluminescent immunoassay. Clin Chem Lab Med. 2014;52(11):1589–1594.
   PubMed Web of Science ®Google Scholar