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Scandinavian Journal of Clinical and Laboratory Investigation Volume 82, 2022 - Issue 7-8
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Articles

Association of ferritin and transferrin saturation with all-cause mortality, and the effect of concurrent inflammation: a danish cohort study

Nikki H. Mitchella Department of Clinical Biochemistry, Copenhagen University Hospital Hvidovre, Hvidovre, DenmarkCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-9330-9319
ORCID Icon,
Henrik L. Jørgensena Department of Clinical Biochemistry, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark
,
Fie J. Vojdemanb Department of Clinical Biochemistry, Holbaek Hospital, Holbaek, Denmark
,
Henriette P. Sennelsc Department of Clinical Biochemistry, Copenhagen University Hospital Bispebjerg and Frederiksberg, Copenhagen, Denmark
,
Christen L. Andersend The Copenhagen Primary Care Laboratory (CopLab) Database, Research Unit for General Practice and Section of General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark;e Department of Haematology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
,
Margit Kriegbaumd The Copenhagen Primary Care Laboratory (CopLab) Database, Research Unit for General Practice and Section of General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark
,
Mia K. Grandd The Copenhagen Primary Care Laboratory (CopLab) Database, Research Unit for General Practice and Section of General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark
,
Christine W. Bangd The Copenhagen Primary Care Laboratory (CopLab) Database, Research Unit for General Practice and Section of General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark
&
Bent S. Linda Department of Clinical Biochemistry, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark
 show all
Pages 525-532 | Received 03 Jul 2022, Accepted 25 Sep 2022, Published online: 11 Oct 2022

References

  • Dev S, Babitt JL. Overview of iron metabolism in health and disease. Hemodial Int. 2017;21(Suppl 1):S6–S20.
  • Cook JD, Baynes RD, Skikne BS. Iron deficiency and the measurement of iron status. Nutr Res Rev. 1992;5(1):198–202.
  • Wang W, Knovich MA, Coffman LG, et al. Serum ferritin: past, present and future. Biochim Biophys Acta. 2010;1800(8):760–769.
  • Koperdanova M, Cullis JO. Interpreting raised serum ferritin levels. BMJ. 2015;351:h3692.
  • Jacobs A, Miller F, Worwood M, et al. Ferritin in the serum of normal subjects and patients with iron deficiency and iron overload. Br Med J. 1972;4(5834):206–208.
  • Gkouvatsos K, Papanikolaou G, Pantopoulos K. Regulation of iron transport and the role of transferrin. Biochim Biophys Acta. 2012;1820(3):188–202.
  • Elsayed ME, Sharif MU, Stack AG. Transferrin saturation: a body iron biomarker. Adv Clin Chem. 2016;75:71–97.
  • World Health Organization, Centers for Disease Control and Prevention. Assessing the iron status of populations. Report of a Joint World Health Organization/Centers for Disease Control and Prevention Technical Consultation on the Assessment of Iron Status at the Population Level, Geneva, Switzerland, 6–8 April 2004, 2nd ed. Geneva: World Health Organization. 2007. ISBN 978-92-4-159610-7.
  • Lee DH, Zacharski LR, Jacobs DR. Jr. Comparison of the serum ferritin and percentage of transferrin saturation as exposure markers of iron-driven oxidative stress-related disease outcomes. Am Heart J. 2006;151(6):1247.e1–1247–e7.
  • Ellervik C, Marott JL, Tybjaerg-Hansen A, et al. Total and cause-specific mortality by moderately and markedly increased ferritin concentrations: general population study and metaanalysis. Clin Chem. 2014;60(11):1419–1428.
  • Schrage B, Rübsamen N, Schulz A, et al. Iron deficiency is a common disorder in general population and independently predicts all-cause mortality: results from the gutenberg health study. Clin Res Cardiol. 2020;109(11):1352–1357.
  • Kadoglou NPE, Biddulph JP, Rafnsson SB, et al. The association of ferritin with cardiovascular and all-cause mortality in community-dwellers: the english longitudinal study of ageing. PLoS One. 2017;12(6):e0178994.
  • Menke A, Muntner P, Fernández-Real JM, et al. The association of biomarkers of iron status with mortality in US adults. Nutr Metab Cardiovasc Dis. 2012;22(9):734–740.
  • Kim KS, Son HG, Hong NS, et al. Associations of serum ferritin and transferrin % saturation with all-cause, cancer, and cardiovascular disease mortality: Third national health and nutrition examination survey follow-up study. J Prev Med Public Health. 2012;45(3):196–203.
  • Ellervik C, Tybjaerg-Hansen A, Nordestgaard BG. Total mortality by transferrin saturation levels: two general population studies and a metaanalysis. Clin Chem. 2011;57(3):459–466.
  • Mainous AG, 3rd, Gill JM, Carek PJ. Elevated serum transferrin saturation and mortality. Ann Fam Med. 2004;2(2):133–138.
  • Stack AG, Mutwali AI, Nguyen HT, et al. Transferrin saturation ratio and risk of total and cardiovascular mortality in the general population. QJM. 2014;107(8):623–633.
  • Statistics Denmark. Population at the first day of the quarter by region, sex, age (5 years age groups), ancestry and country of origin. 2018. http://www.statbank.dk/10021.
  • Janbek J, Kriegbaum M, Grand MK, et al. The copenhagen primary care laboratory pregnancy (CopPreg) database. BMJ Open. 2020;10(5):e034318.
  • Charlson ME, Pompei P, Ales KL, et al. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40(5):373–383.
  • Lynge E, Sandegaard JL, Rebolj M. The danish national patient register. Scand J Public Health. 2011;39(7 Suppl):30–33.
  • Kelly AU, McSorley ST, Patel P, et al. Interpreting iron studies. BMJ. 2017;357:j2513.
  • Pasricha SR, Tye-Din J, Muckenthaler MU, et al. Iron deficiency. Lancet. 2021;397(10270):233–248.
  • World Health Organization. WHO guideline on use of ferritin concentrations to assess iron status in individuals and populations. Geneva: World Health Organization. 2020. ISBN 978-92-4-000012-4.
  • Hentze MW, Muckenthaler MU, Galy B, et al. Two to tango: regulation of mammalian iron metabolism. Cell. 2010;142(1):24–38.
  • Koziol JA, Ho NJ, Felitti VJ, et al. Reference centiles for serum ferritin and percentage of transferrin saturation, with application to mutations of the HFE gene. Clin Chem. 2001;47(10):1804–1810.
  • Kang W, Barad A, Clark AG, et al. Ethnic differences in iron status. Adv Nutr. 2021;12(5):1838–1853.
  • Sennels HP, Jørgensen HL, Hansen AL, et al. Diurnal variation of hematology parameters in healthy young males: the bispebjerg study of diurnal variations. Scand J Clin Lab Invest. 2011;71(7):532–541.

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