304
Views
2
CrossRef citations to date
0
Altmetric
Original Articles

Leukocyte differential and reactive lymphocyte counts from Sysmex XN analyzer in the evaluation of SARS-CoV-2 infection

, , , &
Pages 394-400 | Received 12 Feb 2021, Accepted 08 May 2021, Published online: 09 Jun 2021

References

  • Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497–506.
  • Aktas G. A comprehensive review on rational and effective treatment strategies against an invisible enemy; SARS Cov-2 infection. J Exp Biomed Res. 2020;3(4):293–311.
  • Siddiqi HK, Mehra MR. COVID-19 illness in native and immunosuppressed states: a clinical-therapeutic staging proposal. J Heart Lung Transplant. 2020;39(5):405–407.
  • Chen G, Wu D, Guo W, et al. Clinical and immunologic features in severe and moderate Coronavirus Disease 2019. J Clin Invest. 2020;130(5):2620–2629.
  • Luan RS, Wang X, Sun X, et al. Epidemiology, treatment, and epidemic prevention and control of the coronavirus disease 2019: a review. Sichuan Da Xue Xue Bao Yi Xue Ban. 2020;51(2):131–138.
  • Wu C, Chen X, Cai Y, et al. Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China. JAMA Intern Med. 2020;180(7):934–180943.
  • Kong J, Wang T, Di Z, et al. 1 Analysis of hematological indexes of COVID-19 patients from fever clinics in Suzhou, China. Int J Lab Hem. 2020;42(5):e204–e206.
  • Singh K, Mittal S, Gollapudi S, et al. A meta-analysis of SARS-CoV-2 patients identifies the combinatorial significance of D-dimer, C-reactive protein, lymphocyte, and neutrophil values as a predictor of disease severity. Int J Lab Hem. 2021;43(2):324–325.
  • Frater JL, Zini G, d’Onofrio G, et al. COVID-19 and the clinical hematology laboratory. Int J Lab Hematol. 2020;42(S1):11–18.
  • Fan BE, Chong VCL, Chan SSW, et al. Hematologic parameters in patients with COVID-19 infection. Am J Hematol. 2020;95(6):E131–134.
  • Lippi G, Plebani M, Henry BM. Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: a meta-analysis. Clin Chim Acta. 2020;506:145–148.
  • Rolla R, Vidali M, Puricelli C, et al. Reduced activity of B lymphocytes, recognised by Sysmex XN-2000™ haematology analyser, predicts mortality in patients with coronavirus disease 2019. Int J Lab Hem. 2021;43(1):43e5–43e8.
  • Tan L, Wang Q, Zhang D, et al. Lymphopenia predicts disease severity of COVID-19: a descriptive and predictive study. Sig Transduct Target Ther. 2020;5(1):33.
  • Zini G, Bellesi S, Ramundo F, et al. Morphological anomalies of circulating blood cells in COVID-19. Am J Hematol. 2020;95(7):870–872.
  • Foldes D, Hinton R, Arami S, et al. lymphocytes in SARS-CoV-2 infection (Covid-19). Am J Hematol. 2020;95(7):861–862.
  • Gerard D, Henry S, Thomas B. SARS-CoV-2: a new aetiology for atypical lymphocytes. Br J Haematol. 2020;189(5):845.
  • Weinberg SE, Behdad A, Ji P. Atypical lymphocytes in peripheral blood of patients with COVID-19. Br J Haematol. 2020;190(1):36–39.
  • Chong VCL, Lim KGE, Fan BE, et al. Reactive lymphocytes in patients with COVID-19. Br J Haematol. 2020;189(5):844–844.
  • Wang Z, He Y, Shu H, et al. High-fluorescent lymphocytes are increased in patients with COVID-19. Br J Haematol. 2020;190(2):e76–e78.
  • Singh A, Sood N, Narang V, et al. Morphology of COVID-19–affected cells in peripheral blood film. BMJ Case Rep. 2020;13(5):e236117.
  • Sysmex Educational Enhancement and Development. Haematology: Looking deeper into inflammatory conditions from a laboratory and clinical perspective 2018.
  • Kowalska-Kępczyńska A, Kasprzycka W, Helena Donica H. Innovative assessment practices of inflammation. European J Med Technol. 2020;1(26):1–10.
  • Li G, Fan Y, Lai Y, et al. Coronavirus infections and immune responses. J Med Virol. 2020;92(4):424–432.
  • Xu B, Fan C, Wang A, et al. Suppressed T cell-mediated immunity in patients with COVID-19: A clinical retrospective study in Wuhan. Chin J Infect. 2020;81(1):e51–e60.
  • Yip CYC, Yap ES, De Mel S, et al. Temporal changes in immune blood cell parameters in COVID-19 infection and recovery from severe infection. Br J Haematol. 2020;190(1):33–36.
  • Sun DW, Zhang D, Tian RH, et al. The underlying changes and predicting role of peripheral blood inflammatory cells in severe COVID-19 patients: a sentinel? Clin Chim Acta. 2020; 508:122–129.
  • Chan SSW, Christopher D, Tan GB, et al. Peripheral lymphocyte subset alterations in COVID-19 patients. Int J Lab Hematol. 2020;42(5):e199–e203.
  • Osman J, Lambert J, Temple M, et al. Rapid screening of COVID-19 patients using white blood cell scattergrams, a study on 381 patients. Br J Haematol. 2020;190(5):718–722.
  • Zeng F, Li L, Zeng J, et al. Can we predict the severity of coronavirus disease 2019 with a routine blood test? Pol Arch Intern Med. 2020;130:400–406.
  • Aktas G, Sit M, Dikbas O, et al. Elevated neutrophil-to-lymphocyte ratio in the diagnosis of Hashimoto's thyroiditis. Rev Assoc Med Bras. 2017;63(12):1065–1068.
  • Sit M, Aktas G, Erkol H, at al. Neutrophil to lymphocyte ratio is useful in differentiation of malign and benign thyroid nodules. Puerto Rico Health Sci J. 2019;38:60–63.
  • Duman TT, Aktas G, Atak BM, et al. Neutrophil to lymphocyte ratio as an indicative of diabetic control level in type 2 diabetes mellitus. Afr H Sci. 2019;19(1):1602–1606.
  • Aktas G, Duman TT, Burcin M, et al. Irritable bowel syndrome is associated with novel inflammatory markers derived from hemogram parameters. fmpcr. 2020;22(2):107–110.
  • Yang AP, Liu J, Tao W, et al. The diagnostic and predictive role of NLR, d-NLR and PLR in COVID-19 patients. Int Immunopharmacol. 2020;84:106504.
  • Lagunas‐Rangel FA. Neutrophil‐to‐lymphocyte ratio and lymphocyte‐to‐C‐reactive protein ratio in patients with severe coronavirus disease 2019 (COVID‐19): a meta‐analysis. J Med Virol. 2020;92(10):1733–1734.
  • Sun S, Cai X, Wang H, et al. Abnormalities of peripheral blood system in patients with COVID-19 in Wenzhou, China. Clin Chim Acta. 2020;507:174–180.
  • Linssen J, Ermens A, Berrevoets M, et al. A novel haemocytometric COVID-19 prognostic score developed and validated in an observational multicentre European hospital-based study. eLife. 2020;9:e63195.
  • Wang C, Deng R, Gou L, et al. Preliminary study to identify severe from moderate cases of COVID-19 using combined hematology parameters. Ann Transl Med. 2020;8(9):593–593.
  • Qin C, Zhou L, Hu Z, et al. Dysregulation of immune response in patients with COVID‐19 in Wuhan, China. Clin Infect Dis. 2020;71(15):762–768.
  • Chen ZE, John Wherry EJ. T cell responses in patients with COVID-19. Nat Rev Immunol. 2020;20(9):529–536.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.