12
Views
19
CrossRef citations to date
0
Altmetric
Original Article

Determination of Phenobarbital and Phenytoin in Serum by Ultraviolet Spectrophotometry

Pages 63-69 | Received 26 Apr 1967, Published online: 28 Aug 2009

References

  • Bjerre S., Porter C. J. Simultaneous determination of barbiturates and salicylates by ultraviolet spectrophotometry. Clin. Chem. 1965; 11: 137
  • Bradford L. W., Brackett J. W. Systematic procedure for the identification of dangerous drugs, poison, and narcotics by ultraviolet spectrophotometry. Mikrochim. Acta 1958; 3: 353
  • Buchthal F., Svensmark O., Schiller P. J. Clinical and electroencephalographic correlations with serum levels of diphenylhydantoin. Arch. Neurol. (Chic.) 1960; 2: 624
  • Buchthal F., Svensmark O. Aspects of the pharmacology of phenytoin (Dilantin®) and phenobarbital relevant to their dosage in the treatment of epilepsy. Epilepsia (Amst.) 1959/60; 1: 373
  • Butler T. C., Waddell W. J. Metabolic conversion of primidone (Mysoline) to phenobarbital. Proc. Soc. exp. Biol. 1956; 93: 544
  • Butler T. C., Waddell W. J. N-methylated derivatives of barbituric acid, hydantoin and oxozolidinedione used in the treatment of epilepsy. Neurology 1958; 8: 106
  • Craig L. C., Craig D. Extraction and distribution. Technique of Organic Chemistry, A. Weissberger. Interscience, New York 1950; 3: 259
  • Dill W. A., Kazenko A., Wolf L. M., Glazko A. J. Studies on 5.5-diphenyl-hydantoin (Dilantin) in animals and man. J. Pharmacol. exp. Ther. 1956; 118: 270
  • Dybing F. Estimation of barbiturates in clinical chemistry. Scand. J. clin. Lab. Invest. 1954; 7: 114, Suppl. 20
  • van Haeringen A. De Bepaling van Barbituraten in Bloed en Urine. Pharm. Weekbl. 1962; 97: 172
  • Husby J. Delayed toxicity and serum concentrations of phenytoin. Dan. med. Bull. 1963; 10: 236
  • Jensen B. N. Trimethadione in serum of patients with petit mal epilepsy. Dan. med. Bull. 1962; 9: 74
  • Lous P. Quantitative determination of barbiturates. Acta pharmacol. (Kbh.) 1950; 6: 227
  • Lous P. Blood, serum and cerebrospinal fluid level and renal clearance of phenemal in treated epileptics. Acta pharmacol.(Kbh.) 1954; 10: 166
  • Marino V. S. Analysis of phenytoin and phenobarbitone mixtures. J. Ass. off. agric. Chem. 1965; 48: 582
  • Olesen O. V. Determination by thin-layer chromatography of phenytoin in serum in the presence of barbiturates and other antiepileptic and various drugs. Acta pharmacol.(Kbh.) 1965; 23: 41
  • Olesen O. V. A simplified method for extracting phenytoin from serum and a more sensitive staining reaction for determination by thin-layer chromatography. Acta pharmacol. (Kbh.), In press
  • Olesen O. V., Dam M. The metabolic conversion of primidone (Mysoline®) to phenobarbitone in patients under long-term treatment. Acta neurol. scand., In press.
  • Plaa G. L., Hine C. H. A method for the simultaneous determination of phenobarbital and diphenylhydantoin in blood. J. Lab. clin. Med. 1956; 47: 649
  • Remmer H. The fate of drugs in the organism. Ann. Rev. Pharmacol. 1965; 5: 405
  • Stensrud P. A., Palmer H. Serum phenytoin determinations in epileptics. Epilepsia (Amst.) 1964; 5: 364
  • Svensmark O., Kristensen P. Determination of diphenylhydantoin and phenobarbital in small amounts of serum. J. Lab. clin. Med. 1963; 61: 501
  • Svensmark O., Schiller P. J., Buchthal F. 5.5-Diphenylhydantoin (Dilantin®) blood levels after oral or intravenous dosage in man. Acta pharmacol. (Kbh.) 1960; 16: 331
  • Triedman H. M., Fishman R. A., Yahr M. D. Determination of plasma and cerebrospinal fluid levels of Dilantin in the human. Trans. Amer. neurol. Ass. 1960; 166–170
  • Tveten L. Kvantitative diphenylhydantoin bestemmelser hos pasienter med epilepsi. T. norske Lágeforen. 1963; 83: 1785
  • Wallace J., Biggs J., Dahl E. V. Determination of diphenylhydantoin by ultraviolet spectrophotometry. Analyt. Chem. 1965; 37: 410
  • Westerink D., Glerum J. H. Scheiding en Microbepaling van Fenobarbital en Fenytoine. Pharm. Weekbl. 1964; 99: 657
  • Williams R. T. Detoxication mechanisms in man. Pharm. Ther. 1962; 4: 234

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.